Amino acid dipepetide frequency for Aeromonas virus 65

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.106AlaAla: 3.106 ± 0.238
0.474AlaCys: 0.474 ± 0.078
2.689AlaAsp: 2.689 ± 0.187
2.87AlaGlu: 2.87 ± 0.215
1.797AlaPhe: 1.797 ± 0.15
3.469AlaGly: 3.469 ± 0.387
0.878AlaHis: 0.878 ± 0.117
3.594AlaIle: 3.594 ± 0.21
3.928AlaLys: 3.928 ± 0.254
3.566AlaLeu: 3.566 ± 0.229
1.964AlaMet: 1.964 ± 0.172
2.981AlaAsn: 2.981 ± 0.241
1.365AlaPro: 1.365 ± 0.175
1.546AlaGln: 1.546 ± 0.172
2.438AlaArg: 2.438 ± 0.183
3.023AlaSer: 3.023 ± 0.248
2.884AlaThr: 2.884 ± 0.29
3.037AlaVal: 3.037 ± 0.22
0.571AlaTrp: 0.571 ± 0.085
2.103AlaTyr: 2.103 ± 0.161
0.0AlaXaa: 0.0 ± 0.0
Cys
0.655CysAla: 0.655 ± 0.097
0.251CysCys: 0.251 ± 0.063
0.905CysAsp: 0.905 ± 0.124
0.864CysGlu: 0.864 ± 0.127
0.515CysPhe: 0.515 ± 0.084
1.295CysGly: 1.295 ± 0.193
0.39CysHis: 0.39 ± 0.066
0.85CysIle: 0.85 ± 0.09
0.933CysLys: 0.933 ± 0.12
0.836CysLeu: 0.836 ± 0.102
0.39CysMet: 0.39 ± 0.073
0.613CysAsn: 0.613 ± 0.092
0.641CysPro: 0.641 ± 0.101
0.223CysGln: 0.223 ± 0.048
0.557CysArg: 0.557 ± 0.087
0.85CysSer: 0.85 ± 0.118
0.641CysThr: 0.641 ± 0.103
1.087CysVal: 1.087 ± 0.121
0.251CysTrp: 0.251 ± 0.061
0.543CysTyr: 0.543 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
2.981AspAla: 2.981 ± 0.241
0.724AspCys: 0.724 ± 0.089
4.235AspAsp: 4.235 ± 0.253
4.917AspGlu: 4.917 ± 0.266
3.524AspPhe: 3.524 ± 0.224
5.28AspGly: 5.28 ± 0.288
1.282AspHis: 1.282 ± 0.139
5.349AspIle: 5.349 ± 0.285
4.235AspLys: 4.235 ± 0.294
5.572AspLeu: 5.572 ± 0.301
2.507AspMet: 2.507 ± 0.176
3.051AspAsn: 3.051 ± 0.185
2.675AspPro: 2.675 ± 0.181
1.908AspGln: 1.908 ± 0.161
2.772AspArg: 2.772 ± 0.188
4.123AspSer: 4.123 ± 0.239
3.594AspThr: 3.594 ± 0.224
5.098AspVal: 5.098 ± 0.286
1.198AspTrp: 1.198 ± 0.145
3.51AspTyr: 3.51 ± 0.245
0.0AspXaa: 0.0 ± 0.0
Glu
2.953GluAla: 2.953 ± 0.26
1.156GluCys: 1.156 ± 0.137
4.179GluAsp: 4.179 ± 0.273
4.513GluGlu: 4.513 ± 0.33
3.496GluPhe: 3.496 ± 0.25
3.037GluGly: 3.037 ± 0.203
1.463GluHis: 1.463 ± 0.149
5.544GluIle: 5.544 ± 0.287
4.75GluLys: 4.75 ± 0.324
5.976GluLeu: 5.976 ± 0.301
2.521GluMet: 2.521 ± 0.184
4.068GluAsn: 4.068 ± 0.25
1.602GluPro: 1.602 ± 0.137
2.103GluGln: 2.103 ± 0.185
2.786GluArg: 2.786 ± 0.221
4.569GluSer: 4.569 ± 0.268
3.984GluThr: 3.984 ± 0.212
4.736GluVal: 4.736 ± 0.275
1.045GluTrp: 1.045 ± 0.11
3.608GluTyr: 3.608 ± 0.221
0.0GluXaa: 0.0 ± 0.0
Phe
2.187PheAla: 2.187 ± 0.193
0.543PheCys: 0.543 ± 0.085
4.082PheAsp: 4.082 ± 0.27
3.037PheGlu: 3.037 ± 0.203
1.783PhePhe: 1.783 ± 0.142
3.232PheGly: 3.232 ± 0.206
0.919PheHis: 0.919 ± 0.118
3.329PheIle: 3.329 ± 0.212
3.483PheLys: 3.483 ± 0.232
2.619PheLeu: 2.619 ± 0.195
1.351PheMet: 1.351 ± 0.134
2.911PheAsn: 2.911 ± 0.195
1.63PhePro: 1.63 ± 0.152
1.24PheGln: 1.24 ± 0.139
1.546PheArg: 1.546 ± 0.143
3.037PheSer: 3.037 ± 0.214
2.466PheThr: 2.466 ± 0.159
3.956PheVal: 3.956 ± 0.238
0.585PheTrp: 0.585 ± 0.087
1.922PheTyr: 1.922 ± 0.147
0.0PheXaa: 0.0 ± 0.0
Gly
2.675GlyAla: 2.675 ± 0.26
0.919GlyCys: 0.919 ± 0.134
4.472GlyAsp: 4.472 ± 0.338
4.095GlyGlu: 4.095 ± 0.225
2.953GlyPhe: 2.953 ± 0.213
3.51GlyGly: 3.51 ± 0.237
1.282GlyHis: 1.282 ± 0.151
5.043GlyIle: 5.043 ± 0.262
4.569GlyLys: 4.569 ± 0.272
4.151GlyLeu: 4.151 ± 0.289
2.034GlyMet: 2.034 ± 0.172
3.733GlyAsn: 3.733 ± 0.316
1.128GlyPro: 1.128 ± 0.122
1.602GlyGln: 1.602 ± 0.179
2.716GlyArg: 2.716 ± 0.194
4.277GlySer: 4.277 ± 0.371
4.026GlyThr: 4.026 ± 0.301
5.029GlyVal: 5.029 ± 0.305
1.031GlyTrp: 1.031 ± 0.115
3.483GlyTyr: 3.483 ± 0.206
0.0GlyXaa: 0.0 ± 0.0
His
0.864HisAla: 0.864 ± 0.111
0.251HisCys: 0.251 ± 0.064
1.407HisAsp: 1.407 ± 0.157
1.435HisGlu: 1.435 ± 0.123
0.836HisPhe: 0.836 ± 0.119
1.309HisGly: 1.309 ± 0.134
0.571HisHis: 0.571 ± 0.107
1.699HisIle: 1.699 ± 0.163
1.616HisLys: 1.616 ± 0.188
1.407HisLeu: 1.407 ± 0.155
0.78HisMet: 0.78 ± 0.098
1.323HisAsn: 1.323 ± 0.139
1.087HisPro: 1.087 ± 0.128
0.822HisGln: 0.822 ± 0.098
0.683HisArg: 0.683 ± 0.107
1.212HisSer: 1.212 ± 0.127
0.961HisThr: 0.961 ± 0.131
1.435HisVal: 1.435 ± 0.136
0.279HisTrp: 0.279 ± 0.062
0.919HisTyr: 0.919 ± 0.15
0.0HisXaa: 0.0 ± 0.0
Ile
3.441IleAla: 3.441 ± 0.25
1.156IleCys: 1.156 ± 0.118
5.614IleAsp: 5.614 ± 0.31
5.642IleGlu: 5.642 ± 0.336
2.772IlePhe: 2.772 ± 0.216
4.597IleGly: 4.597 ± 0.32
1.616IleHis: 1.616 ± 0.158
4.667IleIle: 4.667 ± 0.274
5.656IleLys: 5.656 ± 0.287
5.293IleLeu: 5.293 ± 0.278
2.006IleMet: 2.006 ± 0.158
4.667IleAsn: 4.667 ± 0.262
3.051IlePro: 3.051 ± 0.206
2.549IleGln: 2.549 ± 0.16
3.886IleArg: 3.886 ± 0.204
5.363IleSer: 5.363 ± 0.305
4.527IleThr: 4.527 ± 0.254
5.335IleVal: 5.335 ± 0.287
0.71IleTrp: 0.71 ± 0.091
2.953IleTyr: 2.953 ± 0.192
0.014IleXaa: 0.014 ± 0.013
Lys
4.026LysAla: 4.026 ± 0.254
0.85LysCys: 0.85 ± 0.115
5.071LysAsp: 5.071 ± 0.269
5.502LysGlu: 5.502 ± 0.352
3.664LysPhe: 3.664 ± 0.263
3.664LysGly: 3.664 ± 0.254
1.658LysHis: 1.658 ± 0.161
5.683LysIle: 5.683 ± 0.27
5.558LysLys: 5.558 ± 0.337
5.293LysLeu: 5.293 ± 0.313
2.786LysMet: 2.786 ± 0.195
4.235LysAsn: 4.235 ± 0.262
2.326LysPro: 2.326 ± 0.197
2.201LysGln: 2.201 ± 0.158
2.856LysArg: 2.856 ± 0.23
5.28LysSer: 5.28 ± 0.286
4.068LysThr: 4.068 ± 0.229
4.764LysVal: 4.764 ± 0.198
1.087LysTrp: 1.087 ± 0.111
3.817LysTyr: 3.817 ± 0.239
0.0LysXaa: 0.0 ± 0.0
Leu
3.538LeuAla: 3.538 ± 0.243
1.017LeuCys: 1.017 ± 0.128
5.098LeuAsp: 5.098 ± 0.27
4.862LeuGlu: 4.862 ± 0.24
2.8LeuPhe: 2.8 ± 0.174
4.304LeuGly: 4.304 ± 0.222
1.56LeuHis: 1.56 ± 0.112
4.667LeuIle: 4.667 ± 0.273
5.502LeuLys: 5.502 ± 0.299
4.068LeuLeu: 4.068 ± 0.229
2.271LeuMet: 2.271 ± 0.176
4.179LeuAsn: 4.179 ± 0.268
2.382LeuPro: 2.382 ± 0.196
1.811LeuGln: 1.811 ± 0.16
2.87LeuArg: 2.87 ± 0.189
4.945LeuSer: 4.945 ± 0.244
4.388LeuThr: 4.388 ± 0.273
5.823LeuVal: 5.823 ± 0.273
0.836LeuTrp: 0.836 ± 0.11
2.981LeuTyr: 2.981 ± 0.206
0.0LeuXaa: 0.0 ± 0.0
Met
1.588MetAla: 1.588 ± 0.142
0.474MetCys: 0.474 ± 0.089
1.978MetAsp: 1.978 ± 0.158
1.908MetGlu: 1.908 ± 0.151
1.532MetPhe: 1.532 ± 0.151
1.867MetGly: 1.867 ± 0.161
0.404MetHis: 0.404 ± 0.075
2.493MetIle: 2.493 ± 0.173
3.886MetLys: 3.886 ± 0.268
2.271MetLeu: 2.271 ± 0.178
1.142MetMet: 1.142 ± 0.136
2.187MetAsn: 2.187 ± 0.177
0.585MetPro: 0.585 ± 0.091
0.78MetGln: 0.78 ± 0.114
0.989MetArg: 0.989 ± 0.106
2.145MetSer: 2.145 ± 0.17
1.867MetThr: 1.867 ± 0.158
2.689MetVal: 2.689 ± 0.199
0.334MetTrp: 0.334 ± 0.062
1.184MetTyr: 1.184 ± 0.131
0.0MetXaa: 0.0 ± 0.0
Asn
2.8AsnAla: 2.8 ± 0.22
0.697AsnCys: 0.697 ± 0.103
3.413AsnAsp: 3.413 ± 0.216
3.705AsnGlu: 3.705 ± 0.235
2.591AsnPhe: 2.591 ± 0.199
4.653AsnGly: 4.653 ± 0.331
1.351AsnHis: 1.351 ± 0.129
4.444AsnIle: 4.444 ± 0.254
4.068AsnLys: 4.068 ± 0.238
4.277AsnLeu: 4.277 ± 0.271
1.63AsnMet: 1.63 ± 0.147
2.87AsnAsn: 2.87 ± 0.237
2.493AsnPro: 2.493 ± 0.221
2.09AsnGln: 2.09 ± 0.176
2.828AsnArg: 2.828 ± 0.188
3.371AsnSer: 3.371 ± 0.183
2.925AsnThr: 2.925 ± 0.281
3.9AsnVal: 3.9 ± 0.248
0.905AsnTrp: 0.905 ± 0.11
2.507AsnTyr: 2.507 ± 0.196
0.0AsnXaa: 0.0 ± 0.0
Pro
1.393ProAla: 1.393 ± 0.161
0.362ProCys: 0.362 ± 0.077
2.521ProAsp: 2.521 ± 0.191
3.065ProGlu: 3.065 ± 0.232
1.588ProPhe: 1.588 ± 0.133
1.156ProGly: 1.156 ± 0.163
0.878ProHis: 0.878 ± 0.119
2.02ProIle: 2.02 ± 0.15
2.076ProLys: 2.076 ± 0.167
1.908ProLeu: 1.908 ± 0.191
0.933ProMet: 0.933 ± 0.115
2.48ProAsn: 2.48 ± 0.201
0.627ProPro: 0.627 ± 0.091
0.975ProGln: 0.975 ± 0.148
1.184ProArg: 1.184 ± 0.122
2.647ProSer: 2.647 ± 0.183
2.187ProThr: 2.187 ± 0.209
2.312ProVal: 2.312 ± 0.171
0.474ProTrp: 0.474 ± 0.078
1.686ProTyr: 1.686 ± 0.14
0.0ProXaa: 0.0 ± 0.0
Gln
1.574GlnAla: 1.574 ± 0.175
0.167GlnCys: 0.167 ± 0.053
1.588GlnAsp: 1.588 ± 0.16
2.131GlnGlu: 2.131 ± 0.176
1.602GlnPhe: 1.602 ± 0.145
1.407GlnGly: 1.407 ± 0.177
0.432GlnHis: 0.432 ± 0.084
2.675GlnIle: 2.675 ± 0.199
1.992GlnLys: 1.992 ± 0.15
2.493GlnLeu: 2.493 ± 0.21
0.933GlnMet: 0.933 ± 0.1
1.518GlnAsn: 1.518 ± 0.16
0.947GlnPro: 0.947 ± 0.133
0.864GlnGln: 0.864 ± 0.124
1.463GlnArg: 1.463 ± 0.134
1.727GlnSer: 1.727 ± 0.137
1.755GlnThr: 1.755 ± 0.189
2.076GlnVal: 2.076 ± 0.198
0.488GlnTrp: 0.488 ± 0.084
1.783GlnTyr: 1.783 ± 0.139
0.0GlnXaa: 0.0 ± 0.0
Arg
2.159ArgAla: 2.159 ± 0.199
0.488ArgCys: 0.488 ± 0.083
2.884ArgAsp: 2.884 ± 0.224
3.009ArgGlu: 3.009 ± 0.187
2.173ArgPhe: 2.173 ± 0.153
2.842ArgGly: 2.842 ± 0.185
0.655ArgHis: 0.655 ± 0.102
3.524ArgIle: 3.524 ± 0.24
3.037ArgLys: 3.037 ± 0.191
3.079ArgLeu: 3.079 ± 0.193
1.156ArgMet: 1.156 ± 0.131
2.159ArgAsn: 2.159 ± 0.178
0.933ArgPro: 0.933 ± 0.108
1.337ArgGln: 1.337 ± 0.141
1.825ArgArg: 1.825 ± 0.157
3.009ArgSer: 3.009 ± 0.204
2.173ArgThr: 2.173 ± 0.163
3.079ArgVal: 3.079 ± 0.227
0.738ArgTrp: 0.738 ± 0.094
2.187ArgTyr: 2.187 ± 0.169
0.0ArgXaa: 0.0 ± 0.0
Ser
3.106SerAla: 3.106 ± 0.247
0.933SerCys: 0.933 ± 0.112
4.611SerAsp: 4.611 ± 0.264
4.137SerGlu: 4.137 ± 0.29
2.953SerPhe: 2.953 ± 0.19
5.266SerGly: 5.266 ± 0.341
1.142SerHis: 1.142 ± 0.111
5.293SerIle: 5.293 ± 0.29
4.931SerLys: 4.931 ± 0.297
4.806SerLeu: 4.806 ± 0.257
2.257SerMet: 2.257 ± 0.158
3.455SerAsn: 3.455 ± 0.229
2.271SerPro: 2.271 ± 0.167
2.02SerGln: 2.02 ± 0.16
2.897SerArg: 2.897 ± 0.224
4.277SerSer: 4.277 ± 0.289
3.594SerThr: 3.594 ± 0.31
4.653SerVal: 4.653 ± 0.254
0.919SerTrp: 0.919 ± 0.106
3.218SerTyr: 3.218 ± 0.192
0.0SerXaa: 0.0 ± 0.0
Thr
2.828ThrAla: 2.828 ± 0.344
0.71ThrCys: 0.71 ± 0.103
3.483ThrAsp: 3.483 ± 0.225
3.106ThrGlu: 3.106 ± 0.177
2.521ThrPhe: 2.521 ± 0.181
3.984ThrGly: 3.984 ± 0.344
1.574ThrHis: 1.574 ± 0.135
4.221ThrIle: 4.221 ± 0.257
4.137ThrLys: 4.137 ± 0.233
4.179ThrLeu: 4.179 ± 0.25
1.449ThrMet: 1.449 ± 0.129
3.329ThrAsn: 3.329 ± 0.248
2.814ThrPro: 2.814 ± 0.233
1.936ThrGln: 1.936 ± 0.194
2.187ThrArg: 2.187 ± 0.201
3.705ThrSer: 3.705 ± 0.269
3.385ThrThr: 3.385 ± 0.306
4.165ThrVal: 4.165 ± 0.275
0.724ThrTrp: 0.724 ± 0.103
2.41ThrTyr: 2.41 ± 0.205
0.0ThrXaa: 0.0 ± 0.0
Val
3.427ValAla: 3.427 ± 0.259
1.142ValCys: 1.142 ± 0.144
5.28ValAsp: 5.28 ± 0.258
5.628ValGlu: 5.628 ± 0.316
3.483ValPhe: 3.483 ± 0.229
4.221ValGly: 4.221 ± 0.28
1.477ValHis: 1.477 ± 0.137
5.447ValIle: 5.447 ± 0.275
5.405ValLys: 5.405 ± 0.255
4.402ValLeu: 4.402 ± 0.233
2.257ValMet: 2.257 ± 0.188
3.914ValAsn: 3.914 ± 0.274
2.09ValPro: 2.09 ± 0.182
1.755ValGln: 1.755 ± 0.146
3.232ValArg: 3.232 ± 0.214
5.433ValSer: 5.433 ± 0.269
4.068ValThr: 4.068 ± 0.24
5.6ValVal: 5.6 ± 0.262
1.17ValTrp: 1.17 ± 0.123
3.636ValTyr: 3.636 ± 0.236
0.0ValXaa: 0.0 ± 0.0
Trp
0.738TrpAla: 0.738 ± 0.105
0.348TrpCys: 0.348 ± 0.066
1.24TrpAsp: 1.24 ± 0.131
0.766TrpGlu: 0.766 ± 0.1
0.794TrpPhe: 0.794 ± 0.103
0.738TrpGly: 0.738 ± 0.109
0.32TrpHis: 0.32 ± 0.077
1.114TrpIle: 1.114 ± 0.127
1.226TrpLys: 1.226 ± 0.134
0.85TrpLeu: 0.85 ± 0.106
0.446TrpMet: 0.446 ± 0.073
0.864TrpAsn: 0.864 ± 0.099
0.279TrpPro: 0.279 ± 0.062
0.39TrpGln: 0.39 ± 0.07
0.571TrpArg: 0.571 ± 0.096
0.766TrpSer: 0.766 ± 0.098
0.599TrpThr: 0.599 ± 0.098
1.323TrpVal: 1.323 ± 0.143
0.223TrpTrp: 0.223 ± 0.054
0.627TrpTyr: 0.627 ± 0.09
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.243TyrAla: 2.243 ± 0.182
0.627TyrCys: 0.627 ± 0.085
3.789TyrAsp: 3.789 ± 0.221
2.897TyrGlu: 2.897 ± 0.206
2.48TyrPhe: 2.48 ± 0.17
2.897TyrGly: 2.897 ± 0.225
1.045TyrHis: 1.045 ± 0.122
3.859TyrIle: 3.859 ± 0.202
3.399TyrLys: 3.399 ± 0.22
2.856TyrLeu: 2.856 ± 0.211
1.477TyrMet: 1.477 ± 0.141
2.981TyrAsn: 2.981 ± 0.221
1.546TyrPro: 1.546 ± 0.164
1.463TyrGln: 1.463 ± 0.146
2.159TyrArg: 2.159 ± 0.179
2.995TyrSer: 2.995 ± 0.181
2.758TyrThr: 2.758 ± 0.216
2.967TyrVal: 2.967 ± 0.211
0.641TyrTrp: 0.641 ± 0.1
2.201TyrTyr: 2.201 ± 0.158
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.014XaaTrp: 0.014 ± 0.013
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 437 proteins (71788 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski