Amino acid dipepetide frequency for Vibrio phage Rostov 7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.279AlaAla: 10.279 ± 2.447
0.629AlaCys: 0.629 ± 0.267
4.93AlaAsp: 4.93 ± 0.533
6.188AlaGlu: 6.188 ± 0.764
3.356AlaPhe: 3.356 ± 0.491
5.874AlaGly: 5.874 ± 1.05
0.524AlaHis: 0.524 ± 0.31
3.776AlaIle: 3.776 ± 0.613
5.14AlaLys: 5.14 ± 0.691
7.552AlaLeu: 7.552 ± 0.884
2.832AlaMet: 2.832 ± 0.921
3.356AlaAsn: 3.356 ± 0.717
3.147AlaPro: 3.147 ± 0.63
3.042AlaGln: 3.042 ± 0.798
3.461AlaArg: 3.461 ± 0.488
6.188AlaSer: 6.188 ± 0.959
4.405AlaThr: 4.405 ± 0.938
5.874AlaVal: 5.874 ± 0.865
1.993AlaTrp: 1.993 ± 0.516
1.678AlaTyr: 1.678 ± 0.332
0.0AlaXaa: 0.0 ± 0.0
Cys
1.364CysAla: 1.364 ± 0.462
0.21CysCys: 0.21 ± 0.155
0.629CysAsp: 0.629 ± 0.309
0.629CysGlu: 0.629 ± 0.249
0.42CysPhe: 0.42 ± 0.17
1.364CysGly: 1.364 ± 0.36
0.105CysHis: 0.105 ± 0.092
0.524CysIle: 0.524 ± 0.244
0.629CysLys: 0.629 ± 0.263
0.629CysLeu: 0.629 ± 0.24
0.21CysMet: 0.21 ± 0.133
0.734CysAsn: 0.734 ± 0.255
0.629CysPro: 0.629 ± 0.303
0.734CysGln: 0.734 ± 0.257
0.524CysArg: 0.524 ± 0.216
0.734CysSer: 0.734 ± 0.351
0.21CysThr: 0.21 ± 0.13
0.42CysVal: 0.42 ± 0.222
0.105CysTrp: 0.105 ± 0.118
0.21CysTyr: 0.21 ± 0.138
0.0CysXaa: 0.0 ± 0.0
Asp
5.035AspAla: 5.035 ± 0.807
0.734AspCys: 0.734 ± 0.288
3.461AspAsp: 3.461 ± 0.748
4.72AspGlu: 4.72 ± 0.669
1.573AspPhe: 1.573 ± 0.343
4.93AspGly: 4.93 ± 0.599
1.364AspHis: 1.364 ± 0.347
4.196AspIle: 4.196 ± 0.721
3.881AspLys: 3.881 ± 0.651
6.503AspLeu: 6.503 ± 1.005
0.839AspMet: 0.839 ± 0.295
2.727AspAsn: 2.727 ± 0.549
3.147AspPro: 3.147 ± 0.809
3.042AspGln: 3.042 ± 0.585
2.727AspArg: 2.727 ± 0.551
3.671AspSer: 3.671 ± 0.593
1.888AspThr: 1.888 ± 0.501
4.3AspVal: 4.3 ± 0.817
1.364AspTrp: 1.364 ± 0.417
1.888AspTyr: 1.888 ± 0.454
0.0AspXaa: 0.0 ± 0.0
Glu
5.349GluAla: 5.349 ± 0.711
0.734GluCys: 0.734 ± 0.291
3.356GluAsp: 3.356 ± 0.736
3.881GluGlu: 3.881 ± 0.745
3.671GluPhe: 3.671 ± 0.676
4.405GluGly: 4.405 ± 0.683
0.839GluHis: 0.839 ± 0.3
4.405GluIle: 4.405 ± 0.661
4.091GluLys: 4.091 ± 0.8
6.818GluLeu: 6.818 ± 1.035
1.993GluMet: 1.993 ± 0.525
2.203GluAsn: 2.203 ± 0.393
1.468GluPro: 1.468 ± 0.459
3.986GluGln: 3.986 ± 0.558
3.252GluArg: 3.252 ± 0.53
4.51GluSer: 4.51 ± 0.784
3.461GluThr: 3.461 ± 0.558
4.405GluVal: 4.405 ± 0.86
1.783GluTrp: 1.783 ± 0.449
3.042GluTyr: 3.042 ± 0.58
0.0GluXaa: 0.0 ± 0.0
Phe
2.622PheAla: 2.622 ± 0.52
0.524PheCys: 0.524 ± 0.25
2.832PheAsp: 2.832 ± 0.59
3.671PheGlu: 3.671 ± 0.546
0.944PhePhe: 0.944 ± 0.306
3.147PheGly: 3.147 ± 0.465
0.629PheHis: 0.629 ± 0.319
2.412PheIle: 2.412 ± 0.61
2.727PheLys: 2.727 ± 0.574
1.993PheLeu: 1.993 ± 0.356
0.944PheMet: 0.944 ± 0.303
1.678PheAsn: 1.678 ± 0.442
1.049PhePro: 1.049 ± 0.271
0.734PheGln: 0.734 ± 0.282
1.154PheArg: 1.154 ± 0.379
3.252PheSer: 3.252 ± 0.666
2.622PheThr: 2.622 ± 0.386
2.727PheVal: 2.727 ± 0.53
0.944PheTrp: 0.944 ± 0.268
0.839PheTyr: 0.839 ± 0.26
0.0PheXaa: 0.0 ± 0.0
Gly
5.559GlyAla: 5.559 ± 1.064
0.839GlyCys: 0.839 ± 0.337
4.51GlyAsp: 4.51 ± 0.665
5.244GlyGlu: 5.244 ± 0.773
3.461GlyPhe: 3.461 ± 0.527
4.51GlyGly: 4.51 ± 0.605
0.944GlyHis: 0.944 ± 0.286
3.566GlyIle: 3.566 ± 0.537
4.51GlyLys: 4.51 ± 0.657
4.615GlyLeu: 4.615 ± 0.639
1.364GlyMet: 1.364 ± 0.458
3.776GlyAsn: 3.776 ± 0.68
1.678GlyPro: 1.678 ± 0.389
2.937GlyGln: 2.937 ± 0.607
3.986GlyArg: 3.986 ± 0.622
5.244GlySer: 5.244 ± 0.949
3.881GlyThr: 3.881 ± 0.791
4.615GlyVal: 4.615 ± 0.873
1.678GlyTrp: 1.678 ± 0.319
3.356GlyTyr: 3.356 ± 0.558
0.0GlyXaa: 0.0 ± 0.0
His
0.944HisAla: 0.944 ± 0.35
0.42HisCys: 0.42 ± 0.188
1.049HisAsp: 1.049 ± 0.353
0.944HisGlu: 0.944 ± 0.356
0.944HisPhe: 0.944 ± 0.343
1.364HisGly: 1.364 ± 0.41
0.629HisHis: 0.629 ± 0.263
1.259HisIle: 1.259 ± 0.4
1.154HisLys: 1.154 ± 0.438
1.049HisLeu: 1.049 ± 0.248
0.315HisMet: 0.315 ± 0.163
0.42HisAsn: 0.42 ± 0.192
0.839HisPro: 0.839 ± 0.28
0.839HisGln: 0.839 ± 0.333
0.629HisArg: 0.629 ± 0.239
1.049HisSer: 1.049 ± 0.35
1.154HisThr: 1.154 ± 0.382
1.154HisVal: 1.154 ± 0.312
0.21HisTrp: 0.21 ± 0.151
0.21HisTyr: 0.21 ± 0.144
0.0HisXaa: 0.0 ± 0.0
Ile
6.293IleAla: 6.293 ± 0.845
0.839IleCys: 0.839 ± 0.267
5.874IleAsp: 5.874 ± 0.918
5.035IleGlu: 5.035 ± 0.955
1.259IlePhe: 1.259 ± 0.325
3.252IleGly: 3.252 ± 0.636
0.944IleHis: 0.944 ± 0.306
3.042IleIle: 3.042 ± 0.624
3.776IleLys: 3.776 ± 0.664
3.986IleLeu: 3.986 ± 0.689
1.259IleMet: 1.259 ± 0.377
3.881IleAsn: 3.881 ± 0.65
2.203IlePro: 2.203 ± 0.626
2.098IleGln: 2.098 ± 0.4
3.252IleArg: 3.252 ± 0.514
4.93IleSer: 4.93 ± 0.818
3.776IleThr: 3.776 ± 0.559
2.937IleVal: 2.937 ± 0.773
0.839IleTrp: 0.839 ± 0.304
2.203IleTyr: 2.203 ± 0.633
0.0IleXaa: 0.0 ± 0.0
Lys
5.035LysAla: 5.035 ± 0.833
0.42LysCys: 0.42 ± 0.185
3.881LysAsp: 3.881 ± 0.615
3.566LysGlu: 3.566 ± 0.61
2.622LysPhe: 2.622 ± 0.578
3.881LysGly: 3.881 ± 0.809
1.259LysHis: 1.259 ± 0.352
4.091LysIle: 4.091 ± 0.848
5.559LysLys: 5.559 ± 1.054
5.14LysLeu: 5.14 ± 0.764
2.203LysMet: 2.203 ± 0.467
2.832LysAsn: 2.832 ± 0.608
3.356LysPro: 3.356 ± 0.596
3.776LysGln: 3.776 ± 0.594
4.51LysArg: 4.51 ± 0.604
5.035LysSer: 5.035 ± 0.737
4.091LysThr: 4.091 ± 0.756
5.349LysVal: 5.349 ± 0.747
0.839LysTrp: 0.839 ± 0.345
2.098LysTyr: 2.098 ± 0.44
0.0LysXaa: 0.0 ± 0.0
Leu
7.762LeuAla: 7.762 ± 0.943
0.944LeuCys: 0.944 ± 0.346
5.244LeuAsp: 5.244 ± 0.772
4.825LeuGlu: 4.825 ± 0.764
3.356LeuPhe: 3.356 ± 0.526
6.608LeuGly: 6.608 ± 1.127
1.154LeuHis: 1.154 ± 0.404
4.825LeuIle: 4.825 ± 0.763
6.188LeuLys: 6.188 ± 0.828
6.293LeuLeu: 6.293 ± 0.771
1.678LeuMet: 1.678 ± 0.401
3.461LeuAsn: 3.461 ± 0.543
3.671LeuPro: 3.671 ± 0.754
2.832LeuGln: 2.832 ± 0.529
4.091LeuArg: 4.091 ± 0.649
5.454LeuSer: 5.454 ± 0.857
5.14LeuThr: 5.14 ± 0.615
4.51LeuVal: 4.51 ± 0.674
1.049LeuTrp: 1.049 ± 0.308
2.203LeuTyr: 2.203 ± 0.485
0.0LeuXaa: 0.0 ± 0.0
Met
2.412MetAla: 2.412 ± 0.84
0.42MetCys: 0.42 ± 0.17
0.839MetAsp: 0.839 ± 0.254
0.524MetGlu: 0.524 ± 0.238
1.049MetPhe: 1.049 ± 0.318
2.098MetGly: 2.098 ± 0.555
0.0MetHis: 0.0 ± 0.0
1.259MetIle: 1.259 ± 0.311
2.098MetLys: 2.098 ± 0.556
2.937MetLeu: 2.937 ± 0.515
0.524MetMet: 0.524 ± 0.271
1.468MetAsn: 1.468 ± 0.378
1.259MetPro: 1.259 ± 0.404
0.629MetGln: 0.629 ± 0.321
0.944MetArg: 0.944 ± 0.192
1.049MetSer: 1.049 ± 0.356
1.573MetThr: 1.573 ± 0.383
1.678MetVal: 1.678 ± 0.432
0.21MetTrp: 0.21 ± 0.218
0.524MetTyr: 0.524 ± 0.259
0.0MetXaa: 0.0 ± 0.0
Asn
3.042AsnAla: 3.042 ± 0.704
0.524AsnCys: 0.524 ± 0.2
1.259AsnAsp: 1.259 ± 0.316
1.993AsnGlu: 1.993 ± 0.475
2.203AsnPhe: 2.203 ± 0.538
4.196AsnGly: 4.196 ± 0.589
1.049AsnHis: 1.049 ± 0.366
3.147AsnIle: 3.147 ± 0.561
3.042AsnLys: 3.042 ± 0.546
3.671AsnLeu: 3.671 ± 0.498
1.154AsnMet: 1.154 ± 0.358
2.517AsnAsn: 2.517 ± 0.533
2.832AsnPro: 2.832 ± 0.488
2.098AsnGln: 2.098 ± 0.533
2.727AsnArg: 2.727 ± 0.608
1.888AsnSer: 1.888 ± 0.441
3.042AsnThr: 3.042 ± 0.613
2.937AsnVal: 2.937 ± 0.485
1.259AsnTrp: 1.259 ± 0.372
1.259AsnTyr: 1.259 ± 0.412
0.0AsnXaa: 0.0 ± 0.0
Pro
2.832ProAla: 2.832 ± 0.526
0.524ProCys: 0.524 ± 0.3
3.042ProAsp: 3.042 ± 0.57
3.671ProGlu: 3.671 ± 0.642
1.259ProPhe: 1.259 ± 0.27
2.412ProGly: 2.412 ± 0.436
0.21ProHis: 0.21 ± 0.134
2.203ProIle: 2.203 ± 0.458
2.412ProLys: 2.412 ± 0.507
2.937ProLeu: 2.937 ± 0.462
1.259ProMet: 1.259 ± 0.364
1.783ProAsn: 1.783 ± 0.366
0.524ProPro: 0.524 ± 0.193
1.259ProGln: 1.259 ± 0.373
1.783ProArg: 1.783 ± 0.446
3.042ProSer: 3.042 ± 0.59
2.832ProThr: 2.832 ± 0.564
2.412ProVal: 2.412 ± 0.545
0.629ProTrp: 0.629 ± 0.303
1.154ProTyr: 1.154 ± 0.354
0.0ProXaa: 0.0 ± 0.0
Gln
4.196GlnAla: 4.196 ± 1.053
0.105GlnCys: 0.105 ± 0.118
2.308GlnAsp: 2.308 ± 0.549
2.203GlnGlu: 2.203 ± 0.491
1.154GlnPhe: 1.154 ± 0.334
1.888GlnGly: 1.888 ± 0.532
0.839GlnHis: 0.839 ± 0.251
3.042GlnIle: 3.042 ± 0.58
3.042GlnLys: 3.042 ± 0.646
4.405GlnLeu: 4.405 ± 0.679
0.944GlnMet: 0.944 ± 0.294
2.098GlnAsn: 2.098 ± 0.422
1.154GlnPro: 1.154 ± 0.32
2.832GlnGln: 2.832 ± 0.608
2.832GlnArg: 2.832 ± 0.323
2.412GlnSer: 2.412 ± 0.554
2.098GlnThr: 2.098 ± 0.442
2.832GlnVal: 2.832 ± 0.598
0.734GlnTrp: 0.734 ± 0.254
0.944GlnTyr: 0.944 ± 0.33
0.0GlnXaa: 0.0 ± 0.0
Arg
4.3ArgAla: 4.3 ± 0.79
0.315ArgCys: 0.315 ± 0.164
2.937ArgAsp: 2.937 ± 0.611
3.986ArgGlu: 3.986 ± 0.625
1.468ArgPhe: 1.468 ± 0.365
3.252ArgGly: 3.252 ± 0.552
0.629ArgHis: 0.629 ± 0.278
3.252ArgIle: 3.252 ± 0.591
2.622ArgLys: 2.622 ± 0.576
5.244ArgLeu: 5.244 ± 0.588
1.468ArgMet: 1.468 ± 0.391
2.098ArgAsn: 2.098 ± 0.534
1.364ArgPro: 1.364 ± 0.46
2.203ArgGln: 2.203 ± 0.484
2.727ArgArg: 2.727 ± 0.561
1.993ArgSer: 1.993 ± 0.413
3.042ArgThr: 3.042 ± 0.549
3.461ArgVal: 3.461 ± 0.52
0.734ArgTrp: 0.734 ± 0.319
2.412ArgTyr: 2.412 ± 0.617
0.0ArgXaa: 0.0 ± 0.0
Ser
4.72SerAla: 4.72 ± 0.875
0.734SerCys: 0.734 ± 0.316
4.091SerAsp: 4.091 ± 0.563
5.14SerGlu: 5.14 ± 0.818
1.678SerPhe: 1.678 ± 0.36
5.559SerGly: 5.559 ± 0.831
1.573SerHis: 1.573 ± 0.298
5.664SerIle: 5.664 ± 0.976
5.664SerLys: 5.664 ± 0.701
5.035SerLeu: 5.035 ± 0.697
1.364SerMet: 1.364 ± 0.387
3.356SerAsn: 3.356 ± 0.656
2.203SerPro: 2.203 ± 0.436
2.517SerGln: 2.517 ± 0.579
2.622SerArg: 2.622 ± 0.553
5.14SerSer: 5.14 ± 0.831
3.042SerThr: 3.042 ± 0.51
3.986SerVal: 3.986 ± 0.649
1.049SerTrp: 1.049 ± 0.318
1.573SerTyr: 1.573 ± 0.458
0.0SerXaa: 0.0 ± 0.0
Thr
5.664ThrAla: 5.664 ± 0.933
0.629ThrCys: 0.629 ± 0.277
3.566ThrAsp: 3.566 ± 0.637
3.986ThrGlu: 3.986 ± 0.663
2.517ThrPhe: 2.517 ± 0.562
4.405ThrGly: 4.405 ± 0.678
1.259ThrHis: 1.259 ± 0.389
3.461ThrIle: 3.461 ± 0.603
3.776ThrLys: 3.776 ± 0.638
3.671ThrLeu: 3.671 ± 0.675
1.259ThrMet: 1.259 ± 0.395
1.678ThrAsn: 1.678 ± 0.403
3.252ThrPro: 3.252 ± 0.436
1.993ThrGln: 1.993 ± 0.518
2.727ThrArg: 2.727 ± 0.757
3.147ThrSer: 3.147 ± 0.575
3.042ThrThr: 3.042 ± 0.58
4.196ThrVal: 4.196 ± 0.906
0.734ThrTrp: 0.734 ± 0.233
1.888ThrTyr: 1.888 ± 0.442
0.0ThrXaa: 0.0 ± 0.0
Val
4.091ValAla: 4.091 ± 0.667
0.42ValCys: 0.42 ± 0.2
4.93ValAsp: 4.93 ± 0.76
3.881ValGlu: 3.881 ± 0.743
2.098ValPhe: 2.098 ± 0.415
4.615ValGly: 4.615 ± 0.504
1.364ValHis: 1.364 ± 0.448
4.615ValIle: 4.615 ± 0.825
5.664ValLys: 5.664 ± 0.68
4.405ValLeu: 4.405 ± 0.9
1.049ValMet: 1.049 ± 0.302
3.986ValAsn: 3.986 ± 0.59
3.252ValPro: 3.252 ± 0.562
2.622ValGln: 2.622 ± 0.545
2.622ValArg: 2.622 ± 0.501
4.615ValSer: 4.615 ± 0.796
4.3ValThr: 4.3 ± 0.867
5.035ValVal: 5.035 ± 0.715
0.839ValTrp: 0.839 ± 0.256
2.098ValTyr: 2.098 ± 0.486
0.0ValXaa: 0.0 ± 0.0
Trp
1.049TrpAla: 1.049 ± 0.226
0.524TrpCys: 0.524 ± 0.279
1.259TrpAsp: 1.259 ± 0.325
1.049TrpGlu: 1.049 ± 0.298
1.049TrpPhe: 1.049 ± 0.374
1.364TrpGly: 1.364 ± 0.438
0.315TrpHis: 0.315 ± 0.174
0.944TrpIle: 0.944 ± 0.263
1.468TrpLys: 1.468 ± 0.471
1.888TrpLeu: 1.888 ± 0.453
0.42TrpMet: 0.42 ± 0.18
0.524TrpAsn: 0.524 ± 0.227
0.21TrpPro: 0.21 ± 0.166
0.839TrpGln: 0.839 ± 0.294
1.154TrpArg: 1.154 ± 0.365
0.944TrpSer: 0.944 ± 0.268
1.259TrpThr: 1.259 ± 0.448
1.154TrpVal: 1.154 ± 0.359
0.21TrpTrp: 0.21 ± 0.149
0.42TrpTyr: 0.42 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.678TyrAla: 1.678 ± 0.505
0.524TyrCys: 0.524 ± 0.206
1.993TyrAsp: 1.993 ± 0.544
2.517TyrGlu: 2.517 ± 0.523
1.364TyrPhe: 1.364 ± 0.321
1.259TyrGly: 1.259 ± 0.336
0.944TyrHis: 0.944 ± 0.268
1.993TyrIle: 1.993 ± 0.474
2.098TyrLys: 2.098 ± 0.373
2.517TyrLeu: 2.517 ± 0.525
0.315TyrMet: 0.315 ± 0.154
1.259TyrAsn: 1.259 ± 0.357
0.944TyrPro: 0.944 ± 0.422
1.049TyrGln: 1.049 ± 0.339
1.783TyrArg: 1.783 ± 0.41
2.412TyrSer: 2.412 ± 0.461
1.993TyrThr: 1.993 ± 0.375
2.517TyrVal: 2.517 ± 0.609
0.839TyrTrp: 0.839 ± 0.336
1.154TyrTyr: 1.154 ± 0.428
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 35 proteins (9535 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski