Amino acid dipepetide frequency for Nitrosomonas mobilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.797AlaAla: 9.797 ± 0.144
1.094AlaCys: 1.094 ± 0.036
4.832AlaAsp: 4.832 ± 0.072
5.531AlaGlu: 5.531 ± 0.097
3.408AlaPhe: 3.408 ± 0.065
7.024AlaGly: 7.024 ± 0.105
2.149AlaHis: 2.149 ± 0.052
6.329AlaIle: 6.329 ± 0.098
3.842AlaLys: 3.842 ± 0.085
10.326AlaLeu: 10.326 ± 0.105
2.599AlaMet: 2.599 ± 0.066
3.316AlaAsn: 3.316 ± 0.065
3.133AlaPro: 3.133 ± 0.06
4.078AlaGln: 4.078 ± 0.069
5.628AlaArg: 5.628 ± 0.097
5.283AlaSer: 5.283 ± 0.074
4.771AlaThr: 4.771 ± 0.081
6.333AlaVal: 6.333 ± 0.103
1.226AlaTrp: 1.226 ± 0.039
2.414AlaTyr: 2.414 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.917CysAla: 0.917 ± 0.034
0.164CysCys: 0.164 ± 0.015
0.568CysAsp: 0.568 ± 0.027
0.563CysGlu: 0.563 ± 0.027
0.458CysPhe: 0.458 ± 0.023
0.932CysGly: 0.932 ± 0.037
0.416CysHis: 0.416 ± 0.028
0.549CysIle: 0.549 ± 0.024
0.384CysLys: 0.384 ± 0.022
1.073CysLeu: 1.073 ± 0.036
0.248CysMet: 0.248 ± 0.017
0.372CysAsn: 0.372 ± 0.021
0.517CysPro: 0.517 ± 0.024
0.474CysGln: 0.474 ± 0.024
0.665CysArg: 0.665 ± 0.027
0.674CysSer: 0.674 ± 0.025
0.526CysThr: 0.526 ± 0.025
0.674CysVal: 0.674 ± 0.029
0.15CysTrp: 0.15 ± 0.013
0.339CysTyr: 0.339 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.567AspAla: 4.567 ± 0.073
0.581AspCys: 0.581 ± 0.027
2.623AspAsp: 2.623 ± 0.063
3.442AspGlu: 3.442 ± 0.068
2.474AspPhe: 2.474 ± 0.061
3.638AspGly: 3.638 ± 0.072
1.275AspHis: 1.275 ± 0.039
3.391AspIle: 3.391 ± 0.07
2.55AspLys: 2.55 ± 0.059
5.163AspLeu: 5.163 ± 0.091
1.266AspMet: 1.266 ± 0.038
2.056AspAsn: 2.056 ± 0.07
2.453AspPro: 2.453 ± 0.059
2.141AspGln: 2.141 ± 0.05
2.916AspArg: 2.916 ± 0.064
2.96AspSer: 2.96 ± 0.061
2.75AspThr: 2.75 ± 0.064
3.18AspVal: 3.18 ± 0.065
0.891AspTrp: 0.891 ± 0.034
1.761AspTyr: 1.761 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.436GluAla: 5.436 ± 0.091
0.503GluCys: 0.503 ± 0.022
2.477GluAsp: 2.477 ± 0.058
3.085GluGlu: 3.085 ± 0.081
2.216GluPhe: 2.216 ± 0.049
3.153GluGly: 3.153 ± 0.066
1.415GluHis: 1.415 ± 0.045
4.623GluIle: 4.623 ± 0.082
3.289GluLys: 3.289 ± 0.069
5.976GluLeu: 5.976 ± 0.09
1.582GluMet: 1.582 ± 0.037
2.609GluAsn: 2.609 ± 0.053
1.988GluPro: 1.988 ± 0.054
3.153GluGln: 3.153 ± 0.072
3.744GluArg: 3.744 ± 0.079
3.372GluSer: 3.372 ± 0.06
3.357GluThr: 3.357 ± 0.061
3.5GluVal: 3.5 ± 0.069
0.748GluTrp: 0.748 ± 0.033
1.498GluTyr: 1.498 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.657PheAla: 3.657 ± 0.065
0.518PheCys: 0.518 ± 0.027
2.563PheAsp: 2.563 ± 0.064
2.349PheGlu: 2.349 ± 0.055
1.929PhePhe: 1.929 ± 0.048
3.022PheGly: 3.022 ± 0.059
0.903PheHis: 0.903 ± 0.029
2.438PheIle: 2.438 ± 0.059
1.541PheLys: 1.541 ± 0.038
3.911PheLeu: 3.911 ± 0.078
0.974PheMet: 0.974 ± 0.035
1.706PheAsn: 1.706 ± 0.046
1.756PhePro: 1.756 ± 0.044
1.412PheGln: 1.412 ± 0.044
2.067PheArg: 2.067 ± 0.052
3.219PheSer: 3.219 ± 0.066
2.245PheThr: 2.245 ± 0.057
2.608PheVal: 2.608 ± 0.06
0.549PheTrp: 0.549 ± 0.031
1.313PheTyr: 1.313 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
5.459GlyAla: 5.459 ± 0.101
0.927GlyCys: 0.927 ± 0.042
3.324GlyAsp: 3.324 ± 0.071
4.099GlyGlu: 4.099 ± 0.074
3.191GlyPhe: 3.191 ± 0.063
4.946GlyGly: 4.946 ± 0.102
1.754GlyHis: 1.754 ± 0.048
4.96GlyIle: 4.96 ± 0.084
4.015GlyLys: 4.015 ± 0.081
7.344GlyLeu: 7.344 ± 0.107
2.068GlyMet: 2.068 ± 0.05
2.7GlyAsn: 2.7 ± 0.064
1.773GlyPro: 1.773 ± 0.049
2.727GlyGln: 2.727 ± 0.051
3.997GlyArg: 3.997 ± 0.071
4.103GlySer: 4.103 ± 0.072
3.602GlyThr: 3.602 ± 0.068
5.035GlyVal: 5.035 ± 0.096
1.048GlyTrp: 1.048 ± 0.039
2.315GlyTyr: 2.315 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.424HisAla: 2.424 ± 0.063
0.308HisCys: 0.308 ± 0.018
1.251HisAsp: 1.251 ± 0.041
1.357HisGlu: 1.357 ± 0.039
1.129HisPhe: 1.129 ± 0.042
1.928HisGly: 1.928 ± 0.057
0.895HisHis: 0.895 ± 0.034
1.499HisIle: 1.499 ± 0.045
0.998HisLys: 0.998 ± 0.041
2.512HisLeu: 2.512 ± 0.056
0.532HisMet: 0.532 ± 0.022
0.894HisAsn: 0.894 ± 0.029
1.491HisPro: 1.491 ± 0.043
1.129HisGln: 1.129 ± 0.033
1.38HisArg: 1.38 ± 0.041
1.426HisSer: 1.426 ± 0.038
1.327HisThr: 1.327 ± 0.038
1.455HisVal: 1.455 ± 0.043
0.317HisTrp: 0.317 ± 0.02
0.873HisTyr: 0.873 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.438IleAla: 6.438 ± 0.094
0.659IleCys: 0.659 ± 0.031
3.983IleAsp: 3.983 ± 0.072
4.326IleGlu: 4.326 ± 0.078
2.636IlePhe: 2.636 ± 0.059
4.865IleGly: 4.865 ± 0.081
1.473IleHis: 1.473 ± 0.045
3.868IleIle: 3.868 ± 0.078
2.963IleLys: 2.963 ± 0.064
6.129IleLeu: 6.129 ± 0.093
1.425IleMet: 1.425 ± 0.041
2.897IleAsn: 2.897 ± 0.055
3.053IlePro: 3.053 ± 0.059
2.42IleGln: 2.42 ± 0.057
3.86IleArg: 3.86 ± 0.067
4.148IleSer: 4.148 ± 0.061
3.643IleThr: 3.643 ± 0.079
4.232IleVal: 4.232 ± 0.082
0.724IleTrp: 0.724 ± 0.032
1.764IleTyr: 1.764 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
3.595LysAla: 3.595 ± 0.079
0.307LysCys: 0.307 ± 0.017
1.973LysAsp: 1.973 ± 0.051
2.367LysGlu: 2.367 ± 0.06
1.448LysPhe: 1.448 ± 0.041
2.494LysGly: 2.494 ± 0.059
1.203LysHis: 1.203 ± 0.038
3.252LysIle: 3.252 ± 0.064
2.49LysLys: 2.49 ± 0.071
5.004LysLeu: 5.004 ± 0.078
1.221LysMet: 1.221 ± 0.041
2.157LysAsn: 2.157 ± 0.059
2.136LysPro: 2.136 ± 0.053
2.459LysGln: 2.459 ± 0.059
2.798LysArg: 2.798 ± 0.057
2.723LysSer: 2.723 ± 0.06
2.878LysThr: 2.878 ± 0.061
2.719LysVal: 2.719 ± 0.053
0.529LysTrp: 0.529 ± 0.024
1.183LysTyr: 1.183 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
11.037LeuAla: 11.037 ± 0.142
1.143LeuCys: 1.143 ± 0.037
5.916LeuAsp: 5.916 ± 0.09
5.768LeuGlu: 5.768 ± 0.091
4.087LeuPhe: 4.087 ± 0.075
7.087LeuGly: 7.087 ± 0.108
2.536LeuHis: 2.536 ± 0.059
6.657LeuIle: 6.657 ± 0.091
4.712LeuLys: 4.712 ± 0.069
12.444LeuLeu: 12.444 ± 0.219
2.61LeuMet: 2.61 ± 0.05
3.879LeuAsn: 3.879 ± 0.069
5.588LeuPro: 5.588 ± 0.093
4.69LeuGln: 4.69 ± 0.09
6.389LeuArg: 6.389 ± 0.099
7.167LeuSer: 7.167 ± 0.107
6.145LeuThr: 6.145 ± 0.093
6.824LeuVal: 6.824 ± 0.1
1.193LeuTrp: 1.193 ± 0.05
2.543LeuTyr: 2.543 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.434MetAla: 2.434 ± 0.056
0.179MetCys: 0.179 ± 0.014
1.102MetAsp: 1.102 ± 0.031
1.382MetGlu: 1.382 ± 0.039
0.743MetPhe: 0.743 ± 0.029
1.613MetGly: 1.613 ± 0.039
0.608MetHis: 0.608 ± 0.025
1.568MetIle: 1.568 ± 0.043
1.249MetLys: 1.249 ± 0.039
3.047MetLeu: 3.047 ± 0.059
0.661MetMet: 0.661 ± 0.033
1.101MetAsn: 1.101 ± 0.036
1.324MetPro: 1.324 ± 0.038
1.288MetGln: 1.288 ± 0.043
1.521MetArg: 1.521 ± 0.04
1.497MetSer: 1.497 ± 0.041
1.623MetThr: 1.623 ± 0.044
1.723MetVal: 1.723 ± 0.045
0.189MetTrp: 0.189 ± 0.014
0.405MetTyr: 0.405 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.315AsnAla: 3.315 ± 0.074
0.423AsnCys: 0.423 ± 0.025
1.879AsnAsp: 1.879 ± 0.053
2.055AsnGlu: 2.055 ± 0.05
1.667AsnPhe: 1.667 ± 0.045
2.639AsnGly: 2.639 ± 0.059
1.023AsnHis: 1.023 ± 0.034
2.576AsnIle: 2.576 ± 0.061
1.681AsnLys: 1.681 ± 0.052
4.17AsnLeu: 4.17 ± 0.067
0.879AsnMet: 0.879 ± 0.035
1.639AsnAsn: 1.639 ± 0.07
2.159AsnPro: 2.159 ± 0.055
1.902AsnGln: 1.902 ± 0.049
2.317AsnArg: 2.317 ± 0.059
2.262AsnSer: 2.262 ± 0.097
2.126AsnThr: 2.126 ± 0.055
2.207AsnVal: 2.207 ± 0.056
0.58AsnTrp: 0.58 ± 0.024
1.145AsnTyr: 1.145 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
4.239ProAla: 4.239 ± 0.074
0.405ProCys: 0.405 ± 0.024
3.023ProAsp: 3.023 ± 0.066
3.191ProGlu: 3.191 ± 0.06
1.776ProPhe: 1.776 ± 0.051
3.327ProGly: 3.327 ± 0.068
1.01ProHis: 1.01 ± 0.034
2.485ProIle: 2.485 ± 0.054
1.547ProLys: 1.547 ± 0.042
4.507ProLeu: 4.507 ± 0.069
0.94ProMet: 0.94 ± 0.032
1.494ProAsn: 1.494 ± 0.041
1.932ProPro: 1.932 ± 0.065
1.778ProGln: 1.778 ± 0.047
2.056ProArg: 2.056 ± 0.052
2.397ProSer: 2.397 ± 0.051
2.067ProThr: 2.067 ± 0.048
3.792ProVal: 3.792 ± 0.069
0.588ProTrp: 0.588 ± 0.029
1.238ProTyr: 1.238 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
4.567GlnAla: 4.567 ± 0.073
0.393GlnCys: 0.393 ± 0.023
1.936GlnAsp: 1.936 ± 0.048
2.346GlnGlu: 2.346 ± 0.055
1.704GlnPhe: 1.704 ± 0.045
2.737GlnGly: 2.737 ± 0.059
1.344GlnHis: 1.344 ± 0.039
2.979GlnIle: 2.979 ± 0.061
2.017GlnLys: 2.017 ± 0.055
4.839GlnLeu: 4.839 ± 0.091
1.037GlnMet: 1.037 ± 0.034
1.62GlnAsn: 1.62 ± 0.052
2.102GlnPro: 2.102 ± 0.052
2.776GlnGln: 2.776 ± 0.08
2.651GlnArg: 2.651 ± 0.056
2.611GlnSer: 2.611 ± 0.058
2.47GlnThr: 2.47 ± 0.055
2.768GlnVal: 2.768 ± 0.054
0.595GlnTrp: 0.595 ± 0.026
1.176GlnTyr: 1.176 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
4.841ArgAla: 4.841 ± 0.089
0.617ArgCys: 0.617 ± 0.029
2.982ArgAsp: 2.982 ± 0.062
3.823ArgGlu: 3.823 ± 0.068
2.63ArgPhe: 2.63 ± 0.053
3.332ArgGly: 3.332 ± 0.064
1.679ArgHis: 1.679 ± 0.047
4.146ArgIle: 4.146 ± 0.069
2.79ArgLys: 2.79 ± 0.059
6.726ArgLeu: 6.726 ± 0.117
1.608ArgMet: 1.608 ± 0.043
2.367ArgAsn: 2.367 ± 0.058
2.222ArgPro: 2.222 ± 0.048
3.001ArgGln: 3.001 ± 0.063
3.461ArgArg: 3.461 ± 0.074
3.234ArgSer: 3.234 ± 0.064
2.681ArgThr: 2.681 ± 0.062
3.537ArgVal: 3.537 ± 0.076
0.957ArgTrp: 0.957 ± 0.033
2.026ArgTyr: 2.026 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.398SerAla: 5.398 ± 0.074
0.719SerCys: 0.719 ± 0.029
3.195SerAsp: 3.195 ± 0.075
3.267SerGlu: 3.267 ± 0.054
2.498SerPhe: 2.498 ± 0.059
5.268SerGly: 5.268 ± 0.087
1.486SerHis: 1.486 ± 0.041
3.951SerIle: 3.951 ± 0.062
2.511SerLys: 2.511 ± 0.059
6.633SerLeu: 6.633 ± 0.107
1.627SerMet: 1.627 ± 0.046
2.261SerAsn: 2.261 ± 0.066
2.614SerPro: 2.614 ± 0.059
2.406SerGln: 2.406 ± 0.061
3.517SerArg: 3.517 ± 0.058
3.814SerSer: 3.814 ± 0.078
3.183SerThr: 3.183 ± 0.058
3.95SerVal: 3.95 ± 0.07
0.757SerTrp: 0.757 ± 0.031
1.581SerTyr: 1.581 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.165ThrAla: 5.165 ± 0.077
0.548ThrCys: 0.548 ± 0.026
2.887ThrAsp: 2.887 ± 0.059
2.954ThrGlu: 2.954 ± 0.061
2.103ThrPhe: 2.103 ± 0.051
4.52ThrGly: 4.52 ± 0.082
1.382ThrHis: 1.382 ± 0.038
3.443ThrIle: 3.443 ± 0.065
1.869ThrLys: 1.869 ± 0.049
6.395ThrLeu: 6.395 ± 0.09
1.151ThrMet: 1.151 ± 0.034
1.761ThrAsn: 1.761 ± 0.044
2.805ThrPro: 2.805 ± 0.057
2.272ThrGln: 2.272 ± 0.05
3.077ThrArg: 3.077 ± 0.062
3.211ThrSer: 3.211 ± 0.067
2.942ThrThr: 2.942 ± 0.063
3.809ThrVal: 3.809 ± 0.08
0.582ThrTrp: 0.582 ± 0.031
1.313ThrTyr: 1.313 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
6.377ValAla: 6.377 ± 0.105
0.673ValCys: 0.673 ± 0.027
3.623ValAsp: 3.623 ± 0.069
3.797ValGlu: 3.797 ± 0.064
2.688ValPhe: 2.688 ± 0.061
4.149ValGly: 4.149 ± 0.081
1.393ValHis: 1.393 ± 0.042
4.611ValIle: 4.611 ± 0.081
2.902ValLys: 2.902 ± 0.065
6.927ValLeu: 6.927 ± 0.118
1.898ValMet: 1.898 ± 0.05
2.493ValAsn: 2.493 ± 0.056
2.802ValPro: 2.802 ± 0.061
2.201ValGln: 2.201 ± 0.054
3.648ValArg: 3.648 ± 0.076
4.25ValSer: 4.25 ± 0.071
3.93ValThr: 3.93 ± 0.068
4.779ValVal: 4.779 ± 0.089
0.756ValTrp: 0.756 ± 0.028
1.684ValTyr: 1.684 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.851TrpAla: 0.851 ± 0.035
0.159TrpCys: 0.159 ± 0.014
0.513TrpAsp: 0.513 ± 0.026
0.628TrpGlu: 0.628 ± 0.025
0.568TrpPhe: 0.568 ± 0.033
0.739TrpGly: 0.739 ± 0.033
0.379TrpHis: 0.379 ± 0.02
0.787TrpIle: 0.787 ± 0.032
0.576TrpLys: 0.576 ± 0.024
1.927TrpLeu: 1.927 ± 0.063
0.386TrpMet: 0.386 ± 0.02
0.445TrpAsn: 0.445 ± 0.025
0.533TrpPro: 0.533 ± 0.026
0.875TrpGln: 0.875 ± 0.037
0.988TrpArg: 0.988 ± 0.032
0.68TrpSer: 0.68 ± 0.029
0.551TrpThr: 0.551 ± 0.023
0.868TrpVal: 0.868 ± 0.03
0.214TrpTrp: 0.214 ± 0.018
0.374TrpTyr: 0.374 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.596TyrAla: 2.596 ± 0.063
0.344TyrCys: 0.344 ± 0.021
1.427TyrAsp: 1.427 ± 0.041
1.395TyrGlu: 1.395 ± 0.041
1.328TyrPhe: 1.328 ± 0.045
1.976TyrGly: 1.976 ± 0.049
0.8TyrHis: 0.8 ± 0.028
1.397TyrIle: 1.397 ± 0.043
1.009TyrLys: 1.009 ± 0.037
3.363TyrLeu: 3.363 ± 0.067
0.543TyrMet: 0.543 ± 0.025
0.877TyrAsn: 0.877 ± 0.038
1.412TyrPro: 1.412 ± 0.045
1.484TyrGln: 1.484 ± 0.042
1.981TyrArg: 1.981 ± 0.051
1.605TyrSer: 1.605 ± 0.049
1.372TyrThr: 1.372 ± 0.034
1.585TyrVal: 1.585 ± 0.044
0.448TyrTrp: 0.448 ± 0.021
0.958TyrTyr: 0.958 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3034 proteins (867340 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski