Amino acid dipepetide frequency for Penicillium camemberti FM 013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.161AlaAla: 8.161 ± 0.059	1.138AlaCys: 1.138 ± 0.02	4.106AlaAsp: 4.106 ± 0.028	4.884AlaGlu: 4.884 ± 0.035	3.157AlaPhe: 3.157 ± 0.025	5.519AlaGly: 5.519 ± 0.035	1.789AlaHis: 1.789 ± 0.019	4.406AlaIle: 4.406 ± 0.03	3.77AlaLys: 3.77 ± 0.035	7.65AlaLeu: 7.65 ± 0.04	1.987AlaMet: 1.987 ± 0.02	2.924AlaAsn: 2.924 ± 0.028	4.588AlaPro: 4.588 ± 0.039	3.269AlaGln: 3.269 ± 0.028	4.64AlaArg: 4.64 ± 0.029	7.017AlaSer: 7.017 ± 0.048	5.15AlaThr: 5.15 ± 0.037	5.216AlaVal: 5.216 ± 0.032	1.157AlaTrp: 1.157 ± 0.018	2.128AlaTyr: 2.128 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.006CysAla: 1.006 ± 0.016	0.279CysCys: 0.279 ± 0.007	0.74CysAsp: 0.74 ± 0.012	0.638CysGlu: 0.638 ± 0.011	0.592CysPhe: 0.592 ± 0.009	0.982CysGly: 0.982 ± 0.014	0.379CysHis: 0.379 ± 0.009	0.782CysIle: 0.782 ± 0.011	0.508CysLys: 0.508 ± 0.011	1.377CysLeu: 1.377 ± 0.016	0.295CysMet: 0.295 ± 0.007	0.462CysAsn: 0.462 ± 0.009	0.694CysPro: 0.694 ± 0.012	0.513CysGln: 0.513 ± 0.011	0.816CysArg: 0.816 ± 0.015	1.0CysSer: 1.0 ± 0.015	0.768CysThr: 0.768 ± 0.019	0.86CysVal: 0.86 ± 0.013	0.222CysTrp: 0.222 ± 0.006	0.386CysTyr: 0.386 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.361AspAla: 4.361 ± 0.031	0.666AspCys: 0.666 ± 0.012	3.801AspAsp: 3.801 ± 0.034	4.194AspGlu: 4.194 ± 0.031	2.165AspPhe: 2.165 ± 0.018	3.807AspGly: 3.807 ± 0.028	1.361AspHis: 1.361 ± 0.016	3.265AspIle: 3.265 ± 0.028	2.259AspLys: 2.259 ± 0.028	5.205AspLeu: 5.205 ± 0.031	1.286AspMet: 1.286 ± 0.014	1.942AspAsn: 1.942 ± 0.019	3.377AspPro: 3.377 ± 0.029	2.045AspGln: 2.045 ± 0.015	3.072AspArg: 3.072 ± 0.028	4.213AspSer: 4.213 ± 0.027	3.069AspThr: 3.069 ± 0.024	3.52AspVal: 3.52 ± 0.026	0.907AspTrp: 0.907 ± 0.013	1.587AspTyr: 1.587 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.016GluAla: 5.016 ± 0.038	0.676GluCys: 0.676 ± 0.011	4.018GluAsp: 4.018 ± 0.032	5.048GluGlu: 5.048 ± 0.047	1.999GluPhe: 1.999 ± 0.021	3.568GluGly: 3.568 ± 0.028	1.431GluHis: 1.431 ± 0.015	3.252GluIle: 3.252 ± 0.027	3.451GluLys: 3.451 ± 0.03	5.12GluLeu: 5.12 ± 0.031	1.493GluMet: 1.493 ± 0.02	2.393GluAsn: 2.393 ± 0.022	2.825GluPro: 2.825 ± 0.039	2.445GluGln: 2.445 ± 0.022	3.707GluArg: 3.707 ± 0.03	4.491GluSer: 4.491 ± 0.031	3.659GluThr: 3.659 ± 0.028	3.438GluVal: 3.438 ± 0.026	0.89GluTrp: 0.89 ± 0.012	1.701GluTyr: 1.701 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.071PheAla: 3.071 ± 0.024	0.613PheCys: 0.613 ± 0.011	2.328PheAsp: 2.328 ± 0.019	2.183PheGlu: 2.183 ± 0.022	1.735PhePhe: 1.735 ± 0.022	2.895PheGly: 2.895 ± 0.027	0.971PheHis: 0.971 ± 0.013	1.963PheIle: 1.963 ± 0.021	1.481PheLys: 1.481 ± 0.017	3.646PheLeu: 3.646 ± 0.03	0.857PheMet: 0.857 ± 0.012	1.499PheAsn: 1.499 ± 0.015	2.067PhePro: 2.067 ± 0.019	1.489PheGln: 1.489 ± 0.018	1.968PheArg: 1.968 ± 0.019	3.066PheSer: 3.066 ± 0.022	2.192PheThr: 2.192 ± 0.02	2.441PheVal: 2.441 ± 0.022	0.68PheTrp: 0.68 ± 0.011	1.159PheTyr: 1.159 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.111GlyAla: 5.111 ± 0.038	0.937GlyCys: 0.937 ± 0.014	3.495GlyAsp: 3.495 ± 0.023	3.444GlyGlu: 3.444 ± 0.028	2.88GlyPhe: 2.88 ± 0.024	5.23GlyGly: 5.23 ± 0.049	1.744GlyHis: 1.744 ± 0.024	3.727GlyIle: 3.727 ± 0.027	3.191GlyLys: 3.191 ± 0.027	6.193GlyLeu: 6.193 ± 0.035	1.6GlyMet: 1.6 ± 0.019	2.552GlyAsn: 2.552 ± 0.021	3.324GlyPro: 3.324 ± 0.029	2.558GlyGln: 2.558 ± 0.03	3.871GlyArg: 3.871 ± 0.03	5.714GlySer: 5.714 ± 0.044	3.927GlyThr: 3.927 ± 0.029	4.32GlyVal: 4.32 ± 0.029	1.177GlyTrp: 1.177 ± 0.015	2.157GlyTyr: 2.157 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.838HisAla: 1.838 ± 0.019	0.38HisCys: 0.38 ± 0.012	1.333HisAsp: 1.333 ± 0.015	1.382HisGlu: 1.382 ± 0.016	0.967HisPhe: 0.967 ± 0.012	1.763HisGly: 1.763 ± 0.019	0.823HisHis: 0.823 ± 0.015	1.33HisIle: 1.33 ± 0.015	0.91HisLys: 0.91 ± 0.013	2.379HisLeu: 2.379 ± 0.025	0.546HisMet: 0.546 ± 0.009	0.912HisAsn: 0.912 ± 0.012	1.694HisPro: 1.694 ± 0.017	1.022HisGln: 1.022 ± 0.014	1.624HisArg: 1.624 ± 0.018	1.959HisSer: 1.959 ± 0.019	1.372HisThr: 1.372 ± 0.015	1.461HisVal: 1.461 ± 0.018	0.381HisTrp: 0.381 ± 0.008	0.716HisTyr: 0.716 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.361IleAla: 4.361 ± 0.031	0.874IleCys: 0.874 ± 0.013	2.969IleAsp: 2.969 ± 0.023	2.971IleGlu: 2.971 ± 0.022	2.182IlePhe: 2.182 ± 0.02	3.421IleGly: 3.421 ± 0.031	1.308IleHis: 1.308 ± 0.016	2.74IleIle: 2.74 ± 0.022	2.15IleLys: 2.15 ± 0.022	4.879IleLeu: 4.879 ± 0.035	1.121IleMet: 1.121 ± 0.014	1.883IleAsn: 1.883 ± 0.016	3.32IlePro: 3.32 ± 0.025	2.086IleGln: 2.086 ± 0.021	2.851IleArg: 2.851 ± 0.027	4.191IleSer: 4.191 ± 0.028	2.968IleThr: 2.968 ± 0.026	3.28IleVal: 3.28 ± 0.028	0.81IleTrp: 0.81 ± 0.015	1.532IleTyr: 1.532 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.888LysAla: 3.888 ± 0.04	0.539LysCys: 0.539 ± 0.011	2.638LysAsp: 2.638 ± 0.021	3.156LysGlu: 3.156 ± 0.026	1.458LysPhe: 1.458 ± 0.016	2.786LysGly: 2.786 ± 0.026	1.095LysHis: 1.095 ± 0.013	2.26LysIle: 2.26 ± 0.021	2.978LysLys: 2.978 ± 0.055	3.894LysLeu: 3.894 ± 0.028	1.029LysMet: 1.029 ± 0.02	1.734LysAsn: 1.734 ± 0.022	2.608LysPro: 2.608 ± 0.026	1.791LysGln: 1.791 ± 0.02	3.187LysArg: 3.187 ± 0.025	3.524LysSer: 3.524 ± 0.025	2.768LysThr: 2.768 ± 0.031	2.696LysVal: 2.696 ± 0.023	0.691LysTrp: 0.691 ± 0.011	1.348LysTyr: 1.348 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.767LeuAla: 7.767 ± 0.042	1.309LeuCys: 1.309 ± 0.017	5.264LeuAsp: 5.264 ± 0.031	5.565LeuGlu: 5.565 ± 0.036	3.518LeuPhe: 3.518 ± 0.027	6.102LeuGly: 6.102 ± 0.04	2.339LeuHis: 2.339 ± 0.021	4.199LeuIle: 4.199 ± 0.034	4.05LeuLys: 4.05 ± 0.032	8.657LeuLeu: 8.657 ± 0.06	1.897LeuMet: 1.897 ± 0.018	3.304LeuAsn: 3.304 ± 0.028	5.469LeuPro: 5.469 ± 0.031	3.966LeuGln: 3.966 ± 0.031	5.73LeuArg: 5.73 ± 0.035	7.56LeuSer: 7.56 ± 0.044	4.807LeuThr: 4.807 ± 0.029	5.543LeuVal: 5.543 ± 0.042	1.268LeuTrp: 1.268 ± 0.016	2.457LeuTyr: 2.457 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.217MetAla: 2.217 ± 0.017	0.271MetCys: 0.271 ± 0.006	1.297MetAsp: 1.297 ± 0.017	1.336MetGlu: 1.336 ± 0.016	0.811MetPhe: 0.811 ± 0.013	1.543MetGly: 1.543 ± 0.017	0.519MetHis: 0.519 ± 0.011	1.119MetIle: 1.119 ± 0.013	1.033MetLys: 1.033 ± 0.019	1.917MetLeu: 1.917 ± 0.018	0.601MetMet: 0.601 ± 0.01	0.856MetAsn: 0.856 ± 0.011	1.274MetPro: 1.274 ± 0.018	0.908MetGln: 0.908 ± 0.013	1.269MetArg: 1.269 ± 0.015	1.987MetSer: 1.987 ± 0.019	1.372MetThr: 1.372 ± 0.015	1.404MetVal: 1.404 ± 0.017	0.281MetTrp: 0.281 ± 0.007	0.526MetTyr: 0.526 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.084AsnAla: 3.084 ± 0.026	0.502AsnCys: 0.502 ± 0.009	1.991AsnAsp: 1.991 ± 0.024	2.106AsnGlu: 2.106 ± 0.02	1.411AsnPhe: 1.411 ± 0.015	2.864AsnGly: 2.864 ± 0.029	0.923AsnHis: 0.923 ± 0.014	2.184AsnIle: 2.184 ± 0.019	1.545AsnLys: 1.545 ± 0.018	3.366AsnLeu: 3.366 ± 0.027	0.905AsnMet: 0.905 ± 0.011	1.484AsnAsn: 1.484 ± 0.018	2.613AsnPro: 2.613 ± 0.022	1.431AsnGln: 1.431 ± 0.018	1.984AsnArg: 1.984 ± 0.018	2.834AsnSer: 2.834 ± 0.023	2.321AsnThr: 2.321 ± 0.027	2.329AsnVal: 2.329 ± 0.018	0.596AsnTrp: 0.596 ± 0.011	1.097AsnTyr: 1.097 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.979ProAla: 4.979 ± 0.044	0.61ProCys: 0.61 ± 0.011	3.209ProAsp: 3.209 ± 0.023	3.881ProGlu: 3.881 ± 0.036	2.154ProPhe: 2.154 ± 0.025	3.818ProGly: 3.818 ± 0.037	1.373ProHis: 1.373 ± 0.018	2.734ProIle: 2.734 ± 0.021	2.557ProLys: 2.557 ± 0.024	4.796ProLeu: 4.796 ± 0.031	1.17ProMet: 1.17 ± 0.015	2.273ProAsn: 2.273 ± 0.02	4.503ProPro: 4.503 ± 0.059	2.444ProGln: 2.444 ± 0.029	3.422ProArg: 3.422 ± 0.033	5.988ProSer: 5.988 ± 0.05	4.111ProThr: 4.111 ± 0.038	3.608ProVal: 3.608 ± 0.028	0.794ProTrp: 0.794 ± 0.014	1.497ProTyr: 1.497 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.346GlnAla: 3.346 ± 0.028	0.494GlnCys: 0.494 ± 0.011	2.089GlnAsp: 2.089 ± 0.021	2.403GlnGlu: 2.403 ± 0.022	1.376GlnPhe: 1.376 ± 0.015	2.442GlnGly: 2.442 ± 0.023	1.087GlnHis: 1.087 ± 0.014	2.039GlnIle: 2.039 ± 0.019	1.997GlnLys: 1.997 ± 0.024	3.518GlnLeu: 3.518 ± 0.03	0.945GlnMet: 0.945 ± 0.013	1.678GlnAsn: 1.678 ± 0.027	2.546GlnPro: 2.546 ± 0.032	2.139GlnGln: 2.139 ± 0.036	2.575GlnArg: 2.575 ± 0.023	3.321GlnSer: 3.321 ± 0.027	2.457GlnThr: 2.457 ± 0.022	2.232GlnVal: 2.232 ± 0.019	0.627GlnTrp: 0.627 ± 0.01	1.209GlnTyr: 1.209 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.481ArgAla: 4.481 ± 0.031	0.76ArgCys: 0.76 ± 0.013	3.298ArgAsp: 3.298 ± 0.03	3.637ArgGlu: 3.637 ± 0.03	2.182ArgPhe: 2.182 ± 0.021	3.668ArgGly: 3.668 ± 0.034	1.558ArgHis: 1.558 ± 0.018	2.93ArgIle: 2.93 ± 0.026	3.255ArgLys: 3.255 ± 0.025	5.488ArgLeu: 5.488 ± 0.033	1.316ArgMet: 1.316 ± 0.015	2.227ArgAsn: 2.227 ± 0.02	3.39ArgPro: 3.39 ± 0.035	2.543ArgGln: 2.543 ± 0.023	4.769ArgArg: 4.769 ± 0.043	4.783ArgSer: 4.783 ± 0.04	3.238ArgThr: 3.238 ± 0.024	3.401ArgVal: 3.401 ± 0.024	0.962ArgTrp: 0.962 ± 0.014	1.656ArgTyr: 1.656 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.544SerAla: 6.544 ± 0.042	0.956SerCys: 0.956 ± 0.014	4.366SerAsp: 4.366 ± 0.033	4.332SerGlu: 4.332 ± 0.03	3.132SerPhe: 3.132 ± 0.024	5.533SerGly: 5.533 ± 0.04	2.087SerHis: 2.087 ± 0.02	4.247SerIle: 4.247 ± 0.028	3.655SerLys: 3.655 ± 0.026	7.539SerLeu: 7.539 ± 0.041	1.812SerMet: 1.812 ± 0.019	3.15SerAsn: 3.15 ± 0.027	5.56SerPro: 5.56 ± 0.052	3.412SerGln: 3.412 ± 0.026	4.932SerArg: 4.932 ± 0.04	8.589SerSer: 8.589 ± 0.078	5.765SerThr: 5.765 ± 0.043	4.761SerVal: 4.761 ± 0.029	1.202SerTrp: 1.202 ± 0.014	2.124SerTyr: 2.124 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	5.066ThrAla: 5.066 ± 0.037	0.795ThrCys: 0.795 ± 0.014	2.964ThrAsp: 2.964 ± 0.024	3.365ThrGlu: 3.365 ± 0.025	2.256ThrPhe: 2.256 ± 0.018	4.185ThrGly: 4.185 ± 0.03	1.362ThrHis: 1.362 ± 0.016	3.22ThrIle: 3.22 ± 0.024	2.63ThrLys: 2.63 ± 0.029	5.354ThrLeu: 5.354 ± 0.032	1.26ThrMet: 1.26 ± 0.015	2.174ThrAsn: 2.174 ± 0.021	4.328ThrPro: 4.328 ± 0.041	2.27ThrGln: 2.27 ± 0.027	3.192ThrArg: 3.192 ± 0.024	5.366ThrSer: 5.366 ± 0.04	4.285ThrThr: 4.285 ± 0.046	3.778ThrVal: 3.778 ± 0.029	0.875ThrTrp: 0.875 ± 0.013	1.625ThrTyr: 1.625 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.076ValAla: 5.076 ± 0.032	0.87ValCys: 0.87 ± 0.013	3.694ValAsp: 3.694 ± 0.027	3.705ValGlu: 3.705 ± 0.032	2.544ValPhe: 2.544 ± 0.024	3.986ValGly: 3.986 ± 0.03	1.474ValHis: 1.474 ± 0.015	3.164ValIle: 3.164 ± 0.025	2.713ValLys: 2.713 ± 0.025	5.63ValLeu: 5.63 ± 0.041	1.373ValMet: 1.373 ± 0.014	2.309ValAsn: 2.309 ± 0.025	3.549ValPro: 3.549 ± 0.025	2.456ValGln: 2.456 ± 0.022	3.3ValArg: 3.3 ± 0.024	4.804ValSer: 4.804 ± 0.033	3.512ValThr: 3.512 ± 0.029	4.193ValVal: 4.193 ± 0.034	0.874ValTrp: 0.874 ± 0.012	1.746ValTyr: 1.746 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.162TrpAla: 1.162 ± 0.015	0.202TrpCys: 0.202 ± 0.006	0.895TrpAsp: 0.895 ± 0.015	0.862TrpGlu: 0.862 ± 0.011	0.556TrpPhe: 0.556 ± 0.01	0.956TrpGly: 0.956 ± 0.015	0.37TrpHis: 0.37 ± 0.009	0.847TrpIle: 0.847 ± 0.011	0.85TrpLys: 0.85 ± 0.013	1.418TrpLeu: 1.418 ± 0.017	0.399TrpMet: 0.399 ± 0.009	0.686TrpAsn: 0.686 ± 0.011	0.63TrpPro: 0.63 ± 0.01	0.577TrpGln: 0.577 ± 0.009	0.968TrpArg: 0.968 ± 0.014	1.143TrpSer: 1.143 ± 0.016	0.949TrpThr: 0.949 ± 0.015	0.917TrpVal: 0.917 ± 0.013	0.301TrpTrp: 0.301 ± 0.008	0.466TrpTyr: 0.466 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.12TyrAla: 2.12 ± 0.02	0.426TyrCys: 0.426 ± 0.009	1.607TyrAsp: 1.607 ± 0.019	1.53TyrGlu: 1.53 ± 0.018	1.23TyrPhe: 1.23 ± 0.016	2.083TyrGly: 2.083 ± 0.022	0.801TyrHis: 0.801 ± 0.011	1.49TyrIle: 1.49 ± 0.017	1.086TyrLys: 1.086 ± 0.013	2.742TyrLeu: 2.742 ± 0.022	0.652TyrMet: 0.652 ± 0.011	1.129TyrAsn: 1.129 ± 0.014	1.56TyrPro: 1.56 ± 0.018	1.158TyrGln: 1.158 ± 0.013	1.662TyrArg: 1.662 ± 0.018	2.15TyrSer: 2.15 ± 0.019	1.659TyrThr: 1.659 ± 0.018	1.578TyrVal: 1.578 ± 0.016	0.457TyrTrp: 0.457 ± 0.009	0.952TyrTyr: 0.952 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 14390 proteins (6205998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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