Amino acid dipepetide frequency for Lactobacillus vaccinostercus DSM 20634

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.698AlaAla: 7.698 ± 0.142
0.435AlaCys: 0.435 ± 0.024
4.917AlaAsp: 4.917 ± 0.096
3.973AlaGlu: 3.973 ± 0.089
3.227AlaPhe: 3.227 ± 0.071
6.073AlaGly: 6.073 ± 0.113
1.939AlaHis: 1.939 ± 0.052
6.063AlaIle: 6.063 ± 0.094
4.77AlaLys: 4.77 ± 0.093
7.972AlaLeu: 7.972 ± 0.116
2.221AlaMet: 2.221 ± 0.062
3.525AlaAsn: 3.525 ± 0.076
2.395AlaPro: 2.395 ± 0.054
4.717AlaGln: 4.717 ± 0.095
3.121AlaArg: 3.121 ± 0.075
4.698AlaSer: 4.698 ± 0.12
5.825AlaThr: 5.825 ± 0.113
6.071AlaVal: 6.071 ± 0.101
0.703AlaTrp: 0.703 ± 0.033
2.478AlaTyr: 2.478 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.412CysAla: 0.412 ± 0.027
0.056CysCys: 0.056 ± 0.009
0.37CysAsp: 0.37 ± 0.025
0.284CysGlu: 0.284 ± 0.02
0.275CysPhe: 0.275 ± 0.02
0.506CysGly: 0.506 ± 0.03
0.17CysHis: 0.17 ± 0.014
0.328CysIle: 0.328 ± 0.02
0.162CysLys: 0.162 ± 0.015
0.588CysLeu: 0.588 ± 0.032
0.105CysMet: 0.105 ± 0.013
0.171CysAsn: 0.171 ± 0.016
0.228CysPro: 0.228 ± 0.02
0.286CysGln: 0.286 ± 0.022
0.203CysArg: 0.203 ± 0.016
0.295CysSer: 0.295 ± 0.02
0.286CysThr: 0.286 ± 0.024
0.404CysVal: 0.404 ± 0.024
0.083CysTrp: 0.083 ± 0.011
0.215CysTyr: 0.215 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.383AspAla: 4.383 ± 0.091
0.295AspCys: 0.295 ± 0.022
3.978AspAsp: 3.978 ± 0.088
4.13AspGlu: 4.13 ± 0.099
2.535AspPhe: 2.535 ± 0.061
3.846AspGly: 3.846 ± 0.09
1.818AspHis: 1.818 ± 0.053
3.418AspIle: 3.418 ± 0.08
2.743AspLys: 2.743 ± 0.065
5.295AspLeu: 5.295 ± 0.096
1.42AspMet: 1.42 ± 0.044
2.376AspAsn: 2.376 ± 0.063
2.271AspPro: 2.271 ± 0.061
3.763AspGln: 3.763 ± 0.09
2.694AspArg: 2.694 ± 0.064
2.998AspSer: 2.998 ± 0.157
3.063AspThr: 3.063 ± 0.066
4.122AspVal: 4.122 ± 0.08
0.756AspTrp: 0.756 ± 0.03
2.398AspTyr: 2.398 ± 0.056
0.001AspXaa: 0.001 ± 0.001
Glu
4.173GluAla: 4.173 ± 0.084
0.211GluCys: 0.211 ± 0.014
2.723GluAsp: 2.723 ± 0.07
2.781GluGlu: 2.781 ± 0.087
2.162GluPhe: 2.162 ± 0.064
2.463GluGly: 2.463 ± 0.065
1.303GluHis: 1.303 ± 0.042
3.978GluIle: 3.978 ± 0.076
3.422GluLys: 3.422 ± 0.086
5.516GluLeu: 5.516 ± 0.099
1.701GluMet: 1.701 ± 0.051
2.572GluAsn: 2.572 ± 0.061
1.606GluPro: 1.606 ± 0.049
3.219GluGln: 3.219 ± 0.07
2.512GluArg: 2.512 ± 0.057
2.795GluSer: 2.795 ± 0.063
3.363GluThr: 3.363 ± 0.077
3.509GluVal: 3.509 ± 0.079
0.471GluTrp: 0.471 ± 0.028
1.59GluTyr: 1.59 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.362PheAla: 3.362 ± 0.075
0.321PheCys: 0.321 ± 0.022
3.023PheAsp: 3.023 ± 0.069
2.396PheGlu: 2.396 ± 0.062
1.948PhePhe: 1.948 ± 0.066
3.442PheGly: 3.442 ± 0.072
0.9PheHis: 0.9 ± 0.037
2.909PheIle: 2.909 ± 0.064
2.326PheLys: 2.326 ± 0.063
3.597PheLeu: 3.597 ± 0.073
1.042PheMet: 1.042 ± 0.041
2.203PheAsn: 2.203 ± 0.055
1.386PhePro: 1.386 ± 0.047
1.541PheGln: 1.541 ± 0.053
1.307PheArg: 1.307 ± 0.042
2.817PheSer: 2.817 ± 0.073
2.49PheThr: 2.49 ± 0.07
3.026PheVal: 3.026 ± 0.062
0.515PheTrp: 0.515 ± 0.032
1.583PheTyr: 1.583 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
5.103GlyAla: 5.103 ± 0.102
0.461GlyCys: 0.461 ± 0.025
3.544GlyAsp: 3.544 ± 0.081
3.127GlyGlu: 3.127 ± 0.069
3.03GlyPhe: 3.03 ± 0.067
4.315GlyGly: 4.315 ± 0.093
1.695GlyHis: 1.695 ± 0.049
5.509GlyIle: 5.509 ± 0.094
3.917GlyLys: 3.917 ± 0.076
6.451GlyLeu: 6.451 ± 0.1
2.026GlyMet: 2.026 ± 0.054
2.732GlyAsn: 2.732 ± 0.078
1.65GlyPro: 1.65 ± 0.048
3.184GlyGln: 3.184 ± 0.08
2.66GlyArg: 2.66 ± 0.065
3.985GlySer: 3.985 ± 0.166
4.653GlyThr: 4.653 ± 0.105
5.191GlyVal: 5.191 ± 0.099
0.82GlyTrp: 0.82 ± 0.035
2.838GlyTyr: 2.838 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.767HisAla: 1.767 ± 0.052
0.159HisCys: 0.159 ± 0.014
1.451HisAsp: 1.451 ± 0.052
1.402HisGlu: 1.402 ± 0.039
1.193HisPhe: 1.193 ± 0.038
1.727HisGly: 1.727 ± 0.054
0.904HisHis: 0.904 ± 0.038
1.341HisIle: 1.341 ± 0.043
0.99HisLys: 0.99 ± 0.038
2.375HisLeu: 2.375 ± 0.067
0.528HisMet: 0.528 ± 0.027
0.943HisAsn: 0.943 ± 0.04
1.133HisPro: 1.133 ± 0.039
1.609HisGln: 1.609 ± 0.045
1.187HisArg: 1.187 ± 0.04
1.212HisSer: 1.212 ± 0.039
1.175HisThr: 1.175 ± 0.04
1.753HisVal: 1.753 ± 0.051
0.345HisTrp: 0.345 ± 0.022
1.117HisTyr: 1.117 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
6.169IleAla: 6.169 ± 0.092
0.536IleCys: 0.536 ± 0.028
4.45IleAsp: 4.45 ± 0.086
3.936IleGlu: 3.936 ± 0.078
2.898IlePhe: 2.898 ± 0.07
5.523IleGly: 5.523 ± 0.107
1.44IleHis: 1.44 ± 0.049
4.912IleIle: 4.912 ± 0.095
4.013IleLys: 4.013 ± 0.079
6.175IleLeu: 6.175 ± 0.096
1.827IleMet: 1.827 ± 0.055
3.397IleAsn: 3.397 ± 0.07
2.706IlePro: 2.706 ± 0.071
2.787IleGln: 2.787 ± 0.064
2.643IleArg: 2.643 ± 0.071
4.673IleSer: 4.673 ± 0.094
4.496IleThr: 4.496 ± 0.083
5.378IleVal: 5.378 ± 0.087
0.639IleTrp: 0.639 ± 0.032
2.16IleTyr: 2.16 ± 0.06
0.001IleXaa: 0.001 ± 0.001
Lys
4.077LysAla: 4.077 ± 0.097
0.167LysCys: 0.167 ± 0.014
2.796LysAsp: 2.796 ± 0.076
2.974LysGlu: 2.974 ± 0.08
1.884LysPhe: 1.884 ± 0.053
2.723LysGly: 2.723 ± 0.072
1.274LysHis: 1.274 ± 0.038
4.125LysIle: 4.125 ± 0.082
3.975LysLys: 3.975 ± 0.091
5.14LysLeu: 5.14 ± 0.084
2.142LysMet: 2.142 ± 0.055
2.728LysAsn: 2.728 ± 0.06
1.787LysPro: 1.787 ± 0.054
3.537LysGln: 3.537 ± 0.073
2.788LysArg: 2.788 ± 0.066
2.908LysSer: 2.908 ± 0.076
3.743LysThr: 3.743 ± 0.097
3.69LysVal: 3.69 ± 0.082
0.567LysTrp: 0.567 ± 0.031
2.13LysTyr: 2.13 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
8.714LeuAla: 8.714 ± 0.101
0.548LeuCys: 0.548 ± 0.03
5.361LeuAsp: 5.361 ± 0.101
4.404LeuGlu: 4.404 ± 0.091
4.077LeuPhe: 4.077 ± 0.096
6.547LeuGly: 6.547 ± 0.115
1.933LeuHis: 1.933 ± 0.048
7.136LeuIle: 7.136 ± 0.119
5.675LeuLys: 5.675 ± 0.092
9.01LeuLeu: 9.01 ± 0.156
2.766LeuMet: 2.766 ± 0.073
4.657LeuAsn: 4.657 ± 0.094
4.023LeuPro: 4.023 ± 0.074
3.849LeuGln: 3.849 ± 0.069
3.663LeuArg: 3.663 ± 0.068
6.6LeuSer: 6.6 ± 0.118
7.007LeuThr: 7.007 ± 0.116
6.976LeuVal: 6.976 ± 0.107
0.817LeuTrp: 0.817 ± 0.036
2.697LeuTyr: 2.697 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.591MetAla: 2.591 ± 0.065
0.147MetCys: 0.147 ± 0.014
1.429MetAsp: 1.429 ± 0.043
1.126MetGlu: 1.126 ± 0.039
0.926MetPhe: 0.926 ± 0.037
1.877MetGly: 1.877 ± 0.057
0.547MetHis: 0.547 ± 0.031
2.218MetIle: 2.218 ± 0.061
1.767MetLys: 1.767 ± 0.048
2.573MetLeu: 2.573 ± 0.063
0.964MetMet: 0.964 ± 0.039
1.38MetAsn: 1.38 ± 0.044
1.079MetPro: 1.079 ± 0.041
1.288MetGln: 1.288 ± 0.042
1.045MetArg: 1.045 ± 0.046
1.671MetSer: 1.671 ± 0.053
2.149MetThr: 2.149 ± 0.053
1.946MetVal: 1.946 ± 0.051
0.199MetTrp: 0.199 ± 0.017
0.713MetTyr: 0.713 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.486AsnAla: 3.486 ± 0.077
0.277AsnCys: 0.277 ± 0.021
2.745AsnAsp: 2.745 ± 0.064
2.55AsnGlu: 2.55 ± 0.066
1.877AsnPhe: 1.877 ± 0.056
3.499AsnGly: 3.499 ± 0.102
1.296AsnHis: 1.296 ± 0.045
2.715AsnIle: 2.715 ± 0.065
2.158AsnLys: 2.158 ± 0.069
4.062AsnLeu: 4.062 ± 0.078
1.239AsnMet: 1.239 ± 0.038
2.115AsnAsn: 2.115 ± 0.064
2.025AsnPro: 2.025 ± 0.057
2.715AsnGln: 2.715 ± 0.065
2.119AsnArg: 2.119 ± 0.06
2.509AsnSer: 2.509 ± 0.087
2.451AsnThr: 2.451 ± 0.066
2.987AsnVal: 2.987 ± 0.063
0.636AsnTrp: 0.636 ± 0.034
1.831AsnTyr: 1.831 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
3.112ProAla: 3.112 ± 0.074
0.14ProCys: 0.14 ± 0.014
2.327ProAsp: 2.327 ± 0.066
2.489ProGlu: 2.489 ± 0.065
1.594ProPhe: 1.594 ± 0.055
2.149ProGly: 2.149 ± 0.062
0.819ProHis: 0.819 ± 0.035
2.551ProIle: 2.551 ± 0.062
1.813ProLys: 1.813 ± 0.056
3.317ProLeu: 3.317 ± 0.059
0.79ProMet: 0.79 ± 0.032
1.624ProAsn: 1.624 ± 0.051
0.533ProPro: 0.533 ± 0.028
1.661ProGln: 1.661 ± 0.047
1.225ProArg: 1.225 ± 0.04
2.063ProSer: 2.063 ± 0.063
2.551ProThr: 2.551 ± 0.067
2.912ProVal: 2.912 ± 0.069
0.339ProTrp: 0.339 ± 0.022
1.247ProTyr: 1.247 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.404GlnAla: 4.404 ± 0.091
0.193GlnCys: 0.193 ± 0.019
2.194GlnAsp: 2.194 ± 0.053
2.341GlnGlu: 2.341 ± 0.058
2.086GlnPhe: 2.086 ± 0.061
2.466GlnGly: 2.466 ± 0.066
1.337GlnHis: 1.337 ± 0.046
3.801GlnIle: 3.801 ± 0.08
2.898GlnLys: 2.898 ± 0.061
6.346GlnLeu: 6.346 ± 0.112
1.447GlnMet: 1.447 ± 0.048
2.248GlnAsn: 2.248 ± 0.054
1.828GlnPro: 1.828 ± 0.061
3.479GlnGln: 3.479 ± 0.089
2.659GlnArg: 2.659 ± 0.06
2.887GlnSer: 2.887 ± 0.068
3.577GlnThr: 3.577 ± 0.077
3.539GlnVal: 3.539 ± 0.069
0.559GlnTrp: 0.559 ± 0.027
1.71GlnTyr: 1.71 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.889ArgAla: 2.889 ± 0.07
0.207ArgCys: 0.207 ± 0.02
2.308ArgAsp: 2.308 ± 0.061
2.379ArgGlu: 2.379 ± 0.063
1.923ArgPhe: 1.923 ± 0.055
2.315ArgGly: 2.315 ± 0.061
1.242ArgHis: 1.242 ± 0.041
2.706ArgIle: 2.706 ± 0.06
2.269ArgLys: 2.269 ± 0.062
4.315ArgLeu: 4.315 ± 0.094
1.137ArgMet: 1.137 ± 0.036
1.855ArgAsn: 1.855 ± 0.052
1.575ArgPro: 1.575 ± 0.052
2.819ArgGln: 2.819 ± 0.062
2.285ArgArg: 2.285 ± 0.07
2.081ArgSer: 2.081 ± 0.058
2.131ArgThr: 2.131 ± 0.057
2.867ArgVal: 2.867 ± 0.064
0.457ArgTrp: 0.457 ± 0.026
1.787ArgTyr: 1.787 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.014SerAla: 5.014 ± 0.128
0.25SerCys: 0.25 ± 0.02
3.744SerAsp: 3.744 ± 0.22
3.132SerGlu: 3.132 ± 0.067
2.652SerPhe: 2.652 ± 0.056
4.483SerGly: 4.483 ± 0.107
1.39SerHis: 1.39 ± 0.04
4.042SerIle: 4.042 ± 0.087
2.916SerLys: 2.916 ± 0.072
5.829SerLeu: 5.829 ± 0.098
1.616SerMet: 1.616 ± 0.059
2.591SerAsn: 2.591 ± 0.085
1.778SerPro: 1.778 ± 0.047
2.947SerGln: 2.947 ± 0.07
2.375SerArg: 2.375 ± 0.056
4.171SerSer: 4.171 ± 0.179
4.1SerThr: 4.1 ± 0.367
4.114SerVal: 4.114 ± 0.085
0.641SerTrp: 0.641 ± 0.029
2.099SerTyr: 2.099 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.62ThrAla: 5.62 ± 0.104
0.275ThrCys: 0.275 ± 0.024
4.004ThrAsp: 4.004 ± 0.08
2.976ThrGlu: 2.976 ± 0.069
2.613ThrPhe: 2.613 ± 0.054
4.863ThrGly: 4.863 ± 0.101
1.47ThrHis: 1.47 ± 0.047
4.946ThrIle: 4.946 ± 0.095
3.559ThrLys: 3.559 ± 0.085
5.909ThrLeu: 5.909 ± 0.093
1.561ThrMet: 1.561 ± 0.054
3.003ThrAsn: 3.003 ± 0.071
2.822ThrPro: 2.822 ± 0.086
2.876ThrGln: 2.876 ± 0.076
2.19ThrArg: 2.19 ± 0.065
4.231ThrSer: 4.231 ± 0.322
5.106ThrThr: 5.106 ± 0.124
5.296ThrVal: 5.296 ± 0.126
0.622ThrTrp: 0.622 ± 0.034
2.24ThrTyr: 2.24 ± 0.07
0.003ThrXaa: 0.003 ± 0.002
Val
6.757ValAla: 6.757 ± 0.108
0.464ValCys: 0.464 ± 0.026
4.292ValAsp: 4.292 ± 0.096
3.434ValGlu: 3.434 ± 0.072
2.832ValPhe: 2.832 ± 0.065
4.985ValGly: 4.985 ± 0.104
1.374ValHis: 1.374 ± 0.043
5.395ValIle: 5.395 ± 0.099
4.032ValLys: 4.032 ± 0.078
6.86ValLeu: 6.86 ± 0.112
1.988ValMet: 1.988 ± 0.056
3.314ValAsn: 3.314 ± 0.073
2.791ValPro: 2.791 ± 0.085
2.727ValGln: 2.727 ± 0.058
2.516ValArg: 2.516 ± 0.07
4.713ValSer: 4.713 ± 0.096
5.463ValThr: 5.463 ± 0.107
5.675ValVal: 5.675 ± 0.105
0.699ValTrp: 0.699 ± 0.035
2.181ValTyr: 2.181 ± 0.064
0.001ValXaa: 0.001 ± 0.001
Trp
0.645TrpAla: 0.645 ± 0.034
0.069TrpCys: 0.069 ± 0.009
0.464TrpAsp: 0.464 ± 0.027
0.404TrpGlu: 0.404 ± 0.028
0.534TrpPhe: 0.534 ± 0.033
0.666TrpGly: 0.666 ± 0.03
0.381TrpHis: 0.381 ± 0.019
0.74TrpIle: 0.74 ± 0.034
0.404TrpLys: 0.404 ± 0.025
1.383TrpLeu: 1.383 ± 0.049
0.316TrpMet: 0.316 ± 0.018
0.472TrpAsn: 0.472 ± 0.03
0.306TrpPro: 0.306 ± 0.021
0.766TrpGln: 0.766 ± 0.032
0.534TrpArg: 0.534 ± 0.029
0.583TrpSer: 0.583 ± 0.03
0.57TrpThr: 0.57 ± 0.029
0.675TrpVal: 0.675 ± 0.031
0.193TrpTrp: 0.193 ± 0.016
0.343TrpTyr: 0.343 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.447TyrAla: 2.447 ± 0.064
0.214TyrCys: 0.214 ± 0.015
2.184TyrAsp: 2.184 ± 0.06
1.831TyrGlu: 1.831 ± 0.059
1.869TyrPhe: 1.869 ± 0.055
2.424TyrGly: 2.424 ± 0.065
1.079TyrHis: 1.079 ± 0.037
1.923TyrIle: 1.923 ± 0.057
1.346TyrLys: 1.346 ± 0.044
3.746TyrLeu: 3.746 ± 0.082
0.797TyrMet: 0.797 ± 0.037
1.386TyrAsn: 1.386 ± 0.042
1.334TyrPro: 1.334 ± 0.042
2.229TyrGln: 2.229 ± 0.058
1.82TyrArg: 1.82 ± 0.054
1.994TyrSer: 1.994 ± 0.052
1.986TyrThr: 1.986 ± 0.071
2.361TyrVal: 2.361 ± 0.053
0.386TyrTrp: 0.386 ± 0.025
1.492TyrTyr: 1.492 ± 0.056
0.001TyrXaa: 0.001 ± 0.002
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.002
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.001
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.003XaaVal: 0.003 ± 0.002
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.076XaaXaa: 0.076 ± 0.05
Statistics based on 2398 proteins (735279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski