Amino acid dipepetide frequency for Salmonella phage RE2010

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.391AlaAla: 12.391 ± 2.636
0.976AlaCys: 0.976 ± 0.37
5.269AlaAsp: 5.269 ± 0.745
6.44AlaGlu: 6.44 ± 0.991
3.415AlaPhe: 3.415 ± 0.462
5.952AlaGly: 5.952 ± 0.824
1.366AlaHis: 1.366 ± 0.351
4.293AlaIle: 4.293 ± 0.484
4.976AlaLys: 4.976 ± 0.758
9.757AlaLeu: 9.757 ± 1.131
2.537AlaMet: 2.537 ± 0.723
2.342AlaAsn: 2.342 ± 0.367
3.61AlaPro: 3.61 ± 0.596
4.488AlaGln: 4.488 ± 0.868
5.952AlaArg: 5.952 ± 0.812
6.83AlaSer: 6.83 ± 0.8
5.171AlaThr: 5.171 ± 0.705
7.025AlaVal: 7.025 ± 0.976
0.878AlaTrp: 0.878 ± 0.27
3.22AlaTyr: 3.22 ± 0.447
0.0AlaXaa: 0.0 ± 0.0
Cys
0.781CysAla: 0.781 ± 0.312
0.0CysCys: 0.0 ± 0.0
0.585CysAsp: 0.585 ± 0.227
0.585CysGlu: 0.585 ± 0.232
0.293CysPhe: 0.293 ± 0.178
0.683CysGly: 0.683 ± 0.279
0.098CysHis: 0.098 ± 0.11
0.488CysIle: 0.488 ± 0.279
0.293CysLys: 0.293 ± 0.18
1.171CysLeu: 1.171 ± 0.449
0.39CysMet: 0.39 ± 0.209
0.683CysAsn: 0.683 ± 0.28
0.878CysPro: 0.878 ± 0.311
0.39CysGln: 0.39 ± 0.232
0.683CysArg: 0.683 ± 0.257
0.878CysSer: 0.878 ± 0.351
0.878CysThr: 0.878 ± 0.231
0.683CysVal: 0.683 ± 0.216
0.585CysTrp: 0.585 ± 0.266
0.195CysTyr: 0.195 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
6.147AspAla: 6.147 ± 0.75
0.488AspCys: 0.488 ± 0.211
4.0AspAsp: 4.0 ± 0.518
4.488AspGlu: 4.488 ± 0.625
2.147AspPhe: 2.147 ± 0.649
5.171AspGly: 5.171 ± 0.718
0.976AspHis: 0.976 ± 0.282
3.513AspIle: 3.513 ± 0.548
3.025AspLys: 3.025 ± 0.554
5.269AspLeu: 5.269 ± 0.718
1.366AspMet: 1.366 ± 0.364
2.244AspAsn: 2.244 ± 0.43
1.854AspPro: 1.854 ± 0.382
1.756AspGln: 1.756 ± 0.349
2.83AspArg: 2.83 ± 0.673
2.634AspSer: 2.634 ± 0.617
3.708AspThr: 3.708 ± 0.791
3.708AspVal: 3.708 ± 0.555
0.39AspTrp: 0.39 ± 0.15
2.83AspTyr: 2.83 ± 0.441
0.0AspXaa: 0.0 ± 0.0
Glu
4.976GluAla: 4.976 ± 0.734
0.878GluCys: 0.878 ± 0.3
3.122GluAsp: 3.122 ± 0.663
3.122GluGlu: 3.122 ± 0.486
1.756GluPhe: 1.756 ± 0.419
3.122GluGly: 3.122 ± 0.481
0.683GluHis: 0.683 ± 0.225
4.586GluIle: 4.586 ± 0.54
3.708GluLys: 3.708 ± 0.524
7.903GluLeu: 7.903 ± 0.981
2.147GluMet: 2.147 ± 0.477
2.634GluAsn: 2.634 ± 0.609
2.439GluPro: 2.439 ± 0.554
4.098GluGln: 4.098 ± 0.8
3.415GluArg: 3.415 ± 0.566
3.708GluSer: 3.708 ± 0.562
3.415GluThr: 3.415 ± 0.598
4.098GluVal: 4.098 ± 0.696
0.976GluTrp: 0.976 ± 0.325
1.854GluTyr: 1.854 ± 0.507
0.0GluXaa: 0.0 ± 0.0
Phe
2.927PheAla: 2.927 ± 0.497
0.39PheCys: 0.39 ± 0.186
2.439PheAsp: 2.439 ± 0.536
2.244PheGlu: 2.244 ± 0.348
0.878PhePhe: 0.878 ± 0.289
1.659PheGly: 1.659 ± 0.582
0.878PheHis: 0.878 ± 0.25
1.171PheIle: 1.171 ± 0.408
1.268PheLys: 1.268 ± 0.373
2.537PheLeu: 2.537 ± 0.43
0.976PheMet: 0.976 ± 0.356
2.439PheAsn: 2.439 ± 0.541
1.366PhePro: 1.366 ± 0.378
0.878PheGln: 0.878 ± 0.351
2.342PheArg: 2.342 ± 0.505
2.732PheSer: 2.732 ± 0.517
2.147PheThr: 2.147 ± 0.552
2.049PheVal: 2.049 ± 0.478
0.781PheTrp: 0.781 ± 0.3
0.781PheTyr: 0.781 ± 0.201
0.0PheXaa: 0.0 ± 0.0
Gly
5.562GlyAla: 5.562 ± 0.832
0.878GlyCys: 0.878 ± 0.299
3.708GlyAsp: 3.708 ± 0.387
3.415GlyGlu: 3.415 ± 0.691
2.147GlyPhe: 2.147 ± 0.48
5.366GlyGly: 5.366 ± 1.028
1.561GlyHis: 1.561 ± 0.514
3.025GlyIle: 3.025 ± 0.516
4.098GlyLys: 4.098 ± 0.549
6.342GlyLeu: 6.342 ± 0.786
1.951GlyMet: 1.951 ± 0.498
3.22GlyAsn: 3.22 ± 0.7
2.147GlyPro: 2.147 ± 0.392
1.951GlyGln: 1.951 ± 0.433
3.122GlyArg: 3.122 ± 0.481
3.317GlySer: 3.317 ± 0.633
3.61GlyThr: 3.61 ± 0.616
5.366GlyVal: 5.366 ± 0.992
1.171GlyTrp: 1.171 ± 0.264
0.976GlyTyr: 0.976 ± 0.348
0.0GlyXaa: 0.0 ± 0.0
His
1.366HisAla: 1.366 ± 0.585
0.195HisCys: 0.195 ± 0.166
0.488HisAsp: 0.488 ± 0.242
0.781HisGlu: 0.781 ± 0.305
0.976HisPhe: 0.976 ± 0.363
1.171HisGly: 1.171 ± 0.352
0.878HisHis: 0.878 ± 0.306
1.268HisIle: 1.268 ± 0.404
1.171HisLys: 1.171 ± 0.356
1.854HisLeu: 1.854 ± 0.427
0.976HisMet: 0.976 ± 0.292
0.585HisAsn: 0.585 ± 0.232
0.683HisPro: 0.683 ± 0.299
0.781HisGln: 0.781 ± 0.249
0.976HisArg: 0.976 ± 0.265
1.756HisSer: 1.756 ± 0.533
1.073HisThr: 1.073 ± 0.334
0.976HisVal: 0.976 ± 0.264
0.585HisTrp: 0.585 ± 0.289
0.976HisTyr: 0.976 ± 0.332
0.0HisXaa: 0.0 ± 0.0
Ile
4.976IleAla: 4.976 ± 0.649
0.781IleCys: 0.781 ± 0.321
3.317IleAsp: 3.317 ± 0.531
3.513IleGlu: 3.513 ± 0.646
1.268IlePhe: 1.268 ± 0.331
2.927IleGly: 2.927 ± 0.735
0.683IleHis: 0.683 ± 0.249
2.927IleIle: 2.927 ± 0.614
3.025IleLys: 3.025 ± 0.535
2.83IleLeu: 2.83 ± 0.468
1.756IleMet: 1.756 ± 0.496
4.0IleAsn: 4.0 ± 0.578
2.634IlePro: 2.634 ± 0.668
1.854IleGln: 1.854 ± 0.479
3.708IleArg: 3.708 ± 0.541
4.098IleSer: 4.098 ± 0.633
4.0IleThr: 4.0 ± 0.64
2.634IleVal: 2.634 ± 0.55
0.488IleTrp: 0.488 ± 0.181
1.073IleTyr: 1.073 ± 0.279
0.0IleXaa: 0.0 ± 0.0
Lys
5.659LysAla: 5.659 ± 0.653
0.39LysCys: 0.39 ± 0.203
2.83LysAsp: 2.83 ± 0.58
3.708LysGlu: 3.708 ± 0.633
1.756LysPhe: 1.756 ± 0.458
3.122LysGly: 3.122 ± 0.476
0.781LysHis: 0.781 ± 0.296
2.927LysIle: 2.927 ± 0.56
3.708LysLys: 3.708 ± 0.614
4.488LysLeu: 4.488 ± 0.69
0.976LysMet: 0.976 ± 0.322
2.537LysAsn: 2.537 ± 0.56
2.244LysPro: 2.244 ± 0.512
2.244LysGln: 2.244 ± 0.374
4.488LysArg: 4.488 ± 0.732
4.0LysSer: 4.0 ± 0.573
2.537LysThr: 2.537 ± 0.432
3.025LysVal: 3.025 ± 0.44
0.878LysTrp: 0.878 ± 0.363
2.244LysTyr: 2.244 ± 0.443
0.0LysXaa: 0.0 ± 0.0
Leu
10.05LeuAla: 10.05 ± 1.034
0.976LeuCys: 0.976 ± 0.35
6.049LeuAsp: 6.049 ± 0.743
5.659LeuGlu: 5.659 ± 0.53
3.415LeuPhe: 3.415 ± 0.743
4.879LeuGly: 4.879 ± 0.959
1.366LeuHis: 1.366 ± 0.387
4.781LeuIle: 4.781 ± 0.685
4.391LeuLys: 4.391 ± 0.609
8.489LeuLeu: 8.489 ± 0.872
3.122LeuMet: 3.122 ± 0.514
5.464LeuAsn: 5.464 ± 0.913
4.879LeuPro: 4.879 ± 0.745
4.488LeuGln: 4.488 ± 0.753
6.928LeuArg: 6.928 ± 1.162
6.928LeuSer: 6.928 ± 0.944
6.732LeuThr: 6.732 ± 1.013
4.781LeuVal: 4.781 ± 0.777
1.073LeuTrp: 1.073 ± 0.288
3.025LeuTyr: 3.025 ± 0.637
0.0LeuXaa: 0.0 ± 0.0
Met
3.61MetAla: 3.61 ± 0.628
0.293MetCys: 0.293 ± 0.178
1.561MetAsp: 1.561 ± 0.365
1.464MetGlu: 1.464 ± 0.287
1.073MetPhe: 1.073 ± 0.308
1.854MetGly: 1.854 ± 0.747
0.683MetHis: 0.683 ± 0.232
0.585MetIle: 0.585 ± 0.214
1.366MetLys: 1.366 ± 0.353
1.659MetLeu: 1.659 ± 0.386
1.171MetMet: 1.171 ± 0.455
1.268MetAsn: 1.268 ± 0.35
0.878MetPro: 0.878 ± 0.309
1.366MetGln: 1.366 ± 0.317
1.366MetArg: 1.366 ± 0.4
2.439MetSer: 2.439 ± 0.466
1.171MetThr: 1.171 ± 0.393
1.854MetVal: 1.854 ± 0.349
0.39MetTrp: 0.39 ± 0.188
0.488MetTyr: 0.488 ± 0.27
0.0MetXaa: 0.0 ± 0.0
Asn
3.415AsnAla: 3.415 ± 0.811
0.781AsnCys: 0.781 ± 0.339
2.244AsnAsp: 2.244 ± 0.557
3.122AsnGlu: 3.122 ± 0.45
1.073AsnPhe: 1.073 ± 0.364
4.098AsnGly: 4.098 ± 0.7
0.683AsnHis: 0.683 ± 0.351
2.83AsnIle: 2.83 ± 0.534
2.537AsnLys: 2.537 ± 0.583
5.074AsnLeu: 5.074 ± 0.705
0.488AsnMet: 0.488 ± 0.208
1.951AsnAsn: 1.951 ± 0.482
3.708AsnPro: 3.708 ± 0.628
1.464AsnGln: 1.464 ± 0.35
3.22AsnArg: 3.22 ± 0.535
2.927AsnSer: 2.927 ± 0.476
1.464AsnThr: 1.464 ± 0.479
2.83AsnVal: 2.83 ± 0.518
0.585AsnTrp: 0.585 ± 0.341
0.976AsnTyr: 0.976 ± 0.315
0.0AsnXaa: 0.0 ± 0.0
Pro
4.683ProAla: 4.683 ± 0.609
0.683ProCys: 0.683 ± 0.236
3.122ProAsp: 3.122 ± 0.696
3.025ProGlu: 3.025 ± 0.408
0.878ProPhe: 0.878 ± 0.287
2.244ProGly: 2.244 ± 0.46
1.171ProHis: 1.171 ± 0.466
1.756ProIle: 1.756 ± 0.459
2.049ProLys: 2.049 ± 0.402
4.781ProLeu: 4.781 ± 0.589
0.683ProMet: 0.683 ± 0.234
1.268ProAsn: 1.268 ± 0.496
2.439ProPro: 2.439 ± 0.501
1.171ProGln: 1.171 ± 0.292
2.244ProArg: 2.244 ± 0.513
2.83ProSer: 2.83 ± 0.502
2.147ProThr: 2.147 ± 0.407
3.415ProVal: 3.415 ± 0.636
0.293ProTrp: 0.293 ± 0.145
1.659ProTyr: 1.659 ± 0.519
0.0ProXaa: 0.0 ± 0.0
Gln
3.708GlnAla: 3.708 ± 0.625
0.39GlnCys: 0.39 ± 0.218
3.025GlnAsp: 3.025 ± 0.67
1.854GlnGlu: 1.854 ± 0.44
0.878GlnPhe: 0.878 ± 0.323
2.439GlnGly: 2.439 ± 0.471
0.488GlnHis: 0.488 ± 0.193
1.659GlnIle: 1.659 ± 0.527
2.049GlnLys: 2.049 ± 0.515
4.683GlnLeu: 4.683 ± 0.628
1.171GlnMet: 1.171 ± 0.384
1.756GlnAsn: 1.756 ± 0.412
1.854GlnPro: 1.854 ± 0.414
2.634GlnGln: 2.634 ± 0.72
4.196GlnArg: 4.196 ± 0.733
2.927GlnSer: 2.927 ± 0.517
2.244GlnThr: 2.244 ± 0.581
2.049GlnVal: 2.049 ± 0.459
0.781GlnTrp: 0.781 ± 0.237
0.976GlnTyr: 0.976 ± 0.334
0.0GlnXaa: 0.0 ± 0.0
Arg
5.659ArgAla: 5.659 ± 0.759
0.585ArgCys: 0.585 ± 0.212
2.634ArgAsp: 2.634 ± 0.388
4.781ArgGlu: 4.781 ± 0.732
1.854ArgPhe: 1.854 ± 0.421
3.61ArgGly: 3.61 ± 0.657
2.537ArgHis: 2.537 ± 0.633
3.903ArgIle: 3.903 ± 0.597
4.098ArgLys: 4.098 ± 0.992
6.928ArgLeu: 6.928 ± 0.898
1.171ArgMet: 1.171 ± 0.328
3.415ArgAsn: 3.415 ± 0.647
1.659ArgPro: 1.659 ± 0.353
3.708ArgGln: 3.708 ± 0.698
5.952ArgArg: 5.952 ± 0.803
3.025ArgSer: 3.025 ± 0.534
2.927ArgThr: 2.927 ± 0.473
4.488ArgVal: 4.488 ± 0.72
1.464ArgTrp: 1.464 ± 0.346
1.464ArgTyr: 1.464 ± 0.322
0.0ArgXaa: 0.0 ± 0.0
Ser
6.83SerAla: 6.83 ± 0.923
0.585SerCys: 0.585 ± 0.264
3.22SerAsp: 3.22 ± 0.494
3.415SerGlu: 3.415 ± 0.868
3.025SerPhe: 3.025 ± 0.589
4.391SerGly: 4.391 ± 0.739
1.366SerHis: 1.366 ± 0.405
3.513SerIle: 3.513 ± 0.709
2.537SerLys: 2.537 ± 0.567
6.635SerLeu: 6.635 ± 0.801
1.756SerMet: 1.756 ± 0.42
2.732SerAsn: 2.732 ± 0.467
2.439SerPro: 2.439 ± 0.442
2.244SerGln: 2.244 ± 0.445
4.196SerArg: 4.196 ± 0.683
3.708SerSer: 3.708 ± 0.72
4.098SerThr: 4.098 ± 0.444
4.391SerVal: 4.391 ± 0.691
1.366SerTrp: 1.366 ± 0.304
1.366SerTyr: 1.366 ± 0.287
0.0SerXaa: 0.0 ± 0.0
Thr
4.976ThrAla: 4.976 ± 0.758
0.878ThrCys: 0.878 ± 0.273
4.586ThrAsp: 4.586 ± 0.706
3.513ThrGlu: 3.513 ± 0.73
1.854ThrPhe: 1.854 ± 0.464
4.391ThrGly: 4.391 ± 0.715
0.976ThrHis: 0.976 ± 0.37
2.927ThrIle: 2.927 ± 0.633
3.61ThrLys: 3.61 ± 0.726
5.366ThrLeu: 5.366 ± 0.646
1.268ThrMet: 1.268 ± 0.308
2.147ThrAsn: 2.147 ± 0.409
2.537ThrPro: 2.537 ± 0.455
1.268ThrGln: 1.268 ± 0.317
2.634ThrArg: 2.634 ± 0.585
2.83ThrSer: 2.83 ± 0.375
3.805ThrThr: 3.805 ± 0.917
5.074ThrVal: 5.074 ± 0.715
0.585ThrTrp: 0.585 ± 0.33
1.366ThrTyr: 1.366 ± 0.375
0.0ThrXaa: 0.0 ± 0.0
Val
6.049ValAla: 6.049 ± 1.025
0.488ValCys: 0.488 ± 0.2
4.196ValAsp: 4.196 ± 0.94
4.683ValGlu: 4.683 ± 0.949
1.854ValPhe: 1.854 ± 0.399
3.513ValGly: 3.513 ± 0.662
0.976ValHis: 0.976 ± 0.28
3.025ValIle: 3.025 ± 0.585
4.391ValLys: 4.391 ± 0.715
6.635ValLeu: 6.635 ± 0.769
2.049ValMet: 2.049 ± 0.539
3.025ValAsn: 3.025 ± 0.584
2.537ValPro: 2.537 ± 0.493
3.122ValGln: 3.122 ± 0.618
4.0ValArg: 4.0 ± 0.522
3.903ValSer: 3.903 ± 0.466
3.61ValThr: 3.61 ± 0.645
4.391ValVal: 4.391 ± 0.782
0.488ValTrp: 0.488 ± 0.265
2.049ValTyr: 2.049 ± 0.573
0.0ValXaa: 0.0 ± 0.0
Trp
1.171TrpAla: 1.171 ± 0.325
0.195TrpCys: 0.195 ± 0.133
0.488TrpAsp: 0.488 ± 0.236
0.878TrpGlu: 0.878 ± 0.297
0.39TrpPhe: 0.39 ± 0.172
0.293TrpGly: 0.293 ± 0.133
0.488TrpHis: 0.488 ± 0.202
0.878TrpIle: 0.878 ± 0.312
0.878TrpLys: 0.878 ± 0.255
2.049TrpLeu: 2.049 ± 0.482
0.098TrpMet: 0.098 ± 0.103
0.585TrpAsn: 0.585 ± 0.235
0.683TrpPro: 0.683 ± 0.258
0.683TrpGln: 0.683 ± 0.278
1.464TrpArg: 1.464 ± 0.477
0.683TrpSer: 0.683 ± 0.314
0.781TrpThr: 0.781 ± 0.252
0.683TrpVal: 0.683 ± 0.211
0.39TrpTrp: 0.39 ± 0.173
0.683TrpTyr: 0.683 ± 0.263
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.951TyrAla: 1.951 ± 0.332
0.39TyrCys: 0.39 ± 0.213
1.659TyrAsp: 1.659 ± 0.423
1.951TyrGlu: 1.951 ± 0.478
1.951TyrPhe: 1.951 ± 0.717
2.049TyrGly: 2.049 ± 0.459
0.878TyrHis: 0.878 ± 0.311
2.439TyrIle: 2.439 ± 0.575
1.366TyrLys: 1.366 ± 0.376
3.122TyrLeu: 3.122 ± 0.561
0.39TyrMet: 0.39 ± 0.21
1.171TyrAsn: 1.171 ± 0.407
1.073TyrPro: 1.073 ± 0.397
1.171TyrGln: 1.171 ± 0.315
2.147TyrArg: 2.147 ± 0.486
1.659TyrSer: 1.659 ± 0.561
1.073TyrThr: 1.073 ± 0.311
1.464TyrVal: 1.464 ± 0.377
0.293TyrTrp: 0.293 ± 0.19
0.683TyrTyr: 0.683 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (10250 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski