Amino acid dipepetide frequency for Mycobacterium talmoniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.948AlaAla: 22.948 ± 0.228	1.0AlaCys: 1.0 ± 0.028	9.009AlaAsp: 9.009 ± 0.09	7.851AlaGlu: 7.851 ± 0.085	3.482AlaPhe: 3.482 ± 0.051	12.37AlaGly: 12.37 ± 0.113	2.825AlaHis: 2.825 ± 0.045	5.078AlaIle: 5.078 ± 0.056	2.94AlaLys: 2.94 ± 0.05	13.54AlaLeu: 13.54 ± 0.111	2.833AlaMet: 2.833 ± 0.048	2.674AlaAsn: 2.674 ± 0.047	6.592AlaPro: 6.592 ± 0.079	4.316AlaGln: 4.316 ± 0.058	8.967AlaArg: 8.967 ± 0.079	5.779AlaSer: 5.779 ± 0.067	7.677AlaThr: 7.677 ± 0.081	12.306AlaVal: 12.306 ± 0.106	1.717AlaTrp: 1.717 ± 0.034	2.365AlaTyr: 2.365 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.138CysAla: 1.138 ± 0.028	0.098CysCys: 0.098 ± 0.008	0.536CysAsp: 0.536 ± 0.019	0.379CysGlu: 0.379 ± 0.017	0.241CysPhe: 0.241 ± 0.011	0.922CysGly: 0.922 ± 0.026	0.196CysHis: 0.196 ± 0.01	0.247CysIle: 0.247 ± 0.012	0.128CysLys: 0.128 ± 0.009	0.674CysLeu: 0.674 ± 0.02	0.135CysMet: 0.135 ± 0.009	0.153CysAsn: 0.153 ± 0.01	0.546CysPro: 0.546 ± 0.021	0.243CysGln: 0.243 ± 0.013	0.596CysArg: 0.596 ± 0.022	0.447CysSer: 0.447 ± 0.016	0.489CysThr: 0.489 ± 0.017	0.665CysVal: 0.665 ± 0.021	0.141CysTrp: 0.141 ± 0.011	0.215CysTyr: 0.215 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.262AspAla: 8.262 ± 0.07	0.459AspCys: 0.459 ± 0.018	4.319AspAsp: 4.319 ± 0.06	3.742AspGlu: 3.742 ± 0.057	1.814AspPhe: 1.814 ± 0.032	6.013AspGly: 6.013 ± 0.075	1.469AspHis: 1.469 ± 0.03	2.517AspIle: 2.517 ± 0.041	1.306AspLys: 1.306 ± 0.032	6.149AspLeu: 6.149 ± 0.074	0.972AspMet: 0.972 ± 0.023	1.277AspAsn: 1.277 ± 0.031	4.771AspPro: 4.771 ± 0.058	1.901AspGln: 1.901 ± 0.035	4.762AspArg: 4.762 ± 0.056	2.507AspSer: 2.507 ± 0.043	3.632AspThr: 3.632 ± 0.05	5.171AspVal: 5.171 ± 0.06	1.009AspTrp: 1.009 ± 0.027	1.597AspTyr: 1.597 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.796GluAla: 5.796 ± 0.071	0.327GluCys: 0.327 ± 0.016	2.292GluAsp: 2.292 ± 0.047	2.326GluGlu: 2.326 ± 0.045	1.799GluPhe: 1.799 ± 0.039	2.843GluGly: 2.843 ± 0.046	1.579GluHis: 1.579 ± 0.033	2.427GluIle: 2.427 ± 0.037	1.14GluLys: 1.14 ± 0.032	6.644GluLeu: 6.644 ± 0.079	0.999GluMet: 0.999 ± 0.025	0.961GluAsn: 0.961 ± 0.026	2.925GluPro: 2.925 ± 0.05	2.197GluGln: 2.197 ± 0.04	4.118GluArg: 4.118 ± 0.057	2.319GluSer: 2.319 ± 0.033	2.455GluThr: 2.455 ± 0.04	4.232GluVal: 4.232 ± 0.063	0.674GluTrp: 0.674 ± 0.019	1.043GluTyr: 1.043 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.125PheAla: 4.125 ± 0.061	0.337PheCys: 0.337 ± 0.014	2.515PheAsp: 2.515 ± 0.038	1.513PheGlu: 1.513 ± 0.031	0.946PhePhe: 0.946 ± 0.029	3.512PheGly: 3.512 ± 0.051	0.654PheHis: 0.654 ± 0.019	1.056PheIle: 1.056 ± 0.026	0.521PheLys: 0.521 ± 0.017	2.423PheLeu: 2.423 ± 0.042	0.474PheMet: 0.474 ± 0.017	0.72PheAsn: 0.72 ± 0.021	1.492PhePro: 1.492 ± 0.033	0.691PheGln: 0.691 ± 0.022	1.706PheArg: 1.706 ± 0.035	1.574PheSer: 1.574 ± 0.03	2.167PheThr: 2.167 ± 0.04	2.541PheVal: 2.541 ± 0.041	0.454PheTrp: 0.454 ± 0.018	0.75PheTyr: 0.75 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.586GlyAla: 10.586 ± 0.097	0.888GlyCys: 0.888 ± 0.027	5.024GlyAsp: 5.024 ± 0.063	4.123GlyGlu: 4.123 ± 0.054	3.037GlyPhe: 3.037 ± 0.044	7.619GlyGly: 7.619 ± 0.084	2.084GlyHis: 2.084 ± 0.037	3.941GlyIle: 3.941 ± 0.048	2.236GlyLys: 2.236 ± 0.04	8.789GlyLeu: 8.789 ± 0.07	2.117GlyMet: 2.117 ± 0.039	1.757GlyAsn: 1.757 ± 0.037	4.691GlyPro: 4.691 ± 0.061	3.018GlyGln: 3.018 ± 0.048	6.295GlyArg: 6.295 ± 0.074	4.85GlySer: 4.85 ± 0.059	5.128GlyThr: 5.128 ± 0.049	7.692GlyVal: 7.692 ± 0.061	1.747GlyTrp: 1.747 ± 0.038	2.566GlyTyr: 2.566 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.58HisAla: 2.58 ± 0.043	0.234HisCys: 0.234 ± 0.012	1.533HisAsp: 1.533 ± 0.03	1.004HisGlu: 1.004 ± 0.028	0.71HisPhe: 0.71 ± 0.021	2.329HisGly: 2.329 ± 0.041	0.71HisHis: 0.71 ± 0.024	0.798HisIle: 0.798 ± 0.022	0.387HisLys: 0.387 ± 0.016	2.192HisLeu: 2.192 ± 0.037	0.331HisMet: 0.331 ± 0.016	0.518HisAsn: 0.518 ± 0.02	1.83HisPro: 1.83 ± 0.034	0.749HisGln: 0.749 ± 0.021	2.081HisArg: 2.081 ± 0.036	1.038HisSer: 1.038 ± 0.022	1.386HisThr: 1.386 ± 0.033	1.655HisVal: 1.655 ± 0.036	0.39HisTrp: 0.39 ± 0.016	0.627HisTyr: 0.627 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.135IleAla: 6.135 ± 0.069	0.387IleCys: 0.387 ± 0.013	3.353IleAsp: 3.353 ± 0.056	2.426IleGlu: 2.426 ± 0.047	0.978IlePhe: 0.978 ± 0.029	4.263IleGly: 4.263 ± 0.053	0.814IleHis: 0.814 ± 0.024	1.393IleIle: 1.393 ± 0.036	0.886IleLys: 0.886 ± 0.024	2.853IleLeu: 2.853 ± 0.043	0.572IleMet: 0.572 ± 0.021	1.126IleAsn: 1.126 ± 0.026	2.442IlePro: 2.442 ± 0.042	0.943IleGln: 0.943 ± 0.023	2.618IleArg: 2.618 ± 0.038	2.061IleSer: 2.061 ± 0.035	2.884IleThr: 2.884 ± 0.04	3.402IleVal: 3.402 ± 0.048	0.489IleTrp: 0.489 ± 0.017	0.788IleTyr: 0.788 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.572LysAla: 2.572 ± 0.054	0.115LysCys: 0.115 ± 0.008	1.074LysAsp: 1.074 ± 0.029	0.887LysGlu: 0.887 ± 0.027	0.621LysPhe: 0.621 ± 0.018	1.425LysGly: 1.425 ± 0.038	0.477LysHis: 0.477 ± 0.02	0.988LysIle: 0.988 ± 0.022	0.625LysLys: 0.625 ± 0.021	2.201LysLeu: 2.201 ± 0.04	0.468LysMet: 0.468 ± 0.016	0.507LysAsn: 0.507 ± 0.022	1.427LysPro: 1.427 ± 0.029	0.742LysGln: 0.742 ± 0.024	1.55LysArg: 1.55 ± 0.035	1.153LysSer: 1.153 ± 0.027	1.328LysThr: 1.328 ± 0.031	1.853LysVal: 1.853 ± 0.039	0.293LysTrp: 0.293 ± 0.012	0.463LysTyr: 0.463 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.859LeuAla: 14.859 ± 0.114	0.817LeuCys: 0.817 ± 0.021	6.735LeuAsp: 6.735 ± 0.07	4.105LeuGlu: 4.105 ± 0.061	2.716LeuPhe: 2.716 ± 0.047	9.013LeuGly: 9.013 ± 0.086	2.203LeuHis: 2.203 ± 0.043	4.036LeuIle: 4.036 ± 0.046	1.726LeuLys: 1.726 ± 0.039	9.945LeuLeu: 9.945 ± 0.105	1.721LeuMet: 1.721 ± 0.034	2.08LeuAsn: 2.08 ± 0.037	6.14LeuPro: 6.14 ± 0.068	2.739LeuGln: 2.739 ± 0.04	7.89LeuArg: 7.89 ± 0.08	5.371LeuSer: 5.371 ± 0.055	6.478LeuThr: 6.478 ± 0.063	8.445LeuVal: 8.445 ± 0.091	1.24LeuTrp: 1.24 ± 0.03	1.716LeuTyr: 1.716 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.647MetAla: 2.647 ± 0.041	0.171MetCys: 0.171 ± 0.009	0.848MetAsp: 0.848 ± 0.023	0.626MetGlu: 0.626 ± 0.018	0.62MetPhe: 0.62 ± 0.02	1.424MetGly: 1.424 ± 0.033	0.401MetHis: 0.401 ± 0.017	0.826MetIle: 0.826 ± 0.026	0.426MetLys: 0.426 ± 0.017	2.056MetLeu: 2.056 ± 0.041	0.416MetMet: 0.416 ± 0.018	0.473MetAsn: 0.473 ± 0.017	1.229MetPro: 1.229 ± 0.026	0.557MetGln: 0.557 ± 0.018	1.471MetArg: 1.471 ± 0.033	1.385MetSer: 1.385 ± 0.029	1.808MetThr: 1.808 ± 0.033	1.611MetVal: 1.611 ± 0.031	0.261MetTrp: 0.261 ± 0.012	0.375MetTyr: 0.375 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.618AsnAla: 2.618 ± 0.037	0.178AsnCys: 0.178 ± 0.012	1.2AsnAsp: 1.2 ± 0.028	0.876AsnGlu: 0.876 ± 0.022	0.702AsnPhe: 0.702 ± 0.02	1.952AsnGly: 1.952 ± 0.036	0.487AsnHis: 0.487 ± 0.018	0.928AsnIle: 0.928 ± 0.025	0.458AsnLys: 0.458 ± 0.019	2.135AsnLeu: 2.135 ± 0.038	0.408AsnMet: 0.408 ± 0.017	0.57AsnAsn: 0.57 ± 0.019	1.76AsnPro: 1.76 ± 0.034	0.688AsnGln: 0.688 ± 0.023	1.503AsnArg: 1.503 ± 0.032	0.964AsnSer: 0.964 ± 0.025	1.39AsnThr: 1.39 ± 0.034	1.735AsnVal: 1.735 ± 0.034	0.357AsnTrp: 0.357 ± 0.016	0.589AsnTyr: 0.589 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.966ProAla: 7.966 ± 0.087	0.309ProCys: 0.309 ± 0.016	4.728ProAsp: 4.728 ± 0.059	3.562ProGlu: 3.562 ± 0.051	1.694ProPhe: 1.694 ± 0.04	5.781ProGly: 5.781 ± 0.074	1.34ProHis: 1.34 ± 0.037	2.172ProIle: 2.172 ± 0.034	1.261ProLys: 1.261 ± 0.03	5.083ProLeu: 5.083 ± 0.061	1.19ProMet: 1.19 ± 0.031	1.262ProAsn: 1.262 ± 0.031	3.819ProPro: 3.819 ± 0.075	1.914ProGln: 1.914 ± 0.034	3.706ProArg: 3.706 ± 0.05	2.84ProSer: 2.84 ± 0.045	3.523ProThr: 3.523 ± 0.047	5.255ProVal: 5.255 ± 0.061	0.869ProTrp: 0.869 ± 0.024	1.231ProTyr: 1.231 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.956GlnAla: 3.956 ± 0.051	0.241GlnCys: 0.241 ± 0.012	1.255GlnAsp: 1.255 ± 0.031	1.014GlnGlu: 1.014 ± 0.027	1.016GlnPhe: 1.016 ± 0.028	1.978GlnGly: 1.978 ± 0.033	0.921GlnHis: 0.921 ± 0.023	1.554GlnIle: 1.554 ± 0.033	0.582GlnLys: 0.582 ± 0.021	3.936GlnLeu: 3.936 ± 0.052	0.665GlnMet: 0.665 ± 0.021	0.604GlnAsn: 0.604 ± 0.024	2.063GlnPro: 2.063 ± 0.04	1.471GlnGln: 1.471 ± 0.034	3.114GlnArg: 3.114 ± 0.043	1.342GlnSer: 1.342 ± 0.029	1.644GlnThr: 1.644 ± 0.033	2.781GlnVal: 2.781 ± 0.042	0.536GlnTrp: 0.536 ± 0.017	0.614GlnTyr: 0.614 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.884ArgAla: 8.884 ± 0.081	0.614ArgCys: 0.614 ± 0.021	4.459ArgAsp: 4.459 ± 0.059	3.487ArgGlu: 3.487 ± 0.062	2.476ArgPhe: 2.476 ± 0.042	5.452ArgGly: 5.452 ± 0.062	1.886ArgHis: 1.886 ± 0.037	3.416ArgIle: 3.416 ± 0.044	1.457ArgLys: 1.457 ± 0.032	7.773ArgLeu: 7.773 ± 0.074	1.756ArgMet: 1.756 ± 0.038	1.571ArgAsn: 1.571 ± 0.03	4.089ArgPro: 4.089 ± 0.053	2.384ArgGln: 2.384 ± 0.042	6.962ArgArg: 6.962 ± 0.087	3.729ArgSer: 3.729 ± 0.052	4.014ArgThr: 4.014 ± 0.049	5.877ArgVal: 5.877 ± 0.058	1.509ArgTrp: 1.509 ± 0.031	2.08ArgTyr: 2.08 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.558SerAla: 6.558 ± 0.072	0.412SerCys: 0.412 ± 0.016	2.792SerAsp: 2.792 ± 0.041	2.161SerGlu: 2.161 ± 0.036	1.594SerPhe: 1.594 ± 0.032	5.16SerGly: 5.16 ± 0.054	0.983SerHis: 0.983 ± 0.025	1.927SerIle: 1.927 ± 0.039	1.071SerLys: 1.071 ± 0.028	4.468SerLeu: 4.468 ± 0.053	1.233SerMet: 1.233 ± 0.026	1.021SerAsn: 1.021 ± 0.023	2.919SerPro: 2.919 ± 0.048	1.387SerGln: 1.387 ± 0.026	3.45SerArg: 3.45 ± 0.052	2.748SerSer: 2.748 ± 0.05	3.091SerThr: 3.091 ± 0.049	4.25SerVal: 4.25 ± 0.053	0.946SerTrp: 0.946 ± 0.024	1.329SerTyr: 1.329 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.393ThrAla: 8.393 ± 0.075	0.412ThrCys: 0.412 ± 0.017	3.888ThrAsp: 3.888 ± 0.053	3.13ThrGlu: 3.13 ± 0.047	1.779ThrPhe: 1.779 ± 0.037	5.946ThrGly: 5.946 ± 0.055	1.221ThrHis: 1.221 ± 0.028	2.379ThrIle: 2.379 ± 0.04	1.294ThrLys: 1.294 ± 0.033	5.705ThrLeu: 5.705 ± 0.061	1.16ThrMet: 1.16 ± 0.028	1.284ThrAsn: 1.284 ± 0.03	3.879ThrPro: 3.879 ± 0.054	1.608ThrGln: 1.608 ± 0.032	3.789ThrArg: 3.789 ± 0.052	2.97ThrSer: 2.97 ± 0.042	3.802ThrThr: 3.802 ± 0.062	5.972ThrVal: 5.972 ± 0.067	0.807ThrTrp: 0.807 ± 0.025	1.2ThrTyr: 1.2 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	12.017ValAla: 12.017 ± 0.107	0.774ValCys: 0.774 ± 0.023	5.84ValAsp: 5.84 ± 0.069	4.182ValGlu: 4.182 ± 0.058	2.62ValPhe: 2.62 ± 0.042	7.121ValGly: 7.121 ± 0.07	1.903ValHis: 1.903 ± 0.035	3.851ValIle: 3.851 ± 0.046	1.645ValLys: 1.645 ± 0.033	9.102ValLeu: 9.102 ± 0.08	1.551ValMet: 1.551 ± 0.034	2.066ValAsn: 2.066 ± 0.039	4.645ValPro: 4.645 ± 0.047	2.277ValGln: 2.277 ± 0.036	5.874ValArg: 5.874 ± 0.062	4.463ValSer: 4.463 ± 0.057	5.635ValThr: 5.635 ± 0.052	8.318ValVal: 8.318 ± 0.095	1.073ValTrp: 1.073 ± 0.027	1.624ValTyr: 1.624 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.635TrpAla: 1.635 ± 0.034	0.172TrpCys: 0.172 ± 0.01	0.805TrpAsp: 0.805 ± 0.024	0.674TrpGlu: 0.674 ± 0.021	0.524TrpPhe: 0.524 ± 0.018	0.984TrpGly: 0.984 ± 0.026	0.382TrpHis: 0.382 ± 0.015	0.628TrpIle: 0.628 ± 0.02	0.303TrpLys: 0.303 ± 0.014	1.818TrpLeu: 1.818 ± 0.037	0.341TrpMet: 0.341 ± 0.014	0.396TrpAsn: 0.396 ± 0.016	0.875TrpPro: 0.875 ± 0.024	0.663TrpGln: 0.663 ± 0.02	1.378TrpArg: 1.378 ± 0.032	0.949TrpSer: 0.949 ± 0.024	0.856TrpThr: 0.856 ± 0.024	1.175TrpVal: 1.175 ± 0.028	0.355TrpTrp: 0.355 ± 0.018	0.342TrpTyr: 0.342 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.596TyrAla: 2.596 ± 0.04	0.244TyrCys: 0.244 ± 0.012	1.444TyrAsp: 1.444 ± 0.031	1.026TyrGlu: 1.026 ± 0.026	0.806TyrPhe: 0.806 ± 0.023	2.078TyrGly: 2.078 ± 0.039	0.546TyrHis: 0.546 ± 0.019	0.648TyrIle: 0.648 ± 0.021	0.375TyrLys: 0.375 ± 0.016	2.49TyrLeu: 2.49 ± 0.039	0.29TyrMet: 0.29 ± 0.012	0.48TyrAsn: 0.48 ± 0.017	1.369TyrPro: 1.369 ± 0.031	0.803TyrGln: 0.803 ± 0.021	2.047TyrArg: 2.047 ± 0.041	1.011TyrSer: 1.011 ± 0.027	1.232TyrThr: 1.232 ± 0.029	1.641TyrVal: 1.641 ± 0.037	0.389TyrTrp: 0.389 ± 0.017	0.535TyrTyr: 0.535 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5059 proteins (1588304 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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