Amino acid dipepetide frequency for Candidatus Nitrospira nitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.934AlaAla: 9.934 ± 0.128	1.126AlaCys: 1.126 ± 0.033	4.89AlaAsp: 4.89 ± 0.064	5.86AlaGlu: 5.86 ± 0.08	3.216AlaPhe: 3.216 ± 0.054	7.723AlaGly: 7.723 ± 0.094	2.163AlaHis: 2.163 ± 0.042	5.056AlaIle: 5.056 ± 0.064	4.371AlaLys: 4.371 ± 0.067	10.149AlaLeu: 10.149 ± 0.125	2.644AlaMet: 2.644 ± 0.051	2.363AlaAsn: 2.363 ± 0.058	3.903AlaPro: 3.903 ± 0.057	3.779AlaGln: 3.779 ± 0.06	6.159AlaArg: 6.159 ± 0.079	5.393AlaSer: 5.393 ± 0.061	5.017AlaThr: 5.017 ± 0.068	7.577AlaVal: 7.577 ± 0.094	1.332AlaTrp: 1.332 ± 0.037	2.357AlaTyr: 2.357 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.985CysAla: 0.985 ± 0.033	0.165CysCys: 0.165 ± 0.012	0.524CysAsp: 0.524 ± 0.023	0.532CysGlu: 0.532 ± 0.023	0.37CysPhe: 0.37 ± 0.017	1.013CysGly: 1.013 ± 0.032	0.41CysHis: 0.41 ± 0.024	0.459CysIle: 0.459 ± 0.019	0.358CysLys: 0.358 ± 0.017	1.144CysLeu: 1.144 ± 0.031	0.244CysMet: 0.244 ± 0.015	0.266CysAsn: 0.266 ± 0.014	0.609CysPro: 0.609 ± 0.023	0.346CysGln: 0.346 ± 0.017	0.884CysArg: 0.884 ± 0.032	0.649CysSer: 0.649 ± 0.026	0.495CysThr: 0.495 ± 0.022	0.777CysVal: 0.777 ± 0.026	0.146CysTrp: 0.146 ± 0.011	0.284CysTyr: 0.284 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.648AspAla: 4.648 ± 0.075	0.555AspCys: 0.555 ± 0.021	2.536AspAsp: 2.536 ± 0.061	3.28AspGlu: 3.28 ± 0.054	1.83AspPhe: 1.83 ± 0.047	4.274AspGly: 4.274 ± 0.067	1.439AspHis: 1.439 ± 0.034	2.671AspIle: 2.671 ± 0.053	1.703AspLys: 1.703 ± 0.042	5.885AspLeu: 5.885 ± 0.072	1.09AspMet: 1.09 ± 0.036	1.165AspAsn: 1.165 ± 0.036	3.154AspPro: 3.154 ± 0.065	2.257AspGln: 2.257 ± 0.051	4.344AspArg: 4.344 ± 0.07	2.639AspSer: 2.639 ± 0.051	2.404AspThr: 2.404 ± 0.065	3.973AspVal: 3.973 ± 0.06	0.746AspTrp: 0.746 ± 0.026	1.382AspTyr: 1.382 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.128GluAla: 6.128 ± 0.102	0.504GluCys: 0.504 ± 0.021	2.715GluAsp: 2.715 ± 0.042	4.008GluGlu: 4.008 ± 0.065	2.071GluPhe: 2.071 ± 0.046	4.123GluGly: 4.123 ± 0.073	1.453GluHis: 1.453 ± 0.036	3.429GluIle: 3.429 ± 0.06	2.693GluLys: 2.693 ± 0.053	6.173GluLeu: 6.173 ± 0.085	1.472GluMet: 1.472 ± 0.04	1.439GluAsn: 1.439 ± 0.035	2.571GluPro: 2.571 ± 0.047	3.216GluGln: 3.216 ± 0.061	5.101GluArg: 5.101 ± 0.076	3.584GluSer: 3.584 ± 0.052	3.327GluThr: 3.327 ± 0.051	4.299GluVal: 4.299 ± 0.066	0.89GluTrp: 0.89 ± 0.027	1.429GluTyr: 1.429 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.062PheAla: 3.062 ± 0.049	0.453PheCys: 0.453 ± 0.018	2.113PheAsp: 2.113 ± 0.042	2.113PheGlu: 2.113 ± 0.044	1.391PhePhe: 1.391 ± 0.041	3.049PheGly: 3.049 ± 0.058	0.983PheHis: 0.983 ± 0.031	1.703PheIle: 1.703 ± 0.038	1.304PheLys: 1.304 ± 0.039	3.773PheLeu: 3.773 ± 0.069	0.793PheMet: 0.793 ± 0.026	1.132PheAsn: 1.132 ± 0.037	1.791PhePro: 1.791 ± 0.039	1.304PheGln: 1.304 ± 0.034	2.291PheArg: 2.291 ± 0.049	2.467PheSer: 2.467 ± 0.046	2.15PheThr: 2.15 ± 0.051	2.711PheVal: 2.711 ± 0.043	0.494PheTrp: 0.494 ± 0.024	0.967PheTyr: 0.967 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	6.404GlyAla: 6.404 ± 0.092	1.022GlyCys: 1.022 ± 0.031	3.622GlyAsp: 3.622 ± 0.081	4.484GlyGlu: 4.484 ± 0.066	3.097GlyPhe: 3.097 ± 0.055	6.237GlyGly: 6.237 ± 0.133	1.962GlyHis: 1.962 ± 0.043	4.48GlyIle: 4.48 ± 0.065	3.808GlyLys: 3.808 ± 0.065	8.07GlyLeu: 8.07 ± 0.096	2.16GlyMet: 2.16 ± 0.046	2.248GlyAsn: 2.248 ± 0.072	2.999GlyPro: 2.999 ± 0.056	3.002GlyGln: 3.002 ± 0.05	5.433GlyArg: 5.433 ± 0.078	4.643GlySer: 4.643 ± 0.076	4.872GlyThr: 4.872 ± 0.085	5.701GlyVal: 5.701 ± 0.067	1.224GlyTrp: 1.224 ± 0.036	2.271GlyTyr: 2.271 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.411HisAla: 2.411 ± 0.049	0.338HisCys: 0.338 ± 0.016	1.349HisAsp: 1.349 ± 0.042	1.479HisGlu: 1.479 ± 0.037	0.844HisPhe: 0.844 ± 0.026	1.948HisGly: 1.948 ± 0.042	0.822HisHis: 0.822 ± 0.031	1.216HisIle: 1.216 ± 0.034	0.743HisLys: 0.743 ± 0.023	2.467HisLeu: 2.467 ± 0.052	0.549HisMet: 0.549 ± 0.021	0.581HisAsn: 0.581 ± 0.025	1.595HisPro: 1.595 ± 0.032	0.943HisGln: 0.943 ± 0.03	2.001HisArg: 2.001 ± 0.044	1.319HisSer: 1.319 ± 0.04	1.141HisThr: 1.141 ± 0.031	1.892HisVal: 1.892 ± 0.041	0.355HisTrp: 0.355 ± 0.02	0.672HisTyr: 0.672 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.28IleAla: 5.28 ± 0.067	0.51IleCys: 0.51 ± 0.025	3.155IleAsp: 3.155 ± 0.055	3.738IleGlu: 3.738 ± 0.063	1.68IlePhe: 1.68 ± 0.036	4.723IleGly: 4.723 ± 0.065	1.384IleHis: 1.384 ± 0.037	2.458IleIle: 2.458 ± 0.051	2.163IleLys: 2.163 ± 0.045	5.067IleLeu: 5.067 ± 0.073	1.007IleMet: 1.007 ± 0.033	1.504IleAsn: 1.504 ± 0.035	2.923IlePro: 2.923 ± 0.047	1.964IleGln: 1.964 ± 0.04	3.671IleArg: 3.671 ± 0.056	2.897IleSer: 2.897 ± 0.051	2.993IleThr: 2.993 ± 0.057	4.259IleVal: 4.259 ± 0.066	0.561IleTrp: 0.561 ± 0.021	1.12IleTyr: 1.12 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.048LysAla: 4.048 ± 0.063	0.252LysCys: 0.252 ± 0.014	2.386LysAsp: 2.386 ± 0.046	2.933LysGlu: 2.933 ± 0.057	1.143LysPhe: 1.143 ± 0.032	3.135LysGly: 3.135 ± 0.056	0.885LysHis: 0.885 ± 0.032	2.216LysIle: 2.216 ± 0.048	2.318LysLys: 2.318 ± 0.059	3.843LysLeu: 3.843 ± 0.067	1.03LysMet: 1.03 ± 0.034	1.193LysAsn: 1.193 ± 0.034	2.246LysPro: 2.246 ± 0.052	1.9LysGln: 1.9 ± 0.039	3.002LysArg: 3.002 ± 0.053	2.318LysSer: 2.318 ± 0.045	2.603LysThr: 2.603 ± 0.056	2.947LysVal: 2.947 ± 0.058	0.448LysTrp: 0.448 ± 0.02	0.83LysTyr: 0.83 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.618LeuAla: 10.618 ± 0.135	1.201LeuCys: 1.201 ± 0.031	5.59LeuAsp: 5.59 ± 0.065	5.796LeuGlu: 5.796 ± 0.084	3.864LeuPhe: 3.864 ± 0.063	7.516LeuGly: 7.516 ± 0.093	2.46LeuHis: 2.46 ± 0.05	5.26LeuIle: 5.26 ± 0.08	4.422LeuLys: 4.422 ± 0.069	10.817LeuLeu: 10.817 ± 0.129	2.392LeuMet: 2.392 ± 0.044	3.002LeuAsn: 3.002 ± 0.052	5.303LeuPro: 5.303 ± 0.072	3.677LeuGln: 3.677 ± 0.056	7.263LeuArg: 7.263 ± 0.085	7.076LeuSer: 7.076 ± 0.098	6.332LeuThr: 6.332 ± 0.088	7.532LeuVal: 7.532 ± 0.079	1.201LeuTrp: 1.201 ± 0.03	2.557LeuTyr: 2.557 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.651MetAla: 2.651 ± 0.045	0.189MetCys: 0.189 ± 0.011	1.157MetAsp: 1.157 ± 0.03	1.394MetGlu: 1.394 ± 0.032	0.695MetPhe: 0.695 ± 0.025	1.84MetGly: 1.84 ± 0.04	0.453MetHis: 0.453 ± 0.019	1.363MetIle: 1.363 ± 0.033	1.385MetLys: 1.385 ± 0.037	2.23MetLeu: 2.23 ± 0.049	0.654MetMet: 0.654 ± 0.024	0.91MetAsn: 0.91 ± 0.027	1.38MetPro: 1.38 ± 0.034	0.88MetGln: 0.88 ± 0.026	1.64MetArg: 1.64 ± 0.037	1.529MetSer: 1.529 ± 0.036	1.835MetThr: 1.835 ± 0.039	1.819MetVal: 1.819 ± 0.038	0.235MetTrp: 0.235 ± 0.016	0.385MetTyr: 0.385 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.399AsnAla: 2.399 ± 0.054	0.302AsnCys: 0.302 ± 0.017	1.325AsnAsp: 1.325 ± 0.043	1.47AsnGlu: 1.47 ± 0.04	0.937AsnPhe: 0.937 ± 0.035	2.374AsnGly: 2.374 ± 0.058	0.705AsnHis: 0.705 ± 0.027	1.38AsnIle: 1.38 ± 0.036	0.972AsnLys: 0.972 ± 0.029	2.909AsnLeu: 2.909 ± 0.054	0.63AsnMet: 0.63 ± 0.021	0.815AsnAsn: 0.815 ± 0.031	1.904AsnPro: 1.904 ± 0.041	1.118AsnGln: 1.118 ± 0.034	2.102AsnArg: 2.102 ± 0.039	1.362AsnSer: 1.362 ± 0.035	1.363AsnThr: 1.363 ± 0.042	2.076AsnVal: 2.076 ± 0.045	0.391AsnTrp: 0.391 ± 0.023	0.771AsnTyr: 0.771 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.583ProAla: 4.583 ± 0.061	0.494ProCys: 0.494 ± 0.021	3.175ProAsp: 3.175 ± 0.052	3.254ProGlu: 3.254 ± 0.051	1.958ProPhe: 1.958 ± 0.039	3.801ProGly: 3.801 ± 0.059	1.262ProHis: 1.262 ± 0.034	2.794ProIle: 2.794 ± 0.053	1.876ProLys: 1.876 ± 0.045	4.939ProLeu: 4.939 ± 0.077	1.253ProMet: 1.253 ± 0.032	1.48ProAsn: 1.48 ± 0.033	2.803ProPro: 2.803 ± 0.055	1.746ProGln: 1.746 ± 0.042	2.76ProArg: 2.76 ± 0.05	3.51ProSer: 3.51 ± 0.065	3.031ProThr: 3.031 ± 0.061	3.962ProVal: 3.962 ± 0.062	0.701ProTrp: 0.701 ± 0.028	1.257ProTyr: 1.257 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.491GlnAla: 4.491 ± 0.07	0.319GlnCys: 0.319 ± 0.018	1.927GlnAsp: 1.927 ± 0.041	2.563GlnGlu: 2.563 ± 0.053	1.354GlnPhe: 1.354 ± 0.033	2.942GlnGly: 2.942 ± 0.051	0.858GlnHis: 0.858 ± 0.028	2.061GlnIle: 2.061 ± 0.042	1.495GlnLys: 1.495 ± 0.04	3.918GlnLeu: 3.918 ± 0.069	0.861GlnMet: 0.861 ± 0.027	0.91GlnAsn: 0.91 ± 0.031	1.955GlnPro: 1.955 ± 0.039	1.835GlnGln: 1.835 ± 0.044	2.927GlnArg: 2.927 ± 0.053	2.372GlnSer: 2.372 ± 0.044	2.137GlnThr: 2.137 ± 0.041	2.896GlnVal: 2.896 ± 0.052	0.564GlnTrp: 0.564 ± 0.022	0.959GlnTyr: 0.959 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.059ArgAla: 6.059 ± 0.07	0.798ArgCys: 0.798 ± 0.031	3.556ArgAsp: 3.556 ± 0.059	4.58ArgGlu: 4.58 ± 0.066	2.89ArgPhe: 2.89 ± 0.051	4.343ArgGly: 4.343 ± 0.065	1.862ArgHis: 1.862 ± 0.041	4.024ArgIle: 4.024 ± 0.06	2.804ArgLys: 2.804 ± 0.053	8.073ArgLeu: 8.073 ± 0.09	2.027ArgMet: 2.027 ± 0.043	1.867ArgAsn: 1.867 ± 0.048	3.299ArgPro: 3.299 ± 0.062	3.04ArgGln: 3.04 ± 0.053	5.57ArgArg: 5.57 ± 0.09	4.179ArgSer: 4.179 ± 0.052	3.791ArgThr: 3.791 ± 0.054	5.066ArgVal: 5.066 ± 0.062	1.073ArgTrp: 1.073 ± 0.028	2.109ArgTyr: 2.109 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.461SerAla: 5.461 ± 0.077	0.593SerCys: 0.593 ± 0.025	3.034SerAsp: 3.034 ± 0.048	3.23SerGlu: 3.23 ± 0.059	2.364SerPhe: 2.364 ± 0.047	5.085SerGly: 5.085 ± 0.079	1.514SerHis: 1.514 ± 0.038	3.142SerIle: 3.142 ± 0.054	2.245SerLys: 2.245 ± 0.052	6.458SerLeu: 6.458 ± 0.084	1.593SerMet: 1.593 ± 0.035	1.596SerAsn: 1.596 ± 0.036	3.456SerPro: 3.456 ± 0.06	2.156SerGln: 2.156 ± 0.04	4.235SerArg: 4.235 ± 0.061	3.959SerSer: 3.959 ± 0.054	3.353SerThr: 3.353 ± 0.06	4.441SerVal: 4.441 ± 0.059	0.841SerTrp: 0.841 ± 0.027	1.47SerTyr: 1.47 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.33ThrAla: 5.33 ± 0.072	0.552ThrCys: 0.552 ± 0.024	2.954ThrAsp: 2.954 ± 0.061	2.972ThrGlu: 2.972 ± 0.054	2.141ThrPhe: 2.141 ± 0.043	4.889ThrGly: 4.889 ± 0.084	1.364ThrHis: 1.364 ± 0.036	3.462ThrIle: 3.462 ± 0.06	2.276ThrLys: 2.276 ± 0.049	5.873ThrLeu: 5.873 ± 0.08	1.417ThrMet: 1.417 ± 0.034	1.561ThrAsn: 1.561 ± 0.041	3.201ThrPro: 3.201 ± 0.053	1.895ThrGln: 1.895 ± 0.041	3.254ThrArg: 3.254 ± 0.059	3.229ThrSer: 3.229 ± 0.049	3.356ThrThr: 3.356 ± 0.064	5.115ThrVal: 5.115 ± 0.083	0.693ThrTrp: 0.693 ± 0.026	1.444ThrTyr: 1.444 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.234ValAla: 7.234 ± 0.094	0.816ValCys: 0.816 ± 0.03	3.826ValAsp: 3.826 ± 0.07	4.71ValGlu: 4.71 ± 0.07	2.652ValPhe: 2.652 ± 0.052	5.793ValGly: 5.793 ± 0.09	1.584ValHis: 1.584 ± 0.041	4.103ValIle: 4.103 ± 0.069	3.189ValLys: 3.189 ± 0.062	7.884ValLeu: 7.884 ± 0.099	1.968ValMet: 1.968 ± 0.045	2.151ValAsn: 2.151 ± 0.044	3.735ValPro: 3.735 ± 0.059	2.681ValGln: 2.681 ± 0.038	5.207ValArg: 5.207 ± 0.07	4.848ValSer: 4.848 ± 0.066	4.835ValThr: 4.835 ± 0.075	6.222ValVal: 6.222 ± 0.09	0.911ValTrp: 0.911 ± 0.031	1.658ValTyr: 1.658 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.021TrpAla: 1.021 ± 0.03	0.158TrpCys: 0.158 ± 0.009	0.664TrpAsp: 0.664 ± 0.026	0.763TrpGlu: 0.763 ± 0.025	0.557TrpPhe: 0.557 ± 0.021	0.853TrpGly: 0.853 ± 0.028	0.376TrpHis: 0.376 ± 0.019	0.771TrpIle: 0.771 ± 0.025	0.692TrpLys: 0.692 ± 0.026	1.526TrpLeu: 1.526 ± 0.04	0.392TrpMet: 0.392 ± 0.02	0.477TrpAsn: 0.477 ± 0.018	0.593TrpPro: 0.593 ± 0.023	0.547TrpGln: 0.547 ± 0.021	0.927TrpArg: 0.927 ± 0.029	0.858TrpSer: 0.858 ± 0.027	0.756TrpThr: 0.756 ± 0.028	0.906TrpVal: 0.906 ± 0.029	0.248TrpTrp: 0.248 ± 0.017	0.365TrpTyr: 0.365 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.264TyrAla: 2.264 ± 0.045	0.312TyrCys: 0.312 ± 0.017	1.476TyrAsp: 1.476 ± 0.038	1.465TyrGlu: 1.465 ± 0.034	0.989TyrPhe: 0.989 ± 0.035	2.076TyrGly: 2.076 ± 0.04	0.723TyrHis: 0.723 ± 0.026	1.012TyrIle: 1.012 ± 0.031	0.859TyrLys: 0.859 ± 0.031	2.682TyrLeu: 2.682 ± 0.049	0.449TyrMet: 0.449 ± 0.021	0.65TyrAsn: 0.65 ± 0.027	1.221TyrPro: 1.221 ± 0.034	1.057TyrGln: 1.057 ± 0.03	2.239TyrArg: 2.239 ± 0.039	1.394TyrSer: 1.394 ± 0.034	1.186TyrThr: 1.186 ± 0.034	1.834TyrVal: 1.834 ± 0.039	0.397TyrTrp: 0.397 ± 0.018	0.793TyrTyr: 0.793 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4434 proteins (1215056 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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