Amino acid dipepetide frequency for Loktanella sp. S4079

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.487AlaAla: 14.487 ± 0.181
1.084AlaCys: 1.084 ± 0.035
7.077AlaAsp: 7.077 ± 0.09
7.306AlaGlu: 7.306 ± 0.115
4.193AlaPhe: 4.193 ± 0.067
9.494AlaGly: 9.494 ± 0.096
2.236AlaHis: 2.236 ± 0.047
6.576AlaIle: 6.576 ± 0.09
4.336AlaLys: 4.336 ± 0.069
12.238AlaLeu: 12.238 ± 0.139
3.556AlaMet: 3.556 ± 0.069
3.303AlaAsn: 3.303 ± 0.058
5.054AlaPro: 5.054 ± 0.081
4.86AlaGln: 4.86 ± 0.069
6.879AlaArg: 6.879 ± 0.107
5.487AlaSer: 5.487 ± 0.073
6.235AlaThr: 6.235 ± 0.085
7.947AlaVal: 7.947 ± 0.098
1.317AlaTrp: 1.317 ± 0.037
2.586AlaTyr: 2.586 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.111CysAla: 1.111 ± 0.039
0.109CysCys: 0.109 ± 0.011
0.695CysAsp: 0.695 ± 0.028
0.476CysGlu: 0.476 ± 0.017
0.347CysPhe: 0.347 ± 0.018
0.967CysGly: 0.967 ± 0.032
0.268CysHis: 0.268 ± 0.015
0.481CysIle: 0.481 ± 0.022
0.249CysLys: 0.249 ± 0.016
0.833CysLeu: 0.833 ± 0.037
0.184CysMet: 0.184 ± 0.012
0.262CysAsn: 0.262 ± 0.014
0.467CysPro: 0.467 ± 0.025
0.27CysGln: 0.27 ± 0.016
0.439CysArg: 0.439 ± 0.022
0.496CysSer: 0.496 ± 0.02
0.454CysThr: 0.454 ± 0.021
0.646CysVal: 0.646 ± 0.028
0.13CysTrp: 0.13 ± 0.01
0.225CysTyr: 0.225 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.376AspAla: 7.376 ± 0.093
0.531AspCys: 0.531 ± 0.023
3.851AspAsp: 3.851 ± 0.083
3.741AspGlu: 3.741 ± 0.065
2.431AspPhe: 2.431 ± 0.044
5.645AspGly: 5.645 ± 0.089
1.451AspHis: 1.451 ± 0.042
3.571AspIle: 3.571 ± 0.052
1.761AspLys: 1.761 ± 0.041
6.158AspLeu: 6.158 ± 0.077
1.733AspMet: 1.733 ± 0.042
1.68AspAsn: 1.68 ± 0.045
3.531AspPro: 3.531 ± 0.064
2.452AspGln: 2.452 ± 0.05
3.809AspArg: 3.809 ± 0.058
2.441AspSer: 2.441 ± 0.061
3.155AspThr: 3.155 ± 0.061
4.632AspVal: 4.632 ± 0.071
1.12AspTrp: 1.12 ± 0.037
1.617AspTyr: 1.617 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
6.848GluAla: 6.848 ± 0.109
0.369GluCys: 0.369 ± 0.019
3.052GluAsp: 3.052 ± 0.061
3.36GluGlu: 3.36 ± 0.079
1.94GluPhe: 1.94 ± 0.043
4.192GluGly: 4.192 ± 0.08
1.226GluHis: 1.226 ± 0.036
3.931GluIle: 3.931 ± 0.068
2.322GluLys: 2.322 ± 0.053
5.253GluLeu: 5.253 ± 0.077
1.901GluMet: 1.901 ± 0.045
2.236GluAsn: 2.236 ± 0.046
2.368GluPro: 2.368 ± 0.047
2.233GluGln: 2.233 ± 0.049
3.66GluArg: 3.66 ± 0.064
2.131GluSer: 2.131 ± 0.048
4.106GluThr: 4.106 ± 0.065
4.266GluVal: 4.266 ± 0.08
0.685GluTrp: 0.685 ± 0.027
1.18GluTyr: 1.18 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.646PheAla: 4.646 ± 0.069
0.445PheCys: 0.445 ± 0.019
3.094PheAsp: 3.094 ± 0.053
2.359PheGlu: 2.359 ± 0.054
1.514PhePhe: 1.514 ± 0.046
3.889PheGly: 3.889 ± 0.073
0.784PheHis: 0.784 ± 0.028
1.899PheIle: 1.899 ± 0.049
1.04PheLys: 1.04 ± 0.032
3.251PheLeu: 3.251 ± 0.061
0.932PheMet: 0.932 ± 0.031
1.122PheAsn: 1.122 ± 0.031
1.556PhePro: 1.556 ± 0.039
1.129PheGln: 1.129 ± 0.033
1.982PheArg: 1.982 ± 0.053
2.291PheSer: 2.291 ± 0.048
2.121PheThr: 2.121 ± 0.042
2.929PheVal: 2.929 ± 0.052
0.59PheTrp: 0.59 ± 0.026
1.019PheTyr: 1.019 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
9.015GlyAla: 9.015 ± 0.098
0.826GlyCys: 0.826 ± 0.028
4.783GlyAsp: 4.783 ± 0.086
4.516GlyGlu: 4.516 ± 0.069
3.642GlyPhe: 3.642 ± 0.069
6.793GlyGly: 6.793 ± 0.098
1.846GlyHis: 1.846 ± 0.043
4.817GlyIle: 4.817 ± 0.078
3.284GlyLys: 3.284 ± 0.066
8.364GlyLeu: 8.364 ± 0.103
2.53GlyMet: 2.53 ± 0.054
2.276GlyAsn: 2.276 ± 0.052
3.272GlyPro: 3.272 ± 0.061
3.383GlyGln: 3.383 ± 0.066
5.001GlyArg: 5.001 ± 0.079
4.175GlySer: 4.175 ± 0.067
4.66GlyThr: 4.66 ± 0.075
6.49GlyVal: 6.49 ± 0.091
1.342GlyTrp: 1.342 ± 0.037
2.366GlyTyr: 2.366 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.262HisAla: 2.262 ± 0.051
0.26HisCys: 0.26 ± 0.016
1.345HisAsp: 1.345 ± 0.039
1.123HisGlu: 1.123 ± 0.035
0.856HisPhe: 0.856 ± 0.03
1.822HisGly: 1.822 ± 0.042
0.567HisHis: 0.567 ± 0.028
1.147HisIle: 1.147 ± 0.037
0.628HisLys: 0.628 ± 0.023
2.134HisLeu: 2.134 ± 0.056
0.596HisMet: 0.596 ± 0.023
0.545HisAsn: 0.545 ± 0.024
1.285HisPro: 1.285 ± 0.033
0.708HisGln: 0.708 ± 0.027
1.203HisArg: 1.203 ± 0.035
0.947HisSer: 0.947 ± 0.033
0.913HisThr: 0.913 ± 0.029
1.497HisVal: 1.497 ± 0.037
0.343HisTrp: 0.343 ± 0.016
0.561HisTyr: 0.561 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.974IleAla: 7.974 ± 0.086
0.725IleCys: 0.725 ± 0.029
3.946IleAsp: 3.946 ± 0.062
3.653IleGlu: 3.653 ± 0.062
2.035IlePhe: 2.035 ± 0.048
5.322IleGly: 5.322 ± 0.079
1.016IleHis: 1.016 ± 0.033
2.919IleIle: 2.919 ± 0.056
1.888IleLys: 1.888 ± 0.044
4.887IleLeu: 4.887 ± 0.073
1.356IleMet: 1.356 ± 0.036
1.773IleAsn: 1.773 ± 0.042
2.577IlePro: 2.577 ± 0.054
1.456IleGln: 1.456 ± 0.037
3.044IleArg: 3.044 ± 0.06
3.47IleSer: 3.47 ± 0.066
3.386IleThr: 3.386 ± 0.058
4.334IleVal: 4.334 ± 0.058
0.783IleTrp: 0.783 ± 0.027
1.336IleTyr: 1.336 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.859LysAla: 3.859 ± 0.069
0.203LysCys: 0.203 ± 0.014
1.914LysAsp: 1.914 ± 0.041
1.745LysGlu: 1.745 ± 0.046
1.151LysPhe: 1.151 ± 0.037
2.669LysGly: 2.669 ± 0.056
0.743LysHis: 0.743 ± 0.028
1.991LysIle: 1.991 ± 0.046
1.378LysLys: 1.378 ± 0.04
3.343LysLeu: 3.343 ± 0.063
1.005LysMet: 1.005 ± 0.033
1.039LysAsn: 1.039 ± 0.028
1.818LysPro: 1.818 ± 0.048
1.122LysGln: 1.122 ± 0.033
2.384LysArg: 2.384 ± 0.052
2.268LysSer: 2.268 ± 0.046
2.082LysThr: 2.082 ± 0.045
2.542LysVal: 2.542 ± 0.052
0.459LysTrp: 0.459 ± 0.023
0.751LysTyr: 0.751 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
11.082LeuAla: 11.082 ± 0.128
1.027LeuCys: 1.027 ± 0.038
5.873LeuAsp: 5.873 ± 0.079
4.983LeuGlu: 4.983 ± 0.087
3.442LeuPhe: 3.442 ± 0.075
8.001LeuGly: 8.001 ± 0.108
1.851LeuHis: 1.851 ± 0.044
5.683LeuIle: 5.683 ± 0.079
3.156LeuLys: 3.156 ± 0.069
8.337LeuLeu: 8.337 ± 0.12
2.592LeuMet: 2.592 ± 0.05
3.059LeuAsn: 3.059 ± 0.048
4.99LeuPro: 4.99 ± 0.082
2.955LeuGln: 2.955 ± 0.054
6.461LeuArg: 6.461 ± 0.095
6.802LeuSer: 6.802 ± 0.085
6.035LeuThr: 6.035 ± 0.081
6.432LeuVal: 6.432 ± 0.085
1.256LeuTrp: 1.256 ± 0.042
1.982LeuTyr: 1.982 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.197MetAla: 3.197 ± 0.063
0.22MetCys: 0.22 ± 0.015
1.469MetAsp: 1.469 ± 0.04
1.216MetGlu: 1.216 ± 0.036
0.913MetPhe: 0.913 ± 0.035
2.328MetGly: 2.328 ± 0.048
0.495MetHis: 0.495 ± 0.023
1.85MetIle: 1.85 ± 0.045
1.133MetLys: 1.133 ± 0.034
2.613MetLeu: 2.613 ± 0.052
0.799MetMet: 0.799 ± 0.028
1.017MetAsn: 1.017 ± 0.032
1.526MetPro: 1.526 ± 0.039
1.076MetGln: 1.076 ± 0.029
1.863MetArg: 1.863 ± 0.046
1.803MetSer: 1.803 ± 0.044
2.234MetThr: 2.234 ± 0.051
1.865MetVal: 1.865 ± 0.044
0.275MetTrp: 0.275 ± 0.017
0.382MetTyr: 0.382 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.837AsnAla: 3.837 ± 0.058
0.314AsnCys: 0.314 ± 0.018
1.907AsnAsp: 1.907 ± 0.049
1.524AsnGlu: 1.524 ± 0.039
1.129AsnPhe: 1.129 ± 0.035
2.858AsnGly: 2.858 ± 0.058
0.63AsnHis: 0.63 ± 0.025
1.802AsnIle: 1.802 ± 0.048
0.836AsnLys: 0.836 ± 0.029
2.837AsnLeu: 2.837 ± 0.058
0.887AsnMet: 0.887 ± 0.031
0.896AsnAsn: 0.896 ± 0.036
1.991AsnPro: 1.991 ± 0.051
0.94AsnGln: 0.94 ± 0.034
1.77AsnArg: 1.77 ± 0.046
1.376AsnSer: 1.376 ± 0.034
1.664AsnThr: 1.664 ± 0.043
2.15AsnVal: 2.15 ± 0.048
0.525AsnTrp: 0.525 ± 0.022
0.802AsnTyr: 0.802 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
5.146ProAla: 5.146 ± 0.077
0.361ProCys: 0.361 ± 0.018
3.625ProAsp: 3.625 ± 0.062
3.666ProGlu: 3.666 ± 0.067
1.988ProPhe: 1.988 ± 0.046
3.532ProGly: 3.532 ± 0.059
1.045ProHis: 1.045 ± 0.029
2.64ProIle: 2.64 ± 0.057
1.821ProLys: 1.821 ± 0.046
4.262ProLeu: 4.262 ± 0.072
1.276ProMet: 1.276 ± 0.039
1.574ProAsn: 1.574 ± 0.039
1.834ProPro: 1.834 ± 0.048
1.706ProGln: 1.706 ± 0.041
2.316ProArg: 2.316 ± 0.049
2.522ProSer: 2.522 ± 0.048
2.698ProThr: 2.698 ± 0.041
3.907ProVal: 3.907 ± 0.062
0.609ProTrp: 0.609 ± 0.026
1.12ProTyr: 1.12 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.975GlnAla: 3.975 ± 0.067
0.239GlnCys: 0.239 ± 0.017
1.951GlnAsp: 1.951 ± 0.045
1.928GlnGlu: 1.928 ± 0.046
1.352GlnPhe: 1.352 ± 0.036
2.506GlnGly: 2.506 ± 0.047
0.683GlnHis: 0.683 ± 0.027
2.474GlnIle: 2.474 ± 0.05
1.153GlnLys: 1.153 ± 0.032
3.431GlnLeu: 3.431 ± 0.063
1.24GlnMet: 1.24 ± 0.038
1.128GlnAsn: 1.128 ± 0.034
1.588GlnPro: 1.588 ± 0.042
1.34GlnGln: 1.34 ± 0.04
2.302GlnArg: 2.302 ± 0.05
2.4GlnSer: 2.4 ± 0.058
2.232GlnThr: 2.232 ± 0.047
2.534GlnVal: 2.534 ± 0.055
0.464GlnTrp: 0.464 ± 0.019
0.663GlnTyr: 0.663 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
6.786ArgAla: 6.786 ± 0.086
0.444ArgCys: 0.444 ± 0.022
3.869ArgAsp: 3.869 ± 0.068
3.345ArgGlu: 3.345 ± 0.065
2.485ArgPhe: 2.485 ± 0.046
4.089ArgGly: 4.089 ± 0.061
1.333ArgHis: 1.333 ± 0.039
3.592ArgIle: 3.592 ± 0.057
2.319ArgLys: 2.319 ± 0.058
6.081ArgLeu: 6.081 ± 0.097
1.721ArgMet: 1.721 ± 0.044
1.933ArgAsn: 1.933 ± 0.048
2.762ArgPro: 2.762 ± 0.048
2.189ArgGln: 2.189 ± 0.049
3.98ArgArg: 3.98 ± 0.07
3.044ArgSer: 3.044 ± 0.053
2.786ArgThr: 2.786 ± 0.052
4.327ArgVal: 4.327 ± 0.068
0.827ArgTrp: 0.827 ± 0.031
1.52ArgTyr: 1.52 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.894SerAla: 5.894 ± 0.073
0.466SerCys: 0.466 ± 0.022
3.584SerAsp: 3.584 ± 0.058
3.091SerGlu: 3.091 ± 0.063
2.39SerPhe: 2.39 ± 0.042
5.324SerGly: 5.324 ± 0.079
1.128SerHis: 1.128 ± 0.031
2.789SerIle: 2.789 ± 0.058
1.816SerLys: 1.816 ± 0.048
5.102SerLeu: 5.102 ± 0.085
1.404SerMet: 1.404 ± 0.036
1.675SerAsn: 1.675 ± 0.05
2.523SerPro: 2.523 ± 0.052
1.906SerGln: 1.906 ± 0.045
2.988SerArg: 2.988 ± 0.059
2.68SerSer: 2.68 ± 0.061
2.755SerThr: 2.755 ± 0.048
3.971SerVal: 3.971 ± 0.071
0.727SerTrp: 0.727 ± 0.028
1.546SerTyr: 1.546 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
6.289ThrAla: 6.289 ± 0.078
0.498ThrCys: 0.498 ± 0.027
3.632ThrAsp: 3.632 ± 0.062
3.057ThrGlu: 3.057 ± 0.057
2.236ThrPhe: 2.236 ± 0.041
5.165ThrGly: 5.165 ± 0.089
1.229ThrHis: 1.229 ± 0.035
3.271ThrIle: 3.271 ± 0.058
1.878ThrLys: 1.878 ± 0.049
5.96ThrLeu: 5.96 ± 0.066
1.411ThrMet: 1.411 ± 0.038
1.683ThrAsn: 1.683 ± 0.046
3.389ThrPro: 3.389 ± 0.065
2.038ThrGln: 2.038 ± 0.044
3.159ThrArg: 3.159 ± 0.053
2.93ThrSer: 2.93 ± 0.06
3.213ThrThr: 3.213 ± 0.062
4.507ThrVal: 4.507 ± 0.08
0.678ThrTrp: 0.678 ± 0.024
1.473ThrTyr: 1.473 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
8.562ValAla: 8.562 ± 0.101
0.631ValCys: 0.631 ± 0.027
4.381ValAsp: 4.381 ± 0.074
4.145ValGlu: 4.145 ± 0.07
2.957ValPhe: 2.957 ± 0.055
5.692ValGly: 5.692 ± 0.073
1.357ValHis: 1.357 ± 0.036
4.623ValIle: 4.623 ± 0.069
2.333ValLys: 2.333 ± 0.06
7.068ValLeu: 7.068 ± 0.086
2.214ValMet: 2.214 ± 0.044
2.304ValAsn: 2.304 ± 0.051
3.322ValPro: 3.322 ± 0.056
2.333ValGln: 2.333 ± 0.045
3.77ValArg: 3.77 ± 0.058
4.484ValSer: 4.484 ± 0.066
4.93ValThr: 4.93 ± 0.078
5.717ValVal: 5.717 ± 0.085
0.911ValTrp: 0.911 ± 0.034
1.561ValTyr: 1.561 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.316TrpAla: 1.316 ± 0.041
0.13TrpCys: 0.13 ± 0.011
0.854TrpAsp: 0.854 ± 0.029
0.7TrpGlu: 0.7 ± 0.026
0.571TrpPhe: 0.571 ± 0.025
0.97TrpGly: 0.97 ± 0.036
0.325TrpHis: 0.325 ± 0.016
0.762TrpIle: 0.762 ± 0.033
0.485TrpLys: 0.485 ± 0.024
1.524TrpLeu: 1.524 ± 0.044
0.383TrpMet: 0.383 ± 0.02
0.461TrpAsn: 0.461 ± 0.021
0.66TrpPro: 0.66 ± 0.027
0.604TrpGln: 0.604 ± 0.023
0.966TrpArg: 0.966 ± 0.03
0.786TrpSer: 0.786 ± 0.029
0.747TrpThr: 0.747 ± 0.028
0.917TrpVal: 0.917 ± 0.029
0.216TrpTrp: 0.216 ± 0.016
0.274TrpTyr: 0.274 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.59TyrAla: 2.59 ± 0.047
0.227TyrCys: 0.227 ± 0.016
1.785TyrAsp: 1.785 ± 0.043
1.326TyrGlu: 1.326 ± 0.033
1.018TyrPhe: 1.018 ± 0.033
2.121TyrGly: 2.121 ± 0.049
0.529TyrHis: 0.529 ± 0.022
1.063TyrIle: 1.063 ± 0.031
0.654TyrLys: 0.654 ± 0.025
2.321TyrLeu: 2.321 ± 0.053
0.55TyrMet: 0.55 ± 0.02
0.708TyrAsn: 0.708 ± 0.026
1.135TyrPro: 1.135 ± 0.032
0.885TyrGln: 0.885 ± 0.032
1.456TyrArg: 1.456 ± 0.04
1.226TyrSer: 1.226 ± 0.037
1.289TyrThr: 1.289 ± 0.041
1.687TyrVal: 1.687 ± 0.037
0.393TyrTrp: 0.393 ± 0.02
0.67TyrTyr: 0.67 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3296 proteins (1023294 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski