Amino acid dipepetide frequency for Nakamurella panacisegetis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.77AlaAla: 21.77 ± 0.208	0.9AlaCys: 0.9 ± 0.026	8.577AlaAsp: 8.577 ± 0.087	6.938AlaGlu: 6.938 ± 0.097	3.386AlaPhe: 3.386 ± 0.053	13.823AlaGly: 13.823 ± 0.118	2.393AlaHis: 2.393 ± 0.04	5.022AlaIle: 5.022 ± 0.064	2.802AlaLys: 2.802 ± 0.057	13.027AlaLeu: 13.027 ± 0.125	2.575AlaMet: 2.575 ± 0.048	2.403AlaAsn: 2.403 ± 0.047	6.588AlaPro: 6.588 ± 0.097	3.885AlaGln: 3.885 ± 0.052	8.733AlaArg: 8.733 ± 0.106	7.036AlaSer: 7.036 ± 0.087	8.147AlaThr: 8.147 ± 0.099	12.585AlaVal: 12.585 ± 0.107	1.635AlaTrp: 1.635 ± 0.033	2.268AlaTyr: 2.268 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.866CysAla: 0.866 ± 0.03	0.086CysCys: 0.086 ± 0.008	0.388CysAsp: 0.388 ± 0.018	0.279CysGlu: 0.279 ± 0.015	0.194CysPhe: 0.194 ± 0.012	0.776CysGly: 0.776 ± 0.026	0.167CysHis: 0.167 ± 0.011	0.211CysIle: 0.211 ± 0.012	0.089CysLys: 0.089 ± 0.008	0.627CysLeu: 0.627 ± 0.023	0.104CysMet: 0.104 ± 0.008	0.137CysAsn: 0.137 ± 0.01	0.488CysPro: 0.488 ± 0.023	0.18CysGln: 0.18 ± 0.01	0.521CysArg: 0.521 ± 0.02	0.455CysSer: 0.455 ± 0.018	0.507CysThr: 0.507 ± 0.024	0.593CysVal: 0.593 ± 0.021	0.107CysTrp: 0.107 ± 0.008	0.156CysTyr: 0.156 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.224AspAla: 7.224 ± 0.077	0.379AspCys: 0.379 ± 0.017	3.648AspAsp: 3.648 ± 0.06	3.424AspGlu: 3.424 ± 0.055	1.646AspPhe: 1.646 ± 0.038	6.082AspGly: 6.082 ± 0.078	1.457AspHis: 1.457 ± 0.034	2.159AspIle: 2.159 ± 0.044	1.052AspLys: 1.052 ± 0.036	6.79AspLeu: 6.79 ± 0.075	0.806AspMet: 0.806 ± 0.025	1.053AspAsn: 1.053 ± 0.035	4.73AspPro: 4.73 ± 0.068	1.967AspGln: 1.967 ± 0.036	4.838AspArg: 4.838 ± 0.06	2.736AspSer: 2.736 ± 0.041	2.839AspThr: 2.839 ± 0.045	5.13AspVal: 5.13 ± 0.063	0.851AspTrp: 0.851 ± 0.026	1.093AspTyr: 1.093 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	5.331GluAla: 5.331 ± 0.087	0.26GluCys: 0.26 ± 0.014	1.975GluAsp: 1.975 ± 0.038	1.929GluGlu: 1.929 ± 0.04	1.57GluPhe: 1.57 ± 0.03	2.819GluGly: 2.819 ± 0.047	1.225GluHis: 1.225 ± 0.031	2.496GluIle: 2.496 ± 0.047	1.144GluLys: 1.144 ± 0.029	5.688GluLeu: 5.688 ± 0.078	0.949GluMet: 0.949 ± 0.026	0.964GluAsn: 0.964 ± 0.026	2.78GluPro: 2.78 ± 0.051	1.916GluGln: 1.916 ± 0.039	3.786GluArg: 3.786 ± 0.063	2.559GluSer: 2.559 ± 0.038	2.326GluThr: 2.326 ± 0.043	4.013GluVal: 4.013 ± 0.058	0.616GluTrp: 0.616 ± 0.021	0.921GluTyr: 0.921 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.774PheAla: 3.774 ± 0.045	0.281PheCys: 0.281 ± 0.016	2.211PheAsp: 2.211 ± 0.041	1.223PheGlu: 1.223 ± 0.028	0.901PhePhe: 0.901 ± 0.028	3.29PheGly: 3.29 ± 0.052	0.581PheHis: 0.581 ± 0.02	0.946PheIle: 0.946 ± 0.031	0.488PheLys: 0.488 ± 0.021	2.604PheLeu: 2.604 ± 0.051	0.395PheMet: 0.395 ± 0.018	0.687PheAsn: 0.687 ± 0.019	1.395PhePro: 1.395 ± 0.035	0.699PheGln: 0.699 ± 0.02	1.772PheArg: 1.772 ± 0.033	1.721PheSer: 1.721 ± 0.039	2.088PheThr: 2.088 ± 0.041	2.419PheVal: 2.419 ± 0.051	0.388PheTrp: 0.388 ± 0.017	0.647PheTyr: 0.647 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.743GlyAla: 10.743 ± 0.087	0.751GlyCys: 0.751 ± 0.023	4.9GlyAsp: 4.9 ± 0.065	3.924GlyGlu: 3.924 ± 0.051	2.985GlyPhe: 2.985 ± 0.047	8.186GlyGly: 8.186 ± 0.106	2.179GlyHis: 2.179 ± 0.038	4.126GlyIle: 4.126 ± 0.062	2.152GlyLys: 2.152 ± 0.042	9.384GlyLeu: 9.384 ± 0.088	1.913GlyMet: 1.913 ± 0.039	1.964GlyAsn: 1.964 ± 0.054	5.135GlyPro: 5.135 ± 0.07	3.008GlyGln: 3.008 ± 0.053	7.361GlyArg: 7.361 ± 0.089	6.327GlySer: 6.327 ± 0.085	6.186GlyThr: 6.186 ± 0.098	7.943GlyVal: 7.943 ± 0.085	1.709GlyTrp: 1.709 ± 0.046	2.288GlyTyr: 2.288 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.168HisAla: 2.168 ± 0.041	0.173HisCys: 0.173 ± 0.011	1.217HisAsp: 1.217 ± 0.03	0.9HisGlu: 0.9 ± 0.026	0.626HisPhe: 0.626 ± 0.023	1.968HisGly: 1.968 ± 0.038	0.64HisHis: 0.64 ± 0.018	0.721HisIle: 0.721 ± 0.021	0.272HisLys: 0.272 ± 0.014	2.372HisLeu: 2.372 ± 0.041	0.309HisMet: 0.309 ± 0.014	0.405HisAsn: 0.405 ± 0.018	1.669HisPro: 1.669 ± 0.038	0.705HisGln: 0.705 ± 0.025	1.93HisArg: 1.93 ± 0.04	1.01HisSer: 1.01 ± 0.026	1.117HisThr: 1.117 ± 0.028	1.622HisVal: 1.622 ± 0.03	0.32HisTrp: 0.32 ± 0.015	0.456HisTyr: 0.456 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.149IleAla: 6.149 ± 0.065	0.328IleCys: 0.328 ± 0.015	3.124IleAsp: 3.124 ± 0.046	2.185IleGlu: 2.185 ± 0.039	1.051IlePhe: 1.051 ± 0.029	4.784IleGly: 4.784 ± 0.061	0.683IleHis: 0.683 ± 0.022	1.427IleIle: 1.427 ± 0.038	0.893IleLys: 0.893 ± 0.024	3.153IleLeu: 3.153 ± 0.055	0.527IleMet: 0.527 ± 0.02	1.093IleAsn: 1.093 ± 0.028	2.213IlePro: 2.213 ± 0.035	0.867IleGln: 0.867 ± 0.024	2.768IleArg: 2.768 ± 0.054	2.556IleSer: 2.556 ± 0.049	3.095IleThr: 3.095 ± 0.053	3.596IleVal: 3.596 ± 0.054	0.503IleTrp: 0.503 ± 0.02	0.743IleTyr: 0.743 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.782LysAla: 2.782 ± 0.054	0.093LysCys: 0.093 ± 0.008	1.027LysAsp: 1.027 ± 0.03	0.802LysGlu: 0.802 ± 0.027	0.571LysPhe: 0.571 ± 0.023	1.595LysGly: 1.595 ± 0.039	0.341LysHis: 0.341 ± 0.016	1.057LysIle: 1.057 ± 0.029	0.651LysLys: 0.651 ± 0.023	1.905LysLeu: 1.905 ± 0.033	0.445LysMet: 0.445 ± 0.018	0.492LysAsn: 0.492 ± 0.02	1.225LysPro: 1.225 ± 0.031	0.608LysGln: 0.608 ± 0.021	1.23LysArg: 1.23 ± 0.03	1.291LysSer: 1.291 ± 0.031	1.358LysThr: 1.358 ± 0.036	2.013LysVal: 2.013 ± 0.039	0.257LysTrp: 0.257 ± 0.012	0.46LysTyr: 0.46 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.584LeuAla: 14.584 ± 0.131	0.666LeuCys: 0.666 ± 0.024	6.407LeuAsp: 6.407 ± 0.075	3.985LeuGlu: 3.985 ± 0.063	2.532LeuPhe: 2.532 ± 0.045	8.851LeuGly: 8.851 ± 0.1	1.983LeuHis: 1.983 ± 0.04	4.4LeuIle: 4.4 ± 0.062	1.663LeuLys: 1.663 ± 0.039	10.287LeuLeu: 10.287 ± 0.12	1.648LeuMet: 1.648 ± 0.036	1.831LeuAsn: 1.831 ± 0.038	5.846LeuPro: 5.846 ± 0.084	2.612LeuGln: 2.612 ± 0.047	7.378LeuArg: 7.378 ± 0.084	5.874LeuSer: 5.874 ± 0.059	7.106LeuThr: 7.106 ± 0.078	8.889LeuVal: 8.889 ± 0.087	1.123LeuTrp: 1.123 ± 0.031	1.604LeuTyr: 1.604 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.402MetAla: 2.402 ± 0.048	0.119MetCys: 0.119 ± 0.009	0.892MetAsp: 0.892 ± 0.024	0.605MetGlu: 0.605 ± 0.022	0.509MetPhe: 0.509 ± 0.02	1.3MetGly: 1.3 ± 0.031	0.315MetHis: 0.315 ± 0.014	0.942MetIle: 0.942 ± 0.029	0.407MetLys: 0.407 ± 0.016	1.788MetLeu: 1.788 ± 0.038	0.333MetMet: 0.333 ± 0.018	0.499MetAsn: 0.499 ± 0.018	1.065MetPro: 1.065 ± 0.029	0.46MetGln: 0.46 ± 0.017	1.242MetArg: 1.242 ± 0.03	1.493MetSer: 1.493 ± 0.033	1.951MetThr: 1.951 ± 0.036	1.486MetVal: 1.486 ± 0.035	0.193MetTrp: 0.193 ± 0.009	0.269MetTyr: 0.269 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.51AsnAla: 2.51 ± 0.046	0.182AsnCys: 0.182 ± 0.012	1.083AsnAsp: 1.083 ± 0.031	0.789AsnGlu: 0.789 ± 0.024	0.618AsnPhe: 0.618 ± 0.02	2.185AsnGly: 2.185 ± 0.047	0.405AsnHis: 0.405 ± 0.018	0.854AsnIle: 0.854 ± 0.024	0.439AsnLys: 0.439 ± 0.018	2.022AsnLeu: 2.022 ± 0.041	0.356AsnMet: 0.356 ± 0.015	0.574AsnAsn: 0.574 ± 0.019	1.613AsnPro: 1.613 ± 0.032	0.651AsnGln: 0.651 ± 0.024	1.437AsnArg: 1.437 ± 0.034	1.259AsnSer: 1.259 ± 0.034	1.265AsnThr: 1.265 ± 0.043	1.702AsnVal: 1.702 ± 0.038	0.377AsnTrp: 0.377 ± 0.017	0.499AsnTyr: 0.499 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.545ProAla: 8.545 ± 0.112	0.265ProCys: 0.265 ± 0.014	4.5ProAsp: 4.5 ± 0.068	3.252ProGlu: 3.252 ± 0.057	1.56ProPhe: 1.56 ± 0.039	6.212ProGly: 6.212 ± 0.073	1.151ProHis: 1.151 ± 0.031	2.185ProIle: 2.185 ± 0.038	1.138ProLys: 1.138 ± 0.029	4.695ProLeu: 4.695 ± 0.052	1.064ProMet: 1.064 ± 0.024	1.158ProAsn: 1.158 ± 0.032	3.35ProPro: 3.35 ± 0.079	1.519ProGln: 1.519 ± 0.033	3.318ProArg: 3.318 ± 0.058	3.77ProSer: 3.77 ± 0.063	4.193ProThr: 4.193 ± 0.072	5.546ProVal: 5.546 ± 0.069	0.897ProTrp: 0.897 ± 0.027	1.051ProTyr: 1.051 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.962GlnAla: 3.962 ± 0.052	0.16GlnCys: 0.16 ± 0.009	1.326GlnAsp: 1.326 ± 0.029	1.108GlnGlu: 1.108 ± 0.031	0.862GlnPhe: 0.862 ± 0.025	2.024GlnGly: 2.024 ± 0.037	0.657GlnHis: 0.657 ± 0.02	1.532GlnIle: 1.532 ± 0.032	0.585GlnLys: 0.585 ± 0.021	3.153GlnLeu: 3.153 ± 0.047	0.611GlnMet: 0.611 ± 0.022	0.61GlnAsn: 0.61 ± 0.02	1.777GlnPro: 1.777 ± 0.05	1.24GlnGln: 1.24 ± 0.03	2.3GlnArg: 2.3 ± 0.039	1.487GlnSer: 1.487 ± 0.034	1.676GlnThr: 1.676 ± 0.039	2.906GlnVal: 2.906 ± 0.039	0.486GlnTrp: 0.486 ± 0.018	0.628GlnTyr: 0.628 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.553ArgAla: 8.553 ± 0.102	0.487ArgCys: 0.487 ± 0.019	3.599ArgAsp: 3.599 ± 0.054	3.261ArgGlu: 3.261 ± 0.056	2.104ArgPhe: 2.104 ± 0.043	5.112ArgGly: 5.112 ± 0.062	1.639ArgHis: 1.639 ± 0.031	3.365ArgIle: 3.365 ± 0.052	1.407ArgLys: 1.407 ± 0.038	7.463ArgLeu: 7.463 ± 0.088	1.717ArgMet: 1.717 ± 0.037	1.413ArgAsn: 1.413 ± 0.031	4.748ArgPro: 4.748 ± 0.064	2.175ArgGln: 2.175 ± 0.041	7.001ArgArg: 7.001 ± 0.099	4.672ArgSer: 4.672 ± 0.059	4.69ArgThr: 4.69 ± 0.058	5.394ArgVal: 5.394 ± 0.06	1.297ArgTrp: 1.297 ± 0.034	1.624ArgTyr: 1.624 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	8.25SerAla: 8.25 ± 0.094	0.422SerCys: 0.422 ± 0.022	3.354SerAsp: 3.354 ± 0.047	2.385SerGlu: 2.385 ± 0.044	1.8SerPhe: 1.8 ± 0.042	6.801SerGly: 6.801 ± 0.085	1.072SerHis: 1.072 ± 0.029	2.388SerIle: 2.388 ± 0.033	1.198SerLys: 1.198 ± 0.031	5.157SerLeu: 5.157 ± 0.061	1.253SerMet: 1.253 ± 0.03	1.291SerAsn: 1.291 ± 0.031	3.404SerPro: 3.404 ± 0.055	1.423SerGln: 1.423 ± 0.03	3.798SerArg: 3.798 ± 0.053	4.499SerSer: 4.499 ± 0.091	4.433SerThr: 4.433 ± 0.081	5.398SerVal: 5.398 ± 0.061	1.017SerTrp: 1.017 ± 0.029	1.238SerTyr: 1.238 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	9.179ThrAla: 9.179 ± 0.118	0.462ThrCys: 0.462 ± 0.027	4.0ThrAsp: 4.0 ± 0.051	2.759ThrGlu: 2.759 ± 0.042	1.959ThrPhe: 1.959 ± 0.039	6.894ThrGly: 6.894 ± 0.091	1.17ThrHis: 1.17 ± 0.029	2.55ThrIle: 2.55 ± 0.048	1.347ThrLys: 1.347 ± 0.035	5.877ThrLeu: 5.877 ± 0.068	1.142ThrMet: 1.142 ± 0.03	1.38ThrAsn: 1.38 ± 0.045	4.232ThrPro: 4.232 ± 0.067	1.577ThrGln: 1.577 ± 0.036	3.632ThrArg: 3.632 ± 0.056	4.396ThrSer: 4.396 ± 0.081	4.754ThrThr: 4.754 ± 0.102	6.873ThrVal: 6.873 ± 0.098	0.92ThrTrp: 0.92 ± 0.026	1.433ThrTyr: 1.433 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	11.829ValAla: 11.829 ± 0.105	0.626ValCys: 0.626 ± 0.023	5.657ValAsp: 5.657 ± 0.066	4.106ValGlu: 4.106 ± 0.06	2.469ValPhe: 2.469 ± 0.047	7.654ValGly: 7.654 ± 0.072	1.828ValHis: 1.828 ± 0.042	4.089ValIle: 4.089 ± 0.055	1.809ValLys: 1.809 ± 0.041	9.521ValLeu: 9.521 ± 0.11	1.569ValMet: 1.569 ± 0.033	1.972ValAsn: 1.972 ± 0.039	5.142ValPro: 5.142 ± 0.058	2.319ValGln: 2.319 ± 0.04	5.944ValArg: 5.944 ± 0.067	5.202ValSer: 5.202 ± 0.071	6.566ValThr: 6.566 ± 0.106	9.022ValVal: 9.022 ± 0.105	0.95ValTrp: 0.95 ± 0.025	1.439ValTyr: 1.439 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.612TrpAla: 1.612 ± 0.038	0.118TrpCys: 0.118 ± 0.009	0.777TrpAsp: 0.777 ± 0.026	0.551TrpGlu: 0.551 ± 0.018	0.494TrpPhe: 0.494 ± 0.02	0.974TrpGly: 0.974 ± 0.028	0.352TrpHis: 0.352 ± 0.016	0.687TrpIle: 0.687 ± 0.022	0.301TrpLys: 0.301 ± 0.013	1.505TrpLeu: 1.505 ± 0.039	0.313TrpMet: 0.313 ± 0.014	0.409TrpAsn: 0.409 ± 0.018	0.817TrpPro: 0.817 ± 0.025	0.543TrpGln: 0.543 ± 0.019	1.1TrpArg: 1.1 ± 0.033	1.075TrpSer: 1.075 ± 0.033	1.015TrpThr: 1.015 ± 0.031	1.028TrpVal: 1.028 ± 0.03	0.318TrpTrp: 0.318 ± 0.015	0.277TrpTyr: 0.277 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.261TyrAla: 2.261 ± 0.043	0.173TyrCys: 0.173 ± 0.011	1.24TyrAsp: 1.24 ± 0.036	0.862TyrGlu: 0.862 ± 0.023	0.675TyrPhe: 0.675 ± 0.023	1.837TyrGly: 1.837 ± 0.038	0.364TyrHis: 0.364 ± 0.017	0.58TyrIle: 0.58 ± 0.021	0.364TyrLys: 0.364 ± 0.016	2.251TyrLeu: 2.251 ± 0.037	0.238TyrMet: 0.238 ± 0.012	0.486TyrAsn: 0.486 ± 0.025	1.155TyrPro: 1.155 ± 0.03	0.735TyrGln: 0.735 ± 0.022	1.631TyrArg: 1.631 ± 0.031	1.161TyrSer: 1.161 ± 0.034	1.225TyrThr: 1.225 ± 0.044	1.557TyrVal: 1.557 ± 0.032	0.299TyrTrp: 0.299 ± 0.016	0.471TyrTyr: 0.471 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4387 proteins (1470634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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