Amino acid dipepetide frequency for Sulfodiicoccus acidiphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.069AlaAla: 6.069 ± 0.116
0.453AlaCys: 0.453 ± 0.03
2.808AlaAsp: 2.808 ± 0.064
4.615AlaGlu: 4.615 ± 0.096
3.184AlaPhe: 3.184 ± 0.089
5.482AlaGly: 5.482 ± 0.093
1.041AlaHis: 1.041 ± 0.042
4.273AlaIle: 4.273 ± 0.087
3.935AlaLys: 3.935 ± 0.077
9.209AlaLeu: 9.209 ± 0.141
1.901AlaMet: 1.901 ± 0.056
1.842AlaAsn: 1.842 ± 0.061
2.423AlaPro: 2.423 ± 0.064
1.753AlaGln: 1.753 ± 0.058
4.186AlaArg: 4.186 ± 0.09
5.455AlaSer: 5.455 ± 0.104
3.667AlaThr: 3.667 ± 0.083
7.303AlaVal: 7.303 ± 0.131
0.744AlaTrp: 0.744 ± 0.034
2.527AlaTyr: 2.527 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.35CysAla: 0.35 ± 0.027
0.086CysCys: 0.086 ± 0.011
0.333CysAsp: 0.333 ± 0.027
0.448CysGlu: 0.448 ± 0.03
0.17CysPhe: 0.17 ± 0.017
0.745CysGly: 0.745 ± 0.04
0.146CysHis: 0.146 ± 0.017
0.189CysIle: 0.189 ± 0.018
0.217CysLys: 0.217 ± 0.017
0.491CysLeu: 0.491 ± 0.03
0.106CysMet: 0.106 ± 0.013
0.158CysAsn: 0.158 ± 0.016
0.553CysPro: 0.553 ± 0.036
0.138CysGln: 0.138 ± 0.013
0.422CysArg: 0.422 ± 0.028
0.545CysSer: 0.545 ± 0.03
0.254CysThr: 0.254 ± 0.025
0.51CysVal: 0.51 ± 0.031
0.08CysTrp: 0.08 ± 0.011
0.229CysTyr: 0.229 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.056AspAla: 3.056 ± 0.075
0.294AspCys: 0.294 ± 0.023
1.885AspAsp: 1.885 ± 0.057
3.457AspGlu: 3.457 ± 0.085
2.071AspPhe: 2.071 ± 0.064
3.505AspGly: 3.505 ± 0.082
0.638AspHis: 0.638 ± 0.03
1.968AspIle: 1.968 ± 0.058
1.826AspLys: 1.826 ± 0.056
5.21AspLeu: 5.21 ± 0.097
0.955AspMet: 0.955 ± 0.044
0.982AspAsn: 0.982 ± 0.039
3.091AspPro: 3.091 ± 0.078
1.188AspGln: 1.188 ± 0.051
2.715AspArg: 2.715 ± 0.066
2.79AspSer: 2.79 ± 0.074
1.645AspThr: 1.645 ± 0.051
5.73AspVal: 5.73 ± 0.108
0.552AspTrp: 0.552 ± 0.032
1.948AspTyr: 1.948 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.862GluAla: 5.862 ± 0.115
0.355GluCys: 0.355 ± 0.028
3.432GluAsp: 3.432 ± 0.077
6.873GluGlu: 6.873 ± 0.138
2.447GluPhe: 2.447 ± 0.069
5.786GluGly: 5.786 ± 0.106
0.782GluHis: 0.782 ± 0.039
3.739GluIle: 3.739 ± 0.091
3.807GluLys: 3.807 ± 0.086
8.595GluLeu: 8.595 ± 0.156
1.682GluMet: 1.682 ± 0.055
1.874GluAsn: 1.874 ± 0.063
2.381GluPro: 2.381 ± 0.068
1.527GluGln: 1.527 ± 0.055
4.968GluArg: 4.968 ± 0.111
3.715GluSer: 3.715 ± 0.078
2.683GluThr: 2.683 ± 0.069
8.509GluVal: 8.509 ± 0.142
0.728GluTrp: 0.728 ± 0.034
1.897GluTyr: 1.897 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.613PheAla: 2.613 ± 0.07
0.211PheCys: 0.211 ± 0.02
1.935PheAsp: 1.935 ± 0.054
1.941PheGlu: 1.941 ± 0.056
1.652PhePhe: 1.652 ± 0.055
2.882PheGly: 2.882 ± 0.076
0.737PheHis: 0.737 ± 0.036
1.69PheIle: 1.69 ± 0.055
2.016PheLys: 2.016 ± 0.062
4.884PheLeu: 4.884 ± 0.119
0.854PheMet: 0.854 ± 0.042
1.449PheAsn: 1.449 ± 0.044
2.16PhePro: 2.16 ± 0.066
1.059PheGln: 1.059 ± 0.048
2.292PheArg: 2.292 ± 0.07
3.331PheSer: 3.331 ± 0.086
2.395PheThr: 2.395 ± 0.068
3.756PheVal: 3.756 ± 0.081
0.481PheTrp: 0.481 ± 0.029
1.631PheTyr: 1.631 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.608GlyAla: 5.608 ± 0.12
0.485GlyCys: 0.485 ± 0.026
3.571GlyAsp: 3.571 ± 0.074
5.961GlyGlu: 5.961 ± 0.111
3.209GlyPhe: 3.209 ± 0.08
6.243GlyGly: 6.243 ± 0.121
1.148GlyHis: 1.148 ± 0.044
4.49GlyIle: 4.49 ± 0.091
5.077GlyLys: 5.077 ± 0.1
8.309GlyLeu: 8.309 ± 0.136
1.973GlyMet: 1.973 ± 0.06
2.434GlyAsn: 2.434 ± 0.07
2.674GlyPro: 2.674 ± 0.076
1.727GlyGln: 1.727 ± 0.071
5.159GlyArg: 5.159 ± 0.108
4.896GlySer: 4.896 ± 0.095
4.375GlyThr: 4.375 ± 0.103
7.956GlyVal: 7.956 ± 0.132
1.095GlyTrp: 1.095 ± 0.042
2.816GlyTyr: 2.816 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
0.931HisAla: 0.931 ± 0.041
0.139HisCys: 0.139 ± 0.015
0.614HisAsp: 0.614 ± 0.03
0.857HisGlu: 0.857 ± 0.036
0.691HisPhe: 0.691 ± 0.035
1.27HisGly: 1.27 ± 0.049
0.339HisHis: 0.339 ± 0.024
0.636HisIle: 0.636 ± 0.032
0.499HisLys: 0.499 ± 0.031
1.564HisLeu: 1.564 ± 0.05
0.355HisMet: 0.355 ± 0.026
0.421HisAsn: 0.421 ± 0.025
0.888HisPro: 0.888 ± 0.036
0.318HisGln: 0.318 ± 0.022
0.948HisArg: 0.948 ± 0.041
0.931HisSer: 0.931 ± 0.038
0.721HisThr: 0.721 ± 0.041
1.484HisVal: 1.484 ± 0.056
0.184HisTrp: 0.184 ± 0.018
0.579HisTyr: 0.579 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
4.022IleAla: 4.022 ± 0.093
0.302IleCys: 0.302 ± 0.024
2.655IleAsp: 2.655 ± 0.067
3.373IleGlu: 3.373 ± 0.075
1.78IlePhe: 1.78 ± 0.056
4.025IleGly: 4.025 ± 0.097
0.739IleHis: 0.739 ± 0.034
2.216IleIle: 2.216 ± 0.065
2.335IleLys: 2.335 ± 0.065
4.943IleLeu: 4.943 ± 0.103
1.193IleMet: 1.193 ± 0.046
1.741IleAsn: 1.741 ± 0.059
2.861IlePro: 2.861 ± 0.07
1.147IleGln: 1.147 ± 0.038
3.057IleArg: 3.057 ± 0.079
3.987IleSer: 3.987 ± 0.087
2.699IleThr: 2.699 ± 0.069
4.652IleVal: 4.652 ± 0.097
0.473IleTrp: 0.473 ± 0.027
2.16IleTyr: 2.16 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
3.681LysAla: 3.681 ± 0.081
0.328LysCys: 0.328 ± 0.026
2.395LysAsp: 2.395 ± 0.069
4.868LysGlu: 4.868 ± 0.114
2.231LysPhe: 2.231 ± 0.067
4.436LysGly: 4.436 ± 0.088
0.563LysHis: 0.563 ± 0.032
2.584LysIle: 2.584 ± 0.066
2.491LysLys: 2.491 ± 0.077
6.136LysLeu: 6.136 ± 0.114
1.276LysMet: 1.276 ± 0.047
1.153LysAsn: 1.153 ± 0.046
1.761LysPro: 1.761 ± 0.056
0.972LysGln: 0.972 ± 0.042
3.444LysArg: 3.444 ± 0.083
2.786LysSer: 2.786 ± 0.063
2.119LysThr: 2.119 ± 0.066
6.857LysVal: 6.857 ± 0.113
0.782LysTrp: 0.782 ± 0.036
2.183LysTyr: 2.183 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
8.574LeuAla: 8.574 ± 0.152
0.588LeuCys: 0.588 ± 0.034
5.048LeuAsp: 5.048 ± 0.1
7.215LeuGlu: 7.215 ± 0.125
3.929LeuPhe: 3.929 ± 0.103
9.03LeuGly: 9.03 ± 0.132
1.602LeuHis: 1.602 ± 0.057
5.431LeuIle: 5.431 ± 0.119
6.284LeuLys: 6.284 ± 0.121
11.235LeuLeu: 11.235 ± 0.188
2.557LeuMet: 2.557 ± 0.059
3.927LeuAsn: 3.927 ± 0.086
4.78LeuPro: 4.78 ± 0.09
2.256LeuGln: 2.256 ± 0.067
8.021LeuArg: 8.021 ± 0.131
8.985LeuSer: 8.985 ± 0.138
6.137LeuThr: 6.137 ± 0.109
9.241LeuVal: 9.241 ± 0.135
1.116LeuTrp: 1.116 ± 0.042
3.526LeuTyr: 3.526 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
1.989MetAla: 1.989 ± 0.057
0.131MetCys: 0.131 ± 0.015
1.258MetAsp: 1.258 ± 0.046
1.996MetGlu: 1.996 ± 0.061
0.704MetPhe: 0.704 ± 0.03
2.26MetGly: 2.26 ± 0.068
0.273MetHis: 0.273 ± 0.02
1.346MetIle: 1.346 ± 0.046
1.682MetLys: 1.682 ± 0.053
2.052MetLeu: 2.052 ± 0.058
0.632MetMet: 0.632 ± 0.034
0.889MetAsn: 0.889 ± 0.044
0.814MetPro: 0.814 ± 0.037
0.379MetGln: 0.379 ± 0.023
1.964MetArg: 1.964 ± 0.059
1.746MetSer: 1.746 ± 0.05
1.167MetThr: 1.167 ± 0.042
1.855MetVal: 1.855 ± 0.057
0.277MetTrp: 0.277 ± 0.021
0.651MetTyr: 0.651 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.224AsnAla: 2.224 ± 0.055
0.224AsnCys: 0.224 ± 0.019
1.207AsnAsp: 1.207 ± 0.048
1.794AsnGlu: 1.794 ± 0.059
1.484AsnPhe: 1.484 ± 0.053
2.48AsnGly: 2.48 ± 0.076
0.368AsnHis: 0.368 ± 0.025
1.257AsnIle: 1.257 ± 0.044
1.151AsnLys: 1.151 ± 0.052
3.44AsnLeu: 3.44 ± 0.08
0.699AsnMet: 0.699 ± 0.03
0.852AsnAsn: 0.852 ± 0.038
1.865AsnPro: 1.865 ± 0.055
0.827AsnGln: 0.827 ± 0.049
1.733AsnArg: 1.733 ± 0.053
2.387AsnSer: 2.387 ± 0.07
1.438AsnThr: 1.438 ± 0.047
3.584AsnVal: 3.584 ± 0.097
0.398AsnTrp: 0.398 ± 0.026
1.487AsnTyr: 1.487 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
2.738ProAla: 2.738 ± 0.073
0.256ProCys: 0.256 ± 0.019
2.007ProAsp: 2.007 ± 0.06
3.233ProGlu: 3.233 ± 0.077
2.172ProPhe: 2.172 ± 0.071
3.104ProGly: 3.104 ± 0.077
0.883ProHis: 0.883 ± 0.034
2.429ProIle: 2.429 ± 0.058
2.194ProLys: 2.194 ± 0.062
4.93ProLeu: 4.93 ± 0.096
1.023ProMet: 1.023 ± 0.04
1.55ProAsn: 1.55 ± 0.055
2.368ProPro: 2.368 ± 0.073
1.266ProGln: 1.266 ± 0.047
2.466ProArg: 2.466 ± 0.068
3.732ProSer: 3.732 ± 0.076
2.706ProThr: 2.706 ± 0.072
3.953ProVal: 3.953 ± 0.084
0.595ProTrp: 0.595 ± 0.032
1.959ProTyr: 1.959 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.697GlnAla: 1.697 ± 0.053
0.173GlnCys: 0.173 ± 0.014
1.009GlnAsp: 1.009 ± 0.043
1.679GlnGlu: 1.679 ± 0.055
0.923GlnPhe: 0.923 ± 0.043
1.992GlnGly: 1.992 ± 0.07
0.305GlnHis: 0.305 ± 0.02
1.059GlnIle: 1.059 ± 0.043
0.833GlnLys: 0.833 ± 0.035
2.949GlnLeu: 2.949 ± 0.087
0.537GlnMet: 0.537 ± 0.03
0.531GlnAsn: 0.531 ± 0.03
0.895GlnPro: 0.895 ± 0.047
0.636GlnGln: 0.636 ± 0.043
1.503GlnArg: 1.503 ± 0.062
1.311GlnSer: 1.311 ± 0.049
1.025GlnThr: 1.025 ± 0.048
2.57GlnVal: 2.57 ± 0.076
0.304GlnTrp: 0.304 ± 0.02
0.83GlnTyr: 0.83 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
4.685ArgAla: 4.685 ± 0.092
0.459ArgCys: 0.459 ± 0.032
3.249ArgAsp: 3.249 ± 0.085
6.241ArgGlu: 6.241 ± 0.122
2.2ArgPhe: 2.2 ± 0.064
5.283ArgGly: 5.283 ± 0.098
0.732ArgHis: 0.732 ± 0.032
3.166ArgIle: 3.166 ± 0.077
4.281ArgLys: 4.281 ± 0.097
6.216ArgLeu: 6.216 ± 0.111
1.65ArgMet: 1.65 ± 0.053
2.069ArgAsn: 2.069 ± 0.06
2.611ArgPro: 2.611 ± 0.071
1.247ArgGln: 1.247 ± 0.044
5.245ArgArg: 5.245 ± 0.101
3.728ArgSer: 3.728 ± 0.084
3.229ArgThr: 3.229 ± 0.077
5.474ArgVal: 5.474 ± 0.107
0.801ArgTrp: 0.801 ± 0.035
2.06ArgTyr: 2.06 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.297SerAla: 4.297 ± 0.091
0.485SerCys: 0.485 ± 0.033
2.594SerAsp: 2.594 ± 0.062
3.899SerGlu: 3.899 ± 0.079
3.177SerPhe: 3.177 ± 0.077
5.05SerGly: 5.05 ± 0.089
1.126SerHis: 1.126 ± 0.046
3.668SerIle: 3.668 ± 0.085
4.156SerLys: 4.156 ± 0.09
8.611SerLeu: 8.611 ± 0.139
2.048SerMet: 2.048 ± 0.053
2.124SerAsn: 2.124 ± 0.06
3.911SerPro: 3.911 ± 0.086
1.908SerGln: 1.908 ± 0.058
4.242SerArg: 4.242 ± 0.091
6.214SerSer: 6.214 ± 0.121
4.033SerThr: 4.033 ± 0.095
5.806SerVal: 5.806 ± 0.101
0.972SerTrp: 0.972 ± 0.043
2.522SerTyr: 2.522 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.716ThrAla: 3.716 ± 0.09
0.344ThrCys: 0.344 ± 0.025
1.968ThrAsp: 1.968 ± 0.065
2.766ThrGlu: 2.766 ± 0.068
2.475ThrPhe: 2.475 ± 0.071
4.129ThrGly: 4.129 ± 0.088
0.803ThrHis: 0.803 ± 0.039
2.611ThrIle: 2.611 ± 0.064
2.149ThrLys: 2.149 ± 0.06
5.822ThrLeu: 5.822 ± 0.111
1.281ThrMet: 1.281 ± 0.043
1.578ThrAsn: 1.578 ± 0.066
2.864ThrPro: 2.864 ± 0.075
1.188ThrGln: 1.188 ± 0.045
2.584ThrArg: 2.584 ± 0.063
3.995ThrSer: 3.995 ± 0.087
2.914ThrThr: 2.914 ± 0.109
5.092ThrVal: 5.092 ± 0.109
0.7ThrTrp: 0.7 ± 0.034
2.034ThrTyr: 2.034 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
7.437ValAla: 7.437 ± 0.122
0.517ValCys: 0.517 ± 0.031
5.114ValAsp: 5.114 ± 0.096
7.599ValGlu: 7.599 ± 0.124
3.323ValPhe: 3.323 ± 0.074
7.628ValGly: 7.628 ± 0.127
1.415ValHis: 1.415 ± 0.051
5.296ValIle: 5.296 ± 0.093
6.147ValLys: 6.147 ± 0.111
9.671ValLeu: 9.671 ± 0.135
2.247ValMet: 2.247 ± 0.065
3.579ValAsn: 3.579 ± 0.085
4.529ValPro: 4.529 ± 0.109
2.063ValGln: 2.063 ± 0.062
6.622ValArg: 6.622 ± 0.123
6.74ValSer: 6.74 ± 0.122
5.274ValThr: 5.274 ± 0.107
10.273ValVal: 10.273 ± 0.139
0.963ValTrp: 0.963 ± 0.043
3.112ValTyr: 3.112 ± 0.086
0.0ValXaa: 0.0 ± 0.0
Trp
0.801TrpAla: 0.801 ± 0.036
0.085TrpCys: 0.085 ± 0.012
0.547TrpAsp: 0.547 ± 0.033
0.827TrpGlu: 0.827 ± 0.041
0.512TrpPhe: 0.512 ± 0.032
0.988TrpGly: 0.988 ± 0.039
0.165TrpHis: 0.165 ± 0.017
0.747TrpIle: 0.747 ± 0.036
0.62TrpLys: 0.62 ± 0.035
1.182TrpLeu: 1.182 ± 0.037
0.289TrpMet: 0.289 ± 0.024
0.515TrpAsn: 0.515 ± 0.032
0.408TrpPro: 0.408 ± 0.029
0.243TrpGln: 0.243 ± 0.022
0.975TrpArg: 0.975 ± 0.037
0.819TrpSer: 0.819 ± 0.035
0.654TrpThr: 0.654 ± 0.029
0.926TrpVal: 0.926 ± 0.04
0.193TrpTrp: 0.193 ± 0.02
0.405TrpTyr: 0.405 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.517TyrAla: 2.517 ± 0.069
0.256TyrCys: 0.256 ± 0.023
1.877TyrAsp: 1.877 ± 0.058
1.999TyrGlu: 1.999 ± 0.054
1.639TyrPhe: 1.639 ± 0.054
2.89TyrGly: 2.89 ± 0.078
0.563TyrHis: 0.563 ± 0.029
1.562TyrIle: 1.562 ± 0.062
1.342TyrLys: 1.342 ± 0.051
4.038TyrLeu: 4.038 ± 0.095
0.804TyrMet: 0.804 ± 0.034
1.231TyrAsn: 1.231 ± 0.058
1.727TyrPro: 1.727 ± 0.058
0.919TyrGln: 0.919 ± 0.041
2.079TyrArg: 2.079 ± 0.059
2.75TyrSer: 2.75 ± 0.071
1.879TyrThr: 1.879 ± 0.061
4.019TyrVal: 4.019 ± 0.081
0.462TyrTrp: 0.462 ± 0.027
1.602TyrTyr: 1.602 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2410 proteins (625351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski