Amino acid dipepetide frequency for Oceanimonas sp. (strain GK1 / IBRC-M 10197)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.314AlaAla: 12.314 ± 0.169	1.233AlaCys: 1.233 ± 0.037	5.926AlaAsp: 5.926 ± 0.088	7.558AlaGlu: 7.558 ± 0.112	3.677AlaPhe: 3.677 ± 0.066	9.888AlaGly: 9.888 ± 0.107	2.122AlaHis: 2.122 ± 0.052	5.181AlaIle: 5.181 ± 0.083	2.94AlaLys: 2.94 ± 0.062	13.855AlaLeu: 13.855 ± 0.173	3.252AlaMet: 3.252 ± 0.059	2.829AlaAsn: 2.829 ± 0.064	4.251AlaPro: 4.251 ± 0.076	4.247AlaGln: 4.247 ± 0.065	7.549AlaArg: 7.549 ± 0.105	5.34AlaSer: 5.34 ± 0.069	4.673AlaThr: 4.673 ± 0.072	7.308AlaVal: 7.308 ± 0.092	1.452AlaTrp: 1.452 ± 0.042	2.109AlaTyr: 2.109 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.975CysAla: 0.975 ± 0.032	0.175CysCys: 0.175 ± 0.014	0.609CysAsp: 0.609 ± 0.025	0.567CysGlu: 0.567 ± 0.021	0.408CysPhe: 0.408 ± 0.02	0.965CysGly: 0.965 ± 0.037	0.363CysHis: 0.363 ± 0.021	0.444CysIle: 0.444 ± 0.019	0.27CysLys: 0.27 ± 0.015	1.085CysLeu: 1.085 ± 0.035	0.189CysMet: 0.189 ± 0.015	0.28CysAsn: 0.28 ± 0.018	0.507CysPro: 0.507 ± 0.023	0.369CysGln: 0.369 ± 0.02	0.827CysArg: 0.827 ± 0.026	0.542CysSer: 0.542 ± 0.025	0.483CysThr: 0.483 ± 0.023	0.668CysVal: 0.668 ± 0.024	0.162CysTrp: 0.162 ± 0.012	0.321CysTyr: 0.321 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.369AspAla: 5.369 ± 0.082	0.541AspCys: 0.541 ± 0.023	3.032AspAsp: 3.032 ± 0.077	3.783AspGlu: 3.783 ± 0.069	2.09AspPhe: 2.09 ± 0.046	4.257AspGly: 4.257 ± 0.094	1.221AspHis: 1.221 ± 0.038	3.222AspIle: 3.222 ± 0.068	2.123AspLys: 2.123 ± 0.053	4.769AspLeu: 4.769 ± 0.074	1.493AspMet: 1.493 ± 0.038	1.82AspAsn: 1.82 ± 0.044	2.303AspPro: 2.303 ± 0.052	1.911AspGln: 1.911 ± 0.044	2.95AspArg: 2.95 ± 0.054	2.576AspSer: 2.576 ± 0.054	2.797AspThr: 2.797 ± 0.049	3.035AspVal: 3.035 ± 0.055	1.057AspTrp: 1.057 ± 0.033	1.907AspTyr: 1.907 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.706GluAla: 6.706 ± 0.103	0.478GluCys: 0.478 ± 0.022	2.545GluAsp: 2.545 ± 0.057	3.307GluGlu: 3.307 ± 0.059	1.894GluPhe: 1.894 ± 0.051	3.957GluGly: 3.957 ± 0.063	1.919GluHis: 1.919 ± 0.048	2.628GluIle: 2.628 ± 0.055	2.095GluLys: 2.095 ± 0.055	8.276GluLeu: 8.276 ± 0.095	1.387GluMet: 1.387 ± 0.037	1.54GluAsn: 1.54 ± 0.045	2.732GluPro: 2.732 ± 0.058	5.299GluGln: 5.299 ± 0.087	4.98GluArg: 4.98 ± 0.076	2.631GluSer: 2.631 ± 0.051	2.473GluThr: 2.473 ± 0.047	4.493GluVal: 4.493 ± 0.067	0.73GluTrp: 0.73 ± 0.03	1.375GluTyr: 1.375 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.828PheAla: 3.828 ± 0.064	0.465PheCys: 0.465 ± 0.021	2.456PheAsp: 2.456 ± 0.05	2.281PheGlu: 2.281 ± 0.053	1.385PhePhe: 1.385 ± 0.042	3.283PheGly: 3.283 ± 0.056	0.783PheHis: 0.783 ± 0.028	1.867PheIle: 1.867 ± 0.047	1.077PheLys: 1.077 ± 0.029	2.946PheLeu: 2.946 ± 0.058	0.983PheMet: 0.983 ± 0.037	1.415PheAsn: 1.415 ± 0.037	1.398PhePro: 1.398 ± 0.039	1.047PheGln: 1.047 ± 0.028	1.909PheArg: 1.909 ± 0.047	2.398PheSer: 2.398 ± 0.055	2.002PheThr: 2.002 ± 0.041	2.661PheVal: 2.661 ± 0.059	0.57PheTrp: 0.57 ± 0.029	1.115PheTyr: 1.115 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.005GlyAla: 7.005 ± 0.1	0.947GlyCys: 0.947 ± 0.031	3.929GlyAsp: 3.929 ± 0.079	5.359GlyGlu: 5.359 ± 0.085	3.47GlyPhe: 3.47 ± 0.062	6.041GlyGly: 6.041 ± 0.112	2.084GlyHis: 2.084 ± 0.051	4.379GlyIle: 4.379 ± 0.07	3.325GlyLys: 3.325 ± 0.065	9.964GlyLeu: 9.964 ± 0.111	2.436GlyMet: 2.436 ± 0.052	2.485GlyAsn: 2.485 ± 0.06	2.629GlyPro: 2.629 ± 0.049	3.527GlyGln: 3.527 ± 0.06	5.4GlyArg: 5.4 ± 0.081	4.11GlySer: 4.11 ± 0.077	3.668GlyThr: 3.668 ± 0.076	5.776GlyVal: 5.776 ± 0.079	1.353GlyTrp: 1.353 ± 0.044	2.402GlyTyr: 2.402 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.085HisAla: 2.085 ± 0.044	0.392HisCys: 0.392 ± 0.021	1.243HisAsp: 1.243 ± 0.038	1.227HisGlu: 1.227 ± 0.035	1.089HisPhe: 1.089 ± 0.032	2.09HisGly: 2.09 ± 0.045	0.901HisHis: 0.901 ± 0.034	1.317HisIle: 1.317 ± 0.033	0.795HisLys: 0.795 ± 0.026	2.539HisLeu: 2.539 ± 0.056	0.546HisMet: 0.546 ± 0.022	0.774HisAsn: 0.774 ± 0.028	1.444HisPro: 1.444 ± 0.037	1.33HisGln: 1.33 ± 0.031	1.736HisArg: 1.736 ± 0.044	1.353HisSer: 1.353 ± 0.038	1.161HisThr: 1.161 ± 0.029	1.26HisVal: 1.26 ± 0.037	0.578HisTrp: 0.578 ± 0.024	0.913HisTyr: 0.913 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.168IleAla: 5.168 ± 0.088	0.552IleCys: 0.552 ± 0.024	2.997IleAsp: 2.997 ± 0.055	3.14IleGlu: 3.14 ± 0.061	1.445IlePhe: 1.445 ± 0.038	4.032IleGly: 4.032 ± 0.063	1.102IleHis: 1.102 ± 0.038	2.457IleIle: 2.457 ± 0.055	1.857IleLys: 1.857 ± 0.048	4.105IleLeu: 4.105 ± 0.075	1.146IleMet: 1.146 ± 0.035	1.934IleAsn: 1.934 ± 0.043	2.203IlePro: 2.203 ± 0.054	1.59IleGln: 1.59 ± 0.042	2.968IleArg: 2.968 ± 0.068	2.962IleSer: 2.962 ± 0.055	3.019IleThr: 3.019 ± 0.054	2.912IleVal: 2.912 ± 0.059	0.527IleTrp: 0.527 ± 0.023	1.157IleTyr: 1.157 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.833LysAla: 3.833 ± 0.08	0.187LysCys: 0.187 ± 0.014	1.78LysAsp: 1.78 ± 0.052	1.966LysGlu: 1.966 ± 0.047	0.8LysPhe: 0.8 ± 0.03	2.65LysGly: 2.65 ± 0.051	0.767LysHis: 0.767 ± 0.029	1.383LysIle: 1.383 ± 0.037	1.463LysLys: 1.463 ± 0.05	3.598LysLeu: 3.598 ± 0.066	0.773LysMet: 0.773 ± 0.03	0.939LysAsn: 0.939 ± 0.036	1.864LysPro: 1.864 ± 0.048	1.618LysGln: 1.618 ± 0.046	2.204LysArg: 2.204 ± 0.058	1.586LysSer: 1.586 ± 0.041	1.806LysThr: 1.806 ± 0.042	2.676LysVal: 2.676 ± 0.055	0.314LysTrp: 0.314 ± 0.017	0.721LysTyr: 0.721 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.401LeuAla: 15.401 ± 0.158	1.353LeuCys: 1.353 ± 0.036	6.358LeuAsp: 6.358 ± 0.091	6.861LeuGlu: 6.861 ± 0.089	4.294LeuPhe: 4.294 ± 0.083	9.331LeuGly: 9.331 ± 0.106	2.59LeuHis: 2.59 ± 0.054	4.773LeuIle: 4.773 ± 0.077	4.219LeuLys: 4.219 ± 0.074	14.928LeuLeu: 14.928 ± 0.22	3.045LeuMet: 3.045 ± 0.061	4.12LeuAsn: 4.12 ± 0.077	6.359LeuPro: 6.359 ± 0.097	4.583LeuGln: 4.583 ± 0.088	6.548LeuArg: 6.548 ± 0.095	7.391LeuSer: 7.391 ± 0.105	6.386LeuThr: 6.386 ± 0.093	8.819LeuVal: 8.819 ± 0.118	1.523LeuTrp: 1.523 ± 0.043	2.608LeuTyr: 2.608 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	3.26MetAla: 3.26 ± 0.057	0.174MetCys: 0.174 ± 0.014	1.253MetAsp: 1.253 ± 0.035	1.401MetGlu: 1.401 ± 0.038	0.71MetPhe: 0.71 ± 0.029	1.905MetGly: 1.905 ± 0.045	0.492MetHis: 0.492 ± 0.02	1.174MetIle: 1.174 ± 0.039	1.065MetLys: 1.065 ± 0.034	2.968MetLeu: 2.968 ± 0.057	0.792MetMet: 0.792 ± 0.029	0.942MetAsn: 0.942 ± 0.031	1.25MetPro: 1.25 ± 0.036	1.07MetGln: 1.07 ± 0.031	1.19MetArg: 1.19 ± 0.037	1.707MetSer: 1.707 ± 0.043	1.649MetThr: 1.649 ± 0.042	1.929MetVal: 1.929 ± 0.043	0.18MetTrp: 0.18 ± 0.013	0.411MetTyr: 0.411 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.983AsnAla: 2.983 ± 0.06	0.268AsnCys: 0.268 ± 0.016	1.669AsnAsp: 1.669 ± 0.047	1.796AsnGlu: 1.796 ± 0.045	0.923AsnPhe: 0.923 ± 0.031	2.675AsnGly: 2.675 ± 0.068	0.721AsnHis: 0.721 ± 0.025	1.682AsnIle: 1.682 ± 0.044	1.159AsnLys: 1.159 ± 0.034	3.252AsnLeu: 3.252 ± 0.061	0.802AsnMet: 0.802 ± 0.031	1.021AsnAsn: 1.021 ± 0.039	1.854AsnPro: 1.854 ± 0.043	1.384AsnGln: 1.384 ± 0.042	2.108AsnArg: 2.108 ± 0.047	1.408AsnSer: 1.408 ± 0.041	1.721AsnThr: 1.721 ± 0.045	1.753AsnVal: 1.753 ± 0.042	0.444AsnTrp: 0.444 ± 0.021	0.788AsnTyr: 0.788 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.914ProAla: 5.914 ± 0.104	0.38ProCys: 0.38 ± 0.019	2.811ProAsp: 2.811 ± 0.052	3.9ProGlu: 3.9 ± 0.064	1.753ProPhe: 1.753 ± 0.043	4.17ProGly: 4.17 ± 0.071	1.066ProHis: 1.066 ± 0.03	1.725ProIle: 1.725 ± 0.044	1.271ProLys: 1.271 ± 0.04	5.687ProLeu: 5.687 ± 0.092	1.102ProMet: 1.102 ± 0.032	1.21ProAsn: 1.21 ± 0.037	1.924ProPro: 1.924 ± 0.058	1.699ProGln: 1.699 ± 0.042	2.387ProArg: 2.387 ± 0.045	2.127ProSer: 2.127 ± 0.044	1.801ProThr: 1.801 ± 0.042	4.281ProVal: 4.281 ± 0.075	0.781ProTrp: 0.781 ± 0.031	1.146ProTyr: 1.146 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.93GlnAla: 5.93 ± 0.089	0.386GlnCys: 0.386 ± 0.019	2.168GlnAsp: 2.168 ± 0.054	2.293GlnGlu: 2.293 ± 0.052	1.253GlnPhe: 1.253 ± 0.039	3.982GlnGly: 3.982 ± 0.069	1.272GlnHis: 1.272 ± 0.038	1.737GlnIle: 1.737 ± 0.038	1.255GlnLys: 1.255 ± 0.041	5.899GlnLeu: 5.899 ± 0.093	0.935GlnMet: 0.935 ± 0.033	1.038GlnAsn: 1.038 ± 0.031	2.539GlnPro: 2.539 ± 0.048	3.603GlnGln: 3.603 ± 0.093	3.232GlnArg: 3.232 ± 0.07	2.204GlnSer: 2.204 ± 0.047	2.002GlnThr: 2.002 ± 0.046	3.145GlnVal: 3.145 ± 0.057	0.77GlnTrp: 0.77 ± 0.03	1.038GlnTyr: 1.038 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	5.865ArgAla: 5.865 ± 0.088	0.602ArgCys: 0.602 ± 0.028	3.146ArgAsp: 3.146 ± 0.063	4.361ArgGlu: 4.361 ± 0.067	2.872ArgPhe: 2.872 ± 0.053	3.808ArgGly: 3.808 ± 0.063	2.255ArgHis: 2.255 ± 0.052	3.396ArgIle: 3.396 ± 0.061	1.92ArgLys: 1.92 ± 0.05	9.459ArgLeu: 9.459 ± 0.122	1.509ArgMet: 1.509 ± 0.036	1.839ArgAsn: 1.839 ± 0.046	2.879ArgPro: 2.879 ± 0.056	3.745ArgGln: 3.745 ± 0.069	4.942ArgArg: 4.942 ± 0.086	2.712ArgSer: 2.712 ± 0.056	2.567ArgThr: 2.567 ± 0.052	4.604ArgVal: 4.604 ± 0.074	0.998ArgTrp: 0.998 ± 0.035	1.988ArgTyr: 1.988 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.286SerAla: 5.286 ± 0.08	0.479SerCys: 0.479 ± 0.024	2.411SerAsp: 2.411 ± 0.05	2.962SerGlu: 2.962 ± 0.061	2.05SerPhe: 2.05 ± 0.047	4.885SerGly: 4.885 ± 0.083	1.301SerHis: 1.301 ± 0.036	2.353SerIle: 2.353 ± 0.052	1.562SerLys: 1.562 ± 0.044	6.856SerLeu: 6.856 ± 0.09	1.3SerMet: 1.3 ± 0.035	1.446SerAsn: 1.446 ± 0.037	2.679SerPro: 2.679 ± 0.053	2.258SerGln: 2.258 ± 0.047	4.051SerArg: 4.051 ± 0.065	2.783SerSer: 2.783 ± 0.053	2.382SerThr: 2.382 ± 0.049	3.477SerVal: 3.477 ± 0.054	0.735SerTrp: 0.735 ± 0.027	1.375SerTyr: 1.375 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.838ThrAla: 4.838 ± 0.07	0.381ThrCys: 0.381 ± 0.016	2.562ThrAsp: 2.562 ± 0.049	2.784ThrGlu: 2.784 ± 0.057	1.548ThrPhe: 1.548 ± 0.047	4.673ThrGly: 4.673 ± 0.079	1.107ThrHis: 1.107 ± 0.034	2.228ThrIle: 2.228 ± 0.054	1.133ThrLys: 1.133 ± 0.031	7.21ThrLeu: 7.21 ± 0.097	1.048ThrMet: 1.048 ± 0.027	1.25ThrAsn: 1.25 ± 0.04	2.999ThrPro: 2.999 ± 0.059	2.055ThrGln: 2.055 ± 0.047	3.01ThrArg: 3.01 ± 0.056	2.381ThrSer: 2.381 ± 0.047	2.383ThrThr: 2.383 ± 0.056	3.416ThrVal: 3.416 ± 0.065	0.553ThrTrp: 0.553 ± 0.025	0.935ThrTyr: 0.935 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.637ValAla: 7.637 ± 0.102	0.723ValCys: 0.723 ± 0.028	3.583ValAsp: 3.583 ± 0.065	4.203ValGlu: 4.203 ± 0.066	2.622ValPhe: 2.622 ± 0.049	4.696ValGly: 4.696 ± 0.073	1.506ValHis: 1.506 ± 0.038	3.804ValIle: 3.804 ± 0.075	2.372ValLys: 2.372 ± 0.054	8.298ValLeu: 8.298 ± 0.1	1.967ValMet: 1.967 ± 0.043	2.482ValAsn: 2.482 ± 0.054	3.295ValPro: 3.295 ± 0.06	2.551ValGln: 2.551 ± 0.048	4.229ValArg: 4.229 ± 0.071	4.346ValSer: 4.346 ± 0.063	3.87ValThr: 3.87 ± 0.069	5.422ValVal: 5.422 ± 0.086	0.798ValTrp: 0.798 ± 0.028	1.686ValTyr: 1.686 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.002TrpAla: 1.002 ± 0.035	0.171TrpCys: 0.171 ± 0.013	0.501TrpAsp: 0.501 ± 0.023	0.5TrpGlu: 0.5 ± 0.027	0.534TrpPhe: 0.534 ± 0.023	0.841TrpGly: 0.841 ± 0.031	0.458TrpHis: 0.458 ± 0.025	0.538TrpIle: 0.538 ± 0.025	0.328TrpLys: 0.328 ± 0.019	2.71TrpLeu: 2.71 ± 0.067	0.321TrpMet: 0.321 ± 0.018	0.389TrpAsn: 0.389 ± 0.024	0.773TrpPro: 0.773 ± 0.028	1.287TrpGln: 1.287 ± 0.044	1.106TrpArg: 1.106 ± 0.039	0.724TrpSer: 0.724 ± 0.03	0.5TrpThr: 0.5 ± 0.021	0.884TrpVal: 0.884 ± 0.031	0.27TrpTrp: 0.27 ± 0.018	0.34TrpTyr: 0.34 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.307TyrAla: 2.307 ± 0.05	0.32TyrCys: 0.32 ± 0.018	1.279TyrAsp: 1.279 ± 0.036	1.196TyrGlu: 1.196 ± 0.038	1.052TyrPhe: 1.052 ± 0.036	2.161TyrGly: 2.161 ± 0.05	0.745TyrHis: 0.745 ± 0.03	0.986TyrIle: 0.986 ± 0.031	0.7TyrLys: 0.7 ± 0.031	3.086TyrLeu: 3.086 ± 0.056	0.499TyrMet: 0.499 ± 0.023	0.657TyrAsn: 0.657 ± 0.031	1.25TyrPro: 1.25 ± 0.036	1.508TyrGln: 1.508 ± 0.043	2.138TyrArg: 2.138 ± 0.051	1.349TyrSer: 1.349 ± 0.034	1.15TyrThr: 1.15 ± 0.036	1.57TyrVal: 1.57 ± 0.036	0.384TyrTrp: 0.384 ± 0.02	0.815TyrTyr: 0.815 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3190 proteins (1032523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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