Amino acid dipepetide frequency for Salmonella phage vB_SenS_SB28

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.29AlaAla: 9.29 ± 1.42
0.658AlaCys: 0.658 ± 0.267
3.584AlaAsp: 3.584 ± 0.493
6.218AlaGlu: 6.218 ± 0.846
2.194AlaPhe: 2.194 ± 0.36
6.437AlaGly: 6.437 ± 0.771
0.951AlaHis: 0.951 ± 0.244
5.852AlaIle: 5.852 ± 0.65
6.583AlaLys: 6.583 ± 0.705
6.656AlaLeu: 6.656 ± 0.848
2.706AlaMet: 2.706 ± 0.613
4.608AlaAsn: 4.608 ± 0.679
1.609AlaPro: 1.609 ± 0.312
3.95AlaGln: 3.95 ± 0.651
5.047AlaArg: 5.047 ± 0.546
5.34AlaSer: 5.34 ± 0.856
5.193AlaThr: 5.193 ± 0.862
5.852AlaVal: 5.852 ± 0.72
1.097AlaTrp: 1.097 ± 0.232
2.78AlaTyr: 2.78 ± 0.442
0.0AlaXaa: 0.0 ± 0.0
Cys
1.39CysAla: 1.39 ± 0.347
0.439CysCys: 0.439 ± 0.203
1.024CysAsp: 1.024 ± 0.281
1.756CysGlu: 1.756 ± 0.352
0.293CysPhe: 0.293 ± 0.126
1.609CysGly: 1.609 ± 0.454
0.439CysHis: 0.439 ± 0.157
0.512CysIle: 0.512 ± 0.156
0.878CysLys: 0.878 ± 0.319
1.024CysLeu: 1.024 ± 0.28
0.293CysMet: 0.293 ± 0.143
0.658CysAsn: 0.658 ± 0.235
0.585CysPro: 0.585 ± 0.245
0.219CysGln: 0.219 ± 0.133
1.024CysArg: 1.024 ± 0.263
0.805CysSer: 0.805 ± 0.308
0.366CysThr: 0.366 ± 0.17
0.731CysVal: 0.731 ± 0.265
0.366CysTrp: 0.366 ± 0.164
0.073CysTyr: 0.073 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
6.437AspAla: 6.437 ± 0.731
0.658AspCys: 0.658 ± 0.169
4.389AspAsp: 4.389 ± 0.658
5.486AspGlu: 5.486 ± 0.599
2.999AspPhe: 2.999 ± 0.436
5.779AspGly: 5.779 ± 0.69
0.878AspHis: 0.878 ± 0.278
3.877AspIle: 3.877 ± 0.443
3.877AspLys: 3.877 ± 0.576
2.633AspLeu: 2.633 ± 0.486
2.487AspMet: 2.487 ± 0.379
2.78AspAsn: 2.78 ± 0.471
1.536AspPro: 1.536 ± 0.33
1.17AspGln: 1.17 ± 0.306
2.56AspArg: 2.56 ± 0.413
2.78AspSer: 2.78 ± 0.448
2.926AspThr: 2.926 ± 0.434
4.316AspVal: 4.316 ± 0.735
0.731AspTrp: 0.731 ± 0.221
3.292AspTyr: 3.292 ± 0.464
0.0AspXaa: 0.0 ± 0.0
Glu
4.608GluAla: 4.608 ± 0.622
1.17GluCys: 1.17 ± 0.292
3.731GluAsp: 3.731 ± 0.574
5.047GluGlu: 5.047 ± 0.647
3.072GluPhe: 3.072 ± 0.615
3.511GluGly: 3.511 ± 0.516
0.658GluHis: 0.658 ± 0.249
5.852GluIle: 5.852 ± 0.725
4.243GluLys: 4.243 ± 0.574
6.364GluLeu: 6.364 ± 0.736
2.487GluMet: 2.487 ± 0.465
3.072GluAsn: 3.072 ± 0.518
2.341GluPro: 2.341 ± 0.423
4.169GluGln: 4.169 ± 0.627
4.169GluArg: 4.169 ± 0.613
3.511GluSer: 3.511 ± 0.569
3.438GluThr: 3.438 ± 0.463
3.438GluVal: 3.438 ± 0.488
1.17GluTrp: 1.17 ± 0.282
2.194GluTyr: 2.194 ± 0.394
0.0GluXaa: 0.0 ± 0.0
Phe
2.121PheAla: 2.121 ± 0.394
0.731PheCys: 0.731 ± 0.193
3.292PheAsp: 3.292 ± 0.498
1.609PheGlu: 1.609 ± 0.329
0.951PhePhe: 0.951 ± 0.342
2.78PheGly: 2.78 ± 0.407
0.512PheHis: 0.512 ± 0.177
2.926PheIle: 2.926 ± 0.571
1.902PheLys: 1.902 ± 0.395
1.682PheLeu: 1.682 ± 0.408
1.463PheMet: 1.463 ± 0.419
1.829PheAsn: 1.829 ± 0.437
1.097PhePro: 1.097 ± 0.248
1.097PheGln: 1.097 ± 0.351
1.975PheArg: 1.975 ± 0.353
2.194PheSer: 2.194 ± 0.377
1.829PheThr: 1.829 ± 0.344
2.56PheVal: 2.56 ± 0.454
0.658PheTrp: 0.658 ± 0.224
1.463PheTyr: 1.463 ± 0.345
0.0PheXaa: 0.0 ± 0.0
Gly
5.779GlyAla: 5.779 ± 0.792
1.682GlyCys: 1.682 ± 0.54
4.096GlyAsp: 4.096 ± 0.539
5.413GlyGlu: 5.413 ± 0.567
2.78GlyPhe: 2.78 ± 0.509
4.681GlyGly: 4.681 ± 0.666
1.463GlyHis: 1.463 ± 0.346
4.169GlyIle: 4.169 ± 0.486
5.486GlyLys: 5.486 ± 0.635
4.974GlyLeu: 4.974 ± 0.573
2.048GlyMet: 2.048 ± 0.364
3.365GlyAsn: 3.365 ± 0.452
0.805GlyPro: 0.805 ± 0.255
2.048GlyGln: 2.048 ± 0.5
3.438GlyArg: 3.438 ± 0.527
4.828GlySer: 4.828 ± 0.685
3.731GlyThr: 3.731 ± 0.716
4.901GlyVal: 4.901 ± 0.433
0.878GlyTrp: 0.878 ± 0.258
3.584GlyTyr: 3.584 ± 0.582
0.073GlyXaa: 0.073 ± 0.068
His
1.609HisAla: 1.609 ± 0.39
0.439HisCys: 0.439 ± 0.214
0.878HisAsp: 0.878 ± 0.186
0.805HisGlu: 0.805 ± 0.246
0.731HisPhe: 0.731 ± 0.268
2.048HisGly: 2.048 ± 0.744
0.805HisHis: 0.805 ± 0.343
0.951HisIle: 0.951 ± 0.33
1.463HisLys: 1.463 ± 0.307
1.463HisLeu: 1.463 ± 0.391
0.439HisMet: 0.439 ± 0.177
0.658HisAsn: 0.658 ± 0.195
0.805HisPro: 0.805 ± 0.258
0.439HisGln: 0.439 ± 0.158
1.17HisArg: 1.17 ± 0.297
1.17HisSer: 1.17 ± 0.283
0.658HisThr: 0.658 ± 0.218
1.39HisVal: 1.39 ± 0.348
0.146HisTrp: 0.146 ± 0.106
0.585HisTyr: 0.585 ± 0.191
0.0HisXaa: 0.0 ± 0.0
Ile
5.632IleAla: 5.632 ± 0.624
1.024IleCys: 1.024 ± 0.324
4.755IleAsp: 4.755 ± 0.517
4.681IleGlu: 4.681 ± 0.596
1.829IlePhe: 1.829 ± 0.37
3.292IleGly: 3.292 ± 0.47
1.463IleHis: 1.463 ± 0.262
3.95IleIle: 3.95 ± 0.618
4.755IleLys: 4.755 ± 0.635
3.95IleLeu: 3.95 ± 0.545
1.829IleMet: 1.829 ± 0.431
3.292IleAsn: 3.292 ± 0.468
2.194IlePro: 2.194 ± 0.357
1.829IleGln: 1.829 ± 0.38
3.657IleArg: 3.657 ± 0.626
4.681IleSer: 4.681 ± 0.585
3.584IleThr: 3.584 ± 0.542
4.462IleVal: 4.462 ± 0.475
0.731IleTrp: 0.731 ± 0.257
2.048IleTyr: 2.048 ± 0.458
0.0IleXaa: 0.0 ± 0.0
Lys
6.437LysAla: 6.437 ± 0.779
1.244LysCys: 1.244 ± 0.422
3.877LysAsp: 3.877 ± 0.531
4.169LysGlu: 4.169 ± 0.738
1.975LysPhe: 1.975 ± 0.376
2.78LysGly: 2.78 ± 0.481
1.39LysHis: 1.39 ± 0.412
3.365LysIle: 3.365 ± 0.54
4.169LysLys: 4.169 ± 0.746
5.34LysLeu: 5.34 ± 0.568
2.706LysMet: 2.706 ± 0.412
2.78LysAsn: 2.78 ± 0.474
2.706LysPro: 2.706 ± 0.412
2.78LysGln: 2.78 ± 0.383
3.657LysArg: 3.657 ± 0.59
4.974LysSer: 4.974 ± 0.683
3.657LysThr: 3.657 ± 0.661
3.804LysVal: 3.804 ± 0.512
1.17LysTrp: 1.17 ± 0.34
2.414LysTyr: 2.414 ± 0.358
0.0LysXaa: 0.0 ± 0.0
Leu
5.925LeuAla: 5.925 ± 0.767
0.805LeuCys: 0.805 ± 0.246
3.731LeuAsp: 3.731 ± 0.513
4.974LeuGlu: 4.974 ± 0.575
1.756LeuPhe: 1.756 ± 0.317
4.389LeuGly: 4.389 ± 0.443
1.244LeuHis: 1.244 ± 0.284
4.608LeuIle: 4.608 ± 0.62
4.535LeuLys: 4.535 ± 0.717
4.535LeuLeu: 4.535 ± 0.686
1.902LeuMet: 1.902 ± 0.431
4.389LeuAsn: 4.389 ± 0.742
2.56LeuPro: 2.56 ± 0.497
2.853LeuGln: 2.853 ± 0.476
4.462LeuArg: 4.462 ± 0.49
4.243LeuSer: 4.243 ± 0.611
4.316LeuThr: 4.316 ± 0.564
4.828LeuVal: 4.828 ± 0.734
1.609LeuTrp: 1.609 ± 0.31
2.487LeuTyr: 2.487 ± 0.467
0.0LeuXaa: 0.0 ± 0.0
Met
2.633MetAla: 2.633 ± 0.402
0.439MetCys: 0.439 ± 0.18
1.682MetAsp: 1.682 ± 0.385
1.682MetGlu: 1.682 ± 0.262
1.244MetPhe: 1.244 ± 0.281
1.829MetGly: 1.829 ± 0.337
0.731MetHis: 0.731 ± 0.255
1.536MetIle: 1.536 ± 0.391
2.706MetLys: 2.706 ± 0.415
2.048MetLeu: 2.048 ± 0.409
1.39MetMet: 1.39 ± 0.304
1.902MetAsn: 1.902 ± 0.358
1.317MetPro: 1.317 ± 0.391
1.609MetGln: 1.609 ± 0.359
1.829MetArg: 1.829 ± 0.267
2.341MetSer: 2.341 ± 0.385
1.756MetThr: 1.756 ± 0.348
1.244MetVal: 1.244 ± 0.313
0.512MetTrp: 0.512 ± 0.17
0.878MetTyr: 0.878 ± 0.221
0.0MetXaa: 0.0 ± 0.0
Asn
4.901AsnAla: 4.901 ± 0.601
0.293AsnCys: 0.293 ± 0.154
3.584AsnAsp: 3.584 ± 0.627
3.365AsnGlu: 3.365 ± 0.488
1.317AsnPhe: 1.317 ± 0.338
5.047AsnGly: 5.047 ± 0.664
1.17AsnHis: 1.17 ± 0.352
2.633AsnIle: 2.633 ± 0.403
3.145AsnLys: 3.145 ± 0.527
2.999AsnLeu: 2.999 ± 0.415
0.951AsnMet: 0.951 ± 0.289
2.268AsnAsn: 2.268 ± 0.366
1.756AsnPro: 1.756 ± 0.37
1.317AsnGln: 1.317 ± 0.312
2.633AsnArg: 2.633 ± 0.428
3.218AsnSer: 3.218 ± 0.555
2.121AsnThr: 2.121 ± 0.525
3.438AsnVal: 3.438 ± 0.603
0.585AsnTrp: 0.585 ± 0.231
1.756AsnTyr: 1.756 ± 0.331
0.0AsnXaa: 0.0 ± 0.0
Pro
2.78ProAla: 2.78 ± 0.412
0.439ProCys: 0.439 ± 0.157
1.902ProAsp: 1.902 ± 0.364
2.999ProGlu: 2.999 ± 0.567
0.878ProPhe: 0.878 ± 0.23
1.756ProGly: 1.756 ± 0.338
0.658ProHis: 0.658 ± 0.195
1.536ProIle: 1.536 ± 0.354
2.048ProLys: 2.048 ± 0.394
2.268ProLeu: 2.268 ± 0.458
0.658ProMet: 0.658 ± 0.218
1.463ProAsn: 1.463 ± 0.346
1.244ProPro: 1.244 ± 0.356
1.097ProGln: 1.097 ± 0.328
1.317ProArg: 1.317 ± 0.287
1.829ProSer: 1.829 ± 0.401
1.829ProThr: 1.829 ± 0.356
3.072ProVal: 3.072 ± 0.537
0.512ProTrp: 0.512 ± 0.213
1.463ProTyr: 1.463 ± 0.334
0.0ProXaa: 0.0 ± 0.0
Gln
3.072GlnAla: 3.072 ± 0.634
0.293GlnCys: 0.293 ± 0.14
1.829GlnAsp: 1.829 ± 0.408
2.56GlnGlu: 2.56 ± 0.42
1.39GlnPhe: 1.39 ± 0.321
1.244GlnGly: 1.244 ± 0.299
1.317GlnHis: 1.317 ± 0.34
2.121GlnIle: 2.121 ± 0.403
2.56GlnLys: 2.56 ± 0.433
3.731GlnLeu: 3.731 ± 0.62
1.609GlnMet: 1.609 ± 0.324
1.244GlnAsn: 1.244 ± 0.282
1.317GlnPro: 1.317 ± 0.293
3.584GlnGln: 3.584 ± 1.123
1.902GlnArg: 1.902 ± 0.385
2.853GlnSer: 2.853 ± 0.554
2.048GlnThr: 2.048 ± 0.465
2.853GlnVal: 2.853 ± 0.455
0.439GlnTrp: 0.439 ± 0.15
1.902GlnTyr: 1.902 ± 0.376
0.0GlnXaa: 0.0 ± 0.0
Arg
4.316ArgAla: 4.316 ± 0.551
1.317ArgCys: 1.317 ± 0.411
3.218ArgAsp: 3.218 ± 0.475
3.731ArgGlu: 3.731 ± 0.597
1.829ArgPhe: 1.829 ± 0.327
3.804ArgGly: 3.804 ± 0.583
0.805ArgHis: 0.805 ± 0.227
2.999ArgIle: 2.999 ± 0.509
4.096ArgLys: 4.096 ± 0.546
4.901ArgLeu: 4.901 ± 0.602
1.682ArgMet: 1.682 ± 0.393
2.999ArgAsn: 2.999 ± 0.417
1.097ArgPro: 1.097 ± 0.294
2.487ArgGln: 2.487 ± 0.479
3.218ArgArg: 3.218 ± 0.554
3.072ArgSer: 3.072 ± 0.508
2.121ArgThr: 2.121 ± 0.475
3.657ArgVal: 3.657 ± 0.713
0.805ArgTrp: 0.805 ± 0.225
2.926ArgTyr: 2.926 ± 0.445
0.0ArgXaa: 0.0 ± 0.0
Ser
5.998SerAla: 5.998 ± 1.072
1.024SerCys: 1.024 ± 0.344
4.023SerAsp: 4.023 ± 0.572
4.096SerGlu: 4.096 ± 0.475
2.78SerPhe: 2.78 ± 0.49
6.071SerGly: 6.071 ± 0.561
0.805SerHis: 0.805 ± 0.233
4.023SerIle: 4.023 ± 0.595
4.023SerLys: 4.023 ± 0.585
4.608SerLeu: 4.608 ± 0.61
1.829SerMet: 1.829 ± 0.354
2.268SerAsn: 2.268 ± 0.414
2.487SerPro: 2.487 ± 0.363
2.56SerGln: 2.56 ± 0.467
3.657SerArg: 3.657 ± 0.42
4.243SerSer: 4.243 ± 0.642
3.804SerThr: 3.804 ± 0.626
3.877SerVal: 3.877 ± 0.584
1.097SerTrp: 1.097 ± 0.302
2.048SerTyr: 2.048 ± 0.41
0.0SerXaa: 0.0 ± 0.0
Thr
3.95ThrAla: 3.95 ± 0.818
0.512ThrCys: 0.512 ± 0.168
3.365ThrAsp: 3.365 ± 0.552
4.023ThrGlu: 4.023 ± 0.485
1.756ThrPhe: 1.756 ± 0.434
5.632ThrGly: 5.632 ± 0.738
0.951ThrHis: 0.951 ± 0.24
3.877ThrIle: 3.877 ± 0.543
2.341ThrLys: 2.341 ± 0.455
3.584ThrLeu: 3.584 ± 0.478
1.097ThrMet: 1.097 ± 0.279
2.414ThrAsn: 2.414 ± 0.506
2.78ThrPro: 2.78 ± 0.405
1.975ThrGln: 1.975 ± 0.388
3.145ThrArg: 3.145 ± 0.451
3.877ThrSer: 3.877 ± 0.491
3.511ThrThr: 3.511 ± 0.884
3.218ThrVal: 3.218 ± 0.609
0.731ThrTrp: 0.731 ± 0.308
1.756ThrTyr: 1.756 ± 0.399
0.0ThrXaa: 0.0 ± 0.0
Val
5.413ValAla: 5.413 ± 0.717
0.512ValCys: 0.512 ± 0.226
4.243ValAsp: 4.243 ± 0.566
3.072ValGlu: 3.072 ± 0.513
2.706ValPhe: 2.706 ± 0.53
4.023ValGly: 4.023 ± 0.57
0.951ValHis: 0.951 ± 0.316
5.706ValIle: 5.706 ± 0.6
3.438ValLys: 3.438 ± 0.517
4.316ValLeu: 4.316 ± 0.661
2.414ValMet: 2.414 ± 0.393
4.023ValAsn: 4.023 ± 0.566
1.829ValPro: 1.829 ± 0.4
2.268ValGln: 2.268 ± 0.375
2.853ValArg: 2.853 ± 0.46
5.267ValSer: 5.267 ± 0.608
4.462ValThr: 4.462 ± 0.811
4.828ValVal: 4.828 ± 0.762
1.097ValTrp: 1.097 ± 0.272
2.926ValTyr: 2.926 ± 0.453
0.0ValXaa: 0.0 ± 0.0
Trp
0.878TrpAla: 0.878 ± 0.229
0.293TrpCys: 0.293 ± 0.196
1.024TrpAsp: 1.024 ± 0.216
0.658TrpGlu: 0.658 ± 0.294
0.805TrpPhe: 0.805 ± 0.224
0.512TrpGly: 0.512 ± 0.258
0.658TrpHis: 0.658 ± 0.302
0.658TrpIle: 0.658 ± 0.258
1.097TrpLys: 1.097 ± 0.251
1.317TrpLeu: 1.317 ± 0.309
0.658TrpMet: 0.658 ± 0.312
0.805TrpAsn: 0.805 ± 0.271
0.439TrpPro: 0.439 ± 0.182
0.658TrpGln: 0.658 ± 0.247
1.097TrpArg: 1.097 ± 0.269
0.585TrpSer: 0.585 ± 0.202
0.805TrpThr: 0.805 ± 0.246
1.536TrpVal: 1.536 ± 0.322
0.293TrpTrp: 0.293 ± 0.129
0.512TrpTyr: 0.512 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.365TyrAla: 3.365 ± 0.519
0.512TyrCys: 0.512 ± 0.168
3.365TyrAsp: 3.365 ± 0.515
1.902TyrGlu: 1.902 ± 0.35
1.39TyrPhe: 1.39 ± 0.312
2.999TyrGly: 2.999 ± 0.54
0.805TyrHis: 0.805 ± 0.234
2.487TyrIle: 2.487 ± 0.455
2.048TyrLys: 2.048 ± 0.338
1.756TyrLeu: 1.756 ± 0.402
0.585TyrMet: 0.585 ± 0.233
1.682TyrAsn: 1.682 ± 0.335
1.244TyrPro: 1.244 ± 0.306
1.756TyrGln: 1.756 ± 0.37
2.268TyrArg: 2.268 ± 0.376
3.511TyrSer: 3.511 ± 0.516
2.341TyrThr: 2.341 ± 0.498
2.414TyrVal: 2.414 ± 0.466
0.658TyrTrp: 0.658 ± 0.222
1.244TyrTyr: 1.244 ± 0.279
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.073XaaAla: 0.073 ± 0.068
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (13672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski