Amino acid dipepetide frequency for Haemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.303AlaAla: 5.303 ± 0.144
1.06AlaCys: 1.06 ± 0.046
4.448AlaAsp: 4.448 ± 0.094
6.62AlaGlu: 6.62 ± 0.123
3.502AlaPhe: 3.502 ± 0.09
6.051AlaGly: 6.051 ± 0.244
1.467AlaHis: 1.467 ± 0.049
6.252AlaIle: 6.252 ± 0.103
6.142AlaLys: 6.142 ± 0.116
9.059AlaLeu: 9.059 ± 0.135
2.321AlaMet: 2.321 ± 0.065
3.809AlaAsn: 3.809 ± 0.098
2.303AlaPro: 2.303 ± 0.073
4.023AlaGln: 4.023 ± 0.085
3.593AlaArg: 3.593 ± 0.086
4.241AlaSer: 4.241 ± 0.088
4.545AlaThr: 4.545 ± 0.09
6.198AlaVal: 6.198 ± 0.113
0.794AlaTrp: 0.794 ± 0.042
2.418AlaTyr: 2.418 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.655CysAla: 0.655 ± 0.031
0.174CysCys: 0.174 ± 0.018
0.599CysAsp: 0.599 ± 0.037
0.66CysGlu: 0.66 ± 0.034
0.433CysPhe: 0.433 ± 0.027
0.901CysGly: 0.901 ± 0.044
0.273CysHis: 0.273 ± 0.028
0.61CysIle: 0.61 ± 0.031
0.473CysLys: 0.473 ± 0.03
1.052CysLeu: 1.052 ± 0.048
0.141CysMet: 0.141 ± 0.017
0.402CysAsn: 0.402 ± 0.027
0.448CysPro: 0.448 ± 0.029
0.48CysGln: 0.48 ± 0.032
0.43CysArg: 0.43 ± 0.026
0.591CysSer: 0.591 ± 0.032
0.455CysThr: 0.455 ± 0.03
0.662CysVal: 0.662 ± 0.037
0.112CysTrp: 0.112 ± 0.014
0.356CysTyr: 0.356 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.432AspAla: 3.432 ± 0.076
0.513AspCys: 0.513 ± 0.033
2.446AspAsp: 2.446 ± 0.073
3.927AspGlu: 3.927 ± 0.091
2.587AspPhe: 2.587 ± 0.077
3.305AspGly: 3.305 ± 0.089
0.915AspHis: 0.915 ± 0.041
3.751AspIle: 3.751 ± 0.08
3.613AspLys: 3.613 ± 0.08
5.199AspLeu: 5.199 ± 0.095
1.026AspMet: 1.026 ± 0.044
2.413AspAsn: 2.413 ± 0.07
2.121AspPro: 2.121 ± 0.061
1.661AspGln: 1.661 ± 0.053
2.303AspArg: 2.303 ± 0.065
2.301AspSer: 2.301 ± 0.06
2.327AspThr: 2.327 ± 0.07
3.479AspVal: 3.479 ± 0.095
0.68AspTrp: 0.68 ± 0.04
2.116AspTyr: 2.116 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.371GluAla: 5.371 ± 0.124
0.496GluCys: 0.496 ± 0.032
2.556GluAsp: 2.556 ± 0.067
3.933GluGlu: 3.933 ± 0.09
2.475GluPhe: 2.475 ± 0.067
3.586GluGly: 3.586 ± 0.088
1.358GluHis: 1.358 ± 0.044
5.052GluIle: 5.052 ± 0.095
5.171GluLys: 5.171 ± 0.115
6.863GluLeu: 6.863 ± 0.12
1.963GluMet: 1.963 ± 0.061
3.444GluAsn: 3.444 ± 0.081
2.068GluPro: 2.068 ± 0.061
4.612GluGln: 4.612 ± 0.094
3.568GluArg: 3.568 ± 0.073
2.875GluSer: 2.875 ± 0.081
3.221GluThr: 3.221 ± 0.084
4.264GluVal: 4.264 ± 0.088
0.883GluTrp: 0.883 ± 0.038
1.897GluTyr: 1.897 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.77PheAla: 3.77 ± 0.09
0.579PheCys: 0.579 ± 0.036
2.731PheAsp: 2.731 ± 0.075
2.716PheGlu: 2.716 ± 0.062
1.932PhePhe: 1.932 ± 0.068
3.32PheGly: 3.32 ± 0.085
0.855PheHis: 0.855 ± 0.038
3.082PheIle: 3.082 ± 0.083
2.228PheLys: 2.228 ± 0.07
3.776PheLeu: 3.776 ± 0.086
0.953PheMet: 0.953 ± 0.041
2.207PheAsn: 2.207 ± 0.065
1.548PhePro: 1.548 ± 0.052
1.418PheGln: 1.418 ± 0.05
1.613PheArg: 1.613 ± 0.051
3.182PheSer: 3.182 ± 0.079
2.235PheThr: 2.235 ± 0.069
2.901PheVal: 2.901 ± 0.071
0.516PheTrp: 0.516 ± 0.033
1.585PheTyr: 1.585 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.058GlyAla: 5.058 ± 0.152
0.782GlyCys: 0.782 ± 0.037
3.431GlyAsp: 3.431 ± 0.113
4.729GlyGlu: 4.729 ± 0.151
3.08GlyPhe: 3.08 ± 0.084
4.689GlyGly: 4.689 ± 0.121
1.249GlyHis: 1.249 ± 0.054
5.245GlyIle: 5.245 ± 0.105
5.235GlyLys: 5.235 ± 0.117
6.749GlyLeu: 6.749 ± 0.137
1.752GlyMet: 1.752 ± 0.055
2.934GlyAsn: 2.934 ± 0.097
2.038GlyPro: 2.038 ± 0.333
2.609GlyGln: 2.609 ± 0.07
2.842GlyArg: 2.842 ± 0.079
3.874GlySer: 3.874 ± 0.101
3.436GlyThr: 3.436 ± 0.076
5.048GlyVal: 5.048 ± 0.102
0.868GlyTrp: 0.868 ± 0.04
2.64GlyTyr: 2.64 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.217HisAla: 1.217 ± 0.047
0.362HisCys: 0.362 ± 0.024
0.82HisAsp: 0.82 ± 0.038
0.817HisGlu: 0.817 ± 0.03
1.239HisPhe: 1.239 ± 0.046
1.229HisGly: 1.229 ± 0.053
0.677HisHis: 0.677 ± 0.038
1.634HisIle: 1.634 ± 0.055
1.194HisLys: 1.194 ± 0.044
2.372HisLeu: 2.372 ± 0.072
0.319HisMet: 0.319 ± 0.021
1.021HisAsn: 1.021 ± 0.04
0.976HisPro: 0.976 ± 0.042
1.279HisGln: 1.279 ± 0.046
1.065HisArg: 1.065 ± 0.042
1.396HisSer: 1.396 ± 0.049
1.12HisThr: 1.12 ± 0.046
0.766HisVal: 0.766 ± 0.041
0.28HisTrp: 0.28 ± 0.021
0.908HisTyr: 0.908 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.821IleAla: 6.821 ± 0.114
0.791IleCys: 0.791 ± 0.038
4.062IleAsp: 4.062 ± 0.09
4.911IleGlu: 4.911 ± 0.1
2.744IlePhe: 2.744 ± 0.079
5.25IleGly: 5.25 ± 0.115
1.275IleHis: 1.275 ± 0.042
4.244IleIle: 4.244 ± 0.101
3.856IleLys: 3.856 ± 0.088
6.332IleLeu: 6.332 ± 0.121
1.27IleMet: 1.27 ± 0.045
3.128IleAsn: 3.128 ± 0.081
2.767IlePro: 2.767 ± 0.068
2.8IleGln: 2.8 ± 0.066
2.996IleArg: 2.996 ± 0.072
4.567IleSer: 4.567 ± 0.085
3.831IleThr: 3.831 ± 0.087
4.502IleVal: 4.502 ± 0.095
0.612IleTrp: 0.612 ± 0.036
2.097IleTyr: 2.097 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.897LysAla: 5.897 ± 0.126
0.377LysCys: 0.377 ± 0.028
2.928LysAsp: 2.928 ± 0.072
4.175LysGlu: 4.175 ± 0.097
2.18LysPhe: 2.18 ± 0.066
4.373LysGly: 4.373 ± 0.137
1.209LysHis: 1.209 ± 0.048
4.112LysIle: 4.112 ± 0.091
3.7LysLys: 3.7 ± 0.09
6.099LysLeu: 6.099 ± 0.115
1.886LysMet: 1.886 ± 0.057
2.974LysAsn: 2.974 ± 0.074
2.422LysPro: 2.422 ± 0.062
3.571LysGln: 3.571 ± 0.088
3.126LysArg: 3.126 ± 0.073
3.432LysSer: 3.432 ± 0.084
3.411LysThr: 3.411 ± 0.081
4.375LysVal: 4.375 ± 0.089
0.776LysTrp: 0.776 ± 0.035
1.833LysTyr: 1.833 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
9.809LeuAla: 9.809 ± 0.148
0.959LeuCys: 0.959 ± 0.047
5.526LeuAsp: 5.526 ± 0.12
6.211LeuGlu: 6.211 ± 0.105
4.557LeuPhe: 4.557 ± 0.128
6.838LeuGly: 6.838 ± 0.119
1.977LeuHis: 1.977 ± 0.064
6.428LeuIle: 6.428 ± 0.128
6.09LeuLys: 6.09 ± 0.103
10.298LeuLeu: 10.298 ± 0.201
2.392LeuMet: 2.392 ± 0.066
5.114LeuAsn: 5.114 ± 0.099
4.603LeuPro: 4.603 ± 0.11
4.311LeuGln: 4.311 ± 0.108
4.517LeuArg: 4.517 ± 0.098
7.253LeuSer: 7.253 ± 0.124
5.814LeuThr: 5.814 ± 0.115
6.691LeuVal: 6.691 ± 0.114
1.09LeuTrp: 1.09 ± 0.048
2.693LeuTyr: 2.693 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.398MetAla: 2.398 ± 0.065
0.189MetCys: 0.189 ± 0.017
0.987MetAsp: 0.987 ± 0.038
1.203MetGlu: 1.203 ± 0.047
0.887MetPhe: 0.887 ± 0.042
1.626MetGly: 1.626 ± 0.05
0.4MetHis: 0.4 ± 0.023
1.588MetIle: 1.588 ± 0.052
1.707MetLys: 1.707 ± 0.052
2.556MetLeu: 2.556 ± 0.074
0.728MetMet: 0.728 ± 0.042
1.15MetAsn: 1.15 ± 0.047
1.047MetPro: 1.047 ± 0.038
1.27MetGln: 1.27 ± 0.043
1.074MetArg: 1.074 ± 0.04
1.462MetSer: 1.462 ± 0.046
1.279MetThr: 1.279 ± 0.045
1.495MetVal: 1.495 ± 0.046
0.202MetTrp: 0.202 ± 0.018
0.473MetTyr: 0.473 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.927AsnAla: 3.927 ± 0.106
0.39AsnCys: 0.39 ± 0.028
2.183AsnAsp: 2.183 ± 0.061
2.822AsnGlu: 2.822 ± 0.07
1.79AsnPhe: 1.79 ± 0.054
3.523AsnGly: 3.523 ± 0.099
1.057AsnHis: 1.057 ± 0.044
3.166AsnIle: 3.166 ± 0.071
2.661AsnLys: 2.661 ± 0.078
4.726AsnLeu: 4.726 ± 0.096
1.004AsnMet: 1.004 ± 0.045
2.216AsnAsn: 2.216 ± 0.078
2.503AsnPro: 2.503 ± 0.071
2.324AsnGln: 2.324 ± 0.064
2.117AsnArg: 2.117 ± 0.049
2.527AsnSer: 2.527 ± 0.079
2.264AsnThr: 2.264 ± 0.074
3.244AsnVal: 3.244 ± 0.081
0.548AsnTrp: 0.548 ± 0.033
1.485AsnTyr: 1.485 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
3.067ProAla: 3.067 ± 0.144
0.278ProCys: 0.278 ± 0.022
1.914ProAsp: 1.914 ± 0.05
3.166ProGlu: 3.166 ± 0.076
1.798ProPhe: 1.798 ± 0.053
1.423ProGly: 1.423 ± 0.077
0.882ProHis: 0.882 ± 0.041
2.59ProIle: 2.59 ± 0.069
2.574ProLys: 2.574 ± 0.08
3.932ProLeu: 3.932 ± 0.08
0.935ProMet: 0.935 ± 0.037
2.106ProAsn: 2.106 ± 0.066
1.077ProPro: 1.077 ± 0.048
1.935ProGln: 1.935 ± 0.067
1.472ProArg: 1.472 ± 0.067
2.076ProSer: 2.076 ± 0.058
2.62ProThr: 2.62 ± 0.074
2.645ProVal: 2.645 ± 0.078
0.359ProTrp: 0.359 ± 0.024
1.36ProTyr: 1.36 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.714GlnAla: 4.714 ± 0.096
0.372GlnCys: 0.372 ± 0.026
2.074GlnAsp: 2.074 ± 0.064
2.671GlnGlu: 2.671 ± 0.068
2.089GlnPhe: 2.089 ± 0.063
3.321GlnGly: 3.321 ± 0.105
1.176GlnHis: 1.176 ± 0.059
3.343GlnIle: 3.343 ± 0.09
2.966GlnLys: 2.966 ± 0.075
5.227GlnLeu: 5.227 ± 0.125
1.11GlnMet: 1.11 ± 0.043
2.256GlnAsn: 2.256 ± 0.06
1.762GlnPro: 1.762 ± 0.061
3.594GlnGln: 3.594 ± 0.108
2.42GlnArg: 2.42 ± 0.068
2.585GlnSer: 2.585 ± 0.08
2.498GlnThr: 2.498 ± 0.065
2.926GlnVal: 2.926 ± 0.074
0.642GlnTrp: 0.642 ± 0.039
1.434GlnTyr: 1.434 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.164ArgAla: 3.164 ± 0.072
0.478ArgCys: 0.478 ± 0.033
2.137ArgAsp: 2.137 ± 0.061
3.225ArgGlu: 3.225 ± 0.081
2.385ArgPhe: 2.385 ± 0.07
2.795ArgGly: 2.795 ± 0.107
1.044ArgHis: 1.044 ± 0.043
3.144ArgIle: 3.144 ± 0.07
2.724ArgLys: 2.724 ± 0.073
5.06ArgLeu: 5.06 ± 0.098
1.054ArgMet: 1.054 ± 0.044
1.995ArgAsn: 1.995 ± 0.064
1.558ArgPro: 1.558 ± 0.052
2.389ArgGln: 2.389 ± 0.059
2.188ArgArg: 2.188 ± 0.064
2.344ArgSer: 2.344 ± 0.071
2.053ArgThr: 2.053 ± 0.057
2.967ArgVal: 2.967 ± 0.083
0.538ArgTrp: 0.538 ± 0.033
1.854ArgTyr: 1.854 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.711SerAla: 4.711 ± 0.089
0.523SerCys: 0.523 ± 0.036
2.939SerAsp: 2.939 ± 0.074
3.634SerGlu: 3.634 ± 0.076
2.519SerPhe: 2.519 ± 0.069
4.335SerGly: 4.335 ± 0.077
1.429SerHis: 1.429 ± 0.049
3.809SerIle: 3.809 ± 0.087
3.007SerLys: 3.007 ± 0.075
6.305SerLeu: 6.305 ± 0.117
1.257SerMet: 1.257 ± 0.049
2.463SerAsn: 2.463 ± 0.066
2.253SerPro: 2.253 ± 0.058
2.848SerGln: 2.848 ± 0.072
2.557SerArg: 2.557 ± 0.067
3.341SerSer: 3.341 ± 0.102
2.949SerThr: 2.949 ± 0.091
3.919SerVal: 3.919 ± 0.098
0.667SerTrp: 0.667 ± 0.032
1.907SerTyr: 1.907 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
5.086ThrAla: 5.086 ± 0.087
0.389ThrCys: 0.389 ± 0.027
2.594ThrAsp: 2.594 ± 0.071
3.321ThrGlu: 3.321 ± 0.066
2.245ThrPhe: 2.245 ± 0.067
4.049ThrGly: 4.049 ± 0.126
1.15ThrHis: 1.15 ± 0.048
3.454ThrIle: 3.454 ± 0.075
2.936ThrLys: 2.936 ± 0.079
5.804ThrLeu: 5.804 ± 0.104
1.148ThrMet: 1.148 ± 0.043
2.059ThrAsn: 2.059 ± 0.064
2.511ThrPro: 2.511 ± 0.067
2.465ThrGln: 2.465 ± 0.063
1.944ThrArg: 1.944 ± 0.062
2.862ThrSer: 2.862 ± 0.074
2.901ThrThr: 2.901 ± 0.084
3.588ThrVal: 3.588 ± 0.074
0.486ThrTrp: 0.486 ± 0.029
1.487ThrTyr: 1.487 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
6.367ValAla: 6.367 ± 0.117
0.678ValCys: 0.678 ± 0.026
3.571ValAsp: 3.571 ± 0.078
4.767ValGlu: 4.767 ± 0.103
2.569ValPhe: 2.569 ± 0.069
4.78ValGly: 4.78 ± 0.117
1.168ValHis: 1.168 ± 0.044
4.8ValIle: 4.8 ± 0.085
4.345ValLys: 4.345 ± 0.089
6.537ValLeu: 6.537 ± 0.133
1.666ValMet: 1.666 ± 0.054
2.972ValAsn: 2.972 ± 0.077
2.527ValPro: 2.527 ± 0.062
2.456ValGln: 2.456 ± 0.073
2.953ValArg: 2.953 ± 0.067
4.144ValSer: 4.144 ± 0.084
3.566ValThr: 3.566 ± 0.079
5.096ValVal: 5.096 ± 0.114
0.658ValTrp: 0.658 ± 0.033
1.861ValTyr: 1.861 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.834TrpAla: 0.834 ± 0.039
0.136TrpCys: 0.136 ± 0.014
0.564TrpAsp: 0.564 ± 0.031
0.586TrpGlu: 0.586 ± 0.031
0.556TrpPhe: 0.556 ± 0.035
0.688TrpGly: 0.688 ± 0.04
0.276TrpHis: 0.276 ± 0.023
0.72TrpIle: 0.72 ± 0.043
0.698TrpLys: 0.698 ± 0.036
1.649TrpLeu: 1.649 ± 0.065
0.197TrpMet: 0.197 ± 0.017
0.518TrpAsn: 0.518 ± 0.031
0.151TrpPro: 0.151 ± 0.017
0.976TrpGln: 0.976 ± 0.052
0.536TrpArg: 0.536 ± 0.033
0.539TrpSer: 0.539 ± 0.03
0.46TrpThr: 0.46 ± 0.028
0.782TrpVal: 0.782 ± 0.036
0.144TrpTrp: 0.144 ± 0.017
0.321TrpTyr: 0.321 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.547TyrAla: 2.547 ± 0.074
0.38TyrCys: 0.38 ± 0.027
1.601TyrAsp: 1.601 ± 0.053
1.56TyrGlu: 1.56 ± 0.05
1.58TyrPhe: 1.58 ± 0.047
2.203TyrGly: 2.203 ± 0.064
0.855TyrHis: 0.855 ± 0.033
1.833TyrIle: 1.833 ± 0.069
1.535TyrLys: 1.535 ± 0.05
3.579TyrLeu: 3.579 ± 0.097
0.599TyrMet: 0.599 ± 0.03
1.297TyrAsn: 1.297 ± 0.052
1.525TyrPro: 1.525 ± 0.045
2.162TyrGln: 2.162 ± 0.066
1.785TyrArg: 1.785 ± 0.049
1.781TyrSer: 1.781 ± 0.053
1.494TyrThr: 1.494 ± 0.049
1.934TyrVal: 1.934 ± 0.06
0.475TyrTrp: 0.475 ± 0.031
1.097TyrTyr: 1.097 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2002 proteins (604561 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski