Amino acid dipepetide frequency for Rhodococcus sp. CUA-806

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.603AlaAla: 17.603 ± 0.213
0.942AlaCys: 0.942 ± 0.029
7.802AlaAsp: 7.802 ± 0.093
7.403AlaGlu: 7.403 ± 0.091
3.513AlaPhe: 3.513 ± 0.07
10.246AlaGly: 10.246 ± 0.109
2.548AlaHis: 2.548 ± 0.056
5.364AlaIle: 5.364 ± 0.074
2.812AlaLys: 2.812 ± 0.061
12.946AlaLeu: 12.946 ± 0.131
2.759AlaMet: 2.759 ± 0.052
2.217AlaAsn: 2.217 ± 0.049
5.621AlaPro: 5.621 ± 0.089
3.6AlaGln: 3.6 ± 0.058
8.258AlaArg: 8.258 ± 0.09
7.307AlaSer: 7.307 ± 0.088
7.143AlaThr: 7.143 ± 0.082
11.521AlaVal: 11.521 ± 0.11
1.423AlaTrp: 1.423 ± 0.039
2.185AlaTyr: 2.185 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.015CysAla: 1.015 ± 0.035
0.111CysCys: 0.111 ± 0.01
0.459CysAsp: 0.459 ± 0.017
0.41CysGlu: 0.41 ± 0.021
0.22CysPhe: 0.22 ± 0.014
0.888CysGly: 0.888 ± 0.03
0.153CysHis: 0.153 ± 0.012
0.297CysIle: 0.297 ± 0.016
0.119CysLys: 0.119 ± 0.011
0.601CysLeu: 0.601 ± 0.024
0.137CysMet: 0.137 ± 0.011
0.164CysAsn: 0.164 ± 0.013
0.446CysPro: 0.446 ± 0.022
0.156CysGln: 0.156 ± 0.012
0.575CysArg: 0.575 ± 0.027
0.614CysSer: 0.614 ± 0.028
0.524CysThr: 0.524 ± 0.023
0.602CysVal: 0.602 ± 0.025
0.118CysTrp: 0.118 ± 0.011
0.157CysTyr: 0.157 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.908AspAla: 7.908 ± 0.094
0.401AspCys: 0.401 ± 0.02
3.834AspAsp: 3.834 ± 0.067
3.954AspGlu: 3.954 ± 0.06
1.753AspPhe: 1.753 ± 0.045
5.77AspGly: 5.77 ± 0.089
1.431AspHis: 1.431 ± 0.037
2.969AspIle: 2.969 ± 0.057
1.279AspLys: 1.279 ± 0.041
6.171AspLeu: 6.171 ± 0.085
0.993AspMet: 0.993 ± 0.035
1.303AspAsn: 1.303 ± 0.031
4.213AspPro: 4.213 ± 0.066
1.712AspGln: 1.712 ± 0.043
4.824AspArg: 4.824 ± 0.081
3.61AspSer: 3.61 ± 0.059
3.439AspThr: 3.439 ± 0.061
5.401AspVal: 5.401 ± 0.081
0.92AspTrp: 0.92 ± 0.029
1.326AspTyr: 1.326 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.859GluAla: 5.859 ± 0.089
0.369GluCys: 0.369 ± 0.018
2.909GluAsp: 2.909 ± 0.057
2.73GluGlu: 2.73 ± 0.058
2.019GluPhe: 2.019 ± 0.047
3.395GluGly: 3.395 ± 0.067
1.603GluHis: 1.603 ± 0.041
2.811GluIle: 2.811 ± 0.057
1.481GluLys: 1.481 ± 0.039
6.79GluLeu: 6.79 ± 0.09
1.196GluMet: 1.196 ± 0.032
1.502GluAsn: 1.502 ± 0.047
2.864GluPro: 2.864 ± 0.061
2.273GluGln: 2.273 ± 0.051
4.761GluArg: 4.761 ± 0.077
3.61GluSer: 3.61 ± 0.059
2.949GluThr: 2.949 ± 0.055
4.511GluVal: 4.511 ± 0.068
0.841GluTrp: 0.841 ± 0.029
1.198GluTyr: 1.198 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.016PheAla: 4.016 ± 0.077
0.276PheCys: 0.276 ± 0.015
2.691PheAsp: 2.691 ± 0.059
1.798PheGlu: 1.798 ± 0.041
1.013PhePhe: 1.013 ± 0.036
3.452PheGly: 3.452 ± 0.065
0.63PheHis: 0.63 ± 0.028
1.043PheIle: 1.043 ± 0.038
0.477PheLys: 0.477 ± 0.023
2.626PheLeu: 2.626 ± 0.057
0.495PheMet: 0.495 ± 0.025
0.583PheAsn: 0.583 ± 0.024
1.345PhePro: 1.345 ± 0.036
0.712PheGln: 0.712 ± 0.032
1.763PheArg: 1.763 ± 0.045
1.866PheSer: 1.866 ± 0.041
2.073PheThr: 2.073 ± 0.042
3.043PheVal: 3.043 ± 0.06
0.427PheTrp: 0.427 ± 0.023
0.68PheTyr: 0.68 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.315GlyAla: 9.315 ± 0.104
0.793GlyCys: 0.793 ± 0.028
4.786GlyAsp: 4.786 ± 0.071
4.453GlyGlu: 4.453 ± 0.065
3.038GlyPhe: 3.038 ± 0.05
7.092GlyGly: 7.092 ± 0.1
2.027GlyHis: 2.027 ± 0.042
4.325GlyIle: 4.325 ± 0.073
2.303GlyLys: 2.303 ± 0.057
8.004GlyLeu: 8.004 ± 0.109
1.969GlyMet: 1.969 ± 0.042
1.971GlyAsn: 1.971 ± 0.051
4.11GlyPro: 4.11 ± 0.061
2.363GlyGln: 2.363 ± 0.051
6.002GlyArg: 6.002 ± 0.08
5.862GlySer: 5.862 ± 0.076
5.392GlyThr: 5.392 ± 0.078
7.61GlyVal: 7.61 ± 0.091
1.515GlyTrp: 1.515 ± 0.04
2.18GlyTyr: 2.18 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.407HisAla: 2.407 ± 0.054
0.229HisCys: 0.229 ± 0.016
1.248HisAsp: 1.248 ± 0.041
1.253HisGlu: 1.253 ± 0.037
0.663HisPhe: 0.663 ± 0.022
2.012HisGly: 2.012 ± 0.04
0.748HisHis: 0.748 ± 0.027
0.898HisIle: 0.898 ± 0.031
0.37HisLys: 0.37 ± 0.021
2.096HisLeu: 2.096 ± 0.043
0.39HisMet: 0.39 ± 0.019
0.431HisAsn: 0.431 ± 0.02
1.486HisPro: 1.486 ± 0.037
0.634HisGln: 0.634 ± 0.026
1.955HisArg: 1.955 ± 0.047
1.344HisSer: 1.344 ± 0.039
1.185HisThr: 1.185 ± 0.034
1.708HisVal: 1.708 ± 0.045
0.339HisTrp: 0.339 ± 0.017
0.498HisTyr: 0.498 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.658IleAla: 6.658 ± 0.077
0.372IleCys: 0.372 ± 0.019
3.856IleAsp: 3.856 ± 0.066
3.186IleGlu: 3.186 ± 0.062
1.063IlePhe: 1.063 ± 0.033
4.725IleGly: 4.725 ± 0.066
0.797IleHis: 0.797 ± 0.029
1.542IleIle: 1.542 ± 0.044
0.791IleLys: 0.791 ± 0.031
3.638IleLeu: 3.638 ± 0.071
0.669IleMet: 0.669 ± 0.022
0.932IleAsn: 0.932 ± 0.033
2.429IlePro: 2.429 ± 0.052
0.875IleGln: 0.875 ± 0.027
2.686IleArg: 2.686 ± 0.046
2.715IleSer: 2.715 ± 0.053
2.815IleThr: 2.815 ± 0.054
4.307IleVal: 4.307 ± 0.076
0.464IleTrp: 0.464 ± 0.021
0.804IleTyr: 0.804 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
2.538LysAla: 2.538 ± 0.071
0.114LysCys: 0.114 ± 0.011
1.166LysAsp: 1.166 ± 0.037
1.021LysGlu: 1.021 ± 0.038
0.74LysPhe: 0.74 ± 0.027
1.491LysGly: 1.491 ± 0.042
0.501LysHis: 0.501 ± 0.025
1.153LysIle: 1.153 ± 0.037
0.893LysLys: 0.893 ± 0.042
2.201LysLeu: 2.201 ± 0.051
0.527LysMet: 0.527 ± 0.022
0.621LysAsn: 0.621 ± 0.024
1.282LysPro: 1.282 ± 0.038
0.736LysGln: 0.736 ± 0.025
1.549LysArg: 1.549 ± 0.044
1.456LysSer: 1.456 ± 0.036
1.435LysThr: 1.435 ± 0.041
1.797LysVal: 1.797 ± 0.05
0.326LysTrp: 0.326 ± 0.019
0.589LysTyr: 0.589 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
13.24LeuAla: 13.24 ± 0.136
0.794LeuCys: 0.794 ± 0.026
7.104LeuAsp: 7.104 ± 0.084
4.828LeuGlu: 4.828 ± 0.068
2.835LeuPhe: 2.835 ± 0.055
8.942LeuGly: 8.942 ± 0.1
2.006LeuHis: 2.006 ± 0.048
4.091LeuIle: 4.091 ± 0.078
1.666LeuLys: 1.666 ± 0.047
9.564LeuLeu: 9.564 ± 0.126
1.724LeuMet: 1.724 ± 0.039
1.884LeuAsn: 1.884 ± 0.052
5.422LeuPro: 5.422 ± 0.085
2.351LeuGln: 2.351 ± 0.04
7.199LeuArg: 7.199 ± 0.096
5.918LeuSer: 5.918 ± 0.064
6.45LeuThr: 6.45 ± 0.076
8.796LeuVal: 8.796 ± 0.11
1.204LeuTrp: 1.204 ± 0.038
1.737LeuTyr: 1.737 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.34MetAla: 2.34 ± 0.046
0.158MetCys: 0.158 ± 0.013
0.972MetAsp: 0.972 ± 0.03
0.726MetGlu: 0.726 ± 0.027
0.671MetPhe: 0.671 ± 0.025
1.427MetGly: 1.427 ± 0.039
0.479MetHis: 0.479 ± 0.021
1.092MetIle: 1.092 ± 0.03
0.535MetLys: 0.535 ± 0.025
2.077MetLeu: 2.077 ± 0.045
0.408MetMet: 0.408 ± 0.019
0.637MetAsn: 0.637 ± 0.031
1.113MetPro: 1.113 ± 0.036
0.604MetGln: 0.604 ± 0.028
1.505MetArg: 1.505 ± 0.04
1.774MetSer: 1.774 ± 0.039
1.801MetThr: 1.801 ± 0.041
1.562MetVal: 1.562 ± 0.041
0.294MetTrp: 0.294 ± 0.018
0.388MetTyr: 0.388 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.527AsnAla: 2.527 ± 0.051
0.156AsnCys: 0.156 ± 0.013
1.222AsnAsp: 1.222 ± 0.036
1.104AsnGlu: 1.104 ± 0.032
0.706AsnPhe: 0.706 ± 0.031
1.952AsnGly: 1.952 ± 0.044
0.421AsnHis: 0.421 ± 0.022
1.024AsnIle: 1.024 ± 0.033
0.523AsnLys: 0.523 ± 0.023
1.959AsnLeu: 1.959 ± 0.045
0.402AsnMet: 0.402 ± 0.019
0.548AsnAsn: 0.548 ± 0.025
1.545AsnPro: 1.545 ± 0.037
0.642AsnGln: 0.642 ± 0.026
1.499AsnArg: 1.499 ± 0.04
1.419AsnSer: 1.419 ± 0.037
1.442AsnThr: 1.442 ± 0.037
1.741AsnVal: 1.741 ± 0.041
0.341AsnTrp: 0.341 ± 0.018
0.564AsnTyr: 0.564 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.12ProAla: 6.12 ± 0.087
0.312ProCys: 0.312 ± 0.018
3.924ProAsp: 3.924 ± 0.056
3.581ProGlu: 3.581 ± 0.067
1.556ProPhe: 1.556 ± 0.039
4.821ProGly: 4.821 ± 0.078
1.112ProHis: 1.112 ± 0.028
2.317ProIle: 2.317 ± 0.047
1.253ProLys: 1.253 ± 0.036
4.667ProLeu: 4.667 ± 0.07
1.12ProMet: 1.12 ± 0.034
1.261ProAsn: 1.261 ± 0.037
2.667ProPro: 2.667 ± 0.062
1.601ProGln: 1.601 ± 0.041
3.324ProArg: 3.324 ± 0.058
3.644ProSer: 3.644 ± 0.061
3.723ProThr: 3.723 ± 0.072
4.719ProVal: 4.719 ± 0.072
0.761ProTrp: 0.761 ± 0.028
1.007ProTyr: 1.007 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.109GlnAla: 3.109 ± 0.06
0.204GlnCys: 0.204 ± 0.016
1.19GlnAsp: 1.19 ± 0.032
1.182GlnGlu: 1.182 ± 0.033
1.012GlnPhe: 1.012 ± 0.033
1.904GlnGly: 1.904 ± 0.041
0.68GlnHis: 0.68 ± 0.026
1.453GlnIle: 1.453 ± 0.036
0.655GlnLys: 0.655 ± 0.03
3.249GlnLeu: 3.249 ± 0.049
0.659GlnMet: 0.659 ± 0.024
0.678GlnAsn: 0.678 ± 0.026
1.565GlnPro: 1.565 ± 0.042
1.235GlnGln: 1.235 ± 0.035
2.425GlnArg: 2.425 ± 0.052
1.695GlnSer: 1.695 ± 0.042
1.436GlnThr: 1.436 ± 0.035
2.31GlnVal: 2.31 ± 0.049
0.593GlnTrp: 0.593 ± 0.022
0.691GlnTyr: 0.691 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
7.912ArgAla: 7.912 ± 0.092
0.613ArgCys: 0.613 ± 0.023
3.917ArgAsp: 3.917 ± 0.061
4.113ArgGlu: 4.113 ± 0.068
2.322ArgPhe: 2.322 ± 0.049
5.176ArgGly: 5.176 ± 0.083
1.634ArgHis: 1.634 ± 0.035
3.685ArgIle: 3.685 ± 0.055
1.833ArgLys: 1.833 ± 0.045
6.615ArgLeu: 6.615 ± 0.087
1.849ArgMet: 1.849 ± 0.042
1.586ArgAsn: 1.586 ± 0.039
3.546ArgPro: 3.546 ± 0.066
2.052ArgGln: 2.052 ± 0.051
6.358ArgArg: 6.358 ± 0.109
5.029ArgSer: 5.029 ± 0.069
4.882ArgThr: 4.882 ± 0.078
5.471ArgVal: 5.471 ± 0.078
1.291ArgTrp: 1.291 ± 0.036
1.666ArgTyr: 1.666 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.866SerAla: 7.866 ± 0.091
0.467SerCys: 0.467 ± 0.023
3.798SerAsp: 3.798 ± 0.061
3.604SerGlu: 3.604 ± 0.061
1.953SerPhe: 1.953 ± 0.049
6.142SerGly: 6.142 ± 0.076
1.178SerHis: 1.178 ± 0.037
3.097SerIle: 3.097 ± 0.049
1.471SerLys: 1.471 ± 0.039
5.526SerLeu: 5.526 ± 0.073
1.739SerMet: 1.739 ± 0.043
1.475SerAsn: 1.475 ± 0.043
3.411SerPro: 3.411 ± 0.061
1.597SerGln: 1.597 ± 0.044
4.172SerArg: 4.172 ± 0.069
4.443SerSer: 4.443 ± 0.079
4.541SerThr: 4.541 ± 0.061
5.658SerVal: 5.658 ± 0.081
0.981SerTrp: 0.981 ± 0.029
1.301SerTyr: 1.301 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
8.052ThrAla: 8.052 ± 0.098
0.432ThrCys: 0.432 ± 0.021
4.002ThrAsp: 4.002 ± 0.061
3.545ThrGlu: 3.545 ± 0.062
1.898ThrPhe: 1.898 ± 0.044
5.543ThrGly: 5.543 ± 0.076
1.256ThrHis: 1.256 ± 0.038
2.788ThrIle: 2.788 ± 0.049
1.275ThrLys: 1.275 ± 0.039
5.811ThrLeu: 5.811 ± 0.076
1.289ThrMet: 1.289 ± 0.035
1.21ThrAsn: 1.21 ± 0.037
3.832ThrPro: 3.832 ± 0.067
1.49ThrGln: 1.49 ± 0.042
3.947ThrArg: 3.947 ± 0.066
4.203ThrSer: 4.203 ± 0.065
4.414ThrThr: 4.414 ± 0.073
6.337ThrVal: 6.337 ± 0.083
0.894ThrTrp: 0.894 ± 0.03
1.287ThrTyr: 1.287 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
10.936ValAla: 10.936 ± 0.109
0.691ValCys: 0.691 ± 0.027
6.376ValAsp: 6.376 ± 0.097
5.011ValGlu: 5.011 ± 0.074
2.739ValPhe: 2.739 ± 0.059
7.293ValGly: 7.293 ± 0.088
1.987ValHis: 1.987 ± 0.05
3.835ValIle: 3.835 ± 0.067
1.652ValLys: 1.652 ± 0.041
9.493ValLeu: 9.493 ± 0.129
1.547ValMet: 1.547 ± 0.04
1.829ValAsn: 1.829 ± 0.038
4.713ValPro: 4.713 ± 0.075
2.182ValGln: 2.182 ± 0.046
5.911ValArg: 5.911 ± 0.074
5.496ValSer: 5.496 ± 0.073
5.635ValThr: 5.635 ± 0.092
8.933ValVal: 8.933 ± 0.114
1.065ValTrp: 1.065 ± 0.035
1.439ValTyr: 1.439 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.539TrpAla: 1.539 ± 0.043
0.154TrpCys: 0.154 ± 0.012
0.693TrpAsp: 0.693 ± 0.027
0.609TrpGlu: 0.609 ± 0.02
0.535TrpPhe: 0.535 ± 0.022
0.973TrpGly: 0.973 ± 0.033
0.324TrpHis: 0.324 ± 0.02
0.755TrpIle: 0.755 ± 0.029
0.398TrpLys: 0.398 ± 0.024
1.514TrpLeu: 1.514 ± 0.042
0.378TrpMet: 0.378 ± 0.02
0.452TrpAsn: 0.452 ± 0.023
0.722TrpPro: 0.722 ± 0.026
0.526TrpGln: 0.526 ± 0.023
1.098TrpArg: 1.098 ± 0.032
1.044TrpSer: 1.044 ± 0.034
1.016TrpThr: 1.016 ± 0.031
1.125TrpVal: 1.125 ± 0.032
0.37TrpTrp: 0.37 ± 0.021
0.296TrpTyr: 0.296 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.25TyrAla: 2.25 ± 0.043
0.177TyrCys: 0.177 ± 0.012
1.264TyrAsp: 1.264 ± 0.039
1.163TyrGlu: 1.163 ± 0.033
0.758TyrPhe: 0.758 ± 0.027
1.867TyrGly: 1.867 ± 0.045
0.377TyrHis: 0.377 ± 0.02
0.786TyrIle: 0.786 ± 0.029
0.349TyrLys: 0.349 ± 0.021
2.209TyrLeu: 2.209 ± 0.048
0.311TyrMet: 0.311 ± 0.016
0.453TyrAsn: 0.453 ± 0.023
1.153TyrPro: 1.153 ± 0.038
0.586TyrGln: 0.586 ± 0.026
1.74TyrArg: 1.74 ± 0.037
1.371TyrSer: 1.371 ± 0.035
1.21TyrThr: 1.21 ± 0.035
1.613TyrVal: 1.613 ± 0.045
0.355TyrTrp: 0.355 ± 0.018
0.446TyrTyr: 0.446 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3844 proteins (1045091 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski