Amino acid dipepetide frequency for Eimeria mitis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
87.231AlaAla: 87.231 ± 0.84
1.442AlaCys: 1.442 ± 0.024
4.837AlaAsp: 4.837 ± 0.049
7.694AlaGlu: 7.694 ± 0.08
2.125AlaPhe: 2.125 ± 0.026
7.237AlaGly: 7.237 ± 0.063
1.296AlaHis: 1.296 ± 0.019
2.032AlaIle: 2.032 ± 0.024
2.878AlaLys: 2.878 ± 0.044
7.165AlaLeu: 7.165 ± 0.061
1.108AlaMet: 1.108 ± 0.018
1.763AlaAsn: 1.763 ± 0.021
7.357AlaPro: 7.357 ± 0.083
3.179AlaGln: 3.179 ± 0.035
4.132AlaArg: 4.132 ± 0.039
7.269AlaSer: 7.269 ± 0.05
8.913AlaThr: 8.913 ± 0.081
6.677AlaVal: 6.677 ± 0.063
0.683AlaTrp: 0.683 ± 0.013
1.195AlaTyr: 1.195 ± 0.02
0.0AlaXaa: 0.0 ± 0.0
Cys
1.067CysAla: 1.067 ± 0.02
1.685CysCys: 1.685 ± 0.033
0.443CysAsp: 0.443 ± 0.011
0.567CysGlu: 0.567 ± 0.015
0.567CysPhe: 0.567 ± 0.015
1.067CysGly: 1.067 ± 0.019
0.207CysHis: 0.207 ± 0.007
0.679CysIle: 0.679 ± 0.013
0.449CysLys: 0.449 ± 0.013
1.771CysLeu: 1.771 ± 0.024
0.462CysMet: 0.462 ± 0.01
0.412CysAsn: 0.412 ± 0.01
0.711CysPro: 0.711 ± 0.023
0.343CysGln: 0.343 ± 0.009
1.042CysArg: 1.042 ± 0.018
2.786CysSer: 2.786 ± 0.038
0.796CysThr: 0.796 ± 0.016
0.912CysVal: 0.912 ± 0.017
0.241CysTrp: 0.241 ± 0.009
0.27CysTyr: 0.27 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
4.575AspAla: 4.575 ± 0.053
0.676AspCys: 0.676 ± 0.014
2.001AspAsp: 2.001 ± 0.039
2.72AspGlu: 2.72 ± 0.032
0.902AspPhe: 0.902 ± 0.017
2.407AspGly: 2.407 ± 0.033
0.412AspHis: 0.412 ± 0.011
1.29AspIle: 1.29 ± 0.019
1.359AspLys: 1.359 ± 0.032
2.503AspLeu: 2.503 ± 0.033
0.592AspMet: 0.592 ± 0.012
0.742AspAsn: 0.742 ± 0.016
1.959AspPro: 1.959 ± 0.03
0.905AspGln: 0.905 ± 0.016
1.968AspArg: 1.968 ± 0.041
3.141AspSer: 3.141 ± 0.029
2.026AspThr: 2.026 ± 0.024
1.858AspVal: 1.858 ± 0.027
0.372AspTrp: 0.372 ± 0.01
0.505AspTyr: 0.505 ± 0.013
0.0AspXaa: 0.0 ± 0.0
Glu
7.505GluAla: 7.505 ± 0.079
0.656GluCys: 0.656 ± 0.019
2.729GluAsp: 2.729 ± 0.035
7.515GluGlu: 7.515 ± 0.137
1.018GluPhe: 1.018 ± 0.018
4.457GluGly: 4.457 ± 0.048
0.866GluHis: 0.866 ± 0.014
1.407GluIle: 1.407 ± 0.024
3.15GluLys: 3.15 ± 0.07
4.427GluLeu: 4.427 ± 0.051
0.921GluMet: 0.921 ± 0.016
1.171GluAsn: 1.171 ± 0.022
2.099GluPro: 2.099 ± 0.029
5.526GluGln: 5.526 ± 0.067
3.563GluArg: 3.563 ± 0.051
2.718GluSer: 2.718 ± 0.039
4.086GluThr: 4.086 ± 0.07
2.47GluVal: 2.47 ± 0.03
0.475GluTrp: 0.475 ± 0.01
0.741GluTyr: 0.741 ± 0.014
0.0GluXaa: 0.0 ± 0.0
Phe
2.073PheAla: 2.073 ± 0.025
0.641PheCys: 0.641 ± 0.012
0.87PheAsp: 0.87 ± 0.017
0.96PheGlu: 0.96 ± 0.018
0.922PhePhe: 0.922 ± 0.017
1.301PheGly: 1.301 ± 0.026
0.365PheHis: 0.365 ± 0.009
0.814PheIle: 0.814 ± 0.016
0.652PheLys: 0.652 ± 0.015
2.284PheLeu: 2.284 ± 0.03
0.362PheMet: 0.362 ± 0.01
0.521PheAsn: 0.521 ± 0.011
1.034PhePro: 1.034 ± 0.016
0.634PheGln: 0.634 ± 0.013
1.134PheArg: 1.134 ± 0.016
2.004PheSer: 2.004 ± 0.024
0.921PheThr: 0.921 ± 0.018
1.564PheVal: 1.564 ± 0.023
0.237PheTrp: 0.237 ± 0.007
0.476PheTyr: 0.476 ± 0.011
0.0PheXaa: 0.0 ± 0.0
Gly
7.392GlyAla: 7.392 ± 0.08
1.153GlyCys: 1.153 ± 0.022
3.059GlyAsp: 3.059 ± 0.045
3.625GlyGlu: 3.625 ± 0.038
1.44GlyPhe: 1.44 ± 0.02
7.098GlyGly: 7.098 ± 0.095
0.78GlyHis: 0.78 ± 0.015
1.461GlyIle: 1.461 ± 0.024
1.666GlyLys: 1.666 ± 0.023
4.12GlyLeu: 4.12 ± 0.039
0.759GlyMet: 0.759 ± 0.014
1.141GlyAsn: 1.141 ± 0.022
4.445GlyPro: 4.445 ± 0.093
1.636GlyGln: 1.636 ± 0.024
3.089GlyArg: 3.089 ± 0.032
5.169GlySer: 5.169 ± 0.049
2.494GlyThr: 2.494 ± 0.03
3.332GlyVal: 3.332 ± 0.036
0.573GlyTrp: 0.573 ± 0.011
0.856GlyTyr: 0.856 ± 0.017
0.0GlyXaa: 0.0 ± 0.0
His
1.882HisAla: 1.882 ± 0.023
0.374HisCys: 0.374 ± 0.009
0.554HisAsp: 0.554 ± 0.012
1.109HisGlu: 1.109 ± 0.016
0.492HisPhe: 0.492 ± 0.012
0.948HisGly: 0.948 ± 0.017
1.904HisHis: 1.904 ± 0.07
0.628HisIle: 0.628 ± 0.012
0.788HisLys: 0.788 ± 0.015
2.078HisLeu: 2.078 ± 0.026
0.41HisMet: 0.41 ± 0.01
0.497HisAsn: 0.497 ± 0.011
1.473HisPro: 1.473 ± 0.023
3.179HisGln: 3.179 ± 0.066
1.532HisArg: 1.532 ± 0.023
1.514HisSer: 1.514 ± 0.019
0.943HisThr: 0.943 ± 0.016
0.776HisVal: 0.776 ± 0.013
0.217HisTrp: 0.217 ± 0.008
0.33HisTyr: 0.33 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
2.115IleAla: 2.115 ± 0.027
0.619IleCys: 0.619 ± 0.011
1.236IleAsp: 1.236 ± 0.025
1.617IleGlu: 1.617 ± 0.025
0.653IlePhe: 0.653 ± 0.012
1.223IleGly: 1.223 ± 0.02
0.652IleHis: 0.652 ± 0.016
0.841IleIle: 0.841 ± 0.02
1.023IleLys: 1.023 ± 0.02
1.849IleLeu: 1.849 ± 0.028
0.35IleMet: 0.35 ± 0.011
0.78IleAsn: 0.78 ± 0.016
1.364IlePro: 1.364 ± 0.024
1.169IleGln: 1.169 ± 0.02
1.4IleArg: 1.4 ± 0.018
2.162IleSer: 2.162 ± 0.029
1.116IleThr: 1.116 ± 0.022
1.159IleVal: 1.159 ± 0.021
0.216IleTrp: 0.216 ± 0.007
0.523IleTyr: 0.523 ± 0.012
0.0IleXaa: 0.0 ± 0.0
Lys
2.989LysAla: 2.989 ± 0.047
0.409LysCys: 0.409 ± 0.01
1.394LysAsp: 1.394 ± 0.022
3.605LysGlu: 3.605 ± 0.077
0.543LysPhe: 0.543 ± 0.012
2.224LysGly: 2.224 ± 0.034
0.793LysHis: 0.793 ± 0.012
0.885LysIle: 0.885 ± 0.017
2.748LysLys: 2.748 ± 0.074
2.436LysLeu: 2.436 ± 0.031
0.549LysMet: 0.549 ± 0.014
0.904LysAsn: 0.904 ± 0.015
1.573LysPro: 1.573 ± 0.032
3.918LysGln: 3.918 ± 0.044
2.516LysArg: 2.516 ± 0.031
1.63LysSer: 1.63 ± 0.025
1.863LysThr: 1.863 ± 0.028
1.252LysVal: 1.252 ± 0.021
0.268LysTrp: 0.268 ± 0.009
0.549LysTyr: 0.549 ± 0.012
0.0LysXaa: 0.0 ± 0.0
Leu
5.925LeuAla: 5.925 ± 0.049
1.512LeuCys: 1.512 ± 0.019
2.455LeuAsp: 2.455 ± 0.032
3.913LeuGlu: 3.913 ± 0.044
2.114LeuPhe: 2.114 ± 0.032
3.971LeuGly: 3.971 ± 0.039
2.407LeuHis: 2.407 ± 0.025
1.793LeuIle: 1.793 ± 0.025
2.715LeuLys: 2.715 ± 0.035
17.043LeuLeu: 17.043 ± 0.171
1.356LeuMet: 1.356 ± 0.021
1.497LeuAsn: 1.497 ± 0.022
5.266LeuPro: 5.266 ± 0.042
12.343LeuGln: 12.343 ± 0.122
5.682LeuArg: 5.682 ± 0.052
5.992LeuSer: 5.992 ± 0.045
2.827LeuThr: 2.827 ± 0.034
3.475LeuVal: 3.475 ± 0.04
0.875LeuTrp: 0.875 ± 0.017
1.387LeuTyr: 1.387 ± 0.018
0.0LeuXaa: 0.0 ± 0.0
Met
0.995MetAla: 0.995 ± 0.017
0.182MetCys: 0.182 ± 0.007
0.48MetAsp: 0.48 ± 0.011
0.842MetGlu: 0.842 ± 0.016
0.301MetPhe: 0.301 ± 0.009
0.901MetGly: 0.901 ± 0.018
0.515MetHis: 0.515 ± 0.012
0.322MetIle: 0.322 ± 0.009
0.645MetLys: 0.645 ± 0.014
1.614MetLeu: 1.614 ± 0.023
0.384MetMet: 0.384 ± 0.013
0.345MetAsn: 0.345 ± 0.01
0.729MetPro: 0.729 ± 0.014
1.761MetGln: 1.761 ± 0.028
1.021MetArg: 1.021 ± 0.016
0.771MetSer: 0.771 ± 0.012
0.536MetThr: 0.536 ± 0.012
0.603MetVal: 0.603 ± 0.021
0.149MetTrp: 0.149 ± 0.005
0.275MetTyr: 0.275 ± 0.007
0.0MetXaa: 0.0 ± 0.0
Asn
1.892AsnAla: 1.892 ± 0.025
0.52AsnCys: 0.52 ± 0.013
0.763AsnAsp: 0.763 ± 0.015
1.148AsnGlu: 1.148 ± 0.021
0.487AsnPhe: 0.487 ± 0.013
1.241AsnGly: 1.241 ± 0.021
0.419AsnHis: 0.419 ± 0.01
0.812AsnIle: 0.812 ± 0.017
1.142AsnLys: 1.142 ± 0.017
1.291AsnLeu: 1.291 ± 0.022
0.334AsnMet: 0.334 ± 0.009
1.365AsnAsn: 1.365 ± 0.034
1.248AsnPro: 1.248 ± 0.018
0.782AsnGln: 0.782 ± 0.016
1.222AsnArg: 1.222 ± 0.022
4.219AsnSer: 4.219 ± 0.064
1.41AsnThr: 1.41 ± 0.018
0.848AsnVal: 0.848 ± 0.017
0.188AsnTrp: 0.188 ± 0.007
0.319AsnTyr: 0.319 ± 0.01
0.0AsnXaa: 0.0 ± 0.0
Pro
7.594ProAla: 7.594 ± 0.065
0.763ProCys: 0.763 ± 0.017
1.52ProAsp: 1.52 ± 0.021
2.775ProGlu: 2.775 ± 0.039
1.448ProPhe: 1.448 ± 0.024
2.937ProGly: 2.937 ± 0.045
1.499ProHis: 1.499 ± 0.023
1.144ProIle: 1.144 ± 0.017
1.612ProLys: 1.612 ± 0.031
5.552ProLeu: 5.552 ± 0.049
0.727ProMet: 0.727 ± 0.017
0.894ProAsn: 0.894 ± 0.015
6.897ProPro: 6.897 ± 0.1
4.257ProGln: 4.257 ± 0.055
2.841ProArg: 2.841 ± 0.034
4.893ProSer: 4.893 ± 0.057
2.742ProThr: 2.742 ± 0.035
2.555ProVal: 2.555 ± 0.029
0.583ProTrp: 0.583 ± 0.013
0.805ProTyr: 0.805 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
3.262GlnAla: 3.262 ± 0.038
0.495GlnCys: 0.495 ± 0.011
1.575GlnAsp: 1.575 ± 0.022
5.528GlnGlu: 5.528 ± 0.067
0.707GlnPhe: 0.707 ± 0.014
2.721GlnGly: 2.721 ± 0.035
4.853GlnHis: 4.853 ± 0.078
1.148GlnIle: 1.148 ± 0.019
3.363GlnLys: 3.363 ± 0.046
9.381GlnLeu: 9.381 ± 0.093
1.256GlnMet: 1.256 ± 0.022
1.011GlnAsn: 1.011 ± 0.015
3.609GlnPro: 3.609 ± 0.053
91.176GlnGln: 91.176 ± 1.058
5.284GlnArg: 5.284 ± 0.047
2.053GlnSer: 2.053 ± 0.024
2.387GlnThr: 2.387 ± 0.022
1.86GlnVal: 1.86 ± 0.023
0.531GlnTrp: 0.531 ± 0.012
0.712GlnTyr: 0.712 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
4.27ArgAla: 4.27 ± 0.041
1.262ArgCys: 1.262 ± 0.018
2.102ArgAsp: 2.102 ± 0.037
3.851ArgGlu: 3.851 ± 0.046
1.216ArgPhe: 1.216 ± 0.02
4.049ArgGly: 4.049 ± 0.049
1.394ArgHis: 1.394 ± 0.019
1.533ArgIle: 1.533 ± 0.019
2.255ArgLys: 2.255 ± 0.031
5.325ArgLeu: 5.325 ± 0.051
1.103ArgMet: 1.103 ± 0.016
1.359ArgAsn: 1.359 ± 0.02
2.409ArgPro: 2.409 ± 0.029
4.549ArgGln: 4.549 ± 0.053
5.72ArgArg: 5.72 ± 0.06
4.764ArgSer: 4.764 ± 0.047
2.061ArgThr: 2.061 ± 0.025
2.584ArgVal: 2.584 ± 0.027
0.64ArgTrp: 0.64 ± 0.013
0.874ArgTyr: 0.874 ± 0.017
0.0ArgXaa: 0.0 ± 0.0
Ser
7.48SerAla: 7.48 ± 0.055
1.881SerCys: 1.881 ± 0.028
2.34SerAsp: 2.34 ± 0.032
2.942SerGlu: 2.942 ± 0.038
2.007SerPhe: 2.007 ± 0.025
4.381SerGly: 4.381 ± 0.047
1.032SerHis: 1.032 ± 0.017
2.254SerIle: 2.254 ± 0.031
2.687SerLys: 2.687 ± 0.033
6.048SerLeu: 6.048 ± 0.051
1.014SerMet: 1.014 ± 0.015
4.544SerAsn: 4.544 ± 0.066
4.925SerPro: 4.925 ± 0.053
2.159SerGln: 2.159 ± 0.026
5.168SerArg: 5.168 ± 0.047
37.106SerSer: 37.106 ± 0.455
4.012SerThr: 4.012 ± 0.042
3.365SerVal: 3.365 ± 0.031
0.683SerTrp: 0.683 ± 0.014
0.934SerTyr: 0.934 ± 0.015
0.0SerXaa: 0.0 ± 0.0
Thr
10.44ThrAla: 10.44 ± 0.099
0.623ThrCys: 0.623 ± 0.017
1.848ThrAsp: 1.848 ± 0.026
3.313ThrGlu: 3.313 ± 0.053
0.837ThrPhe: 0.837 ± 0.016
2.662ThrGly: 2.662 ± 0.03
0.85ThrHis: 0.85 ± 0.016
1.138ThrIle: 1.138 ± 0.027
1.646ThrLys: 1.646 ± 0.027
2.94ThrLeu: 2.94 ± 0.031
0.492ThrMet: 0.492 ± 0.013
1.24ThrAsn: 1.24 ± 0.019
3.537ThrPro: 3.537 ± 0.042
2.036ThrGln: 2.036 ± 0.023
2.016ThrArg: 2.016 ± 0.02
3.397ThrSer: 3.397 ± 0.041
3.651ThrThr: 3.651 ± 0.053
2.047ThrVal: 2.047 ± 0.029
0.316ThrTrp: 0.316 ± 0.01
0.633ThrTyr: 0.633 ± 0.014
0.0ThrXaa: 0.0 ± 0.0
Val
5.847ValAla: 5.847 ± 0.057
1.097ValCys: 1.097 ± 0.02
1.877ValAsp: 1.877 ± 0.028
2.608ValGlu: 2.608 ± 0.034
1.335ValPhe: 1.335 ± 0.019
2.663ValGly: 2.663 ± 0.035
0.934ValHis: 0.934 ± 0.015
1.031ValIle: 1.031 ± 0.019
1.318ValLys: 1.318 ± 0.02
4.494ValLeu: 4.494 ± 0.046
0.707ValMet: 0.707 ± 0.017
0.849ValAsn: 0.849 ± 0.016
2.317ValPro: 2.317 ± 0.032
2.231ValGln: 2.231 ± 0.025
2.17ValArg: 2.17 ± 0.027
3.76ValSer: 3.76 ± 0.037
1.643ValThr: 1.643 ± 0.027
3.196ValVal: 3.196 ± 0.053
0.468ValTrp: 0.468 ± 0.011
1.126ValTyr: 1.126 ± 0.019
0.0ValXaa: 0.0 ± 0.0
Trp
0.604TrpAla: 0.604 ± 0.012
0.168TrpCys: 0.168 ± 0.006
0.305TrpAsp: 0.305 ± 0.009
0.448TrpGlu: 0.448 ± 0.01
0.206TrpPhe: 0.206 ± 0.008
0.97TrpGly: 0.97 ± 0.018
0.154TrpHis: 0.154 ± 0.006
0.231TrpIle: 0.231 ± 0.007
0.351TrpLys: 0.351 ± 0.009
0.96TrpLeu: 0.96 ± 0.016
0.185TrpMet: 0.185 ± 0.007
0.181TrpAsn: 0.181 ± 0.006
0.334TrpPro: 0.334 ± 0.008
0.549TrpGln: 0.549 ± 0.015
0.854TrpArg: 0.854 ± 0.017
0.523TrpSer: 0.523 ± 0.011
0.312TrpThr: 0.312 ± 0.009
0.441TrpVal: 0.441 ± 0.012
0.156TrpTrp: 0.156 ± 0.007
0.098TrpTyr: 0.098 ± 0.005
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.075TyrAla: 1.075 ± 0.018
0.321TyrCys: 0.321 ± 0.012
0.528TyrAsp: 0.528 ± 0.012
0.721TyrGlu: 0.721 ± 0.016
0.451TyrPhe: 0.451 ± 0.012
0.829TyrGly: 0.829 ± 0.016
0.295TyrHis: 0.295 ± 0.01
0.625TyrIle: 0.625 ± 0.015
0.599TyrLys: 0.599 ± 0.012
1.27TyrLeu: 1.27 ± 0.018
0.299TyrMet: 0.299 ± 0.009
0.434TyrAsn: 0.434 ± 0.011
0.749TyrPro: 0.749 ± 0.015
0.578TyrGln: 0.578 ± 0.013
0.965TyrArg: 0.965 ± 0.016
1.088TyrSer: 1.088 ± 0.02
0.923TyrThr: 0.923 ± 0.015
0.698TyrVal: 0.698 ± 0.014
0.161TyrTrp: 0.161 ± 0.006
0.318TyrTyr: 0.318 ± 0.012
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10057 proteins (4481553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski