Amino acid dipepetide frequency for Saprolegnia parasitica (strain CBS 223.65)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.659AlaAla: 12.659 ± 0.062	1.922AlaCys: 1.922 ± 0.017	4.943AlaAsp: 4.943 ± 0.028	4.372AlaGlu: 4.372 ± 0.03	4.066AlaPhe: 4.066 ± 0.028	4.904AlaGly: 4.904 ± 0.038	2.809AlaHis: 2.809 ± 0.021	5.095AlaIle: 5.095 ± 0.025	5.139AlaLys: 5.139 ± 0.033	11.693AlaLeu: 11.693 ± 0.051	3.138AlaMet: 3.138 ± 0.02	3.319AlaAsn: 3.319 ± 0.022	6.324AlaPro: 6.324 ± 0.038	3.654AlaGln: 3.654 ± 0.025	5.719AlaArg: 5.719 ± 0.031	9.181AlaSer: 9.181 ± 0.046	8.475AlaThr: 8.475 ± 0.042	6.925AlaVal: 6.925 ± 0.032	1.407AlaTrp: 1.407 ± 0.015	2.798AlaTyr: 2.798 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.828CysAla: 1.828 ± 0.018	0.4CysCys: 0.4 ± 0.009	1.125CysAsp: 1.125 ± 0.015	0.729CysGlu: 0.729 ± 0.009	0.758CysPhe: 0.758 ± 0.009	1.252CysGly: 1.252 ± 0.014	0.55CysHis: 0.55 ± 0.008	0.896CysIle: 0.896 ± 0.01	0.708CysLys: 0.708 ± 0.011	1.847CysLeu: 1.847 ± 0.016	0.464CysMet: 0.464 ± 0.007	0.608CysAsn: 0.608 ± 0.009	1.011CysPro: 1.011 ± 0.02	0.547CysGln: 0.547 ± 0.008	1.031CysArg: 1.031 ± 0.013	1.295CysSer: 1.295 ± 0.014	1.222CysThr: 1.222 ± 0.015	1.548CysVal: 1.548 ± 0.015	0.224CysTrp: 0.224 ± 0.006	0.529CysTyr: 0.529 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.958AspAla: 7.958 ± 0.037	0.884AspCys: 0.884 ± 0.012	5.888AspAsp: 5.888 ± 0.048	4.174AspGlu: 4.174 ± 0.032	1.819AspPhe: 1.819 ± 0.018	3.931AspGly: 3.931 ± 0.025	1.361AspHis: 1.361 ± 0.012	2.37AspIle: 2.37 ± 0.018	2.031AspLys: 2.031 ± 0.018	4.98AspLeu: 4.98 ± 0.027	1.514AspMet: 1.514 ± 0.013	1.473AspAsn: 1.473 ± 0.014	2.484AspPro: 2.484 ± 0.018	1.429AspGln: 1.429 ± 0.014	2.658AspArg: 2.658 ± 0.019	2.64AspSer: 2.64 ± 0.023	2.809AspThr: 2.809 ± 0.021	5.506AspVal: 5.506 ± 0.028	0.676AspTrp: 0.676 ± 0.01	1.263AspTyr: 1.263 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	5.988GluAla: 5.988 ± 0.037	0.829GluCys: 0.829 ± 0.01	2.774GluAsp: 2.774 ± 0.023	2.697GluGlu: 2.697 ± 0.028	1.558GluPhe: 1.558 ± 0.016	2.167GluGly: 2.167 ± 0.018	1.483GluHis: 1.483 ± 0.014	2.164GluIle: 2.164 ± 0.018	2.612GluLys: 2.612 ± 0.025	5.441GluLeu: 5.441 ± 0.034	1.488GluMet: 1.488 ± 0.013	1.491GluAsn: 1.491 ± 0.014	2.269GluPro: 2.269 ± 0.021	1.566GluGln: 1.566 ± 0.016	3.168GluArg: 3.168 ± 0.024	3.154GluSer: 3.154 ± 0.024	3.448GluThr: 3.448 ± 0.022	3.098GluVal: 3.098 ± 0.024	0.741GluTrp: 0.741 ± 0.01	1.455GluTyr: 1.455 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	3.677PheAla: 3.677 ± 0.027	0.778PheCys: 0.778 ± 0.011	2.167PheAsp: 2.167 ± 0.019	2.054PheGlu: 2.054 ± 0.016	1.541PhePhe: 1.541 ± 0.017	2.776PheGly: 2.776 ± 0.026	1.018PheHis: 1.018 ± 0.011	1.23PheIle: 1.23 ± 0.015	1.288PheLys: 1.288 ± 0.012	3.843PheLeu: 3.843 ± 0.025	0.785PheMet: 0.785 ± 0.01	1.208PheAsn: 1.208 ± 0.012	1.54PhePro: 1.54 ± 0.015	1.445PheGln: 1.445 ± 0.014	1.906PheArg: 1.906 ± 0.016	2.377PheSer: 2.377 ± 0.018	1.943PheThr: 1.943 ± 0.017	3.007PheVal: 3.007 ± 0.024	0.485PheTrp: 0.485 ± 0.008	1.106PheTyr: 1.106 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.569GlyAla: 5.569 ± 0.045	1.172GlyCys: 1.172 ± 0.016	3.334GlyAsp: 3.334 ± 0.025	2.145GlyGlu: 2.145 ± 0.02	2.359GlyPhe: 2.359 ± 0.019	3.936GlyGly: 3.936 ± 0.055	1.992GlyHis: 1.992 ± 0.021	2.464GlyIle: 2.464 ± 0.022	2.34GlyLys: 2.34 ± 0.023	5.675GlyLeu: 5.675 ± 0.027	1.298GlyMet: 1.298 ± 0.014	1.969GlyAsn: 1.969 ± 0.02	2.325GlyPro: 2.325 ± 0.02	1.81GlyGln: 1.81 ± 0.017	3.214GlyArg: 3.214 ± 0.025	4.126GlySer: 4.126 ± 0.04	3.216GlyThr: 3.216 ± 0.033	4.327GlyVal: 4.327 ± 0.03	0.797GlyTrp: 0.797 ± 0.009	1.875GlyTyr: 1.875 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	3.481HisAla: 3.481 ± 0.023	0.609HisCys: 0.609 ± 0.009	1.773HisAsp: 1.773 ± 0.015	1.659HisGlu: 1.659 ± 0.016	0.99HisPhe: 0.99 ± 0.012	2.139HisGly: 2.139 ± 0.021	0.95HisHis: 0.95 ± 0.011	1.127HisIle: 1.127 ± 0.012	1.002HisLys: 1.002 ± 0.011	3.083HisLeu: 3.083 ± 0.024	0.729HisMet: 0.729 ± 0.011	0.772HisAsn: 0.772 ± 0.01	1.445HisPro: 1.445 ± 0.014	0.897HisGln: 0.897 ± 0.011	1.885HisArg: 1.885 ± 0.017	1.515HisSer: 1.515 ± 0.014	1.497HisThr: 1.497 ± 0.014	2.727HisVal: 2.727 ± 0.02	0.446HisTrp: 0.446 ± 0.007	0.743HisTyr: 0.743 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.805IleAla: 4.805 ± 0.027	0.736IleCys: 0.736 ± 0.009	2.615IleAsp: 2.615 ± 0.017	2.486IleGlu: 2.486 ± 0.021	1.491IlePhe: 1.491 ± 0.017	2.443IleGly: 2.443 ± 0.019	0.97IleHis: 0.97 ± 0.01	1.33IleIle: 1.33 ± 0.016	1.707IleLys: 1.707 ± 0.016	3.834IleLeu: 3.834 ± 0.024	0.852IleMet: 0.852 ± 0.011	1.272IleAsn: 1.272 ± 0.014	1.879IlePro: 1.879 ± 0.016	1.66IleGln: 1.66 ± 0.016	1.92IleArg: 1.92 ± 0.016	2.48IleSer: 2.48 ± 0.02	2.077IleThr: 2.077 ± 0.019	3.475IleVal: 3.475 ± 0.021	0.442IleTrp: 0.442 ± 0.008	1.138IleTyr: 1.138 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.567LysAla: 4.567 ± 0.031	0.715LysCys: 0.715 ± 0.009	2.26LysAsp: 2.26 ± 0.02	2.271LysGlu: 2.271 ± 0.024	1.151LysPhe: 1.151 ± 0.015	1.948LysGly: 1.948 ± 0.019	1.287LysHis: 1.287 ± 0.013	1.58LysIle: 1.58 ± 0.014	2.935LysLys: 2.935 ± 0.033	4.103LysLeu: 4.103 ± 0.03	1.059LysMet: 1.059 ± 0.014	1.245LysAsn: 1.245 ± 0.015	2.274LysPro: 2.274 ± 0.021	1.734LysGln: 1.734 ± 0.017	3.071LysArg: 3.071 ± 0.021	2.63LysSer: 2.63 ± 0.02	2.827LysThr: 2.827 ± 0.021	2.613LysVal: 2.613 ± 0.018	0.555LysTrp: 0.555 ± 0.008	1.218LysTyr: 1.218 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	10.855LeuAla: 10.855 ± 0.049	2.045LeuCys: 2.045 ± 0.016	6.135LeuAsp: 6.135 ± 0.029	5.957LeuGlu: 5.957 ± 0.037	3.742LeuPhe: 3.742 ± 0.027	5.881LeuGly: 5.881 ± 0.03	3.815LeuHis: 3.815 ± 0.029	2.913LeuIle: 2.913 ± 0.023	3.895LeuLys: 3.895 ± 0.029	12.117LeuLeu: 12.117 ± 0.067	2.039LeuMet: 2.039 ± 0.016	2.809LeuAsn: 2.809 ± 0.021	5.821LeuPro: 5.821 ± 0.03	5.32LeuGln: 5.32 ± 0.032	7.129LeuArg: 7.129 ± 0.04	7.549LeuSer: 7.549 ± 0.035	5.602LeuThr: 5.602 ± 0.03	7.912LeuVal: 7.912 ± 0.038	1.324LeuTrp: 1.324 ± 0.016	2.81LeuTyr: 2.81 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.994MetAla: 2.994 ± 0.02	0.379MetCys: 0.379 ± 0.007	1.68MetAsp: 1.68 ± 0.016	1.371MetGlu: 1.371 ± 0.014	0.679MetPhe: 0.679 ± 0.009	1.348MetGly: 1.348 ± 0.014	0.804MetHis: 0.804 ± 0.01	0.739MetIle: 0.739 ± 0.009	0.948MetLys: 0.948 ± 0.012	2.627MetLeu: 2.627 ± 0.018	0.62MetMet: 0.62 ± 0.009	0.728MetAsn: 0.728 ± 0.01	1.229MetPro: 1.229 ± 0.012	1.14MetGln: 1.14 ± 0.012	1.426MetArg: 1.426 ± 0.014	1.617MetSer: 1.617 ± 0.015	1.741MetThr: 1.741 ± 0.014	1.584MetVal: 1.584 ± 0.015	0.297MetTrp: 0.297 ± 0.006	0.754MetTyr: 0.754 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.502AsnAla: 3.502 ± 0.024	0.573AsnCys: 0.573 ± 0.01	2.047AsnAsp: 2.047 ± 0.019	1.659AsnGlu: 1.659 ± 0.014	0.949AsnPhe: 0.949 ± 0.01	2.31AsnGly: 2.31 ± 0.021	0.756AsnHis: 0.756 ± 0.011	1.262AsnIle: 1.262 ± 0.016	1.175AsnLys: 1.175 ± 0.016	2.657AsnLeu: 2.657 ± 0.022	0.77AsnMet: 0.77 ± 0.01	1.111AsnAsn: 1.111 ± 0.015	1.521AsnPro: 1.521 ± 0.014	1.089AsnGln: 1.089 ± 0.012	1.387AsnArg: 1.387 ± 0.014	1.597AsnSer: 1.597 ± 0.015	1.628AsnThr: 1.628 ± 0.015	2.671AsnVal: 2.671 ± 0.019	0.418AsnTrp: 0.418 ± 0.008	0.825AsnTyr: 0.825 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	5.243ProAla: 5.243 ± 0.036	0.755ProCys: 0.755 ± 0.012	2.482ProAsp: 2.482 ± 0.017	2.532ProGlu: 2.532 ± 0.021	1.787ProPhe: 1.787 ± 0.015	2.373ProGly: 2.373 ± 0.021	1.35ProHis: 1.35 ± 0.014	2.098ProIle: 2.098 ± 0.015	2.213ProLys: 2.213 ± 0.021	5.185ProLeu: 5.185 ± 0.027	1.405ProMet: 1.405 ± 0.014	1.562ProAsn: 1.562 ± 0.015	4.256ProPro: 4.256 ± 0.036	1.532ProGln: 1.532 ± 0.015	3.213ProArg: 3.213 ± 0.023	5.409ProSer: 5.409 ± 0.035	4.744ProThr: 4.744 ± 0.031	3.554ProVal: 3.554 ± 0.027	0.693ProTrp: 0.693 ± 0.009	1.23ProTyr: 1.23 ± 0.011	0.0ProXaa: 0.0 ± 0.0
Gln	3.84GlnAla: 3.84 ± 0.026	0.778GlnCys: 0.778 ± 0.011	1.673GlnAsp: 1.673 ± 0.014	1.677GlnGlu: 1.677 ± 0.015	1.233GlnPhe: 1.233 ± 0.012	1.704GlnGly: 1.704 ± 0.015	1.294GlnHis: 1.294 ± 0.013	1.361GlnIle: 1.361 ± 0.015	1.556GlnLys: 1.556 ± 0.015	4.541GlnLeu: 4.541 ± 0.029	0.87GlnMet: 0.87 ± 0.01	0.959GlnAsn: 0.959 ± 0.013	1.752GlnPro: 1.752 ± 0.016	1.826GlnGln: 1.826 ± 0.026	2.919GlnArg: 2.919 ± 0.02	2.494GlnSer: 2.494 ± 0.018	2.1GlnThr: 2.1 ± 0.02	2.469GlnVal: 2.469 ± 0.019	0.678GlnTrp: 0.678 ± 0.009	1.114GlnTyr: 1.114 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	5.627ArgAla: 5.627 ± 0.03	1.168ArgCys: 1.168 ± 0.014	3.278ArgAsp: 3.278 ± 0.024	2.732ArgGlu: 2.732 ± 0.023	2.248ArgPhe: 2.248 ± 0.018	3.095ArgGly: 3.095 ± 0.021	2.025ArgHis: 2.025 ± 0.017	2.443ArgIle: 2.443 ± 0.017	2.675ArgLys: 2.675 ± 0.024	6.418ArgLeu: 6.418 ± 0.036	1.359ArgMet: 1.359 ± 0.013	1.73ArgAsn: 1.73 ± 0.015	2.952ArgPro: 2.952 ± 0.024	2.474ArgGln: 2.474 ± 0.017	4.921ArgArg: 4.921 ± 0.038	4.137ArgSer: 4.137 ± 0.025	3.115ArgThr: 3.115 ± 0.022	4.16ArgVal: 4.16 ± 0.024	0.853ArgTrp: 0.853 ± 0.01	1.56ArgTyr: 1.56 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	6.991SerAla: 6.991 ± 0.035	1.235SerCys: 1.235 ± 0.014	3.767SerAsp: 3.767 ± 0.021	2.841SerGlu: 2.841 ± 0.017	2.934SerPhe: 2.934 ± 0.02	4.031SerGly: 4.031 ± 0.049	1.785SerHis: 1.785 ± 0.015	3.411SerIle: 3.411 ± 0.021	2.685SerLys: 2.685 ± 0.022	7.6SerLeu: 7.6 ± 0.033	2.048SerMet: 2.048 ± 0.018	2.171SerAsn: 2.171 ± 0.019	4.355SerPro: 4.355 ± 0.029	2.095SerGln: 2.095 ± 0.016	3.668SerArg: 3.668 ± 0.023	7.196SerSer: 7.196 ± 0.047	5.358SerThr: 5.358 ± 0.035	5.34SerVal: 5.34 ± 0.03	0.954SerTrp: 0.954 ± 0.011	1.921SerTyr: 1.921 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	6.107ThrAla: 6.107 ± 0.03	1.219ThrCys: 1.219 ± 0.015	3.005ThrAsp: 3.005 ± 0.022	2.705ThrGlu: 2.705 ± 0.02	2.36ThrPhe: 2.36 ± 0.019	3.115ThrGly: 3.115 ± 0.034	1.656ThrHis: 1.656 ± 0.014	2.904ThrIle: 2.904 ± 0.021	3.013ThrLys: 3.013 ± 0.02	6.936ThrLeu: 6.936 ± 0.033	1.643ThrMet: 1.643 ± 0.015	2.027ThrAsn: 2.027 ± 0.017	4.396ThrPro: 4.396 ± 0.031	2.113ThrGln: 2.113 ± 0.017	3.204ThrArg: 3.204 ± 0.018	5.571ThrSer: 5.571 ± 0.032	5.689ThrThr: 5.689 ± 0.045	3.974ThrVal: 3.974 ± 0.03	0.884ThrTrp: 0.884 ± 0.011	1.802ThrTyr: 1.802 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	8.886ValAla: 8.886 ± 0.039	1.472ValCys: 1.472 ± 0.015	4.532ValAsp: 4.532 ± 0.023	3.576ValGlu: 3.576 ± 0.025	2.819ValPhe: 2.819 ± 0.021	4.066ValGly: 4.066 ± 0.029	2.37ValHis: 2.37 ± 0.018	2.468ValIle: 2.468 ± 0.017	2.448ValLys: 2.448 ± 0.02	8.653ValLeu: 8.653 ± 0.039	1.496ValMet: 1.496 ± 0.012	1.978ValAsn: 1.978 ± 0.018	3.99ValPro: 3.99 ± 0.029	3.068ValGln: 3.068 ± 0.022	4.058ValArg: 4.058 ± 0.022	4.744ValSer: 4.744 ± 0.03	4.188ValThr: 4.188 ± 0.031	6.703ValVal: 6.703 ± 0.038	0.982ValTrp: 0.982 ± 0.011	2.186ValTyr: 2.186 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.115TrpAla: 1.115 ± 0.012	0.27TrpCys: 0.27 ± 0.007	0.695TrpAsp: 0.695 ± 0.01	0.497TrpGlu: 0.497 ± 0.008	0.529TrpPhe: 0.529 ± 0.008	0.638TrpGly: 0.638 ± 0.01	0.447TrpHis: 0.447 ± 0.008	0.586TrpIle: 0.586 ± 0.008	0.598TrpLys: 0.598 ± 0.009	1.514TrpLeu: 1.514 ± 0.014	0.347TrpMet: 0.347 ± 0.007	0.478TrpAsn: 0.478 ± 0.008	0.649TrpPro: 0.649 ± 0.011	0.55TrpGln: 0.55 ± 0.009	0.995TrpArg: 0.995 ± 0.014	1.052TrpSer: 1.052 ± 0.014	1.024TrpThr: 1.024 ± 0.011	0.846TrpVal: 0.846 ± 0.011	0.185TrpTrp: 0.185 ± 0.005	0.402TrpTyr: 0.402 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.85TyrAla: 2.85 ± 0.022	0.631TyrCys: 0.631 ± 0.01	1.677TyrAsp: 1.677 ± 0.016	1.459TyrGlu: 1.459 ± 0.016	1.158TyrPhe: 1.158 ± 0.012	1.887TyrGly: 1.887 ± 0.02	0.743TyrHis: 0.743 ± 0.009	1.168TyrIle: 1.168 ± 0.012	1.078TyrLys: 1.078 ± 0.012	2.922TyrLeu: 2.922 ± 0.02	0.778TyrMet: 0.778 ± 0.011	0.996TyrAsn: 0.996 ± 0.013	1.144TyrPro: 1.144 ± 0.013	0.891TyrGln: 0.891 ± 0.011	1.478TyrArg: 1.478 ± 0.014	1.623TyrSer: 1.623 ± 0.015	1.623TyrThr: 1.623 ± 0.016	2.245TyrVal: 2.245 ± 0.018	0.375TyrTrp: 0.375 ± 0.007	0.965TyrTyr: 0.965 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 20052 proteins (8654731 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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