Amino acid dipepetide frequency for Oceanibaculum indicum P24

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.602AlaAla: 17.602 ± 0.198	1.148AlaCys: 1.148 ± 0.039	7.253AlaAsp: 7.253 ± 0.088	8.468AlaGlu: 8.468 ± 0.103	4.09AlaPhe: 4.09 ± 0.064	11.59AlaGly: 11.59 ± 0.12	2.13AlaHis: 2.13 ± 0.05	6.239AlaIle: 6.239 ± 0.078	4.003AlaLys: 4.003 ± 0.069	14.61AlaLeu: 14.61 ± 0.158	3.646AlaMet: 3.646 ± 0.057	2.767AlaAsn: 2.767 ± 0.056	5.493AlaPro: 5.493 ± 0.094	3.932AlaGln: 3.932 ± 0.067	8.547AlaArg: 8.547 ± 0.1	5.912AlaSer: 5.912 ± 0.077	5.804AlaThr: 5.804 ± 0.082	8.848AlaVal: 8.848 ± 0.103	1.391AlaTrp: 1.391 ± 0.033	2.84AlaTyr: 2.84 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.932CysAla: 0.932 ± 0.027	0.112CysCys: 0.112 ± 0.009	0.509CysAsp: 0.509 ± 0.019	0.396CysGlu: 0.396 ± 0.02	0.359CysPhe: 0.359 ± 0.017	0.95CysGly: 0.95 ± 0.029	0.241CysHis: 0.241 ± 0.015	0.377CysIle: 0.377 ± 0.017	0.181CysLys: 0.181 ± 0.013	0.893CysLeu: 0.893 ± 0.031	0.149CysMet: 0.149 ± 0.01	0.193CysAsn: 0.193 ± 0.012	0.479CysPro: 0.479 ± 0.021	0.251CysGln: 0.251 ± 0.014	0.669CysArg: 0.669 ± 0.025	0.385CysSer: 0.385 ± 0.019	0.428CysThr: 0.428 ± 0.02	0.55CysVal: 0.55 ± 0.022	0.114CysTrp: 0.114 ± 0.01	0.206CysTyr: 0.206 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.481AspAla: 6.481 ± 0.095	0.469AspCys: 0.469 ± 0.022	2.625AspAsp: 2.625 ± 0.056	3.188AspGlu: 3.188 ± 0.055	2.243AspPhe: 2.243 ± 0.047	5.482AspGly: 5.482 ± 0.082	1.182AspHis: 1.182 ± 0.037	3.361AspIle: 3.361 ± 0.056	1.733AspLys: 1.733 ± 0.048	5.885AspLeu: 5.885 ± 0.084	1.464AspMet: 1.464 ± 0.035	1.125AspAsn: 1.125 ± 0.031	3.556AspPro: 3.556 ± 0.059	1.563AspGln: 1.563 ± 0.035	4.61AspArg: 4.61 ± 0.071	2.62AspSer: 2.62 ± 0.046	2.633AspThr: 2.633 ± 0.05	3.698AspVal: 3.698 ± 0.056	1.068AspTrp: 1.068 ± 0.028	1.514AspTyr: 1.514 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.453GluAla: 8.453 ± 0.104	0.328GluCys: 0.328 ± 0.016	2.913GluAsp: 2.913 ± 0.055	3.802GluGlu: 3.802 ± 0.073	1.579GluPhe: 1.579 ± 0.038	4.772GluGly: 4.772 ± 0.062	1.039GluHis: 1.039 ± 0.03	3.461GluIle: 3.461 ± 0.059	2.558GluLys: 2.558 ± 0.053	5.22GluLeu: 5.22 ± 0.064	1.872GluMet: 1.872 ± 0.037	1.49GluAsn: 1.49 ± 0.04	2.627GluPro: 2.627 ± 0.048	2.325GluGln: 2.325 ± 0.052	4.812GluArg: 4.812 ± 0.079	2.587GluSer: 2.587 ± 0.051	3.539GluThr: 3.539 ± 0.06	4.019GluVal: 4.019 ± 0.068	0.616GluTrp: 0.616 ± 0.026	0.97GluTyr: 0.97 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.377PheAla: 4.377 ± 0.073	0.398PheCys: 0.398 ± 0.019	2.398PheAsp: 2.398 ± 0.052	2.0PheGlu: 2.0 ± 0.038	1.382PhePhe: 1.382 ± 0.043	3.47PheGly: 3.47 ± 0.054	0.69PheHis: 0.69 ± 0.021	1.591PheIle: 1.591 ± 0.035	0.926PheLys: 0.926 ± 0.032	3.624PheLeu: 3.624 ± 0.066	0.805PheMet: 0.805 ± 0.026	0.89PheAsn: 0.89 ± 0.031	1.596PhePro: 1.596 ± 0.034	1.079PheGln: 1.079 ± 0.03	2.351PheArg: 2.351 ± 0.045	1.958PheSer: 1.958 ± 0.043	1.877PheThr: 1.877 ± 0.038	2.554PheVal: 2.554 ± 0.052	0.566PheTrp: 0.566 ± 0.021	0.928PheTyr: 0.928 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.14GlyAla: 9.14 ± 0.114	0.895GlyCys: 0.895 ± 0.029	4.717GlyAsp: 4.717 ± 0.07	4.934GlyGlu: 4.934 ± 0.065	3.697GlyPhe: 3.697 ± 0.06	7.906GlyGly: 7.906 ± 0.112	1.916GlyHis: 1.916 ± 0.045	4.845GlyIle: 4.845 ± 0.075	3.529GlyLys: 3.529 ± 0.06	9.463GlyLeu: 9.463 ± 0.104	2.702GlyMet: 2.702 ± 0.053	2.262GlyAsn: 2.262 ± 0.049	3.603GlyPro: 3.603 ± 0.054	3.106GlyGln: 3.106 ± 0.061	6.287GlyArg: 6.287 ± 0.077	4.474GlySer: 4.474 ± 0.064	4.912GlyThr: 4.912 ± 0.078	6.128GlyVal: 6.128 ± 0.073	1.515GlyTrp: 1.515 ± 0.036	2.481GlyTyr: 2.481 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.225HisAla: 2.225 ± 0.046	0.232HisCys: 0.232 ± 0.014	1.178HisAsp: 1.178 ± 0.035	0.997HisGlu: 0.997 ± 0.034	0.793HisPhe: 0.793 ± 0.029	1.889HisGly: 1.889 ± 0.047	0.534HisHis: 0.534 ± 0.024	0.955HisIle: 0.955 ± 0.027	0.525HisLys: 0.525 ± 0.025	2.106HisLeu: 2.106 ± 0.043	0.486HisMet: 0.486 ± 0.02	0.462HisAsn: 0.462 ± 0.017	1.453HisPro: 1.453 ± 0.037	0.579HisGln: 0.579 ± 0.023	1.396HisArg: 1.396 ± 0.034	0.847HisSer: 0.847 ± 0.027	0.78HisThr: 0.78 ± 0.029	1.376HisVal: 1.376 ± 0.033	0.335HisTrp: 0.335 ± 0.016	0.529HisTyr: 0.529 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.203IleAla: 7.203 ± 0.087	0.488IleCys: 0.488 ± 0.021	3.718IleAsp: 3.718 ± 0.06	3.46IleGlu: 3.46 ± 0.055	1.675IlePhe: 1.675 ± 0.043	5.168IleGly: 5.168 ± 0.08	0.877IleHis: 0.877 ± 0.03	2.012IleIle: 2.012 ± 0.048	1.153IleLys: 1.153 ± 0.037	4.787IleLeu: 4.787 ± 0.077	0.938IleMet: 0.938 ± 0.03	1.185IleAsn: 1.185 ± 0.031	2.381IlePro: 2.381 ± 0.046	1.219IleGln: 1.219 ± 0.037	3.286IleArg: 3.286 ± 0.05	2.551IleSer: 2.551 ± 0.046	2.532IleThr: 2.532 ± 0.051	4.204IleVal: 4.204 ± 0.068	0.58IleTrp: 0.58 ± 0.027	1.095IleTyr: 1.095 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.4LysAla: 4.4 ± 0.069	0.164LysCys: 0.164 ± 0.012	1.682LysAsp: 1.682 ± 0.043	1.747LysGlu: 1.747 ± 0.048	0.81LysPhe: 0.81 ± 0.029	2.825LysGly: 2.825 ± 0.053	0.575LysHis: 0.575 ± 0.023	1.591LysIle: 1.591 ± 0.046	1.305LysLys: 1.305 ± 0.043	3.564LysLeu: 3.564 ± 0.069	0.758LysMet: 0.758 ± 0.025	0.776LysAsn: 0.776 ± 0.025	2.215LysPro: 2.215 ± 0.062	1.172LysGln: 1.172 ± 0.031	2.403LysArg: 2.403 ± 0.05	1.574LysSer: 1.574 ± 0.04	1.681LysThr: 1.681 ± 0.044	2.388LysVal: 2.388 ± 0.06	0.284LysTrp: 0.284 ± 0.015	0.585LysTyr: 0.585 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.836LeuAla: 14.836 ± 0.163	0.876LeuCys: 0.876 ± 0.028	6.28LeuAsp: 6.28 ± 0.077	5.842LeuGlu: 5.842 ± 0.077	3.837LeuPhe: 3.837 ± 0.071	8.676LeuGly: 8.676 ± 0.1	1.982LeuHis: 1.982 ± 0.042	5.078LeuIle: 5.078 ± 0.068	3.6LeuLys: 3.6 ± 0.059	11.082LeuLeu: 11.082 ± 0.15	2.528LeuMet: 2.528 ± 0.045	2.516LeuAsn: 2.516 ± 0.048	6.344LeuPro: 6.344 ± 0.082	2.933LeuGln: 2.933 ± 0.051	7.283LeuArg: 7.283 ± 0.081	6.272LeuSer: 6.272 ± 0.086	5.985LeuThr: 5.985 ± 0.072	7.552LeuVal: 7.552 ± 0.1	1.25LeuTrp: 1.25 ± 0.038	2.402LeuTyr: 2.402 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.577MetAla: 3.577 ± 0.061	0.136MetCys: 0.136 ± 0.01	1.178MetAsp: 1.178 ± 0.033	1.303MetGlu: 1.303 ± 0.031	0.709MetPhe: 0.709 ± 0.027	1.987MetGly: 1.987 ± 0.043	0.434MetHis: 0.434 ± 0.02	1.307MetIle: 1.307 ± 0.04	1.039MetLys: 1.039 ± 0.03	2.863MetLeu: 2.863 ± 0.052	0.681MetMet: 0.681 ± 0.024	0.731MetAsn: 0.731 ± 0.028	1.598MetPro: 1.598 ± 0.04	0.862MetGln: 0.862 ± 0.028	1.783MetArg: 1.783 ± 0.039	1.612MetSer: 1.612 ± 0.034	1.845MetThr: 1.845 ± 0.037	1.904MetVal: 1.904 ± 0.04	0.201MetTrp: 0.201 ± 0.014	0.366MetTyr: 0.366 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.908AsnAla: 2.908 ± 0.051	0.221AsnCys: 0.221 ± 0.013	1.307AsnAsp: 1.307 ± 0.038	1.136AsnGlu: 1.136 ± 0.034	0.856AsnPhe: 0.856 ± 0.03	2.241AsnGly: 2.241 ± 0.047	0.493AsnHis: 0.493 ± 0.02	1.292AsnIle: 1.292 ± 0.031	0.65AsnLys: 0.65 ± 0.026	2.629AsnLeu: 2.629 ± 0.057	0.652AsnMet: 0.652 ± 0.024	0.662AsnAsn: 0.662 ± 0.025	1.805AsnPro: 1.805 ± 0.037	0.706AsnGln: 0.706 ± 0.026	1.846AsnArg: 1.846 ± 0.043	1.077AsnSer: 1.077 ± 0.028	1.135AsnThr: 1.135 ± 0.034	1.612AsnVal: 1.612 ± 0.041	0.352AsnTrp: 0.352 ± 0.02	0.59AsnTyr: 0.59 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.127ProAla: 7.127 ± 0.098	0.31ProCys: 0.31 ± 0.015	3.794ProAsp: 3.794 ± 0.059	3.94ProGlu: 3.94 ± 0.056	1.942ProPhe: 1.942 ± 0.042	4.826ProGly: 4.826 ± 0.07	1.06ProHis: 1.06 ± 0.029	2.203ProIle: 2.203 ± 0.042	1.673ProLys: 1.673 ± 0.039	5.114ProLeu: 5.114 ± 0.069	1.32ProMet: 1.32 ± 0.034	1.246ProAsn: 1.246 ± 0.034	2.679ProPro: 2.679 ± 0.059	1.573ProGln: 1.573 ± 0.037	2.905ProArg: 2.905 ± 0.053	2.603ProSer: 2.603 ± 0.049	2.392ProThr: 2.392 ± 0.043	4.588ProVal: 4.588 ± 0.059	0.67ProTrp: 0.67 ± 0.024	1.312ProTyr: 1.312 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.564GlnAla: 4.564 ± 0.06	0.182GlnCys: 0.182 ± 0.013	1.521GlnAsp: 1.521 ± 0.04	1.719GlnGlu: 1.719 ± 0.041	0.971GlnPhe: 0.971 ± 0.028	2.517GlnGly: 2.517 ± 0.052	0.721GlnHis: 0.721 ± 0.025	1.693GlnIle: 1.693 ± 0.04	1.039GlnLys: 1.039 ± 0.032	2.871GlnLeu: 2.871 ± 0.054	0.938GlnMet: 0.938 ± 0.03	0.825GlnAsn: 0.825 ± 0.027	2.054GlnPro: 2.054 ± 0.044	1.398GlnGln: 1.398 ± 0.04	2.659GlnArg: 2.659 ± 0.064	1.526GlnSer: 1.526 ± 0.037	1.586GlnThr: 1.586 ± 0.041	2.311GlnVal: 2.311 ± 0.046	0.317GlnTrp: 0.317 ± 0.015	0.557GlnTyr: 0.557 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.634ArgAla: 7.634 ± 0.095	0.588ArgCys: 0.588 ± 0.026	4.182ArgAsp: 4.182 ± 0.066	4.137ArgGlu: 4.137 ± 0.064	2.856ArgPhe: 2.856 ± 0.044	4.855ArgGly: 4.855 ± 0.065	1.797ArgHis: 1.797 ± 0.044	3.989ArgIle: 3.989 ± 0.059	2.392ArgLys: 2.392 ± 0.054	8.849ArgLeu: 8.849 ± 0.122	1.9ArgMet: 1.9 ± 0.046	1.734ArgAsn: 1.734 ± 0.042	3.793ArgPro: 3.793 ± 0.062	2.984ArgGln: 2.984 ± 0.05	5.894ArgArg: 5.894 ± 0.084	3.056ArgSer: 3.056 ± 0.055	3.282ArgThr: 3.282 ± 0.052	4.441ArgVal: 4.441 ± 0.065	1.005ArgTrp: 1.005 ± 0.032	1.832ArgTyr: 1.832 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.839SerAla: 5.839 ± 0.08	0.428SerCys: 0.428 ± 0.019	2.582SerAsp: 2.582 ± 0.047	2.451SerGlu: 2.451 ± 0.053	2.226SerPhe: 2.226 ± 0.042	5.308SerGly: 5.308 ± 0.075	0.996SerHis: 0.996 ± 0.029	2.533SerIle: 2.533 ± 0.049	1.292SerLys: 1.292 ± 0.041	5.475SerLeu: 5.475 ± 0.084	1.309SerMet: 1.309 ± 0.034	1.185SerAsn: 1.185 ± 0.031	2.501SerPro: 2.501 ± 0.04	1.468SerGln: 1.468 ± 0.039	3.338SerArg: 3.338 ± 0.053	2.356SerSer: 2.356 ± 0.051	2.361SerThr: 2.361 ± 0.046	3.876SerVal: 3.876 ± 0.059	0.678SerTrp: 0.678 ± 0.025	1.36SerTyr: 1.36 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.37ThrAla: 6.37 ± 0.081	0.403ThrCys: 0.403 ± 0.022	2.904ThrAsp: 2.904 ± 0.056	2.833ThrGlu: 2.833 ± 0.051	1.524ThrPhe: 1.524 ± 0.036	5.473ThrGly: 5.473 ± 0.076	0.94ThrHis: 0.94 ± 0.029	2.702ThrIle: 2.702 ± 0.06	1.323ThrLys: 1.323 ± 0.038	6.06ThrLeu: 6.06 ± 0.074	1.169ThrMet: 1.169 ± 0.032	1.152ThrAsn: 1.152 ± 0.03	3.267ThrPro: 3.267 ± 0.048	1.477ThrGln: 1.477 ± 0.035	3.111ThrArg: 3.111 ± 0.055	2.379ThrSer: 2.379 ± 0.052	2.451ThrThr: 2.451 ± 0.056	4.488ThrVal: 4.488 ± 0.072	0.497ThrTrp: 0.497 ± 0.021	1.181ThrTyr: 1.181 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.887ValAla: 8.887 ± 0.107	0.625ValCys: 0.625 ± 0.024	3.643ValAsp: 3.643 ± 0.063	4.715ValGlu: 4.715 ± 0.066	2.516ValPhe: 2.516 ± 0.053	5.435ValGly: 5.435 ± 0.069	1.242ValHis: 1.242 ± 0.032	3.719ValIle: 3.719 ± 0.064	2.413ValLys: 2.413 ± 0.048	7.86ValLeu: 7.86 ± 0.084	1.965ValMet: 1.965 ± 0.039	2.024ValAsn: 2.024 ± 0.04	3.986ValPro: 3.986 ± 0.055	2.08ValGln: 2.08 ± 0.041	4.807ValArg: 4.807 ± 0.072	3.995ValSer: 3.995 ± 0.06	4.677ValThr: 4.677 ± 0.065	5.192ValVal: 5.192 ± 0.065	0.875ValTrp: 0.875 ± 0.028	1.43ValTyr: 1.43 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.147TrpAla: 1.147 ± 0.031	0.13TrpCys: 0.13 ± 0.012	0.625TrpAsp: 0.625 ± 0.022	0.598TrpGlu: 0.598 ± 0.023	0.496TrpPhe: 0.496 ± 0.022	0.947TrpGly: 0.947 ± 0.031	0.343TrpHis: 0.343 ± 0.018	0.602TrpIle: 0.602 ± 0.024	0.44TrpLys: 0.44 ± 0.018	1.708TrpLeu: 1.708 ± 0.036	0.363TrpMet: 0.363 ± 0.019	0.362TrpAsn: 0.362 ± 0.019	0.701TrpPro: 0.701 ± 0.025	0.59TrpGln: 0.59 ± 0.026	1.223TrpArg: 1.223 ± 0.033	0.641TrpSer: 0.641 ± 0.022	0.659TrpThr: 0.659 ± 0.029	0.812TrpVal: 0.812 ± 0.027	0.19TrpTrp: 0.19 ± 0.013	0.303TrpTyr: 0.303 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.609TyrAla: 2.609 ± 0.047	0.242TyrCys: 0.242 ± 0.015	1.491TyrAsp: 1.491 ± 0.036	1.315TyrGlu: 1.315 ± 0.036	0.903TyrPhe: 0.903 ± 0.03	2.195TyrGly: 2.195 ± 0.049	0.483TyrHis: 0.483 ± 0.019	0.96TyrIle: 0.96 ± 0.03	0.724TyrLys: 0.724 ± 0.028	2.491TyrLeu: 2.491 ± 0.052	0.471TyrMet: 0.471 ± 0.02	0.585TyrAsn: 0.585 ± 0.024	1.148TyrPro: 1.148 ± 0.031	0.672TyrGln: 0.672 ± 0.025	1.99TyrArg: 1.99 ± 0.042	1.136TyrSer: 1.136 ± 0.03	1.144TyrThr: 1.144 ± 0.034	1.544TyrVal: 1.544 ± 0.035	0.377TyrTrp: 0.377 ± 0.017	0.583TyrTyr: 0.583 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3754 proteins (1192065 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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