Amino acid dipepetide frequency for Acetobacter oeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.854AlaAla: 14.854 ± 0.166	1.367AlaCys: 1.367 ± 0.034	6.258AlaAsp: 6.258 ± 0.077	6.425AlaGlu: 6.425 ± 0.091	3.902AlaPhe: 3.902 ± 0.066	11.007AlaGly: 11.007 ± 0.105	2.347AlaHis: 2.347 ± 0.049	5.696AlaIle: 5.696 ± 0.075	2.993AlaLys: 2.993 ± 0.067	12.53AlaLeu: 12.53 ± 0.139	3.101AlaMet: 3.101 ± 0.055	2.385AlaAsn: 2.385 ± 0.045	5.616AlaPro: 5.616 ± 0.086	3.495AlaGln: 3.495 ± 0.065	8.61AlaArg: 8.61 ± 0.096	6.934AlaSer: 6.934 ± 0.088	6.481AlaThr: 6.481 ± 0.107	8.1AlaVal: 8.1 ± 0.092	1.611AlaTrp: 1.611 ± 0.038	2.224AlaTyr: 2.224 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.197CysAla: 1.197 ± 0.033	0.159CysCys: 0.159 ± 0.011	0.605CysAsp: 0.605 ± 0.025	0.498CysGlu: 0.498 ± 0.018	0.403CysPhe: 0.403 ± 0.017	1.069CysGly: 1.069 ± 0.035	0.316CysHis: 0.316 ± 0.019	0.496CysIle: 0.496 ± 0.021	0.164CysLys: 0.164 ± 0.012	1.055CysLeu: 1.055 ± 0.031	0.18CysMet: 0.18 ± 0.011	0.245CysAsn: 0.245 ± 0.015	0.575CysPro: 0.575 ± 0.024	0.27CysGln: 0.27 ± 0.016	0.721CysArg: 0.721 ± 0.026	0.567CysSer: 0.567 ± 0.023	0.503CysThr: 0.503 ± 0.021	0.755CysVal: 0.755 ± 0.025	0.137CysTrp: 0.137 ± 0.011	0.224CysTyr: 0.224 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.278AspAla: 6.278 ± 0.066	0.536AspCys: 0.536 ± 0.024	3.075AspAsp: 3.075 ± 0.055	3.175AspGlu: 3.175 ± 0.063	1.991AspPhe: 1.991 ± 0.042	5.004AspGly: 5.004 ± 0.068	1.31AspHis: 1.31 ± 0.036	3.107AspIle: 3.107 ± 0.06	1.343AspLys: 1.343 ± 0.041	5.681AspLeu: 5.681 ± 0.073	1.421AspMet: 1.421 ± 0.039	1.372AspAsn: 1.372 ± 0.043	3.468AspPro: 3.468 ± 0.068	1.731AspGln: 1.731 ± 0.039	4.269AspArg: 4.269 ± 0.061	2.649AspSer: 2.649 ± 0.053	3.063AspThr: 3.063 ± 0.056	4.213AspVal: 4.213 ± 0.062	0.929AspTrp: 0.929 ± 0.028	1.443AspTyr: 1.443 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.744GluAla: 6.744 ± 0.092	0.398GluCys: 0.398 ± 0.022	2.685GluAsp: 2.685 ± 0.052	2.757GluGlu: 2.757 ± 0.069	1.559GluPhe: 1.559 ± 0.036	3.751GluGly: 3.751 ± 0.062	1.236GluHis: 1.236 ± 0.032	3.109GluIle: 3.109 ± 0.054	2.244GluLys: 2.244 ± 0.054	4.604GluLeu: 4.604 ± 0.068	1.395GluMet: 1.395 ± 0.034	1.773GluAsn: 1.773 ± 0.043	2.515GluPro: 2.515 ± 0.051	2.055GluGln: 2.055 ± 0.048	4.299GluArg: 4.299 ± 0.075	2.597GluSer: 2.597 ± 0.06	3.809GluThr: 3.809 ± 0.056	3.194GluVal: 3.194 ± 0.062	0.722GluTrp: 0.722 ± 0.028	0.954GluTyr: 0.954 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.912PheAla: 3.912 ± 0.056	0.502PheCys: 0.502 ± 0.022	2.299PheAsp: 2.299 ± 0.053	1.76PheGlu: 1.76 ± 0.039	1.386PhePhe: 1.386 ± 0.041	3.49PheGly: 3.49 ± 0.062	0.888PheHis: 0.888 ± 0.026	1.72PheIle: 1.72 ± 0.041	0.638PheLys: 0.638 ± 0.024	3.519PheLeu: 3.519 ± 0.061	0.86PheMet: 0.86 ± 0.03	0.995PheAsn: 0.995 ± 0.032	1.775PhePro: 1.775 ± 0.043	0.914PheGln: 0.914 ± 0.03	2.659PheArg: 2.659 ± 0.043	2.743PheSer: 2.743 ± 0.047	2.132PheThr: 2.132 ± 0.045	2.591PheVal: 2.591 ± 0.057	0.52PheTrp: 0.52 ± 0.019	0.902PheTyr: 0.902 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.706GlyAla: 8.706 ± 0.105	0.965GlyCys: 0.965 ± 0.035	4.075GlyAsp: 4.075 ± 0.067	4.232GlyGlu: 4.232 ± 0.07	3.549GlyPhe: 3.549 ± 0.06	7.276GlyGly: 7.276 ± 0.145	2.193GlyHis: 2.193 ± 0.045	4.621GlyIle: 4.621 ± 0.07	2.999GlyLys: 2.999 ± 0.053	8.942GlyLeu: 8.942 ± 0.097	2.456GlyMet: 2.456 ± 0.051	2.358GlyAsn: 2.358 ± 0.055	3.585GlyPro: 3.585 ± 0.056	2.999GlyGln: 2.999 ± 0.054	6.114GlyArg: 6.114 ± 0.085	5.216GlySer: 5.216 ± 0.08	5.4GlyThr: 5.4 ± 0.121	6.053GlyVal: 6.053 ± 0.084	1.498GlyTrp: 1.498 ± 0.039	2.29GlyTyr: 2.29 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.454HisAla: 2.454 ± 0.049	0.25HisCys: 0.25 ± 0.015	1.382HisAsp: 1.382 ± 0.033	1.147HisGlu: 1.147 ± 0.033	0.931HisPhe: 0.931 ± 0.028	2.064HisGly: 2.064 ± 0.052	0.701HisHis: 0.701 ± 0.027	1.143HisIle: 1.143 ± 0.031	0.528HisLys: 0.528 ± 0.025	2.243HisLeu: 2.243 ± 0.048	0.551HisMet: 0.551 ± 0.022	0.672HisAsn: 0.672 ± 0.026	1.552HisPro: 1.552 ± 0.039	0.62HisGln: 0.62 ± 0.023	1.581HisArg: 1.581 ± 0.04	1.133HisSer: 1.133 ± 0.033	1.13HisThr: 1.13 ± 0.04	1.747HisVal: 1.747 ± 0.04	0.403HisTrp: 0.403 ± 0.019	0.654HisTyr: 0.654 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.791IleAla: 6.791 ± 0.081	0.553IleCys: 0.553 ± 0.022	3.077IleAsp: 3.077 ± 0.05	3.014IleGlu: 3.014 ± 0.065	1.707IlePhe: 1.707 ± 0.038	4.689IleGly: 4.689 ± 0.073	1.001IleHis: 1.001 ± 0.028	2.413IleIle: 2.413 ± 0.055	1.039IleLys: 1.039 ± 0.036	4.696IleLeu: 4.696 ± 0.074	1.076IleMet: 1.076 ± 0.033	1.389IleAsn: 1.389 ± 0.037	2.819IlePro: 2.819 ± 0.052	1.262IleGln: 1.262 ± 0.036	3.816IleArg: 3.816 ± 0.056	3.421IleSer: 3.421 ± 0.073	3.076IleThr: 3.076 ± 0.06	3.996IleVal: 3.996 ± 0.059	0.613IleTrp: 0.613 ± 0.024	1.034IleTyr: 1.034 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.433LysAla: 3.433 ± 0.069	0.161LysCys: 0.161 ± 0.01	1.512LysAsp: 1.512 ± 0.038	1.366LysGlu: 1.366 ± 0.043	0.777LysPhe: 0.777 ± 0.026	2.269LysGly: 2.269 ± 0.05	0.564LysHis: 0.564 ± 0.024	1.692LysIle: 1.692 ± 0.045	1.322LysLys: 1.322 ± 0.04	2.783LysLeu: 2.783 ± 0.049	0.711LysMet: 0.711 ± 0.025	0.939LysAsn: 0.939 ± 0.029	1.824LysPro: 1.824 ± 0.042	1.035LysGln: 1.035 ± 0.031	2.003LysArg: 2.003 ± 0.049	1.665LysSer: 1.665 ± 0.041	2.011LysThr: 2.011 ± 0.044	1.801LysVal: 1.801 ± 0.047	0.332LysTrp: 0.332 ± 0.017	0.56LysTyr: 0.56 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.26LeuAla: 12.26 ± 0.118	1.188LeuCys: 1.188 ± 0.034	5.562LeuAsp: 5.562 ± 0.08	4.661LeuGlu: 4.661 ± 0.07	3.74LeuPhe: 3.74 ± 0.066	7.524LeuGly: 7.524 ± 0.086	2.351LeuHis: 2.351 ± 0.05	5.114LeuIle: 5.114 ± 0.07	3.086LeuLys: 3.086 ± 0.058	9.768LeuLeu: 9.768 ± 0.132	2.332LeuMet: 2.332 ± 0.052	2.774LeuAsn: 2.774 ± 0.05	6.273LeuPro: 6.273 ± 0.077	2.806LeuGln: 2.806 ± 0.057	7.466LeuArg: 7.466 ± 0.091	7.292LeuSer: 7.292 ± 0.103	6.538LeuThr: 6.538 ± 0.076	6.731LeuVal: 6.731 ± 0.093	1.308LeuTrp: 1.308 ± 0.038	2.053LeuTyr: 2.053 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.863MetAla: 2.863 ± 0.043	0.162MetCys: 0.162 ± 0.011	1.122MetAsp: 1.122 ± 0.031	1.142MetGlu: 1.142 ± 0.035	0.709MetPhe: 0.709 ± 0.025	1.639MetGly: 1.639 ± 0.037	0.468MetHis: 0.468 ± 0.025	1.377MetIle: 1.377 ± 0.038	0.995MetLys: 0.995 ± 0.03	2.538MetLeu: 2.538 ± 0.051	0.679MetMet: 0.679 ± 0.026	0.802MetAsn: 0.802 ± 0.028	1.64MetPro: 1.64 ± 0.041	0.849MetGln: 0.849 ± 0.026	1.792MetArg: 1.792 ± 0.047	1.715MetSer: 1.715 ± 0.038	2.15MetThr: 2.15 ± 0.042	1.518MetVal: 1.518 ± 0.033	0.214MetTrp: 0.214 ± 0.015	0.299MetTyr: 0.299 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.182AsnAla: 3.182 ± 0.056	0.275AsnCys: 0.275 ± 0.016	1.44AsnAsp: 1.44 ± 0.037	1.256AsnGlu: 1.256 ± 0.034	0.952AsnPhe: 0.952 ± 0.032	2.569AsnGly: 2.569 ± 0.056	0.562AsnHis: 0.562 ± 0.023	1.526AsnIle: 1.526 ± 0.043	0.625AsnLys: 0.625 ± 0.024	2.39AsnLeu: 2.39 ± 0.049	0.614AsnMet: 0.614 ± 0.024	0.812AsnAsn: 0.812 ± 0.033	1.778AsnPro: 1.778 ± 0.043	0.805AsnGln: 0.805 ± 0.031	1.827AsnArg: 1.827 ± 0.045	1.387AsnSer: 1.387 ± 0.039	1.518AsnThr: 1.518 ± 0.039	1.938AsnVal: 1.938 ± 0.046	0.483AsnTrp: 0.483 ± 0.023	0.784AsnTyr: 0.784 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	6.597ProAla: 6.597 ± 0.087	0.4ProCys: 0.4 ± 0.02	4.424ProAsp: 4.424 ± 0.072	4.059ProGlu: 4.059 ± 0.065	1.975ProPhe: 1.975 ± 0.044	5.303ProGly: 5.303 ± 0.085	1.277ProHis: 1.277 ± 0.035	1.734ProIle: 1.734 ± 0.041	1.43ProLys: 1.43 ± 0.038	4.952ProLeu: 4.952 ± 0.072	1.124ProMet: 1.124 ± 0.031	1.118ProAsn: 1.118 ± 0.03	3.034ProPro: 3.034 ± 0.068	1.653ProGln: 1.653 ± 0.035	2.88ProArg: 2.88 ± 0.048	3.088ProSer: 3.088 ± 0.053	2.52ProThr: 2.52 ± 0.05	5.381ProVal: 5.381 ± 0.075	0.825ProTrp: 0.825 ± 0.03	1.197ProTyr: 1.197 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.934GlnAla: 3.934 ± 0.079	0.21GlnCys: 0.21 ± 0.013	1.64GlnAsp: 1.64 ± 0.041	1.491GlnGlu: 1.491 ± 0.037	1.121GlnPhe: 1.121 ± 0.032	2.228GlnGly: 2.228 ± 0.042	0.66GlnHis: 0.66 ± 0.025	2.026GlnIle: 2.026 ± 0.042	1.183GlnLys: 1.183 ± 0.032	2.64GlnLeu: 2.64 ± 0.055	0.811GlnMet: 0.811 ± 0.025	1.008GlnAsn: 1.008 ± 0.026	1.749GlnPro: 1.749 ± 0.034	1.236GlnGln: 1.236 ± 0.043	2.119GlnArg: 2.119 ± 0.049	2.01GlnSer: 2.01 ± 0.043	2.063GlnThr: 2.063 ± 0.045	2.095GlnVal: 2.095 ± 0.045	0.399GlnTrp: 0.399 ± 0.021	0.707GlnTyr: 0.707 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.459ArgAla: 7.459 ± 0.082	0.616ArgCys: 0.616 ± 0.026	4.137ArgAsp: 4.137 ± 0.064	4.079ArgGlu: 4.079 ± 0.07	2.935ArgPhe: 2.935 ± 0.055	4.752ArgGly: 4.752 ± 0.07	1.981ArgHis: 1.981 ± 0.04	4.098ArgIle: 4.098 ± 0.068	2.38ArgLys: 2.38 ± 0.049	7.994ArgLeu: 7.994 ± 0.089	1.871ArgMet: 1.871 ± 0.039	2.157ArgAsn: 2.157 ± 0.043	3.641ArgPro: 3.641 ± 0.056	2.747ArgGln: 2.747 ± 0.06	5.863ArgArg: 5.863 ± 0.088	3.961ArgSer: 3.961 ± 0.063	3.821ArgThr: 3.821 ± 0.055	4.821ArgVal: 4.821 ± 0.067	1.016ArgTrp: 1.016 ± 0.033	1.888ArgTyr: 1.888 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.76SerAla: 6.76 ± 0.102	0.613SerCys: 0.613 ± 0.023	3.564SerAsp: 3.564 ± 0.059	3.155SerGlu: 3.155 ± 0.058	2.436SerPhe: 2.436 ± 0.047	6.757SerGly: 6.757 ± 0.153	1.381SerHis: 1.381 ± 0.037	2.67SerIle: 2.67 ± 0.057	1.383SerLys: 1.383 ± 0.034	6.346SerLeu: 6.346 ± 0.091	1.333SerMet: 1.333 ± 0.034	1.398SerAsn: 1.398 ± 0.044	3.413SerPro: 3.413 ± 0.057	1.756SerGln: 1.756 ± 0.041	4.196SerArg: 4.196 ± 0.059	3.927SerSer: 3.927 ± 0.092	3.057SerThr: 3.057 ± 0.066	4.845SerVal: 4.845 ± 0.069	0.881SerTrp: 0.881 ± 0.025	1.424SerTyr: 1.424 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.493ThrAla: 6.493 ± 0.094	0.523ThrCys: 0.523 ± 0.025	3.382ThrAsp: 3.382 ± 0.054	2.874ThrGlu: 2.874 ± 0.048	2.002ThrPhe: 2.002 ± 0.046	6.171ThrGly: 6.171 ± 0.089	1.293ThrHis: 1.293 ± 0.04	3.117ThrIle: 3.117 ± 0.069	1.419ThrLys: 1.419 ± 0.036	6.703ThrLeu: 6.703 ± 0.094	1.287ThrMet: 1.287 ± 0.035	1.439ThrAsn: 1.439 ± 0.045	3.793ThrPro: 3.793 ± 0.07	1.761ThrGln: 1.761 ± 0.044	3.789ThrArg: 3.789 ± 0.057	3.536ThrSer: 3.536 ± 0.075	3.482ThrThr: 3.482 ± 0.072	4.678ThrVal: 4.678 ± 0.085	0.763ThrTrp: 0.763 ± 0.025	1.257ThrTyr: 1.257 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.488ValAla: 8.488 ± 0.098	0.801ValCys: 0.801 ± 0.029	3.622ValAsp: 3.622 ± 0.06	3.641ValGlu: 3.641 ± 0.058	2.707ValPhe: 2.707 ± 0.059	4.958ValGly: 4.958 ± 0.07	1.418ValHis: 1.418 ± 0.038	4.095ValIle: 4.095 ± 0.065	1.879ValLys: 1.879 ± 0.045	7.451ValLeu: 7.451 ± 0.088	2.047ValMet: 2.047 ± 0.044	1.838ValAsn: 1.838 ± 0.04	4.112ValPro: 4.112 ± 0.063	2.006ValGln: 2.006 ± 0.045	5.161ValArg: 5.161 ± 0.068	5.267ValSer: 5.267 ± 0.079	4.99ValThr: 4.99 ± 0.073	5.52ValVal: 5.52 ± 0.075	0.993ValTrp: 0.993 ± 0.031	1.378ValTyr: 1.378 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.168TrpAla: 1.168 ± 0.035	0.195TrpCys: 0.195 ± 0.013	0.693TrpAsp: 0.693 ± 0.026	0.558TrpGlu: 0.558 ± 0.02	0.567TrpPhe: 0.567 ± 0.021	0.933TrpGly: 0.933 ± 0.029	0.437TrpHis: 0.437 ± 0.021	0.724TrpIle: 0.724 ± 0.031	0.548TrpLys: 0.548 ± 0.02	1.829TrpLeu: 1.829 ± 0.056	0.378TrpMet: 0.378 ± 0.016	0.536TrpAsn: 0.536 ± 0.024	0.709TrpPro: 0.709 ± 0.029	0.599TrpGln: 0.599 ± 0.025	1.244TrpArg: 1.244 ± 0.035	0.891TrpSer: 0.891 ± 0.028	0.834TrpThr: 0.834 ± 0.028	0.792TrpVal: 0.792 ± 0.023	0.226TrpTrp: 0.226 ± 0.015	0.333TrpTyr: 0.333 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.364TyrAla: 2.364 ± 0.044	0.263TyrCys: 0.263 ± 0.015	1.505TyrAsp: 1.505 ± 0.041	1.11TyrGlu: 1.11 ± 0.034	0.857TyrPhe: 0.857 ± 0.027	2.074TyrGly: 2.074 ± 0.05	0.503TyrHis: 0.503 ± 0.023	1.005TyrIle: 1.005 ± 0.031	0.563TyrLys: 0.563 ± 0.023	2.159TyrLeu: 2.159 ± 0.052	0.445TyrMet: 0.445 ± 0.019	0.713TyrAsn: 0.713 ± 0.032	1.099TyrPro: 1.099 ± 0.036	0.732TyrGln: 0.732 ± 0.028	1.808TyrArg: 1.808 ± 0.043	1.298TyrSer: 1.298 ± 0.039	1.184TyrThr: 1.184 ± 0.039	1.602TyrVal: 1.602 ± 0.037	0.322TyrTrp: 0.322 ± 0.017	0.641TyrTyr: 0.641 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3655 proteins (1131415 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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