Amino acid dipepetide frequency for Drosophila sturtevanti sigmavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.94AlaAla: 2.94 ± 1.209
0.49AlaCys: 0.49 ± 0.487
2.205AlaAsp: 2.205 ± 0.76
2.94AlaGlu: 2.94 ± 0.606
1.225AlaPhe: 1.225 ± 0.262
3.185AlaGly: 3.185 ± 0.879
1.47AlaHis: 1.47 ± 0.573
2.695AlaIle: 2.695 ± 0.706
2.45AlaLys: 2.45 ± 0.645
5.636AlaLeu: 5.636 ± 1.099
0.98AlaMet: 0.98 ± 0.474
2.45AlaAsn: 2.45 ± 0.955
1.225AlaPro: 1.225 ± 0.462
1.47AlaGln: 1.47 ± 0.652
2.205AlaArg: 2.205 ± 0.969
1.96AlaSer: 1.96 ± 0.712
3.185AlaThr: 3.185 ± 0.822
2.205AlaVal: 2.205 ± 1.445
0.735AlaTrp: 0.735 ± 0.312
1.96AlaTyr: 1.96 ± 0.456
0.0AlaXaa: 0.0 ± 0.0
Cys
0.98CysAla: 0.98 ± 0.529
0.735CysCys: 0.735 ± 0.65
0.98CysAsp: 0.98 ± 0.422
0.735CysGlu: 0.735 ± 0.757
0.735CysPhe: 0.735 ± 0.323
1.225CysGly: 1.225 ± 0.379
0.49CysHis: 0.49 ± 0.254
0.49CysIle: 0.49 ± 0.395
0.98CysLys: 0.98 ± 0.399
2.695CysLeu: 2.695 ± 0.746
0.49CysMet: 0.49 ± 0.254
0.49CysAsn: 0.49 ± 0.254
1.47CysPro: 1.47 ± 0.5
0.49CysGln: 0.49 ± 0.299
0.735CysArg: 0.735 ± 0.581
0.98CysSer: 0.98 ± 0.508
0.735CysThr: 0.735 ± 0.392
2.205CysVal: 2.205 ± 0.924
0.245CysTrp: 0.245 ± 0.149
0.98CysTyr: 0.98 ± 0.438
0.0CysXaa: 0.0 ± 0.0
Asp
1.715AspAla: 1.715 ± 0.61
1.47AspCys: 1.47 ± 0.4
2.94AspAsp: 2.94 ± 0.653
3.185AspGlu: 3.185 ± 0.408
2.205AspPhe: 2.205 ± 1.255
1.96AspGly: 1.96 ± 0.885
1.47AspHis: 1.47 ± 1.161
3.676AspIle: 3.676 ± 1.011
3.185AspLys: 3.185 ± 1.33
9.066AspLeu: 9.066 ± 0.912
0.98AspMet: 0.98 ± 0.512
1.96AspAsn: 1.96 ± 0.72
5.146AspPro: 5.146 ± 1.243
2.94AspGln: 2.94 ± 0.96
2.695AspArg: 2.695 ± 0.511
3.185AspSer: 3.185 ± 0.9
3.431AspThr: 3.431 ± 1.029
1.47AspVal: 1.47 ± 0.54
0.735AspTrp: 0.735 ± 0.286
2.45AspTyr: 2.45 ± 0.323
0.0AspXaa: 0.0 ± 0.0
Glu
1.47GluAla: 1.47 ± 0.581
1.47GluCys: 1.47 ± 0.531
3.431GluAsp: 3.431 ± 0.471
3.431GluGlu: 3.431 ± 1.097
2.94GluPhe: 2.94 ± 0.619
3.921GluGly: 3.921 ± 0.412
1.47GluHis: 1.47 ± 0.531
3.185GluIle: 3.185 ± 1.084
2.45GluLys: 2.45 ± 0.537
5.881GluLeu: 5.881 ± 1.2
1.225GluMet: 1.225 ± 0.512
2.205GluAsn: 2.205 ± 1.029
1.715GluPro: 1.715 ± 0.748
3.185GluGln: 3.185 ± 0.456
1.96GluArg: 1.96 ± 0.612
5.146GluSer: 5.146 ± 0.9
2.45GluThr: 2.45 ± 0.537
4.901GluVal: 4.901 ± 1.515
0.49GluTrp: 0.49 ± 0.254
2.45GluTyr: 2.45 ± 0.891
0.0GluXaa: 0.0 ± 0.0
Phe
1.47PheAla: 1.47 ± 0.479
0.0PheCys: 0.0 ± 0.0
1.96PheAsp: 1.96 ± 1.016
2.205PheGlu: 2.205 ± 0.664
2.45PhePhe: 2.45 ± 1.175
2.695PheGly: 2.695 ± 0.631
0.735PheHis: 0.735 ± 0.27
1.47PheIle: 1.47 ± 0.359
3.185PheLys: 3.185 ± 0.652
4.656PheLeu: 4.656 ± 0.862
0.735PheMet: 0.735 ± 0.388
1.96PheAsn: 1.96 ± 0.754
3.676PhePro: 3.676 ± 0.578
1.96PheGln: 1.96 ± 0.551
3.185PheArg: 3.185 ± 0.888
4.656PheSer: 4.656 ± 1.038
1.715PheThr: 1.715 ± 0.47
2.94PheVal: 2.94 ± 0.659
0.735PheTrp: 0.735 ± 0.323
0.735PheTyr: 0.735 ± 0.423
0.0PheXaa: 0.0 ± 0.0
Gly
2.205GlyAla: 2.205 ± 1.043
0.98GlyCys: 0.98 ± 0.23
2.45GlyAsp: 2.45 ± 0.543
3.676GlyGlu: 3.676 ± 0.633
2.94GlyPhe: 2.94 ± 0.781
3.676GlyGly: 3.676 ± 1.386
2.94GlyHis: 2.94 ± 0.865
3.921GlyIle: 3.921 ± 0.408
3.185GlyLys: 3.185 ± 1.1
8.576GlyLeu: 8.576 ± 1.521
1.715GlyMet: 1.715 ± 1.291
1.47GlyAsn: 1.47 ± 0.605
1.96GlyPro: 1.96 ± 0.352
1.96GlyGln: 1.96 ± 0.666
2.695GlyArg: 2.695 ± 0.91
2.695GlySer: 2.695 ± 0.975
2.94GlyThr: 2.94 ± 1.152
3.676GlyVal: 3.676 ± 0.918
1.47GlyTrp: 1.47 ± 0.359
3.431GlyTyr: 3.431 ± 1.11
0.0GlyXaa: 0.0 ± 0.0
His
1.715HisAla: 1.715 ± 0.402
0.0HisCys: 0.0 ± 0.0
1.47HisAsp: 1.47 ± 0.637
1.47HisGlu: 1.47 ± 0.571
1.47HisPhe: 1.47 ± 0.531
1.47HisGly: 1.47 ± 0.531
0.49HisHis: 0.49 ± 0.274
3.676HisIle: 3.676 ± 1.009
1.47HisLys: 1.47 ± 0.291
2.205HisLeu: 2.205 ± 0.507
0.245HisMet: 0.245 ± 0.317
1.225HisAsn: 1.225 ± 0.449
2.695HisPro: 2.695 ± 0.995
0.98HisGln: 0.98 ± 0.351
1.47HisArg: 1.47 ± 0.504
2.205HisSer: 2.205 ± 0.758
0.735HisThr: 0.735 ± 0.27
2.45HisVal: 2.45 ± 0.804
0.735HisTrp: 0.735 ± 0.27
1.47HisTyr: 1.47 ± 0.545
0.0HisXaa: 0.0 ± 0.0
Ile
1.96IleAla: 1.96 ± 0.862
1.47IleCys: 1.47 ± 0.439
2.45IleAsp: 2.45 ± 0.389
3.185IleGlu: 3.185 ± 0.809
1.715IlePhe: 1.715 ± 0.49
5.636IleGly: 5.636 ± 1.078
1.96IleHis: 1.96 ± 0.783
5.881IleIle: 5.881 ± 1.782
4.656IleLys: 4.656 ± 0.581
6.371IleLeu: 6.371 ± 0.527
2.205IleMet: 2.205 ± 0.744
2.205IleAsn: 2.205 ± 0.397
5.146IlePro: 5.146 ± 1.356
3.185IleGln: 3.185 ± 0.893
3.185IleArg: 3.185 ± 0.952
5.146IleSer: 5.146 ± 0.799
4.901IleThr: 4.901 ± 1.037
2.695IleVal: 2.695 ± 0.615
1.225IleTrp: 1.225 ± 0.404
2.695IleTyr: 2.695 ± 0.703
0.0IleXaa: 0.0 ± 0.0
Lys
3.921LysAla: 3.921 ± 0.916
1.225LysCys: 1.225 ± 0.578
3.921LysAsp: 3.921 ± 0.601
2.45LysGlu: 2.45 ± 0.52
2.205LysPhe: 2.205 ± 0.792
3.431LysGly: 3.431 ± 0.664
0.735LysHis: 0.735 ± 0.312
4.411LysIle: 4.411 ± 1.039
4.411LysLys: 4.411 ± 1.205
6.126LysLeu: 6.126 ± 0.992
2.205LysMet: 2.205 ± 0.9
3.185LysAsn: 3.185 ± 0.734
1.225LysPro: 1.225 ± 0.359
1.47LysGln: 1.47 ± 0.481
3.185LysArg: 3.185 ± 1.057
4.411LysSer: 4.411 ± 1.343
3.431LysThr: 3.431 ± 1.128
3.185LysVal: 3.185 ± 0.745
1.47LysTrp: 1.47 ± 0.464
2.695LysTyr: 2.695 ± 1.169
0.0LysXaa: 0.0 ± 0.0
Leu
5.636LeuAla: 5.636 ± 0.8
1.96LeuCys: 1.96 ± 0.612
5.146LeuAsp: 5.146 ± 1.837
5.391LeuGlu: 5.391 ± 0.703
4.901LeuPhe: 4.901 ± 0.671
6.861LeuGly: 6.861 ± 2.049
2.205LeuHis: 2.205 ± 0.644
7.841LeuIle: 7.841 ± 2.041
5.881LeuLys: 5.881 ± 1.136
8.331LeuLeu: 8.331 ± 1.648
3.431LeuMet: 3.431 ± 0.814
4.656LeuAsn: 4.656 ± 0.799
4.411LeuPro: 4.411 ± 0.885
2.45LeuGln: 2.45 ± 0.727
6.616LeuArg: 6.616 ± 0.974
10.047LeuSer: 10.047 ± 1.192
9.556LeuThr: 9.556 ± 1.314
4.901LeuVal: 4.901 ± 0.868
0.98LeuTrp: 0.98 ± 0.355
3.921LeuTyr: 3.921 ± 0.669
0.0LeuXaa: 0.0 ± 0.0
Met
1.225MetAla: 1.225 ± 0.512
0.735MetCys: 0.735 ± 0.312
0.98MetAsp: 0.98 ± 0.34
2.94MetGlu: 2.94 ± 0.865
1.47MetPhe: 1.47 ± 0.358
2.205MetGly: 2.205 ± 1.281
0.245MetHis: 0.245 ± 0.3
1.715MetIle: 1.715 ± 0.613
1.96MetLys: 1.96 ± 0.821
0.98MetLeu: 0.98 ± 0.399
0.49MetMet: 0.49 ± 0.254
1.225MetAsn: 1.225 ± 0.739
0.735MetPro: 0.735 ± 0.286
0.245MetGln: 0.245 ± 0.317
1.715MetArg: 1.715 ± 0.843
2.205MetSer: 2.205 ± 0.473
1.225MetThr: 1.225 ± 0.777
0.735MetVal: 0.735 ± 0.581
0.49MetTrp: 0.49 ± 0.279
0.49MetTyr: 0.49 ± 0.299
0.0MetXaa: 0.0 ± 0.0
Asn
1.96AsnAla: 1.96 ± 0.669
1.225AsnCys: 1.225 ± 0.676
2.94AsnAsp: 2.94 ± 0.801
2.695AsnGlu: 2.695 ± 0.662
2.45AsnPhe: 2.45 ± 0.539
1.225AsnGly: 1.225 ± 0.745
2.695AsnHis: 2.695 ± 0.434
2.45AsnIle: 2.45 ± 0.63
1.96AsnLys: 1.96 ± 1.436
5.146AsnLeu: 5.146 ± 1.101
1.225AsnMet: 1.225 ± 0.659
2.45AsnAsn: 2.45 ± 0.404
3.676AsnPro: 3.676 ± 0.385
1.47AsnGln: 1.47 ± 0.415
1.225AsnArg: 1.225 ± 0.659
2.94AsnSer: 2.94 ± 0.869
2.205AsnThr: 2.205 ± 0.854
3.431AsnVal: 3.431 ± 0.935
0.735AsnTrp: 0.735 ± 0.423
2.695AsnTyr: 2.695 ± 1.034
0.0AsnXaa: 0.0 ± 0.0
Pro
2.205ProAla: 2.205 ± 0.403
1.225ProCys: 1.225 ± 0.477
5.146ProAsp: 5.146 ± 1.3
4.166ProGlu: 4.166 ± 0.9
1.715ProPhe: 1.715 ± 0.613
3.185ProGly: 3.185 ± 2.535
1.225ProHis: 1.225 ± 0.853
2.205ProIle: 2.205 ± 1.12
2.94ProLys: 2.94 ± 1.273
6.126ProLeu: 6.126 ± 1.059
0.735ProMet: 0.735 ± 0.402
2.45ProAsn: 2.45 ± 0.608
2.45ProPro: 2.45 ± 0.787
1.47ProGln: 1.47 ± 0.678
2.205ProArg: 2.205 ± 0.76
5.146ProSer: 5.146 ± 0.799
1.96ProThr: 1.96 ± 0.909
4.656ProVal: 4.656 ± 1.146
0.735ProTrp: 0.735 ± 0.27
1.225ProTyr: 1.225 ± 0.582
0.245ProXaa: 0.245 ± 0.149
Gln
1.715GlnAla: 1.715 ± 0.613
0.98GlnCys: 0.98 ± 0.597
1.96GlnAsp: 1.96 ± 0.491
1.225GlnGlu: 1.225 ± 0.889
1.96GlnPhe: 1.96 ± 0.798
1.96GlnGly: 1.96 ± 0.745
0.735GlnHis: 0.735 ± 0.392
2.45GlnIle: 2.45 ± 1.248
1.47GlnLys: 1.47 ± 0.478
2.45GlnLeu: 2.45 ± 0.406
1.225GlnMet: 1.225 ± 1.283
2.94GlnAsn: 2.94 ± 0.924
1.715GlnPro: 1.715 ± 0.523
2.205GlnGln: 2.205 ± 0.812
1.715GlnArg: 1.715 ± 0.749
3.676GlnSer: 3.676 ± 0.754
2.205GlnThr: 2.205 ± 0.751
2.205GlnVal: 2.205 ± 0.658
0.49GlnTrp: 0.49 ± 0.484
0.49GlnTyr: 0.49 ± 0.254
0.0GlnXaa: 0.0 ± 0.0
Arg
3.676ArgAla: 3.676 ± 1.121
1.225ArgCys: 1.225 ± 0.349
2.695ArgAsp: 2.695 ± 0.799
3.431ArgGlu: 3.431 ± 0.659
4.166ArgPhe: 4.166 ± 0.909
3.676ArgGly: 3.676 ± 0.822
1.96ArgHis: 1.96 ± 0.959
4.166ArgIle: 4.166 ± 0.818
2.205ArgLys: 2.205 ± 0.852
3.921ArgLeu: 3.921 ± 0.888
1.225ArgMet: 1.225 ± 0.521
1.96ArgAsn: 1.96 ± 0.741
1.715ArgPro: 1.715 ± 0.548
2.205ArgGln: 2.205 ± 0.854
3.185ArgArg: 3.185 ± 1.276
2.45ArgSer: 2.45 ± 0.57
2.45ArgThr: 2.45 ± 0.683
2.45ArgVal: 2.45 ± 1.057
0.98ArgTrp: 0.98 ± 0.597
1.96ArgTyr: 1.96 ± 0.762
0.0ArgXaa: 0.0 ± 0.0
Ser
3.185SerAla: 3.185 ± 0.481
0.49SerCys: 0.49 ± 0.299
3.431SerAsp: 3.431 ± 0.692
3.921SerGlu: 3.921 ± 0.913
1.715SerPhe: 1.715 ± 0.315
3.676SerGly: 3.676 ± 0.357
3.431SerHis: 3.431 ± 0.665
5.636SerIle: 5.636 ± 1.83
3.431SerLys: 3.431 ± 1.03
8.086SerLeu: 8.086 ± 1.652
0.735SerMet: 0.735 ± 0.513
4.901SerAsn: 4.901 ± 0.647
3.921SerPro: 3.921 ± 1.046
2.94SerGln: 2.94 ± 0.436
5.146SerArg: 5.146 ± 1.226
5.881SerSer: 5.881 ± 1.396
3.185SerThr: 3.185 ± 0.899
5.391SerVal: 5.391 ± 0.921
2.45SerTrp: 2.45 ± 0.889
3.676SerTyr: 3.676 ± 1.815
0.0SerXaa: 0.0 ± 0.0
Thr
0.735ThrAla: 0.735 ± 0.286
1.225ThrCys: 1.225 ± 0.449
3.921ThrAsp: 3.921 ± 0.578
2.205ThrGlu: 2.205 ± 0.797
1.96ThrPhe: 1.96 ± 0.412
2.695ThrGly: 2.695 ± 0.501
1.715ThrHis: 1.715 ± 0.491
5.146ThrIle: 5.146 ± 1.232
3.676ThrLys: 3.676 ± 1.781
6.861ThrLeu: 6.861 ± 0.552
0.98ThrMet: 0.98 ± 0.403
2.94ThrAsn: 2.94 ± 0.843
3.676ThrPro: 3.676 ± 1.044
1.715ThrGln: 1.715 ± 0.929
3.431ThrArg: 3.431 ± 0.686
4.166ThrSer: 4.166 ± 1.315
3.921ThrThr: 3.921 ± 2.142
3.431ThrVal: 3.431 ± 0.471
1.47ThrTrp: 1.47 ± 0.5
1.96ThrTyr: 1.96 ± 0.807
0.0ThrXaa: 0.0 ± 0.0
Val
2.205ValAla: 2.205 ± 1.397
0.735ValCys: 0.735 ± 0.738
4.901ValAsp: 4.901 ± 1.694
3.185ValGlu: 3.185 ± 0.894
2.205ValPhe: 2.205 ± 1.029
3.185ValGly: 3.185 ± 0.81
1.47ValHis: 1.47 ± 0.4
2.695ValIle: 2.695 ± 0.401
5.146ValLys: 5.146 ± 0.825
5.146ValLeu: 5.146 ± 0.781
1.47ValMet: 1.47 ± 0.502
3.431ValAsn: 3.431 ± 0.751
2.94ValPro: 2.94 ± 0.41
2.205ValGln: 2.205 ± 0.622
1.96ValArg: 1.96 ± 0.74
3.676ValSer: 3.676 ± 0.742
5.146ValThr: 5.146 ± 1.062
2.695ValVal: 2.695 ± 0.966
0.98ValTrp: 0.98 ± 0.539
3.676ValTyr: 3.676 ± 1.446
0.0ValXaa: 0.0 ± 0.0
Trp
1.47TrpAla: 1.47 ± 0.928
0.245TrpCys: 0.245 ± 0.3
0.735TrpAsp: 0.735 ± 0.417
1.225TrpGlu: 1.225 ± 0.746
0.735TrpPhe: 0.735 ± 0.323
1.225TrpGly: 1.225 ± 0.746
0.735TrpHis: 0.735 ± 0.41
1.47TrpIle: 1.47 ± 1.109
1.47TrpLys: 1.47 ± 0.439
0.735TrpLeu: 0.735 ± 0.388
0.49TrpMet: 0.49 ± 0.274
1.715TrpAsn: 1.715 ± 0.789
0.49TrpPro: 0.49 ± 0.296
0.0TrpGln: 0.0 ± 0.0
1.225TrpArg: 1.225 ± 0.349
1.715TrpSer: 1.715 ± 0.535
0.49TrpThr: 0.49 ± 0.634
0.98TrpVal: 0.98 ± 0.23
0.245TrpTrp: 0.245 ± 0.317
0.49TrpTyr: 0.49 ± 0.299
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.225TyrAla: 1.225 ± 0.587
0.98TyrCys: 0.98 ± 0.508
2.205TyrAsp: 2.205 ± 0.727
1.715TyrGlu: 1.715 ± 0.502
1.96TyrPhe: 1.96 ± 0.464
1.47TyrGly: 1.47 ± 0.665
1.47TyrHis: 1.47 ± 0.571
2.45TyrIle: 2.45 ± 0.847
3.185TyrLys: 3.185 ± 1.175
6.126TyrLeu: 6.126 ± 1.269
0.98TyrMet: 0.98 ± 0.508
0.98TyrAsn: 0.98 ± 0.305
3.431TyrPro: 3.431 ± 0.763
1.225TyrGln: 1.225 ± 0.985
1.96TyrArg: 1.96 ± 0.531
3.185TyrSer: 3.185 ± 1.14
1.96TyrThr: 1.96 ± 1.346
2.45TyrVal: 2.45 ± 1.347
0.49TyrTrp: 0.49 ± 0.279
1.225TyrTyr: 1.225 ± 0.462
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.245XaaIle: 0.245 ± 0.149
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (4082 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski