Amino acid dipepetide frequency for Micromonospora deserti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.673AlaAla: 23.673 ± 0.213
0.954AlaCys: 0.954 ± 0.026
8.883AlaAsp: 8.883 ± 0.072
8.577AlaGlu: 8.577 ± 0.088
3.283AlaPhe: 3.283 ± 0.05
15.335AlaGly: 15.335 ± 0.116
2.579AlaHis: 2.579 ± 0.037
3.873AlaIle: 3.873 ± 0.05
2.263AlaLys: 2.263 ± 0.046
14.389AlaLeu: 14.389 ± 0.115
2.342AlaMet: 2.342 ± 0.039
2.237AlaAsn: 2.237 ± 0.039
7.268AlaPro: 7.268 ± 0.082
3.468AlaGln: 3.468 ± 0.05
10.767AlaArg: 10.767 ± 0.098
5.484AlaSer: 5.484 ± 0.059
8.072AlaThr: 8.072 ± 0.068
13.105AlaVal: 13.105 ± 0.121
1.957AlaTrp: 1.957 ± 0.038
2.853AlaTyr: 2.853 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.982CysAla: 0.982 ± 0.026
0.102CysCys: 0.102 ± 0.007
0.486CysAsp: 0.486 ± 0.015
0.329CysGlu: 0.329 ± 0.014
0.214CysPhe: 0.214 ± 0.011
0.933CysGly: 0.933 ± 0.025
0.195CysHis: 0.195 ± 0.009
0.15CysIle: 0.15 ± 0.008
0.076CysLys: 0.076 ± 0.007
0.708CysLeu: 0.708 ± 0.018
0.109CysMet: 0.109 ± 0.008
0.137CysAsn: 0.137 ± 0.009
0.501CysPro: 0.501 ± 0.018
0.196CysGln: 0.196 ± 0.011
0.654CysArg: 0.654 ± 0.021
0.395CysSer: 0.395 ± 0.015
0.441CysThr: 0.441 ± 0.017
0.628CysVal: 0.628 ± 0.018
0.133CysTrp: 0.133 ± 0.008
0.172CysTyr: 0.172 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.69AspAla: 7.69 ± 0.062
0.394AspCys: 0.394 ± 0.014
3.604AspAsp: 3.604 ± 0.052
3.528AspGlu: 3.528 ± 0.048
1.491AspPhe: 1.491 ± 0.028
6.401AspGly: 6.401 ± 0.068
1.297AspHis: 1.297 ± 0.031
1.677AspIle: 1.677 ± 0.034
0.875AspLys: 0.875 ± 0.024
6.553AspLeu: 6.553 ± 0.062
0.71AspMet: 0.71 ± 0.02
1.012AspAsn: 1.012 ± 0.027
4.879AspPro: 4.879 ± 0.051
1.675AspGln: 1.675 ± 0.032
5.612AspArg: 5.612 ± 0.073
2.213AspSer: 2.213 ± 0.036
2.905AspThr: 2.905 ± 0.046
4.949AspVal: 4.949 ± 0.053
1.004AspTrp: 1.004 ± 0.024
1.162AspTyr: 1.162 ± 0.024
0.0AspXaa: 0.0 ± 0.0
Glu
6.366GluAla: 6.366 ± 0.081
0.332GluCys: 0.332 ± 0.012
2.017GluAsp: 2.017 ± 0.035
2.452GluGlu: 2.452 ± 0.045
1.48GluPhe: 1.48 ± 0.029
3.166GluGly: 3.166 ± 0.047
1.346GluHis: 1.346 ± 0.027
2.137GluIle: 2.137 ± 0.036
1.002GluLys: 1.002 ± 0.027
6.519GluLeu: 6.519 ± 0.073
0.78GluMet: 0.78 ± 0.02
0.823GluAsn: 0.823 ± 0.024
3.491GluPro: 3.491 ± 0.053
2.094GluGln: 2.094 ± 0.039
5.027GluArg: 5.027 ± 0.057
2.099GluSer: 2.099 ± 0.036
2.382GluThr: 2.382 ± 0.043
4.74GluVal: 4.74 ± 0.059
0.739GluTrp: 0.739 ± 0.021
1.084GluTyr: 1.084 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.835PheAla: 3.835 ± 0.053
0.24PheCys: 0.24 ± 0.012
1.963PheAsp: 1.963 ± 0.033
1.173PheGlu: 1.173 ± 0.024
0.845PhePhe: 0.845 ± 0.024
2.99PheGly: 2.99 ± 0.045
0.575PheHis: 0.575 ± 0.017
0.724PheIle: 0.724 ± 0.026
0.396PheLys: 0.396 ± 0.016
2.501PheLeu: 2.501 ± 0.038
0.303PheMet: 0.303 ± 0.014
0.608PheAsn: 0.608 ± 0.02
1.345PhePro: 1.345 ± 0.028
0.645PheGln: 0.645 ± 0.018
1.889PheArg: 1.889 ± 0.033
1.284PheSer: 1.284 ± 0.026
1.973PheThr: 1.973 ± 0.032
2.432PheVal: 2.432 ± 0.036
0.459PheTrp: 0.459 ± 0.019
0.611PheTyr: 0.611 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
11.33GlyAla: 11.33 ± 0.093
0.831GlyCys: 0.831 ± 0.02
5.303GlyAsp: 5.303 ± 0.058
4.796GlyGlu: 4.796 ± 0.05
2.834GlyPhe: 2.834 ± 0.042
9.211GlyGly: 9.211 ± 0.093
2.143GlyHis: 2.143 ± 0.036
3.157GlyIle: 3.157 ± 0.051
1.869GlyLys: 1.869 ± 0.041
9.604GlyLeu: 9.604 ± 0.072
1.943GlyMet: 1.943 ± 0.033
1.834GlyAsn: 1.834 ± 0.038
5.475GlyPro: 5.475 ± 0.061
2.887GlyGln: 2.887 ± 0.041
8.504GlyArg: 8.504 ± 0.082
4.778GlySer: 4.778 ± 0.064
5.823GlyThr: 5.823 ± 0.067
8.301GlyVal: 8.301 ± 0.077
1.999GlyTrp: 1.999 ± 0.037
2.508GlyTyr: 2.508 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.533HisAla: 2.533 ± 0.04
0.197HisCys: 0.197 ± 0.01
1.336HisAsp: 1.336 ± 0.029
1.041HisGlu: 1.041 ± 0.027
0.536HisPhe: 0.536 ± 0.02
2.176HisGly: 2.176 ± 0.039
0.662HisHis: 0.662 ± 0.021
0.526HisIle: 0.526 ± 0.018
0.265HisLys: 0.265 ± 0.013
2.447HisLeu: 2.447 ± 0.036
0.26HisMet: 0.26 ± 0.013
0.38HisAsn: 0.38 ± 0.015
1.82HisPro: 1.82 ± 0.033
0.63HisGln: 0.63 ± 0.019
2.182HisArg: 2.182 ± 0.035
0.856HisSer: 0.856 ± 0.022
1.09HisThr: 1.09 ± 0.024
1.694HisVal: 1.694 ± 0.032
0.351HisTrp: 0.351 ± 0.014
0.451HisTyr: 0.451 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
4.653IleAla: 4.653 ± 0.059
0.29IleCys: 0.29 ± 0.013
2.269IleAsp: 2.269 ± 0.039
1.875IleGlu: 1.875 ± 0.044
0.852IlePhe: 0.852 ± 0.027
3.446IleGly: 3.446 ± 0.049
0.602IleHis: 0.602 ± 0.018
0.945IleIle: 0.945 ± 0.022
0.626IleLys: 0.626 ± 0.019
2.412IleLeu: 2.412 ± 0.044
0.453IleMet: 0.453 ± 0.016
0.778IleAsn: 0.778 ± 0.021
1.651IlePro: 1.651 ± 0.029
0.72IleGln: 0.72 ± 0.021
2.449IleArg: 2.449 ± 0.039
1.66IleSer: 1.66 ± 0.033
2.131IleThr: 2.131 ± 0.035
2.758IleVal: 2.758 ± 0.041
0.438IleTrp: 0.438 ± 0.015
0.627IleTyr: 0.627 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
2.054LysAla: 2.054 ± 0.041
0.109LysCys: 0.109 ± 0.009
0.801LysAsp: 0.801 ± 0.024
0.768LysGlu: 0.768 ± 0.024
0.363LysPhe: 0.363 ± 0.016
1.238LysGly: 1.238 ± 0.033
0.323LysHis: 0.323 ± 0.015
0.789LysIle: 0.789 ± 0.024
0.496LysLys: 0.496 ± 0.024
1.753LysLeu: 1.753 ± 0.041
0.284LysMet: 0.284 ± 0.012
0.36LysAsn: 0.36 ± 0.015
1.119LysPro: 1.119 ± 0.031
0.594LysGln: 0.594 ± 0.02
1.197LysArg: 1.197 ± 0.03
0.842LysSer: 0.842 ± 0.028
0.979LysThr: 0.979 ± 0.029
1.556LysVal: 1.556 ± 0.033
0.219LysTrp: 0.219 ± 0.01
0.34LysTyr: 0.34 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
16.904LeuAla: 16.904 ± 0.13
0.725LeuCys: 0.725 ± 0.021
6.846LeuAsp: 6.846 ± 0.074
3.737LeuGlu: 3.737 ± 0.053
2.617LeuPhe: 2.617 ± 0.043
9.351LeuGly: 9.351 ± 0.082
2.25LeuHis: 2.25 ± 0.039
3.201LeuIle: 3.201 ± 0.05
1.368LeuLys: 1.368 ± 0.033
11.731LeuLeu: 11.731 ± 0.106
1.381LeuMet: 1.381 ± 0.032
1.665LeuAsn: 1.665 ± 0.032
6.769LeuPro: 6.769 ± 0.064
1.865LeuGln: 1.865 ± 0.037
9.34LeuArg: 9.34 ± 0.083
4.719LeuSer: 4.719 ± 0.051
6.885LeuThr: 6.885 ± 0.059
10.084LeuVal: 10.084 ± 0.083
1.305LeuTrp: 1.305 ± 0.029
1.742LeuTyr: 1.742 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.058MetAla: 2.058 ± 0.034
0.107MetCys: 0.107 ± 0.008
0.731MetAsp: 0.731 ± 0.021
0.585MetGlu: 0.585 ± 0.018
0.472MetPhe: 0.472 ± 0.017
1.093MetGly: 1.093 ± 0.023
0.287MetHis: 0.287 ± 0.012
0.668MetIle: 0.668 ± 0.02
0.336MetLys: 0.336 ± 0.011
1.674MetLeu: 1.674 ± 0.033
0.26MetMet: 0.26 ± 0.013
0.349MetAsn: 0.349 ± 0.013
1.05MetPro: 1.05 ± 0.025
0.416MetGln: 0.416 ± 0.014
1.411MetArg: 1.411 ± 0.029
1.133MetSer: 1.133 ± 0.026
1.512MetThr: 1.512 ± 0.035
1.335MetVal: 1.335 ± 0.028
0.211MetTrp: 0.211 ± 0.011
0.278MetTyr: 0.278 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.175AsnAla: 2.175 ± 0.038
0.182AsnCys: 0.182 ± 0.01
0.983AsnAsp: 0.983 ± 0.026
0.76AsnGlu: 0.76 ± 0.023
0.537AsnPhe: 0.537 ± 0.017
1.956AsnGly: 1.956 ± 0.043
0.404AsnHis: 0.404 ± 0.016
0.63AsnIle: 0.63 ± 0.021
0.337AsnLys: 0.337 ± 0.016
1.855AsnLeu: 1.855 ± 0.031
0.27AsnMet: 0.27 ± 0.013
0.508AsnAsn: 0.508 ± 0.023
1.516AsnPro: 1.516 ± 0.03
0.576AsnGln: 0.576 ± 0.018
1.429AsnArg: 1.429 ± 0.032
0.916AsnSer: 0.916 ± 0.026
1.098AsnThr: 1.098 ± 0.027
1.473AsnVal: 1.473 ± 0.03
0.345AsnTrp: 0.345 ± 0.013
0.464AsnTyr: 0.464 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
10.447ProAla: 10.447 ± 0.094
0.347ProCys: 0.347 ± 0.014
4.591ProAsp: 4.591 ± 0.058
3.837ProGlu: 3.837 ± 0.049
1.388ProPhe: 1.388 ± 0.029
6.87ProGly: 6.87 ± 0.072
1.222ProHis: 1.222 ± 0.027
1.557ProIle: 1.557 ± 0.031
0.952ProLys: 0.952 ± 0.026
5.364ProLeu: 5.364 ± 0.053
0.976ProMet: 0.976 ± 0.024
1.043ProAsn: 1.043 ± 0.026
4.283ProPro: 4.283 ± 0.062
1.602ProGln: 1.602 ± 0.033
4.139ProArg: 4.139 ± 0.049
2.847ProSer: 2.847 ± 0.041
3.9ProThr: 3.9 ± 0.053
6.069ProVal: 6.069 ± 0.062
0.96ProTrp: 0.96 ± 0.023
1.32ProTyr: 1.32 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.572GlnAla: 3.572 ± 0.05
0.155GlnCys: 0.155 ± 0.009
1.053GlnAsp: 1.053 ± 0.026
1.106GlnGlu: 1.106 ± 0.024
0.73GlnPhe: 0.73 ± 0.023
1.847GlnGly: 1.847 ± 0.035
0.596GlnHis: 0.596 ± 0.018
1.112GlnIle: 1.112 ± 0.025
0.449GlnLys: 0.449 ± 0.018
3.216GlnLeu: 3.216 ± 0.048
0.436GlnMet: 0.436 ± 0.016
0.472GlnAsn: 0.472 ± 0.017
1.89GlnPro: 1.89 ± 0.034
1.119GlnGln: 1.119 ± 0.029
2.76GlnArg: 2.76 ± 0.046
1.07GlnSer: 1.07 ± 0.021
1.353GlnThr: 1.353 ± 0.03
2.835GlnVal: 2.835 ± 0.044
0.507GlnTrp: 0.507 ± 0.018
0.553GlnTyr: 0.553 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
10.655ArgAla: 10.655 ± 0.094
0.655ArgCys: 0.655 ± 0.018
4.673ArgAsp: 4.673 ± 0.056
4.279ArgGlu: 4.279 ± 0.058
2.503ArgPhe: 2.503 ± 0.033
6.022ArgGly: 6.022 ± 0.067
2.246ArgHis: 2.246 ± 0.033
3.18ArgIle: 3.18 ± 0.042
1.265ArgLys: 1.265 ± 0.03
9.63ArgLeu: 9.63 ± 0.095
1.864ArgMet: 1.864 ± 0.033
1.483ArgAsn: 1.483 ± 0.032
5.71ArgPro: 5.71 ± 0.068
2.668ArgGln: 2.668 ± 0.04
9.184ArgArg: 9.184 ± 0.094
3.987ArgSer: 3.987 ± 0.046
4.844ArgThr: 4.844 ± 0.054
6.791ArgVal: 6.791 ± 0.07
1.79ArgTrp: 1.79 ± 0.036
2.126ArgTyr: 2.126 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.119SerAla: 6.119 ± 0.059
0.38SerCys: 0.38 ± 0.012
2.263SerAsp: 2.263 ± 0.034
1.87SerGlu: 1.87 ± 0.039
1.45SerPhe: 1.45 ± 0.03
5.33SerGly: 5.33 ± 0.061
0.849SerHis: 0.849 ± 0.023
1.478SerIle: 1.478 ± 0.033
0.725SerLys: 0.725 ± 0.021
4.192SerLeu: 4.192 ± 0.055
0.948SerMet: 0.948 ± 0.023
0.886SerAsn: 0.886 ± 0.026
2.999SerPro: 2.999 ± 0.038
1.096SerGln: 1.096 ± 0.023
3.638SerArg: 3.638 ± 0.051
2.343SerSer: 2.343 ± 0.045
3.057SerThr: 3.057 ± 0.045
3.993SerVal: 3.993 ± 0.048
0.914SerTrp: 0.914 ± 0.023
1.25SerTyr: 1.25 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
8.652ThrAla: 8.652 ± 0.072
0.459ThrCys: 0.459 ± 0.018
3.602ThrAsp: 3.602 ± 0.054
2.91ThrGlu: 2.91 ± 0.042
1.643ThrPhe: 1.643 ± 0.033
6.85ThrGly: 6.85 ± 0.067
1.063ThrHis: 1.063 ± 0.024
1.911ThrIle: 1.911 ± 0.042
0.899ThrLys: 0.899 ± 0.028
5.743ThrLeu: 5.743 ± 0.056
0.968ThrMet: 0.968 ± 0.024
1.139ThrAsn: 1.139 ± 0.028
4.081ThrPro: 4.081 ± 0.047
1.19ThrGln: 1.19 ± 0.029
4.147ThrArg: 4.147 ± 0.048
2.969ThrSer: 2.969 ± 0.041
3.756ThrThr: 3.756 ± 0.063
6.423ThrVal: 6.423 ± 0.071
0.991ThrTrp: 0.991 ± 0.024
1.333ThrTyr: 1.333 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
12.984ValAla: 12.984 ± 0.118
0.729ValCys: 0.729 ± 0.02
5.94ValAsp: 5.94 ± 0.061
4.788ValGlu: 4.788 ± 0.048
2.387ValPhe: 2.387 ± 0.043
7.699ValGly: 7.699 ± 0.077
1.878ValHis: 1.878 ± 0.033
2.944ValIle: 2.944 ± 0.043
1.427ValLys: 1.427 ± 0.032
9.827ValLeu: 9.827 ± 0.084
1.189ValMet: 1.189 ± 0.025
1.848ValAsn: 1.848 ± 0.033
5.642ValPro: 5.642 ± 0.054
2.039ValGln: 2.039 ± 0.036
7.482ValArg: 7.482 ± 0.076
4.237ValSer: 4.237 ± 0.046
6.314ValThr: 6.314 ± 0.069
9.039ValVal: 9.039 ± 0.086
1.175ValTrp: 1.175 ± 0.026
1.563ValTyr: 1.563 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.769TrpAla: 1.769 ± 0.031
0.168TrpCys: 0.168 ± 0.009
0.795TrpAsp: 0.795 ± 0.02
0.619TrpGlu: 0.619 ± 0.019
0.545TrpPhe: 0.545 ± 0.019
1.027TrpGly: 1.027 ± 0.027
0.43TrpHis: 0.43 ± 0.015
0.543TrpIle: 0.543 ± 0.017
0.277TrpLys: 0.277 ± 0.015
2.007TrpLeu: 2.007 ± 0.035
0.292TrpMet: 0.292 ± 0.014
0.421TrpAsn: 0.421 ± 0.017
0.973TrpPro: 0.973 ± 0.02
0.652TrpGln: 0.652 ± 0.018
1.73TrpArg: 1.73 ± 0.034
1.031TrpSer: 1.031 ± 0.028
1.028TrpThr: 1.028 ± 0.025
1.153TrpVal: 1.153 ± 0.028
0.421TrpTrp: 0.421 ± 0.017
0.411TrpTyr: 0.411 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.91TyrAla: 2.91 ± 0.04
0.186TyrCys: 0.186 ± 0.009
1.491TyrAsp: 1.491 ± 0.034
1.047TyrGlu: 1.047 ± 0.026
0.62TyrPhe: 0.62 ± 0.021
2.188TyrGly: 2.188 ± 0.037
0.485TyrHis: 0.485 ± 0.016
0.435TyrIle: 0.435 ± 0.016
0.281TyrLys: 0.281 ± 0.015
2.362TyrLeu: 2.362 ± 0.036
0.2TyrMet: 0.2 ± 0.011
0.432TyrAsn: 0.432 ± 0.017
1.252TyrPro: 1.252 ± 0.026
0.698TyrGln: 0.698 ± 0.019
2.017TyrArg: 2.017 ± 0.038
0.915TyrSer: 0.915 ± 0.025
1.184TyrThr: 1.184 ± 0.028
1.772TyrVal: 1.772 ± 0.03
0.372TyrTrp: 0.372 ± 0.012
0.467TyrTyr: 0.467 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5968 proteins (1882724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski