Amino acid dipepetide frequency for Formosa sp. Hel1_33_131

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.531AlaAla: 4.531 ± 0.089	0.561AlaCys: 0.561 ± 0.029	3.338AlaAsp: 3.338 ± 0.074	3.589AlaGlu: 3.589 ± 0.074	3.444AlaPhe: 3.444 ± 0.06	3.988AlaGly: 3.988 ± 0.087	1.17AlaHis: 1.17 ± 0.04	5.258AlaIle: 5.258 ± 0.086	4.346AlaLys: 4.346 ± 0.091	6.629AlaLeu: 6.629 ± 0.104	1.422AlaMet: 1.422 ± 0.054	3.561AlaAsn: 3.561 ± 0.081	2.05AlaPro: 2.05 ± 0.051	2.606AlaGln: 2.606 ± 0.063	1.807AlaArg: 1.807 ± 0.055	4.396AlaSer: 4.396 ± 0.085	4.165AlaThr: 4.165 ± 0.104	4.274AlaVal: 4.274 ± 0.089	0.609AlaTrp: 0.609 ± 0.026	2.514AlaTyr: 2.514 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.514CysAla: 0.514 ± 0.048	0.102CysCys: 0.102 ± 0.012	0.536CysAsp: 0.536 ± 0.035	0.478CysGlu: 0.478 ± 0.024	0.465CysPhe: 0.465 ± 0.031	0.653CysGly: 0.653 ± 0.031	0.176CysHis: 0.176 ± 0.014	0.588CysIle: 0.588 ± 0.029	0.456CysLys: 0.456 ± 0.023	0.647CysLeu: 0.647 ± 0.026	0.153CysMet: 0.153 ± 0.014	0.453CysAsn: 0.453 ± 0.03	0.355CysPro: 0.355 ± 0.028	0.235CysGln: 0.235 ± 0.017	0.189CysArg: 0.189 ± 0.015	0.6CysSer: 0.6 ± 0.039	0.413CysThr: 0.413 ± 0.023	0.492CysVal: 0.492 ± 0.033	0.053CysTrp: 0.053 ± 0.009	0.305CysTyr: 0.305 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.213AspAla: 4.213 ± 0.084	0.479AspCys: 0.479 ± 0.027	2.858AspAsp: 2.858 ± 0.072	3.306AspGlu: 3.306 ± 0.069	3.672AspPhe: 3.672 ± 0.065	3.83AspGly: 3.83 ± 0.094	0.983AspHis: 0.983 ± 0.035	4.229AspIle: 4.229 ± 0.082	3.559AspLys: 3.559 ± 0.085	5.58AspLeu: 5.58 ± 0.083	1.013AspMet: 1.013 ± 0.037	2.912AspAsn: 2.912 ± 0.074	2.012AspPro: 2.012 ± 0.072	1.755AspGln: 1.755 ± 0.049	1.824AspArg: 1.824 ± 0.048	3.55AspSer: 3.55 ± 0.069	3.316AspThr: 3.316 ± 0.076	3.738AspVal: 3.738 ± 0.078	0.707AspTrp: 0.707 ± 0.03	2.809AspTyr: 2.809 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.786GluAla: 4.786 ± 0.087	0.392GluCys: 0.392 ± 0.025	3.514GluAsp: 3.514 ± 0.065	4.011GluGlu: 4.011 ± 0.09	3.187GluPhe: 3.187 ± 0.071	3.847GluGly: 3.847 ± 0.067	1.121GluHis: 1.121 ± 0.038	5.186GluIle: 5.186 ± 0.076	4.651GluLys: 4.651 ± 0.096	6.119GluLeu: 6.119 ± 0.094	1.428GluMet: 1.428 ± 0.046	4.176GluAsn: 4.176 ± 0.073	1.501GluPro: 1.501 ± 0.046	2.081GluGln: 2.081 ± 0.057	2.257GluArg: 2.257 ± 0.064	3.679GluSer: 3.679 ± 0.07	4.309GluThr: 4.309 ± 0.074	4.316GluVal: 4.316 ± 0.072	0.611GluTrp: 0.611 ± 0.026	2.17GluTyr: 2.17 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.748PheAla: 2.748 ± 0.068	0.464PheCys: 0.464 ± 0.028	3.506PheAsp: 3.506 ± 0.075	3.901PheGlu: 3.901 ± 0.075	2.467PhePhe: 2.467 ± 0.062	3.681PheGly: 3.681 ± 0.079	0.759PheHis: 0.759 ± 0.029	3.834PheIle: 3.834 ± 0.082	4.068PheLys: 4.068 ± 0.078	4.512PheLeu: 4.512 ± 0.087	1.116PheMet: 1.116 ± 0.039	3.256PheAsn: 3.256 ± 0.078	1.555PhePro: 1.555 ± 0.049	1.599PheGln: 1.599 ± 0.043	1.532PheArg: 1.532 ± 0.048	4.178PheSer: 4.178 ± 0.082	3.286PheThr: 3.286 ± 0.092	3.057PheVal: 3.057 ± 0.062	0.609PheTrp: 0.609 ± 0.031	2.165PheTyr: 2.165 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	4.382GlyAla: 4.382 ± 0.089	0.652GlyCys: 0.652 ± 0.043	3.529GlyAsp: 3.529 ± 0.074	3.205GlyGlu: 3.205 ± 0.071	3.767GlyPhe: 3.767 ± 0.073	4.661GlyGly: 4.661 ± 0.114	1.115GlyHis: 1.115 ± 0.039	5.078GlyIle: 5.078 ± 0.097	4.203GlyLys: 4.203 ± 0.081	5.632GlyLeu: 5.632 ± 0.092	1.535GlyMet: 1.535 ± 0.049	3.393GlyAsn: 3.393 ± 0.086	1.395GlyPro: 1.395 ± 0.058	2.036GlyGln: 2.036 ± 0.052	2.076GlyArg: 2.076 ± 0.059	4.417GlySer: 4.417 ± 0.085	4.549GlyThr: 4.549 ± 0.102	4.738GlyVal: 4.738 ± 0.081	0.715GlyTrp: 0.715 ± 0.026	2.731GlyTyr: 2.731 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.006HisAla: 1.006 ± 0.034	0.201HisCys: 0.201 ± 0.016	0.781HisAsp: 0.781 ± 0.033	0.907HisGlu: 0.907 ± 0.029	1.113HisPhe: 1.113 ± 0.035	0.953HisGly: 0.953 ± 0.037	0.441HisHis: 0.441 ± 0.024	1.405HisIle: 1.405 ± 0.041	1.258HisLys: 1.258 ± 0.042	1.853HisLeu: 1.853 ± 0.051	0.304HisMet: 0.304 ± 0.017	0.999HisAsn: 0.999 ± 0.036	0.919HisPro: 0.919 ± 0.038	0.77HisGln: 0.77 ± 0.029	0.625HisArg: 0.625 ± 0.026	1.199HisSer: 1.199 ± 0.039	0.99HisThr: 0.99 ± 0.038	0.926HisVal: 0.926 ± 0.04	0.213HisTrp: 0.213 ± 0.017	0.863HisTyr: 0.863 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.027IleAla: 5.027 ± 0.083	0.708IleCys: 0.708 ± 0.046	5.058IleAsp: 5.058 ± 0.093	5.609IleGlu: 5.609 ± 0.078	3.395IlePhe: 3.395 ± 0.068	5.013IleGly: 5.013 ± 0.101	1.453IleHis: 1.453 ± 0.043	5.622IleIle: 5.622 ± 0.104	5.64IleLys: 5.64 ± 0.097	6.729IleLeu: 6.729 ± 0.113	1.324IleMet: 1.324 ± 0.044	4.652IleAsn: 4.652 ± 0.091	3.121IlePro: 3.121 ± 0.073	2.714IleGln: 2.714 ± 0.058	2.367IleArg: 2.367 ± 0.059	6.044IleSer: 6.044 ± 0.087	4.92IleThr: 4.92 ± 0.095	4.775IleVal: 4.775 ± 0.078	0.598IleTrp: 0.598 ± 0.029	2.758IleTyr: 2.758 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.853LysAla: 4.853 ± 0.103	0.328LysCys: 0.328 ± 0.02	4.056LysAsp: 4.056 ± 0.087	5.272LysGlu: 5.272 ± 0.102	2.927LysPhe: 2.927 ± 0.061	4.211LysGly: 4.211 ± 0.092	1.416LysHis: 1.416 ± 0.049	5.909LysIle: 5.909 ± 0.101	6.05LysLys: 6.05 ± 0.13	6.529LysLeu: 6.529 ± 0.106	1.828LysMet: 1.828 ± 0.054	4.853LysAsn: 4.853 ± 0.097	2.188LysPro: 2.188 ± 0.058	2.806LysGln: 2.806 ± 0.068	2.836LysArg: 2.836 ± 0.067	4.92LysSer: 4.92 ± 0.094	5.085LysThr: 5.085 ± 0.094	4.258LysVal: 4.258 ± 0.085	0.714LysTrp: 0.714 ± 0.03	2.664LysTyr: 2.664 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.469LeuAla: 5.469 ± 0.092	0.676LeuCys: 0.676 ± 0.03	5.243LeuAsp: 5.243 ± 0.077	6.74LeuGlu: 6.74 ± 0.099	4.741LeuPhe: 4.741 ± 0.091	5.793LeuGly: 5.793 ± 0.089	1.552LeuHis: 1.552 ± 0.051	7.126LeuIle: 7.126 ± 0.125	8.018LeuLys: 8.018 ± 0.13	8.125LeuLeu: 8.125 ± 0.126	2.093LeuMet: 2.093 ± 0.049	6.085LeuAsn: 6.085 ± 0.099	3.337LeuPro: 3.337 ± 0.073	3.069LeuGln: 3.069 ± 0.073	3.098LeuArg: 3.098 ± 0.066	6.963LeuSer: 6.963 ± 0.099	5.452LeuThr: 5.452 ± 0.094	5.468LeuVal: 5.468 ± 0.107	0.773LeuTrp: 0.773 ± 0.033	3.012LeuTyr: 3.012 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.519MetAla: 1.519 ± 0.048	0.137MetCys: 0.137 ± 0.013	1.213MetAsp: 1.213 ± 0.038	1.29MetGlu: 1.29 ± 0.043	0.833MetPhe: 0.833 ± 0.038	1.318MetGly: 1.318 ± 0.047	0.406MetHis: 0.406 ± 0.023	1.504MetIle: 1.504 ± 0.051	2.046MetLys: 2.046 ± 0.049	1.761MetLeu: 1.761 ± 0.048	0.486MetMet: 0.486 ± 0.029	1.343MetAsn: 1.343 ± 0.041	0.771MetPro: 0.771 ± 0.032	0.725MetGln: 0.725 ± 0.028	0.781MetArg: 0.781 ± 0.035	1.475MetSer: 1.475 ± 0.047	1.166MetThr: 1.166 ± 0.035	1.234MetVal: 1.234 ± 0.043	0.143MetTrp: 0.143 ± 0.014	0.699MetTyr: 0.699 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.884AsnAla: 3.884 ± 0.073	0.501AsnCys: 0.501 ± 0.027	3.069AsnAsp: 3.069 ± 0.069	3.496AsnGlu: 3.496 ± 0.07	3.139AsnPhe: 3.139 ± 0.075	4.034AsnGly: 4.034 ± 0.095	1.075AsnHis: 1.075 ± 0.04	4.469AsnIle: 4.469 ± 0.075	3.999AsnLys: 3.999 ± 0.078	5.384AsnLeu: 5.384 ± 0.098	1.218AsnMet: 1.218 ± 0.04	3.795AsnAsn: 3.795 ± 0.097	2.958AsnPro: 2.958 ± 0.085	2.285AsnGln: 2.285 ± 0.057	2.051AsnArg: 2.051 ± 0.062	4.424AsnSer: 4.424 ± 0.092	4.33AsnThr: 4.33 ± 0.101	3.438AsnVal: 3.438 ± 0.076	0.714AsnTrp: 0.714 ± 0.031	2.913AsnTyr: 2.913 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.862ProAla: 1.862 ± 0.068	0.227ProCys: 0.227 ± 0.016	1.907ProAsp: 1.907 ± 0.059	2.555ProGlu: 2.555 ± 0.062	1.867ProPhe: 1.867 ± 0.042	1.706ProGly: 1.706 ± 0.051	0.609ProHis: 0.609 ± 0.028	2.753ProIle: 2.753 ± 0.065	2.513ProLys: 2.513 ± 0.063	3.154ProLeu: 3.154 ± 0.075	0.67ProMet: 0.67 ± 0.028	2.468ProAsn: 2.468 ± 0.065	0.869ProPro: 0.869 ± 0.039	1.179ProGln: 1.179 ± 0.04	0.885ProArg: 0.885 ± 0.036	2.428ProSer: 2.428 ± 0.059	2.521ProThr: 2.521 ± 0.094	2.282ProVal: 2.282 ± 0.06	0.328ProTrp: 0.328 ± 0.021	1.349ProTyr: 1.349 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.032GlnAla: 2.032 ± 0.052	0.232GlnCys: 0.232 ± 0.022	1.572GlnAsp: 1.572 ± 0.042	2.122GlnGlu: 2.122 ± 0.052	1.755GlnPhe: 1.755 ± 0.043	1.946GlnGly: 1.946 ± 0.068	0.639GlnHis: 0.639 ± 0.027	2.655GlnIle: 2.655 ± 0.059	2.879GlnLys: 2.879 ± 0.072	3.832GlnLeu: 3.832 ± 0.066	0.828GlnMet: 0.828 ± 0.031	2.272GlnAsn: 2.272 ± 0.06	1.115GlnPro: 1.115 ± 0.038	1.354GlnGln: 1.354 ± 0.051	1.244GlnArg: 1.244 ± 0.042	2.207GlnSer: 2.207 ± 0.051	2.353GlnThr: 2.353 ± 0.068	1.92GlnVal: 1.92 ± 0.042	0.387GlnTrp: 0.387 ± 0.024	1.259GlnTyr: 1.259 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.035ArgAla: 2.035 ± 0.056	0.213ArgCys: 0.213 ± 0.017	1.663ArgAsp: 1.663 ± 0.046	1.83ArgGlu: 1.83 ± 0.053	1.802ArgPhe: 1.802 ± 0.051	1.912ArgGly: 1.912 ± 0.045	0.579ArgHis: 0.579 ± 0.025	2.707ArgIle: 2.707 ± 0.058	2.442ArgLys: 2.442 ± 0.063	3.227ArgLeu: 3.227 ± 0.052	0.841ArgMet: 0.841 ± 0.036	1.87ArgAsn: 1.87 ± 0.053	1.072ArgPro: 1.072 ± 0.038	1.073ArgGln: 1.073 ± 0.044	1.194ArgArg: 1.194 ± 0.039	1.999ArgSer: 1.999 ± 0.055	1.926ArgThr: 1.926 ± 0.053	2.051ArgVal: 2.051 ± 0.052	0.359ArgTrp: 0.359 ± 0.023	1.419ArgTyr: 1.419 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.935SerAla: 3.935 ± 0.065	0.647SerCys: 0.647 ± 0.027	4.053SerAsp: 4.053 ± 0.072	4.487SerGlu: 4.487 ± 0.082	3.938SerPhe: 3.938 ± 0.084	4.855SerGly: 4.855 ± 0.08	1.165SerHis: 1.165 ± 0.042	5.523SerIle: 5.523 ± 0.08	5.388SerLys: 5.388 ± 0.087	6.2SerLeu: 6.2 ± 0.111	1.379SerMet: 1.379 ± 0.044	4.429SerAsn: 4.429 ± 0.087	2.257SerPro: 2.257 ± 0.054	2.286SerGln: 2.286 ± 0.06	2.053SerArg: 2.053 ± 0.054	4.906SerSer: 4.906 ± 0.105	4.252SerThr: 4.252 ± 0.077	4.376SerVal: 4.376 ± 0.074	0.731SerTrp: 0.731 ± 0.034	3.03SerTyr: 3.03 ± 0.074	0.0SerXaa: 0.0 ± 0.0
Thr	4.503ThrAla: 4.503 ± 0.099	0.36ThrCys: 0.36 ± 0.022	3.57ThrAsp: 3.57 ± 0.079	3.661ThrGlu: 3.661 ± 0.064	3.249ThrPhe: 3.249 ± 0.071	4.234ThrGly: 4.234 ± 0.09	1.127ThrHis: 1.127 ± 0.037	5.31ThrIle: 5.31 ± 0.11	4.232ThrLys: 4.232 ± 0.081	6.167ThrLeu: 6.167 ± 0.1	0.961ThrMet: 0.961 ± 0.035	3.708ThrAsn: 3.708 ± 0.085	2.992ThrPro: 2.992 ± 0.092	2.247ThrGln: 2.247 ± 0.064	1.57ThrArg: 1.57 ± 0.052	4.46ThrSer: 4.46 ± 0.084	4.714ThrThr: 4.714 ± 0.181	4.315ThrVal: 4.315 ± 0.13	0.639ThrTrp: 0.639 ± 0.046	2.67ThrTyr: 2.67 ± 0.073	0.0ThrXaa: 0.0 ± 0.0
Val	4.032ValAla: 4.032 ± 0.088	0.541ValCys: 0.541 ± 0.031	3.834ValAsp: 3.834 ± 0.089	3.851ValGlu: 3.851 ± 0.082	3.63ValPhe: 3.63 ± 0.073	4.04ValGly: 4.04 ± 0.082	0.994ValHis: 0.994 ± 0.039	4.915ValIle: 4.915 ± 0.089	4.137ValLys: 4.137 ± 0.079	6.23ValLeu: 6.23 ± 0.089	1.207ValMet: 1.207 ± 0.038	3.643ValAsn: 3.643 ± 0.083	2.061ValPro: 2.061 ± 0.052	1.97ValGln: 1.97 ± 0.058	2.0ValArg: 2.0 ± 0.054	4.679ValSer: 4.679 ± 0.085	3.701ValThr: 3.701 ± 0.107	4.333ValVal: 4.333 ± 0.089	0.56ValTrp: 0.56 ± 0.03	2.427ValTyr: 2.427 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.572TrpAla: 0.572 ± 0.025	0.095TrpCys: 0.095 ± 0.01	0.596TrpAsp: 0.596 ± 0.027	0.68TrpGlu: 0.68 ± 0.031	0.569TrpPhe: 0.569 ± 0.028	0.622TrpGly: 0.622 ± 0.029	0.196TrpHis: 0.196 ± 0.018	0.727TrpIle: 0.727 ± 0.031	0.733TrpLys: 0.733 ± 0.034	0.862TrpLeu: 0.862 ± 0.034	0.307TrpMet: 0.307 ± 0.019	0.721TrpAsn: 0.721 ± 0.041	0.192TrpPro: 0.192 ± 0.019	0.344TrpGln: 0.344 ± 0.02	0.383TrpArg: 0.383 ± 0.023	0.663TrpSer: 0.663 ± 0.037	0.634TrpThr: 0.634 ± 0.041	0.611TrpVal: 0.611 ± 0.026	0.103TrpTrp: 0.103 ± 0.01	0.399TrpTyr: 0.399 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.052	0.349TyrCys: 0.349 ± 0.023	2.45TyrAsp: 2.45 ± 0.071	2.353TyrGlu: 2.353 ± 0.047	2.332TyrPhe: 2.332 ± 0.054	2.513TyrGly: 2.513 ± 0.067	0.75TyrHis: 0.75 ± 0.03	2.729TyrIle: 2.729 ± 0.059	3.089TyrLys: 3.089 ± 0.066	3.662TyrLeu: 3.662 ± 0.078	0.735TyrMet: 0.735 ± 0.031	2.587TyrAsn: 2.587 ± 0.066	1.413TyrPro: 1.413 ± 0.052	1.465TyrGln: 1.465 ± 0.042	1.441TyrArg: 1.441 ± 0.047	2.704TyrSer: 2.704 ± 0.064	2.605TyrThr: 2.605 ± 0.079	2.181TyrVal: 2.181 ± 0.053	0.444TyrTrp: 0.444 ± 0.023	1.789TyrTyr: 1.789 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2626 proteins (824978 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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