Amino acid dipepetide frequency for Homalodisca vitripennis reovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.794AlaAla: 4.794 ± 0.862
0.757AlaCys: 0.757 ± 0.3
3.407AlaAsp: 3.407 ± 0.76
1.514AlaGlu: 1.514 ± 0.464
2.65AlaPhe: 2.65 ± 0.66
4.668AlaGly: 4.668 ± 0.586
1.136AlaHis: 1.136 ± 0.312
6.435AlaIle: 6.435 ± 0.765
3.028AlaLys: 3.028 ± 0.612
6.435AlaLeu: 6.435 ± 0.694
2.271AlaMet: 2.271 ± 0.555
2.65AlaAsn: 2.65 ± 0.644
2.019AlaPro: 2.019 ± 0.549
3.028AlaGln: 3.028 ± 0.557
3.533AlaArg: 3.533 ± 0.619
5.678AlaSer: 5.678 ± 0.587
5.173AlaThr: 5.173 ± 0.472
4.921AlaVal: 4.921 ± 0.85
1.009AlaTrp: 1.009 ± 0.268
3.028AlaTyr: 3.028 ± 0.636
0.0AlaXaa: 0.0 ± 0.0
Cys
0.883CysAla: 0.883 ± 0.429
0.126CysCys: 0.126 ± 0.104
1.262CysAsp: 1.262 ± 0.268
0.379CysGlu: 0.379 ± 0.195
0.883CysPhe: 0.883 ± 0.378
1.514CysGly: 1.514 ± 0.294
0.252CysHis: 0.252 ± 0.137
0.883CysIle: 0.883 ± 0.319
0.252CysLys: 0.252 ± 0.2
0.883CysLeu: 0.883 ± 0.218
0.379CysMet: 0.379 ± 0.209
0.757CysAsn: 0.757 ± 0.332
0.757CysPro: 0.757 ± 0.362
0.379CysGln: 0.379 ± 0.239
0.379CysArg: 0.379 ± 0.257
0.505CysSer: 0.505 ± 0.188
0.379CysThr: 0.379 ± 0.163
0.757CysVal: 0.757 ± 0.485
0.0CysTrp: 0.0 ± 0.0
0.126CysTyr: 0.126 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
4.794AspAla: 4.794 ± 0.629
1.262AspCys: 1.262 ± 0.493
3.911AspAsp: 3.911 ± 0.647
3.154AspGlu: 3.154 ± 0.536
2.902AspPhe: 2.902 ± 0.684
2.902AspGly: 2.902 ± 0.718
0.757AspHis: 0.757 ± 0.363
4.037AspIle: 4.037 ± 0.65
2.523AspLys: 2.523 ± 0.429
5.299AspLeu: 5.299 ± 1.019
2.271AspMet: 2.271 ± 0.323
2.523AspAsn: 2.523 ± 0.597
2.397AspPro: 2.397 ± 0.426
1.262AspGln: 1.262 ± 0.291
2.019AspArg: 2.019 ± 0.537
4.921AspSer: 4.921 ± 0.55
4.668AspThr: 4.668 ± 0.569
6.182AspVal: 6.182 ± 0.866
0.505AspTrp: 0.505 ± 0.194
2.397AspTyr: 2.397 ± 0.712
0.0AspXaa: 0.0 ± 0.0
Glu
3.407GluAla: 3.407 ± 0.634
0.505GluCys: 0.505 ± 0.169
3.659GluAsp: 3.659 ± 0.642
2.523GluGlu: 2.523 ± 0.978
1.893GluPhe: 1.893 ± 0.489
2.397GluGly: 2.397 ± 0.476
0.379GluHis: 0.379 ± 0.156
4.29GluIle: 4.29 ± 0.883
3.28GluLys: 3.28 ± 0.878
3.533GluLeu: 3.533 ± 0.499
1.009GluMet: 1.009 ± 0.283
1.262GluAsn: 1.262 ± 0.435
1.009GluPro: 1.009 ± 0.235
1.893GluGln: 1.893 ± 0.364
2.776GluArg: 2.776 ± 0.437
4.921GluSer: 4.921 ± 1.015
2.65GluThr: 2.65 ± 0.479
2.397GluVal: 2.397 ± 0.458
0.757GluTrp: 0.757 ± 0.234
1.893GluTyr: 1.893 ± 0.457
0.0GluXaa: 0.0 ± 0.0
Phe
2.271PheAla: 2.271 ± 0.375
0.505PheCys: 0.505 ± 0.321
1.388PheAsp: 1.388 ± 0.462
1.766PheGlu: 1.766 ± 0.456
1.136PhePhe: 1.136 ± 0.271
2.271PheGly: 2.271 ± 0.611
0.505PheHis: 0.505 ± 0.198
3.154PheIle: 3.154 ± 0.389
3.533PheLys: 3.533 ± 0.469
3.659PheLeu: 3.659 ± 0.581
1.262PheMet: 1.262 ± 0.414
2.397PheAsn: 2.397 ± 0.39
1.388PhePro: 1.388 ± 0.275
1.262PheGln: 1.262 ± 0.417
1.64PheArg: 1.64 ± 0.342
5.425PheSer: 5.425 ± 0.904
3.407PheThr: 3.407 ± 0.53
2.523PheVal: 2.523 ± 0.546
0.252PheTrp: 0.252 ± 0.182
0.883PheTyr: 0.883 ± 0.318
0.0PheXaa: 0.0 ± 0.0
Gly
3.28GlyAla: 3.28 ± 0.749
0.252GlyCys: 0.252 ± 0.22
3.407GlyAsp: 3.407 ± 0.399
2.397GlyGlu: 2.397 ± 0.413
1.766GlyPhe: 1.766 ± 0.447
2.902GlyGly: 2.902 ± 0.619
0.883GlyHis: 0.883 ± 0.325
4.037GlyIle: 4.037 ± 0.714
3.154GlyLys: 3.154 ± 0.843
5.678GlyLeu: 5.678 ± 0.789
1.262GlyMet: 1.262 ± 0.37
2.902GlyAsn: 2.902 ± 0.574
1.766GlyPro: 1.766 ± 0.468
1.893GlyGln: 1.893 ± 0.279
1.64GlyArg: 1.64 ± 0.376
4.668GlySer: 4.668 ± 0.478
1.893GlyThr: 1.893 ± 0.367
4.542GlyVal: 4.542 ± 0.671
0.757GlyTrp: 0.757 ± 0.243
1.893GlyTyr: 1.893 ± 0.624
0.0GlyXaa: 0.0 ± 0.0
His
0.505HisAla: 0.505 ± 0.178
0.252HisCys: 0.252 ± 0.149
1.893HisAsp: 1.893 ± 0.251
0.883HisGlu: 0.883 ± 0.392
0.757HisPhe: 0.757 ± 0.29
1.009HisGly: 1.009 ± 0.402
0.252HisHis: 0.252 ± 0.144
0.505HisIle: 0.505 ± 0.307
0.505HisLys: 0.505 ± 0.217
2.271HisLeu: 2.271 ± 0.567
0.126HisMet: 0.126 ± 0.104
1.009HisAsn: 1.009 ± 0.361
1.893HisPro: 1.893 ± 0.495
1.262HisGln: 1.262 ± 0.412
0.757HisArg: 0.757 ± 0.436
1.64HisSer: 1.64 ± 0.654
0.631HisThr: 0.631 ± 0.26
1.009HisVal: 1.009 ± 0.236
0.126HisTrp: 0.126 ± 0.099
0.631HisTyr: 0.631 ± 0.217
0.0HisXaa: 0.0 ± 0.0
Ile
4.29IleAla: 4.29 ± 0.967
1.136IleCys: 1.136 ± 0.285
4.921IleAsp: 4.921 ± 0.519
3.785IleGlu: 3.785 ± 0.542
2.65IlePhe: 2.65 ± 0.504
4.164IleGly: 4.164 ± 0.746
1.262IleHis: 1.262 ± 0.497
5.173IleIle: 5.173 ± 0.856
4.542IleLys: 4.542 ± 0.405
5.173IleLeu: 5.173 ± 0.675
1.388IleMet: 1.388 ± 0.281
5.173IleAsn: 5.173 ± 0.765
3.533IlePro: 3.533 ± 0.645
1.766IleGln: 1.766 ± 0.296
4.542IleArg: 4.542 ± 0.34
6.939IleSer: 6.939 ± 0.588
5.804IleThr: 5.804 ± 1.138
3.154IleVal: 3.154 ± 0.576
0.505IleTrp: 0.505 ± 0.231
2.776IleTyr: 2.776 ± 0.797
0.0IleXaa: 0.0 ± 0.0
Lys
2.902LysAla: 2.902 ± 0.377
0.883LysCys: 0.883 ± 0.335
4.416LysAsp: 4.416 ± 0.674
2.271LysGlu: 2.271 ± 0.573
2.019LysPhe: 2.019 ± 0.488
1.514LysGly: 1.514 ± 0.455
1.64LysHis: 1.64 ± 0.407
4.542LysIle: 4.542 ± 0.711
3.533LysLys: 3.533 ± 0.673
5.551LysLeu: 5.551 ± 0.742
1.893LysMet: 1.893 ± 0.464
3.154LysAsn: 3.154 ± 0.75
3.154LysPro: 3.154 ± 0.738
1.64LysGln: 1.64 ± 0.453
2.271LysArg: 2.271 ± 0.525
5.93LysSer: 5.93 ± 0.869
4.542LysThr: 4.542 ± 0.856
3.407LysVal: 3.407 ± 0.575
0.631LysTrp: 0.631 ± 0.355
2.65LysTyr: 2.65 ± 0.733
0.0LysXaa: 0.0 ± 0.0
Leu
7.444LeuAla: 7.444 ± 0.548
0.883LeuCys: 0.883 ± 0.469
5.678LeuAsp: 5.678 ± 0.854
3.659LeuGlu: 3.659 ± 0.358
3.28LeuPhe: 3.28 ± 0.398
3.407LeuGly: 3.407 ± 0.498
2.523LeuHis: 2.523 ± 0.59
5.047LeuIle: 5.047 ± 0.775
5.173LeuLys: 5.173 ± 0.973
9.084LeuLeu: 9.084 ± 1.111
2.523LeuMet: 2.523 ± 0.502
5.678LeuAsn: 5.678 ± 0.525
5.173LeuPro: 5.173 ± 0.759
3.154LeuGln: 3.154 ± 0.517
4.164LeuArg: 4.164 ± 0.594
8.706LeuSer: 8.706 ± 0.706
6.813LeuThr: 6.813 ± 0.895
3.785LeuVal: 3.785 ± 0.668
1.009LeuTrp: 1.009 ± 0.322
3.533LeuTyr: 3.533 ± 0.466
0.0LeuXaa: 0.0 ± 0.0
Met
1.009MetAla: 1.009 ± 0.338
0.252MetCys: 0.252 ± 0.197
1.766MetAsp: 1.766 ± 0.267
1.766MetGlu: 1.766 ± 0.485
1.009MetPhe: 1.009 ± 0.218
0.883MetGly: 0.883 ± 0.352
1.009MetHis: 1.009 ± 0.311
1.766MetIle: 1.766 ± 0.303
1.766MetLys: 1.766 ± 0.501
3.028MetLeu: 3.028 ± 0.511
1.136MetMet: 1.136 ± 0.332
0.883MetAsn: 0.883 ± 0.218
0.883MetPro: 0.883 ± 0.406
1.136MetGln: 1.136 ± 0.51
1.388MetArg: 1.388 ± 0.326
3.533MetSer: 3.533 ± 0.81
1.893MetThr: 1.893 ± 0.383
1.893MetVal: 1.893 ± 0.575
0.505MetTrp: 0.505 ± 0.194
0.631MetTyr: 0.631 ± 0.288
0.0MetXaa: 0.0 ± 0.0
Asn
4.542AsnAla: 4.542 ± 0.632
0.631AsnCys: 0.631 ± 0.254
4.29AsnAsp: 4.29 ± 0.676
2.271AsnGlu: 2.271 ± 0.507
2.145AsnPhe: 2.145 ± 0.516
3.154AsnGly: 3.154 ± 0.569
0.757AsnHis: 0.757 ± 0.264
3.659AsnIle: 3.659 ± 0.445
3.785AsnLys: 3.785 ± 0.656
6.056AsnLeu: 6.056 ± 0.732
1.009AsnMet: 1.009 ± 0.36
2.902AsnAsn: 2.902 ± 0.429
2.145AsnPro: 2.145 ± 0.563
1.64AsnGln: 1.64 ± 0.4
1.766AsnArg: 1.766 ± 0.31
3.533AsnSer: 3.533 ± 0.916
3.533AsnThr: 3.533 ± 0.853
5.047AsnVal: 5.047 ± 0.586
0.252AsnTrp: 0.252 ± 0.166
3.28AsnTyr: 3.28 ± 0.574
0.0AsnXaa: 0.0 ± 0.0
Pro
2.271ProAla: 2.271 ± 0.294
0.126ProCys: 0.126 ± 0.124
1.388ProAsp: 1.388 ± 0.3
1.64ProGlu: 1.64 ± 0.507
1.009ProPhe: 1.009 ± 0.426
1.893ProGly: 1.893 ± 0.355
1.262ProHis: 1.262 ± 0.466
3.911ProIle: 3.911 ± 0.646
3.407ProLys: 3.407 ± 0.629
3.154ProLeu: 3.154 ± 0.552
1.262ProMet: 1.262 ± 0.461
2.271ProAsn: 2.271 ± 0.567
2.145ProPro: 2.145 ± 0.423
1.009ProGln: 1.009 ± 0.267
1.514ProArg: 1.514 ± 0.363
3.659ProSer: 3.659 ± 0.511
3.785ProThr: 3.785 ± 0.454
3.659ProVal: 3.659 ± 0.794
0.379ProTrp: 0.379 ± 0.292
1.388ProTyr: 1.388 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
2.902GlnAla: 2.902 ± 0.583
0.379GlnCys: 0.379 ± 0.181
1.009GlnAsp: 1.009 ± 0.316
1.009GlnGlu: 1.009 ± 0.343
0.757GlnPhe: 0.757 ± 0.245
1.766GlnGly: 1.766 ± 0.408
0.126GlnHis: 0.126 ± 0.111
2.271GlnIle: 2.271 ± 0.574
1.64GlnLys: 1.64 ± 0.481
3.407GlnLeu: 3.407 ± 0.571
0.883GlnMet: 0.883 ± 0.403
3.028GlnAsn: 3.028 ± 0.554
1.388GlnPro: 1.388 ± 0.331
0.757GlnGln: 0.757 ± 0.248
1.136GlnArg: 1.136 ± 0.339
3.533GlnSer: 3.533 ± 0.463
1.514GlnThr: 1.514 ± 0.319
2.271GlnVal: 2.271 ± 0.422
0.252GlnTrp: 0.252 ± 0.15
1.388GlnTyr: 1.388 ± 0.401
0.0GlnXaa: 0.0 ± 0.0
Arg
2.65ArgAla: 2.65 ± 0.647
0.505ArgCys: 0.505 ± 0.285
2.776ArgAsp: 2.776 ± 0.561
1.514ArgGlu: 1.514 ± 0.345
2.145ArgPhe: 2.145 ± 0.414
2.145ArgGly: 2.145 ± 0.441
0.379ArgHis: 0.379 ± 0.184
2.397ArgIle: 2.397 ± 0.467
2.145ArgLys: 2.145 ± 0.51
4.416ArgLeu: 4.416 ± 1.031
1.262ArgMet: 1.262 ± 0.393
3.407ArgAsn: 3.407 ± 0.69
1.009ArgPro: 1.009 ± 0.335
1.136ArgGln: 1.136 ± 0.46
1.514ArgArg: 1.514 ± 0.41
3.785ArgSer: 3.785 ± 0.554
2.271ArgThr: 2.271 ± 0.44
4.037ArgVal: 4.037 ± 0.707
0.126ArgTrp: 0.126 ± 0.104
2.271ArgTyr: 2.271 ± 0.525
0.0ArgXaa: 0.0 ± 0.0
Ser
5.93SerAla: 5.93 ± 0.831
0.505SerCys: 0.505 ± 0.258
6.182SerAsp: 6.182 ± 0.656
5.551SerGlu: 5.551 ± 1.181
3.533SerPhe: 3.533 ± 0.551
5.173SerGly: 5.173 ± 0.789
2.145SerHis: 2.145 ± 0.646
7.444SerIle: 7.444 ± 0.779
5.93SerLys: 5.93 ± 0.897
8.201SerLeu: 8.201 ± 0.709
1.893SerMet: 1.893 ± 0.435
4.542SerAsn: 4.542 ± 0.407
2.019SerPro: 2.019 ± 0.453
2.397SerGln: 2.397 ± 0.772
4.164SerArg: 4.164 ± 0.864
11.103SerSer: 11.103 ± 1.847
7.57SerThr: 7.57 ± 0.817
6.056SerVal: 6.056 ± 0.66
0.379SerTrp: 0.379 ± 0.229
3.911SerTyr: 3.911 ± 0.872
0.0SerXaa: 0.0 ± 0.0
Thr
4.542ThrAla: 4.542 ± 0.726
0.379ThrCys: 0.379 ± 0.289
3.911ThrAsp: 3.911 ± 0.807
4.164ThrGlu: 4.164 ± 0.605
3.407ThrPhe: 3.407 ± 0.674
4.037ThrGly: 4.037 ± 0.579
1.009ThrHis: 1.009 ± 0.251
4.921ThrIle: 4.921 ± 0.836
3.533ThrLys: 3.533 ± 0.543
5.678ThrLeu: 5.678 ± 1.158
2.019ThrMet: 2.019 ± 0.472
4.29ThrAsn: 4.29 ± 1.016
3.533ThrPro: 3.533 ± 0.472
2.145ThrGln: 2.145 ± 0.755
2.776ThrArg: 2.776 ± 0.603
5.678ThrSer: 5.678 ± 0.644
6.056ThrThr: 6.056 ± 0.882
4.668ThrVal: 4.668 ± 0.41
0.505ThrTrp: 0.505 ± 0.217
3.154ThrTyr: 3.154 ± 0.619
0.0ThrXaa: 0.0 ± 0.0
Val
4.921ValAla: 4.921 ± 0.678
1.009ValCys: 1.009 ± 0.248
2.523ValAsp: 2.523 ± 0.488
4.037ValGlu: 4.037 ± 0.763
3.533ValPhe: 3.533 ± 0.452
3.028ValGly: 3.028 ± 0.609
0.757ValHis: 0.757 ± 0.205
4.794ValIle: 4.794 ± 0.506
4.29ValLys: 4.29 ± 0.597
5.93ValLeu: 5.93 ± 0.699
2.145ValMet: 2.145 ± 0.382
4.416ValAsn: 4.416 ± 1.028
3.154ValPro: 3.154 ± 1.074
2.271ValGln: 2.271 ± 0.409
2.271ValArg: 2.271 ± 0.248
6.561ValSer: 6.561 ± 0.68
4.542ValThr: 4.542 ± 0.519
5.047ValVal: 5.047 ± 0.806
0.126ValTrp: 0.126 ± 0.11
2.902ValTyr: 2.902 ± 0.583
0.0ValXaa: 0.0 ± 0.0
Trp
0.757TrpAla: 0.757 ± 0.371
0.252TrpCys: 0.252 ± 0.144
0.631TrpAsp: 0.631 ± 0.18
0.379TrpGlu: 0.379 ± 0.157
0.505TrpPhe: 0.505 ± 0.241
0.126TrpGly: 0.126 ± 0.117
0.252TrpHis: 0.252 ± 0.22
0.631TrpIle: 0.631 ± 0.326
0.379TrpLys: 0.379 ± 0.18
0.757TrpLeu: 0.757 ± 0.225
0.379TrpMet: 0.379 ± 0.171
0.631TrpAsn: 0.631 ± 0.247
0.126TrpPro: 0.126 ± 0.12
0.252TrpGln: 0.252 ± 0.146
0.379TrpArg: 0.379 ± 0.237
0.505TrpSer: 0.505 ± 0.216
0.126TrpThr: 0.126 ± 0.11
0.505TrpVal: 0.505 ± 0.183
0.126TrpTrp: 0.126 ± 0.099
0.505TrpTyr: 0.505 ± 0.251
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.037TyrAla: 4.037 ± 0.963
1.136TyrCys: 1.136 ± 0.362
2.271TyrAsp: 2.271 ± 0.5
1.766TyrGlu: 1.766 ± 0.394
2.65TyrPhe: 2.65 ± 0.588
2.019TyrGly: 2.019 ± 0.427
0.631TyrHis: 0.631 ± 0.243
2.902TyrIle: 2.902 ± 0.524
2.145TyrLys: 2.145 ± 0.728
2.523TyrLeu: 2.523 ± 0.516
1.64TyrMet: 1.64 ± 0.511
2.523TyrAsn: 2.523 ± 0.404
1.64TyrPro: 1.64 ± 0.338
1.136TyrGln: 1.136 ± 0.304
1.262TyrArg: 1.262 ± 0.326
3.407TyrSer: 3.407 ± 0.641
3.154TyrThr: 3.154 ± 0.819
2.397TyrVal: 2.397 ± 0.434
0.0TyrTrp: 0.0 ± 0.0
1.893TyrTyr: 1.893 ± 0.492
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (7927 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski