Amino acid dipepetide frequency for Clematis chlorotic mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.114AlaAla: 8.114 ± 3.42
2.705AlaCys: 2.705 ± 1.176
3.381AlaAsp: 3.381 ± 1.444
2.028AlaGlu: 2.028 ± 1.222
5.409AlaPhe: 5.409 ± 1.858
4.733AlaGly: 4.733 ± 3.297
3.381AlaHis: 3.381 ± 1.742
2.705AlaIle: 2.705 ± 1.176
4.733AlaLys: 4.733 ± 0.887
3.381AlaLeu: 3.381 ± 0.562
0.676AlaMet: 0.676 ± 0.755
3.381AlaAsn: 3.381 ± 0.827
2.028AlaPro: 2.028 ± 0.631
2.028AlaGln: 2.028 ± 0.626
6.085AlaArg: 6.085 ± 1.598
5.409AlaSer: 5.409 ± 1.914
2.705AlaThr: 2.705 ± 1.14
4.733AlaVal: 4.733 ± 1.252
1.352AlaTrp: 1.352 ± 0.789
1.352AlaTyr: 1.352 ± 0.814
0.0AlaXaa: 0.0 ± 0.0
Cys
4.057CysAla: 4.057 ± 1.142
0.676CysCys: 0.676 ± 0.407
0.0CysAsp: 0.0 ± 0.0
2.705CysGlu: 2.705 ± 1.176
1.352CysPhe: 1.352 ± 0.814
2.028CysGly: 2.028 ± 0.626
0.0CysHis: 0.0 ± 0.0
2.028CysIle: 2.028 ± 1.222
0.0CysLys: 0.0 ± 0.0
1.352CysLeu: 1.352 ± 0.814
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.352CysPro: 1.352 ± 0.814
1.352CysGln: 1.352 ± 0.564
0.0CysArg: 0.0 ± 0.0
1.352CysSer: 1.352 ± 1.51
2.028CysThr: 2.028 ± 0.626
4.733CysVal: 4.733 ± 1.158
0.0CysTrp: 0.0 ± 0.0
0.676CysTyr: 0.676 ± 0.407
0.0CysXaa: 0.0 ± 0.0
Asp
2.028AspAla: 2.028 ± 0.631
2.705AspCys: 2.705 ± 2.011
4.733AspAsp: 4.733 ± 0.996
4.057AspGlu: 4.057 ± 2.368
1.352AspPhe: 1.352 ± 1.208
4.057AspGly: 4.057 ± 1.317
2.028AspHis: 2.028 ± 0.626
1.352AspIle: 1.352 ± 0.789
2.705AspLys: 2.705 ± 2.452
4.057AspLeu: 4.057 ± 1.748
1.352AspMet: 1.352 ± 0.814
1.352AspAsn: 1.352 ± 0.789
4.057AspPro: 4.057 ± 0.624
3.381AspGln: 3.381 ± 1.503
1.352AspArg: 1.352 ± 0.814
4.733AspSer: 4.733 ± 2.367
4.057AspThr: 4.057 ± 0.678
2.028AspVal: 2.028 ± 0.982
0.676AspTrp: 0.676 ± 0.755
0.676AspTyr: 0.676 ± 0.407
0.0AspXaa: 0.0 ± 0.0
Glu
3.381GluAla: 3.381 ± 1.66
2.705GluCys: 2.705 ± 0.433
3.381GluAsp: 3.381 ± 1.66
7.437GluGlu: 7.437 ± 3.47
2.705GluPhe: 2.705 ± 0.9
3.381GluGly: 3.381 ± 0.824
1.352GluHis: 1.352 ± 0.814
0.0GluIle: 0.0 ± 0.0
4.733GluLys: 4.733 ± 0.887
9.466GluLeu: 9.466 ± 2.662
0.676GluMet: 0.676 ± 0.407
1.352GluAsn: 1.352 ± 0.789
2.028GluPro: 2.028 ± 1.269
0.0GluGln: 0.0 ± 0.0
3.381GluArg: 3.381 ± 1.126
0.676GluSer: 0.676 ± 0.919
2.028GluThr: 2.028 ± 1.222
4.733GluVal: 4.733 ± 1.942
1.352GluTrp: 1.352 ± 0.814
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.352PheAla: 1.352 ± 0.789
2.028PheCys: 2.028 ± 0.915
1.352PheAsp: 1.352 ± 0.814
4.057PheGlu: 4.057 ± 1.262
1.352PhePhe: 1.352 ± 0.918
3.381PheGly: 3.381 ± 1.262
0.676PheHis: 0.676 ± 0.407
2.028PheIle: 2.028 ± 1.748
0.0PheLys: 0.0 ± 0.0
6.085PheLeu: 6.085 ± 2.179
0.676PheMet: 0.676 ± 0.847
2.705PheAsn: 2.705 ± 1.629
2.028PhePro: 2.028 ± 0.626
3.381PheGln: 3.381 ± 0.562
2.028PheArg: 2.028 ± 1.009
2.028PheSer: 2.028 ± 1.927
6.761PheThr: 6.761 ± 1.165
3.381PheVal: 3.381 ± 1.66
0.0PheTrp: 0.0 ± 0.0
0.676PheTyr: 0.676 ± 0.407
0.0PheXaa: 0.0 ± 0.0
Gly
2.028GlyAla: 2.028 ± 0.982
2.028GlyCys: 2.028 ± 1.222
5.409GlyAsp: 5.409 ± 1.77
2.705GlyGlu: 2.705 ± 1.063
2.028GlyPhe: 2.028 ± 0.631
4.733GlyGly: 4.733 ± 0.773
0.0GlyHis: 0.0 ± 0.0
4.057GlyIle: 4.057 ± 0.881
4.733GlyLys: 4.733 ± 0.829
7.437GlyLeu: 7.437 ± 1.604
3.381GlyMet: 3.381 ± 0.646
5.409GlyAsn: 5.409 ± 2.55
2.028GlyPro: 2.028 ± 1.269
1.352GlyGln: 1.352 ± 0.918
1.352GlyArg: 1.352 ± 0.814
4.057GlySer: 4.057 ± 1.105
0.0GlyThr: 0.0 ± 0.0
4.733GlyVal: 4.733 ± 1.248
0.676GlyTrp: 0.676 ± 0.407
2.028GlyTyr: 2.028 ± 0.631
0.0GlyXaa: 0.0 ± 0.0
His
2.028HisAla: 2.028 ± 0.631
0.0HisCys: 0.0 ± 0.0
1.352HisAsp: 1.352 ± 1.208
0.676HisGlu: 0.676 ± 0.755
2.705HisPhe: 2.705 ± 1.135
0.676HisGly: 0.676 ± 0.407
2.028HisHis: 2.028 ± 0.915
2.705HisIle: 2.705 ± 1.176
0.0HisLys: 0.0 ± 0.0
2.705HisLeu: 2.705 ± 0.896
0.676HisMet: 0.676 ± 0.407
1.352HisAsn: 1.352 ± 0.876
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.352HisArg: 1.352 ± 0.814
4.733HisSer: 4.733 ± 1.318
2.705HisThr: 2.705 ± 1.578
2.705HisVal: 2.705 ± 0.433
0.676HisTrp: 0.676 ± 0.407
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.381IleAla: 3.381 ± 0.985
1.352IleCys: 1.352 ± 0.789
1.352IleAsp: 1.352 ± 0.564
0.676IleGlu: 0.676 ± 0.407
1.352IlePhe: 1.352 ± 0.918
2.028IleGly: 2.028 ± 0.631
1.352IleHis: 1.352 ± 1.51
2.705IleIle: 2.705 ± 1.176
2.705IleLys: 2.705 ± 1.941
4.733IleLeu: 4.733 ± 0.773
0.0IleMet: 0.0 ± 0.0
0.0IleAsn: 0.0 ± 0.0
6.761IlePro: 6.761 ± 2.108
2.705IleGln: 2.705 ± 1.176
0.676IleArg: 0.676 ± 0.407
4.733IleSer: 4.733 ± 1.659
4.057IleThr: 4.057 ± 0.755
2.028IleVal: 2.028 ± 2.236
0.676IleTrp: 0.676 ± 1.0
2.705IleTyr: 2.705 ± 1.128
0.0IleXaa: 0.0 ± 0.0
Lys
3.381LysAla: 3.381 ± 1.66
2.028LysCys: 2.028 ± 0.915
3.381LysAsp: 3.381 ± 1.126
3.381LysGlu: 3.381 ± 0.562
3.381LysPhe: 3.381 ± 1.312
4.733LysGly: 4.733 ± 1.252
2.028LysHis: 2.028 ± 0.626
3.381LysIle: 3.381 ± 0.562
4.733LysLys: 4.733 ± 1.846
4.057LysLeu: 4.057 ± 1.7
1.352LysMet: 1.352 ± 0.749
1.352LysAsn: 1.352 ± 1.208
2.028LysPro: 2.028 ± 1.222
1.352LysGln: 1.352 ± 1.51
3.381LysArg: 3.381 ± 1.702
2.028LysSer: 2.028 ± 1.793
2.705LysThr: 2.705 ± 1.817
4.057LysVal: 4.057 ± 1.237
1.352LysTrp: 1.352 ± 0.814
4.733LysTyr: 4.733 ± 0.866
0.676LysXaa: 0.676 ± 0.407
Leu
8.79LeuAla: 8.79 ± 1.32
4.057LeuCys: 4.057 ± 1.605
5.409LeuAsp: 5.409 ± 2.126
5.409LeuGlu: 5.409 ± 1.41
3.381LeuPhe: 3.381 ± 0.824
4.733LeuGly: 4.733 ± 1.665
1.352LeuHis: 1.352 ± 0.876
4.057LeuIle: 4.057 ± 1.819
4.057LeuLys: 4.057 ± 0.881
8.114LeuLeu: 8.114 ± 1.578
2.705LeuMet: 2.705 ± 1.128
5.409LeuAsn: 5.409 ± 1.858
0.0LeuPro: 0.0 ± 0.0
2.028LeuGln: 2.028 ± 1.269
5.409LeuArg: 5.409 ± 0.898
8.114LeuSer: 8.114 ± 1.357
4.733LeuThr: 4.733 ± 2.701
8.79LeuVal: 8.79 ± 1.221
1.352LeuTrp: 1.352 ± 0.918
3.381LeuTyr: 3.381 ± 0.562
0.0LeuXaa: 0.0 ± 0.0
Met
2.705MetAla: 2.705 ± 1.14
0.0MetCys: 0.0 ± 0.0
0.676MetAsp: 0.676 ± 0.919
1.352MetGlu: 1.352 ± 0.564
0.0MetPhe: 0.0 ± 0.0
2.705MetGly: 2.705 ± 1.235
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
3.381MetLys: 3.381 ± 0.562
2.705MetLeu: 2.705 ± 0.433
2.028MetMet: 2.028 ± 0.627
0.676MetAsn: 0.676 ± 0.407
1.352MetPro: 1.352 ± 0.789
2.705MetGln: 2.705 ± 1.176
2.028MetArg: 2.028 ± 0.631
0.676MetSer: 0.676 ± 0.407
1.352MetThr: 1.352 ± 1.51
1.352MetVal: 1.352 ± 0.564
0.0MetTrp: 0.0 ± 0.0
2.028MetTyr: 2.028 ± 0.915
0.0MetXaa: 0.0 ± 0.0
Asn
4.057AsnAla: 4.057 ± 0.624
0.676AsnCys: 0.676 ± 0.755
0.0AsnAsp: 0.0 ± 0.0
3.381AsnGlu: 3.381 ± 0.562
2.028AsnPhe: 2.028 ± 1.351
2.705AsnGly: 2.705 ± 1.176
0.676AsnHis: 0.676 ± 0.755
0.676AsnIle: 0.676 ± 0.407
3.381AsnLys: 3.381 ± 1.312
1.352AsnLeu: 1.352 ± 0.918
0.676AsnMet: 0.676 ± 0.403
2.705AsnAsn: 2.705 ± 1.176
4.733AsnPro: 4.733 ± 0.773
0.0AsnGln: 0.0 ± 0.0
2.028AsnArg: 2.028 ± 0.915
4.733AsnSer: 4.733 ± 2.092
1.352AsnThr: 1.352 ± 0.876
3.381AsnVal: 3.381 ± 0.827
0.676AsnTrp: 0.676 ± 0.407
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
3.381ProAla: 3.381 ± 1.503
1.352ProCys: 1.352 ± 0.814
4.057ProAsp: 4.057 ± 1.83
0.676ProGlu: 0.676 ± 0.407
2.705ProPhe: 2.705 ± 1.176
3.381ProGly: 3.381 ± 1.814
0.676ProHis: 0.676 ± 0.755
3.381ProIle: 3.381 ± 1.814
1.352ProLys: 1.352 ± 1.51
4.057ProLeu: 4.057 ± 1.83
0.676ProMet: 0.676 ± 0.755
0.676ProAsn: 0.676 ± 1.0
2.705ProPro: 2.705 ± 0.985
1.352ProGln: 1.352 ± 0.564
4.733ProArg: 4.733 ± 2.008
3.381ProSer: 3.381 ± 1.208
5.409ProThr: 5.409 ± 1.838
3.381ProVal: 3.381 ± 0.562
0.676ProTrp: 0.676 ± 0.755
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.705GlnAla: 2.705 ± 0.433
2.028GlnCys: 2.028 ± 0.631
1.352GlnAsp: 1.352 ± 0.918
1.352GlnGlu: 1.352 ± 0.564
2.028GlnPhe: 2.028 ± 0.626
0.676GlnGly: 0.676 ± 0.755
1.352GlnHis: 1.352 ± 0.814
2.028GlnIle: 2.028 ± 1.222
3.381GlnLys: 3.381 ± 1.126
3.381GlnLeu: 3.381 ± 0.809
0.676GlnMet: 0.676 ± 0.407
0.0GlnAsn: 0.0 ± 0.0
3.381GlnPro: 3.381 ± 1.503
2.705GlnGln: 2.705 ± 1.176
0.0GlnArg: 0.0 ± 0.0
2.028GlnSer: 2.028 ± 1.748
2.705GlnThr: 2.705 ± 1.14
0.676GlnVal: 0.676 ± 0.755
0.0GlnTrp: 0.0 ± 0.0
2.028GlnTyr: 2.028 ± 0.626
0.0GlnXaa: 0.0 ± 0.0
Arg
6.085ArgAla: 6.085 ± 2.707
0.676ArgCys: 0.676 ± 0.755
4.733ArgAsp: 4.733 ± 1.252
2.705ArgGlu: 2.705 ± 0.9
4.057ArgPhe: 4.057 ± 0.624
4.733ArgGly: 4.733 ± 1.518
2.705ArgHis: 2.705 ± 1.629
0.676ArgIle: 0.676 ± 0.755
2.705ArgLys: 2.705 ± 1.135
4.733ArgLeu: 4.733 ± 1.665
4.057ArgMet: 4.057 ± 1.142
1.352ArgAsn: 1.352 ± 0.564
1.352ArgPro: 1.352 ± 0.918
0.676ArgGln: 0.676 ± 0.407
6.085ArgArg: 6.085 ± 0.918
4.733ArgSer: 4.733 ± 1.158
2.705ArgThr: 2.705 ± 2.011
7.437ArgVal: 7.437 ± 3.237
0.676ArgTrp: 0.676 ± 0.407
2.028ArgTyr: 2.028 ± 0.631
0.0ArgXaa: 0.0 ± 0.0
Ser
3.381SerAla: 3.381 ± 1.444
0.0SerCys: 0.0 ± 0.0
4.057SerAsp: 4.057 ± 1.167
2.028SerGlu: 2.028 ± 0.626
4.057SerPhe: 4.057 ± 1.251
3.381SerGly: 3.381 ± 1.436
2.705SerHis: 2.705 ± 1.326
3.381SerIle: 3.381 ± 0.809
4.057SerLys: 4.057 ± 0.624
8.114SerLeu: 8.114 ± 3.371
2.028SerMet: 2.028 ± 0.631
3.381SerAsn: 3.381 ± 1.947
3.381SerPro: 3.381 ± 1.814
4.057SerGln: 4.057 ± 2.698
7.437SerArg: 7.437 ± 1.365
6.085SerSer: 6.085 ± 3.748
2.028SerThr: 2.028 ± 1.009
8.114SerVal: 8.114 ± 2.677
1.352SerTrp: 1.352 ± 0.789
2.028SerTyr: 2.028 ± 1.009
0.0SerXaa: 0.0 ± 0.0
Thr
5.409ThrAla: 5.409 ± 1.117
0.676ThrCys: 0.676 ± 0.407
2.705ThrAsp: 2.705 ± 1.14
2.705ThrGlu: 2.705 ± 1.135
2.028ThrPhe: 2.028 ± 1.269
0.0ThrGly: 0.0 ± 0.0
2.028ThrHis: 2.028 ± 0.915
4.733ThrIle: 4.733 ± 2.092
6.761ThrLys: 6.761 ± 1.763
3.381ThrLeu: 3.381 ± 0.809
0.676ThrMet: 0.676 ± 0.755
0.676ThrAsn: 0.676 ± 0.919
4.733ThrPro: 4.733 ± 0.996
2.705ThrGln: 2.705 ± 0.433
4.733ThrArg: 4.733 ± 0.996
5.409ThrSer: 5.409 ± 1.476
4.733ThrThr: 4.733 ± 2.643
4.733ThrVal: 4.733 ± 1.765
0.0ThrTrp: 0.0 ± 0.0
0.676ThrTyr: 0.676 ± 1.0
0.0ThrXaa: 0.0 ± 0.0
Val
1.352ValAla: 1.352 ± 0.876
0.0ValCys: 0.0 ± 0.0
5.409ValAsp: 5.409 ± 0.898
5.409ValGlu: 5.409 ± 2.022
3.381ValPhe: 3.381 ± 1.145
5.409ValGly: 5.409 ± 3.101
4.057ValHis: 4.057 ± 1.213
4.057ValIle: 4.057 ± 1.142
5.409ValLys: 5.409 ± 1.176
8.114ValLeu: 8.114 ± 1.835
2.028ValMet: 2.028 ± 0.915
5.409ValAsn: 5.409 ± 2.352
4.057ValPro: 4.057 ± 0.678
0.676ValGln: 0.676 ± 0.755
6.085ValArg: 6.085 ± 1.079
6.085ValSer: 6.085 ± 2.181
5.409ValThr: 5.409 ± 1.35
0.676ValVal: 0.676 ± 0.755
0.0ValTrp: 0.0 ± 0.0
1.352ValTyr: 1.352 ± 0.789
0.0ValXaa: 0.0 ± 0.0
Trp
2.028TrpAla: 2.028 ± 0.631
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.676TrpGlu: 0.676 ± 0.407
0.0TrpPhe: 0.0 ± 0.0
2.028TrpGly: 2.028 ± 1.222
0.0TrpHis: 0.0 ± 0.0
0.676TrpIle: 0.676 ± 0.407
0.0TrpLys: 0.0 ± 0.0
0.676TrpLeu: 0.676 ± 0.407
1.352TrpMet: 1.352 ± 0.789
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.676TrpArg: 0.676 ± 0.755
2.028TrpSer: 2.028 ± 1.876
0.0TrpThr: 0.0 ± 0.0
1.352TrpVal: 1.352 ± 0.789
1.352TrpTrp: 1.352 ± 0.789
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.676TyrAla: 0.676 ± 0.407
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
1.352TyrGlu: 1.352 ± 0.789
0.676TyrPhe: 0.676 ± 0.407
0.676TyrGly: 0.676 ± 0.755
0.676TyrHis: 0.676 ± 0.407
1.352TyrIle: 1.352 ± 2.0
0.676TyrLys: 0.676 ± 0.407
3.381TyrLeu: 3.381 ± 1.66
1.352TyrMet: 1.352 ± 0.564
2.028TyrAsn: 2.028 ± 1.101
0.0TyrPro: 0.0 ± 0.0
2.028TyrGln: 2.028 ± 0.631
6.085TyrArg: 6.085 ± 1.681
2.028TyrSer: 2.028 ± 1.269
2.028TyrThr: 2.028 ± 1.222
1.352TyrVal: 1.352 ± 0.564
0.0TyrTrp: 0.0 ± 0.0
1.352TyrTyr: 1.352 ± 0.564
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.676XaaGly: 0.676 ± 0.407
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski