Amino acid dipepetide frequency for Streptomyces sp. 3213.3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.891AlaAla: 19.891 ± 0.123	1.021AlaCys: 1.021 ± 0.017	8.187AlaAsp: 8.187 ± 0.061	8.308AlaGlu: 8.308 ± 0.066	3.465AlaPhe: 3.465 ± 0.037	12.252AlaGly: 12.252 ± 0.084	2.88AlaHis: 2.88 ± 0.034	3.595AlaIle: 3.595 ± 0.036	3.014AlaLys: 3.014 ± 0.045	14.161AlaLeu: 14.161 ± 0.096	2.373AlaMet: 2.373 ± 0.031	2.163AlaAsn: 2.163 ± 0.03	6.689AlaPro: 6.689 ± 0.064	3.883AlaGln: 3.883 ± 0.037	9.562AlaArg: 9.562 ± 0.078	6.266AlaSer: 6.266 ± 0.059	7.458AlaThr: 7.458 ± 0.06	12.153AlaVal: 12.153 ± 0.083	1.869AlaTrp: 1.869 ± 0.023	2.84AlaTyr: 2.84 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.059CysAla: 1.059 ± 0.02	0.097CysCys: 0.097 ± 0.007	0.456CysAsp: 0.456 ± 0.012	0.381CysGlu: 0.381 ± 0.013	0.215CysPhe: 0.215 ± 0.008	0.911CysGly: 0.911 ± 0.017	0.192CysHis: 0.192 ± 0.008	0.163CysIle: 0.163 ± 0.007	0.114CysLys: 0.114 ± 0.005	0.747CysLeu: 0.747 ± 0.017	0.115CysMet: 0.115 ± 0.005	0.148CysAsn: 0.148 ± 0.007	0.464CysPro: 0.464 ± 0.014	0.175CysGln: 0.175 ± 0.008	0.542CysArg: 0.542 ± 0.015	0.446CysSer: 0.446 ± 0.012	0.519CysThr: 0.519 ± 0.015	0.659CysVal: 0.659 ± 0.014	0.127CysTrp: 0.127 ± 0.005	0.169CysTyr: 0.169 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.395AspAla: 7.395 ± 0.057	0.427AspCys: 0.427 ± 0.012	3.584AspAsp: 3.584 ± 0.033	3.767AspGlu: 3.767 ± 0.044	1.709AspPhe: 1.709 ± 0.02	6.328AspGly: 6.328 ± 0.049	1.455AspHis: 1.455 ± 0.022	1.992AspIle: 1.992 ± 0.028	1.24AspLys: 1.24 ± 0.023	6.17AspLeu: 6.17 ± 0.047	0.828AspMet: 0.828 ± 0.014	1.099AspAsn: 1.099 ± 0.022	4.414AspPro: 4.414 ± 0.047	1.64AspGln: 1.64 ± 0.025	4.655AspArg: 4.655 ± 0.046	2.791AspSer: 2.791 ± 0.029	3.544AspThr: 3.544 ± 0.039	4.691AspVal: 4.691 ± 0.042	1.06AspTrp: 1.06 ± 0.02	1.21AspTyr: 1.21 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.81GluAla: 6.81 ± 0.064	0.348GluCys: 0.348 ± 0.012	2.693GluAsp: 2.693 ± 0.037	3.182GluGlu: 3.182 ± 0.046	1.527GluPhe: 1.527 ± 0.022	4.078GluGly: 4.078 ± 0.041	1.466GluHis: 1.466 ± 0.024	2.201GluIle: 2.201 ± 0.029	1.366GluLys: 1.366 ± 0.022	6.713GluLeu: 6.713 ± 0.057	0.821GluMet: 0.821 ± 0.016	1.059GluAsn: 1.059 ± 0.019	3.157GluPro: 3.157 ± 0.035	2.141GluGln: 2.141 ± 0.031	5.04GluArg: 5.04 ± 0.054	2.601GluSer: 2.601 ± 0.032	2.972GluThr: 2.972 ± 0.031	4.243GluVal: 4.243 ± 0.038	0.771GluTrp: 0.771 ± 0.016	1.118GluTyr: 1.118 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.71PheAla: 3.71 ± 0.036	0.248PheCys: 0.248 ± 0.009	1.996PheAsp: 1.996 ± 0.027	1.428PheGlu: 1.428 ± 0.027	0.878PhePhe: 0.878 ± 0.021	3.076PheGly: 3.076 ± 0.035	0.614PheHis: 0.614 ± 0.016	0.716PheIle: 0.716 ± 0.015	0.556PheLys: 0.556 ± 0.015	2.603PheLeu: 2.603 ± 0.034	0.417PheMet: 0.417 ± 0.013	0.605PheAsn: 0.605 ± 0.013	1.432PhePro: 1.432 ± 0.022	0.727PheGln: 0.727 ± 0.017	1.823PheArg: 1.823 ± 0.027	1.491PheSer: 1.491 ± 0.024	2.143PheThr: 2.143 ± 0.027	2.324PheVal: 2.324 ± 0.033	0.425PheTrp: 0.425 ± 0.014	0.618PheTyr: 0.618 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.669GlyAla: 10.669 ± 0.07	0.809GlyCys: 0.809 ± 0.017	5.074GlyAsp: 5.074 ± 0.042	4.788GlyGlu: 4.788 ± 0.044	2.909GlyPhe: 2.909 ± 0.034	8.609GlyGly: 8.609 ± 0.081	2.33GlyHis: 2.33 ± 0.028	3.587GlyIle: 3.587 ± 0.037	2.471GlyLys: 2.471 ± 0.035	9.286GlyLeu: 9.286 ± 0.056	1.933GlyMet: 1.933 ± 0.026	1.916GlyAsn: 1.916 ± 0.028	4.905GlyPro: 4.905 ± 0.05	2.726GlyGln: 2.726 ± 0.035	7.307GlyArg: 7.307 ± 0.058	5.664GlySer: 5.664 ± 0.062	6.788GlyThr: 6.788 ± 0.065	7.506GlyVal: 7.506 ± 0.058	1.742GlyTrp: 1.742 ± 0.025	2.351GlyTyr: 2.351 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.624HisAla: 2.624 ± 0.033	0.197HisCys: 0.197 ± 0.008	1.404HisAsp: 1.404 ± 0.021	1.191HisGlu: 1.191 ± 0.021	0.674HisPhe: 0.674 ± 0.015	2.395HisGly: 2.395 ± 0.026	0.717HisHis: 0.717 ± 0.018	0.726HisIle: 0.726 ± 0.015	0.38HisLys: 0.38 ± 0.011	2.398HisLeu: 2.398 ± 0.029	0.332HisMet: 0.332 ± 0.011	0.414HisAsn: 0.414 ± 0.011	1.835HisPro: 1.835 ± 0.024	0.65HisGln: 0.65 ± 0.016	2.044HisArg: 2.044 ± 0.028	1.082HisSer: 1.082 ± 0.02	1.444HisThr: 1.444 ± 0.025	1.68HisVal: 1.68 ± 0.025	0.382HisTrp: 0.382 ± 0.011	0.507HisTyr: 0.507 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.913IleAla: 4.913 ± 0.049	0.273IleCys: 0.273 ± 0.009	2.313IleAsp: 2.313 ± 0.028	1.875IleGlu: 1.875 ± 0.025	0.708IlePhe: 0.708 ± 0.017	3.597IleGly: 3.597 ± 0.04	0.653IleHis: 0.653 ± 0.015	0.878IleIle: 0.878 ± 0.021	0.762IleLys: 0.762 ± 0.015	2.516IleLeu: 2.516 ± 0.035	0.456IleMet: 0.456 ± 0.014	0.742IleAsn: 0.742 ± 0.017	1.877IlePro: 1.877 ± 0.027	0.79IleGln: 0.79 ± 0.018	2.252IleArg: 2.252 ± 0.028	1.786IleSer: 1.786 ± 0.025	2.395IleThr: 2.395 ± 0.03	2.848IleVal: 2.848 ± 0.035	0.401IleTrp: 0.401 ± 0.012	0.583IleTyr: 0.583 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.043LysAla: 3.043 ± 0.04	0.129LysCys: 0.129 ± 0.007	1.362LysAsp: 1.362 ± 0.026	1.151LysGlu: 1.151 ± 0.022	0.489LysPhe: 0.489 ± 0.011	1.918LysGly: 1.918 ± 0.029	0.461LysHis: 0.461 ± 0.011	0.911LysIle: 0.911 ± 0.019	0.92LysLys: 0.92 ± 0.027	2.077LysLeu: 2.077 ± 0.031	0.38LysMet: 0.38 ± 0.012	0.583LysAsn: 0.583 ± 0.014	1.374LysPro: 1.374 ± 0.024	0.761LysGln: 0.761 ± 0.019	1.426LysArg: 1.426 ± 0.022	1.357LysSer: 1.357 ± 0.024	1.437LysThr: 1.437 ± 0.026	2.033LysVal: 2.033 ± 0.03	0.311LysTrp: 0.311 ± 0.009	0.514LysTyr: 0.514 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.78LeuAla: 14.78 ± 0.102	0.816LeuCys: 0.816 ± 0.019	6.672LeuAsp: 6.672 ± 0.049	4.357LeuGlu: 4.357 ± 0.043	2.646LeuPhe: 2.646 ± 0.035	9.152LeuGly: 9.152 ± 0.062	2.304LeuHis: 2.304 ± 0.03	3.372LeuIle: 3.372 ± 0.041	2.215LeuLys: 2.215 ± 0.031	11.1LeuLeu: 11.1 ± 0.097	1.628LeuMet: 1.628 ± 0.026	1.829LeuAsn: 1.829 ± 0.03	6.399LeuPro: 6.399 ± 0.052	2.212LeuGln: 2.212 ± 0.026	8.384LeuArg: 8.384 ± 0.073	5.455LeuSer: 5.455 ± 0.043	7.275LeuThr: 7.275 ± 0.058	8.786LeuVal: 8.786 ± 0.065	1.346LeuTrp: 1.346 ± 0.025	1.933LeuTyr: 1.933 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.168MetAla: 2.168 ± 0.026	0.132MetCys: 0.132 ± 0.007	0.874MetAsp: 0.874 ± 0.019	0.716MetGlu: 0.716 ± 0.014	0.462MetPhe: 0.462 ± 0.013	1.306MetGly: 1.306 ± 0.021	0.351MetHis: 0.351 ± 0.01	0.654MetIle: 0.654 ± 0.017	0.419MetLys: 0.419 ± 0.012	1.621MetLeu: 1.621 ± 0.028	0.277MetMet: 0.277 ± 0.01	0.465MetAsn: 0.465 ± 0.012	1.082MetPro: 1.082 ± 0.018	0.446MetGln: 0.446 ± 0.012	1.338MetArg: 1.338 ± 0.023	1.366MetSer: 1.366 ± 0.022	1.627MetThr: 1.627 ± 0.024	1.258MetVal: 1.258 ± 0.02	0.213MetTrp: 0.213 ± 0.008	0.331MetTyr: 0.331 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.329AsnAla: 2.329 ± 0.027	0.179AsnCys: 0.179 ± 0.008	1.019AsnAsp: 1.019 ± 0.02	0.828AsnGlu: 0.828 ± 0.016	0.533AsnPhe: 0.533 ± 0.015	2.173AsnGly: 2.173 ± 0.036	0.439AsnHis: 0.439 ± 0.013	0.698AsnIle: 0.698 ± 0.015	0.459AsnLys: 0.459 ± 0.014	1.764AsnLeu: 1.764 ± 0.024	0.336AsnMet: 0.336 ± 0.01	0.517AsnAsn: 0.517 ± 0.015	1.464AsnPro: 1.464 ± 0.021	0.581AsnGln: 0.581 ± 0.014	1.334AsnArg: 1.334 ± 0.022	1.211AsnSer: 1.211 ± 0.026	1.334AsnThr: 1.334 ± 0.027	1.434AsnVal: 1.434 ± 0.024	0.346AsnTrp: 0.346 ± 0.01	0.474AsnTyr: 0.474 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.15ProAla: 8.15 ± 0.074	0.322ProCys: 0.322 ± 0.011	4.4ProAsp: 4.4 ± 0.041	4.178ProGlu: 4.178 ± 0.042	1.519ProPhe: 1.519 ± 0.025	6.204ProGly: 6.204 ± 0.053	1.368ProHis: 1.368 ± 0.02	1.368ProIle: 1.368 ± 0.02	1.292ProLys: 1.292 ± 0.023	5.349ProLeu: 5.349 ± 0.047	1.011ProMet: 1.011 ± 0.019	1.029ProAsn: 1.029 ± 0.022	3.4ProPro: 3.4 ± 0.056	1.808ProGln: 1.808 ± 0.029	3.699ProArg: 3.699 ± 0.038	3.35ProSer: 3.35 ± 0.038	3.539ProThr: 3.539 ± 0.044	5.395ProVal: 5.395 ± 0.047	0.885ProTrp: 0.885 ± 0.018	1.478ProTyr: 1.478 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.639GlnAla: 3.639 ± 0.032	0.188GlnCys: 0.188 ± 0.007	1.422GlnAsp: 1.422 ± 0.023	1.37GlnGlu: 1.37 ± 0.025	0.766GlnPhe: 0.766 ± 0.018	2.341GlnGly: 2.341 ± 0.028	0.705GlnHis: 0.705 ± 0.016	1.124GlnIle: 1.124 ± 0.021	0.641GlnLys: 0.641 ± 0.018	3.368GlnLeu: 3.368 ± 0.034	0.494GlnMet: 0.494 ± 0.012	0.568GlnAsn: 0.568 ± 0.015	1.753GlnPro: 1.753 ± 0.027	1.313GlnGln: 1.313 ± 0.033	2.307GlnArg: 2.307 ± 0.03	1.393GlnSer: 1.393 ± 0.021	1.484GlnThr: 1.484 ± 0.026	2.485GlnVal: 2.485 ± 0.028	0.497GlnTrp: 0.497 ± 0.013	0.663GlnTyr: 0.663 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.246ArgAla: 9.246 ± 0.066	0.547ArgCys: 0.547 ± 0.014	4.061ArgAsp: 4.061 ± 0.043	4.412ArgGlu: 4.412 ± 0.054	2.255ArgPhe: 2.255 ± 0.029	5.462ArgGly: 5.462 ± 0.045	2.051ArgHis: 2.051 ± 0.029	3.19ArgIle: 3.19 ± 0.028	1.618ArgLys: 1.618 ± 0.025	8.379ArgLeu: 8.379 ± 0.067	1.627ArgMet: 1.627 ± 0.026	1.342ArgAsn: 1.342 ± 0.022	4.693ArgPro: 4.693 ± 0.05	2.32ArgGln: 2.32 ± 0.028	7.245ArgArg: 7.245 ± 0.076	3.949ArgSer: 3.949 ± 0.037	5.365ArgThr: 5.365 ± 0.047	5.688ArgVal: 5.688 ± 0.048	1.329ArgTrp: 1.329 ± 0.021	1.737ArgTyr: 1.737 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	7.135SerAla: 7.135 ± 0.061	0.428SerCys: 0.428 ± 0.012	2.905SerAsp: 2.905 ± 0.033	2.444SerGlu: 2.444 ± 0.032	1.593SerPhe: 1.593 ± 0.023	6.233SerGly: 6.233 ± 0.064	1.06SerHis: 1.06 ± 0.017	1.542SerIle: 1.542 ± 0.025	1.167SerLys: 1.167 ± 0.023	5.058SerLeu: 5.058 ± 0.04	1.12SerMet: 1.12 ± 0.022	1.036SerAsn: 1.036 ± 0.022	3.25SerPro: 3.25 ± 0.039	1.356SerGln: 1.356 ± 0.021	3.628SerArg: 3.628 ± 0.032	3.366SerSer: 3.366 ± 0.046	3.604SerThr: 3.604 ± 0.046	4.497SerVal: 4.497 ± 0.044	1.012SerTrp: 1.012 ± 0.019	1.47SerTyr: 1.47 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.438ThrAla: 9.438 ± 0.071	0.456ThrCys: 0.456 ± 0.014	3.991ThrAsp: 3.991 ± 0.047	3.335ThrGlu: 3.335 ± 0.035	1.74ThrPhe: 1.74 ± 0.028	7.084ThrGly: 7.084 ± 0.061	1.305ThrHis: 1.305 ± 0.022	1.887ThrIle: 1.887 ± 0.03	1.356ThrLys: 1.356 ± 0.025	6.018ThrLeu: 6.018 ± 0.052	0.974ThrMet: 0.974 ± 0.02	1.205ThrAsn: 1.205 ± 0.021	4.447ThrPro: 4.447 ± 0.055	1.52ThrGln: 1.52 ± 0.026	3.929ThrArg: 3.929 ± 0.041	3.658ThrSer: 3.658 ± 0.044	4.511ThrThr: 4.511 ± 0.069	6.451ThrVal: 6.451 ± 0.055	1.021ThrTrp: 1.021 ± 0.019	1.574ThrTyr: 1.574 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	10.509ValAla: 10.509 ± 0.079	0.743ValCys: 0.743 ± 0.017	5.028ValAsp: 5.028 ± 0.041	4.64ValGlu: 4.64 ± 0.047	2.514ValPhe: 2.514 ± 0.031	6.635ValGly: 6.635 ± 0.051	1.932ValHis: 1.932 ± 0.025	2.882ValIle: 2.882 ± 0.033	1.816ValLys: 1.816 ± 0.029	9.379ValLeu: 9.379 ± 0.07	1.432ValMet: 1.432 ± 0.024	1.773ValAsn: 1.773 ± 0.024	5.174ValPro: 5.174 ± 0.045	2.195ValGln: 2.195 ± 0.024	6.933ValArg: 6.933 ± 0.05	4.522ValSer: 4.522 ± 0.039	5.94ValThr: 5.94 ± 0.054	7.975ValVal: 7.975 ± 0.07	1.191ValTrp: 1.191 ± 0.023	1.639ValTyr: 1.639 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.705TrpAla: 1.705 ± 0.025	0.145TrpCys: 0.145 ± 0.005	0.848TrpAsp: 0.848 ± 0.019	0.703TrpGlu: 0.703 ± 0.014	0.518TrpPhe: 0.518 ± 0.013	1.128TrpGly: 1.128 ± 0.02	0.397TrpHis: 0.397 ± 0.012	0.6TrpIle: 0.6 ± 0.014	0.387TrpLys: 0.387 ± 0.011	1.814TrpLeu: 1.814 ± 0.028	0.288TrpMet: 0.288 ± 0.01	0.462TrpAsn: 0.462 ± 0.013	0.822TrpPro: 0.822 ± 0.015	0.638TrpGln: 0.638 ± 0.014	1.293TrpArg: 1.293 ± 0.024	1.034TrpSer: 1.034 ± 0.021	1.166TrpThr: 1.166 ± 0.022	0.977TrpVal: 0.977 ± 0.02	0.346TrpTrp: 0.346 ± 0.011	0.389TrpTyr: 0.389 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.816TyrAla: 2.816 ± 0.031	0.194TyrCys: 0.194 ± 0.008	1.713TyrAsp: 1.713 ± 0.037	1.253TyrGlu: 1.253 ± 0.017	0.707TyrPhe: 0.707 ± 0.014	2.491TyrGly: 2.491 ± 0.032	0.392TyrHis: 0.392 ± 0.011	0.531TyrIle: 0.531 ± 0.012	0.447TyrLys: 0.447 ± 0.012	2.138TyrLeu: 2.138 ± 0.03	0.263TyrMet: 0.263 ± 0.01	0.496TyrAsn: 0.496 ± 0.016	1.113TyrPro: 1.113 ± 0.021	0.639TyrGln: 0.639 ± 0.015	1.774TyrArg: 1.774 ± 0.024	1.115TyrSer: 1.115 ± 0.023	1.355TyrThr: 1.355 ± 0.024	1.771TyrVal: 1.771 ± 0.028	0.387TyrTrp: 0.387 ± 0.012	0.514TyrTyr: 0.514 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9510 proteins (3163011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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