Amino acid dipepetide frequency for Streptomyces albireticuli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.144AlaAla: 23.144 ± 0.207	1.155AlaCys: 1.155 ± 0.023	8.467AlaAsp: 8.467 ± 0.068	9.152AlaGlu: 9.152 ± 0.1	3.719AlaPhe: 3.719 ± 0.048	14.751AlaGly: 14.751 ± 0.11	3.084AlaHis: 3.084 ± 0.036	2.928AlaIle: 2.928 ± 0.049	2.832AlaLys: 2.832 ± 0.059	15.264AlaLeu: 15.264 ± 0.124	2.536AlaMet: 2.536 ± 0.036	1.743AlaAsn: 1.743 ± 0.029	8.049AlaPro: 8.049 ± 0.094	3.351AlaGln: 3.351 ± 0.043	11.415AlaArg: 11.415 ± 0.094	5.658AlaSer: 5.658 ± 0.049	7.09AlaThr: 7.09 ± 0.055	12.936AlaVal: 12.936 ± 0.106	1.872AlaTrp: 1.872 ± 0.027	2.714AlaTyr: 2.714 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.246CysAla: 1.246 ± 0.024	0.092CysCys: 0.092 ± 0.007	0.523CysAsp: 0.523 ± 0.016	0.424CysGlu: 0.424 ± 0.015	0.226CysPhe: 0.226 ± 0.01	1.002CysGly: 1.002 ± 0.025	0.196CysHis: 0.196 ± 0.01	0.131CysIle: 0.131 ± 0.009	0.118CysLys: 0.118 ± 0.008	0.783CysLeu: 0.783 ± 0.022	0.131CysMet: 0.131 ± 0.008	0.119CysAsn: 0.119 ± 0.007	0.516CysPro: 0.516 ± 0.015	0.164CysGln: 0.164 ± 0.008	0.683CysArg: 0.683 ± 0.017	0.42CysSer: 0.42 ± 0.016	0.477CysThr: 0.477 ± 0.016	0.718CysVal: 0.718 ± 0.018	0.125CysTrp: 0.125 ± 0.008	0.156CysTyr: 0.156 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.963AspAla: 7.963 ± 0.069	0.426AspCys: 0.426 ± 0.014	3.353AspAsp: 3.353 ± 0.043	3.657AspGlu: 3.657 ± 0.044	1.617AspPhe: 1.617 ± 0.031	6.532AspGly: 6.532 ± 0.064	1.461AspHis: 1.461 ± 0.026	1.742AspIle: 1.742 ± 0.03	1.179AspLys: 1.179 ± 0.034	5.943AspLeu: 5.943 ± 0.055	0.752AspMet: 0.752 ± 0.019	0.803AspAsn: 0.803 ± 0.022	4.628AspPro: 4.628 ± 0.046	1.3AspGln: 1.3 ± 0.025	5.107AspArg: 5.107 ± 0.053	2.325AspSer: 2.325 ± 0.03	3.076AspThr: 3.076 ± 0.041	4.483AspVal: 4.483 ± 0.045	0.975AspTrp: 0.975 ± 0.022	1.051AspTyr: 1.051 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.806GluAla: 7.806 ± 0.081	0.396GluCys: 0.396 ± 0.013	2.833GluAsp: 2.833 ± 0.038	3.736GluGlu: 3.736 ± 0.052	1.457GluPhe: 1.457 ± 0.029	4.604GluGly: 4.604 ± 0.047	1.486GluHis: 1.486 ± 0.026	2.12GluIle: 2.12 ± 0.028	1.444GluLys: 1.444 ± 0.033	6.914GluLeu: 6.914 ± 0.06	0.823GluMet: 0.823 ± 0.02	0.964GluAsn: 0.964 ± 0.02	3.466GluPro: 3.466 ± 0.049	1.891GluGln: 1.891 ± 0.031	5.84GluArg: 5.84 ± 0.06	2.394GluSer: 2.394 ± 0.033	2.809GluThr: 2.809 ± 0.039	4.303GluVal: 4.303 ± 0.052	0.778GluTrp: 0.778 ± 0.022	0.991GluTyr: 0.991 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.817PheAla: 3.817 ± 0.044	0.281PheCys: 0.281 ± 0.012	1.954PheAsp: 1.954 ± 0.035	1.37PheGlu: 1.37 ± 0.022	0.892PhePhe: 0.892 ± 0.021	2.996PheGly: 2.996 ± 0.034	0.671PheHis: 0.671 ± 0.016	0.644PheIle: 0.644 ± 0.02	0.463PheLys: 0.463 ± 0.017	2.62PheLeu: 2.62 ± 0.033	0.397PheMet: 0.397 ± 0.015	0.497PheAsn: 0.497 ± 0.014	1.453PhePro: 1.453 ± 0.027	0.651PheGln: 0.651 ± 0.018	1.929PheArg: 1.929 ± 0.031	1.441PheSer: 1.441 ± 0.027	2.023PheThr: 2.023 ± 0.033	2.153PheVal: 2.153 ± 0.033	0.404PheTrp: 0.404 ± 0.014	0.551PheTyr: 0.551 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	12.243GlyAla: 12.243 ± 0.089	0.899GlyCys: 0.899 ± 0.024	5.285GlyAsp: 5.285 ± 0.058	5.325GlyGlu: 5.325 ± 0.048	2.905GlyPhe: 2.905 ± 0.041	9.699GlyGly: 9.699 ± 0.093	2.492GlyHis: 2.492 ± 0.035	3.22GlyIle: 3.22 ± 0.041	2.521GlyLys: 2.521 ± 0.046	9.925GlyLeu: 9.925 ± 0.074	2.075GlyMet: 2.075 ± 0.034	1.632GlyAsn: 1.632 ± 0.032	6.067GlyPro: 6.067 ± 0.063	2.541GlyGln: 2.541 ± 0.041	8.59GlyArg: 8.59 ± 0.068	5.236GlySer: 5.236 ± 0.056	6.75GlyThr: 6.75 ± 0.07	7.768GlyVal: 7.768 ± 0.076	1.675GlyTrp: 1.675 ± 0.03	2.17GlyTyr: 2.17 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.774HisAla: 2.774 ± 0.034	0.232HisCys: 0.232 ± 0.011	1.388HisAsp: 1.388 ± 0.026	1.196HisGlu: 1.196 ± 0.026	0.632HisPhe: 0.632 ± 0.018	2.513HisGly: 2.513 ± 0.037	0.731HisHis: 0.731 ± 0.018	0.628HisIle: 0.628 ± 0.017	0.352HisLys: 0.352 ± 0.014	2.55HisLeu: 2.55 ± 0.036	0.338HisMet: 0.338 ± 0.01	0.323HisAsn: 0.323 ± 0.013	1.893HisPro: 1.893 ± 0.032	0.619HisGln: 0.619 ± 0.017	2.179HisArg: 2.179 ± 0.034	1.036HisSer: 1.036 ± 0.025	1.351HisThr: 1.351 ± 0.026	1.676HisVal: 1.676 ± 0.03	0.37HisTrp: 0.37 ± 0.012	0.479HisTyr: 0.479 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.269IleAla: 4.269 ± 0.047	0.271IleCys: 0.271 ± 0.012	1.91IleAsp: 1.91 ± 0.03	1.745IleGlu: 1.745 ± 0.028	0.645IlePhe: 0.645 ± 0.018	3.282IleGly: 3.282 ± 0.042	0.555IleHis: 0.555 ± 0.018	0.71IleIle: 0.71 ± 0.022	0.675IleLys: 0.675 ± 0.02	2.109IleLeu: 2.109 ± 0.031	0.404IleMet: 0.404 ± 0.015	0.606IleAsn: 0.606 ± 0.017	1.587IlePro: 1.587 ± 0.029	0.618IleGln: 0.618 ± 0.017	2.057IleArg: 2.057 ± 0.034	1.534IleSer: 1.534 ± 0.026	1.911IleThr: 1.911 ± 0.031	2.42IleVal: 2.42 ± 0.038	0.343IleTrp: 0.343 ± 0.013	0.445IleTyr: 0.445 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.917LysAla: 2.917 ± 0.051	0.132LysCys: 0.132 ± 0.008	1.344LysAsp: 1.344 ± 0.036	1.19LysGlu: 1.19 ± 0.026	0.426LysPhe: 0.426 ± 0.016	1.903LysGly: 1.903 ± 0.039	0.405LysHis: 0.405 ± 0.012	0.792LysIle: 0.792 ± 0.021	0.823LysLys: 0.823 ± 0.034	1.928LysLeu: 1.928 ± 0.039	0.387LysMet: 0.387 ± 0.015	0.494LysAsn: 0.494 ± 0.017	1.334LysPro: 1.334 ± 0.032	0.613LysGln: 0.613 ± 0.019	1.453LysArg: 1.453 ± 0.025	1.099LysSer: 1.099 ± 0.026	1.139LysThr: 1.139 ± 0.029	1.797LysVal: 1.797 ± 0.037	0.256LysTrp: 0.256 ± 0.011	0.407LysTyr: 0.407 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.764LeuAla: 15.764 ± 0.116	0.898LeuCys: 0.898 ± 0.023	6.674LeuAsp: 6.674 ± 0.062	4.684LeuGlu: 4.684 ± 0.05	2.607LeuPhe: 2.607 ± 0.042	9.617LeuGly: 9.617 ± 0.09	2.356LeuHis: 2.356 ± 0.036	2.967LeuIle: 2.967 ± 0.049	1.898LeuLys: 1.898 ± 0.036	11.453LeuLeu: 11.453 ± 0.1	1.652LeuMet: 1.652 ± 0.028	1.509LeuAsn: 1.509 ± 0.027	6.764LeuPro: 6.764 ± 0.06	1.985LeuGln: 1.985 ± 0.028	9.176LeuArg: 9.176 ± 0.078	5.07LeuSer: 5.07 ± 0.05	7.057LeuThr: 7.057 ± 0.06	8.727LeuVal: 8.727 ± 0.073	1.319LeuTrp: 1.319 ± 0.025	1.794LeuTyr: 1.794 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.297MetAla: 2.297 ± 0.033	0.14MetCys: 0.14 ± 0.008	0.939MetAsp: 0.939 ± 0.021	0.752MetGlu: 0.752 ± 0.019	0.44MetPhe: 0.44 ± 0.016	1.351MetGly: 1.351 ± 0.027	0.336MetHis: 0.336 ± 0.013	0.623MetIle: 0.623 ± 0.017	0.383MetLys: 0.383 ± 0.014	1.662MetLeu: 1.662 ± 0.027	0.296MetMet: 0.296 ± 0.012	0.4MetAsn: 0.4 ± 0.014	1.097MetPro: 1.097 ± 0.024	0.387MetGln: 0.387 ± 0.013	1.436MetArg: 1.436 ± 0.028	1.251MetSer: 1.251 ± 0.02	1.494MetThr: 1.494 ± 0.028	1.27MetVal: 1.27 ± 0.025	0.213MetTrp: 0.213 ± 0.01	0.317MetTyr: 0.317 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.986AsnAla: 1.986 ± 0.034	0.152AsnCys: 0.152 ± 0.009	0.824AsnAsp: 0.824 ± 0.022	0.721AsnGlu: 0.721 ± 0.019	0.434AsnPhe: 0.434 ± 0.015	1.762AsnGly: 1.762 ± 0.037	0.371AsnHis: 0.371 ± 0.015	0.594AsnIle: 0.594 ± 0.016	0.374AsnLys: 0.374 ± 0.015	1.525AsnLeu: 1.525 ± 0.025	0.281AsnMet: 0.281 ± 0.01	0.343AsnAsn: 0.343 ± 0.013	1.228AsnPro: 1.228 ± 0.024	0.417AsnGln: 0.417 ± 0.014	1.175AsnArg: 1.175 ± 0.022	0.825AsnSer: 0.825 ± 0.022	0.987AsnThr: 0.987 ± 0.025	1.258AsnVal: 1.258 ± 0.026	0.238AsnTrp: 0.238 ± 0.011	0.393AsnTyr: 0.393 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	10.016ProAla: 10.016 ± 0.097	0.379ProCys: 0.379 ± 0.011	4.486ProAsp: 4.486 ± 0.047	4.569ProGlu: 4.569 ± 0.054	1.582ProPhe: 1.582 ± 0.029	7.71ProGly: 7.71 ± 0.08	1.427ProHis: 1.427 ± 0.029	1.062ProIle: 1.062 ± 0.021	1.176ProLys: 1.176 ± 0.025	5.576ProLeu: 5.576 ± 0.056	1.012ProMet: 1.012 ± 0.021	0.804ProAsn: 0.804 ± 0.022	3.947ProPro: 3.947 ± 0.07	1.575ProGln: 1.575 ± 0.03	4.464ProArg: 4.464 ± 0.051	3.107ProSer: 3.107 ± 0.039	2.933ProThr: 2.933 ± 0.035	5.793ProVal: 5.793 ± 0.064	0.942ProTrp: 0.942 ± 0.021	1.372ProTyr: 1.372 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.371GlnAla: 3.371 ± 0.045	0.15GlnCys: 0.15 ± 0.009	1.301GlnAsp: 1.301 ± 0.025	1.387GlnGlu: 1.387 ± 0.029	0.607GlnPhe: 0.607 ± 0.018	2.208GlnGly: 2.208 ± 0.037	0.591GlnHis: 0.591 ± 0.016	0.902GlnIle: 0.902 ± 0.019	0.552GlnLys: 0.552 ± 0.019	2.692GlnLeu: 2.692 ± 0.036	0.426GlnMet: 0.426 ± 0.013	0.418GlnAsn: 0.418 ± 0.014	1.493GlnPro: 1.493 ± 0.032	1.053GlnGln: 1.053 ± 0.027	2.275GlnArg: 2.275 ± 0.032	1.038GlnSer: 1.038 ± 0.024	1.048GlnThr: 1.048 ± 0.023	2.069GlnVal: 2.069 ± 0.03	0.402GlnTrp: 0.402 ± 0.014	0.509GlnTyr: 0.509 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	11.078ArgAla: 11.078 ± 0.105	0.673ArgCys: 0.673 ± 0.017	4.384ArgAsp: 4.384 ± 0.049	5.117ArgGlu: 5.117 ± 0.058	2.451ArgPhe: 2.451 ± 0.041	6.281ArgGly: 6.281 ± 0.058	2.243ArgHis: 2.243 ± 0.033	2.919ArgIle: 2.919 ± 0.037	1.721ArgLys: 1.721 ± 0.035	9.223ArgLeu: 9.223 ± 0.076	1.792ArgMet: 1.792 ± 0.029	1.318ArgAsn: 1.318 ± 0.025	5.579ArgPro: 5.579 ± 0.064	2.175ArgGln: 2.175 ± 0.031	8.075ArgArg: 8.075 ± 0.081	3.922ArgSer: 3.922 ± 0.05	5.744ArgThr: 5.744 ± 0.053	6.226ArgVal: 6.226 ± 0.059	1.409ArgTrp: 1.409 ± 0.027	1.813ArgTyr: 1.813 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.542SerAla: 6.542 ± 0.065	0.4SerCys: 0.4 ± 0.013	2.329SerAsp: 2.329 ± 0.035	2.164SerGlu: 2.164 ± 0.032	1.476SerPhe: 1.476 ± 0.026	5.937SerGly: 5.937 ± 0.071	0.967SerHis: 0.967 ± 0.021	1.181SerIle: 1.181 ± 0.025	0.941SerLys: 0.941 ± 0.023	4.742SerLeu: 4.742 ± 0.053	0.978SerMet: 0.978 ± 0.021	0.78SerAsn: 0.78 ± 0.019	3.247SerPro: 3.247 ± 0.044	1.027SerGln: 1.027 ± 0.024	3.623SerArg: 3.623 ± 0.044	2.549SerSer: 2.549 ± 0.044	2.693SerThr: 2.693 ± 0.039	4.146SerVal: 4.146 ± 0.05	0.866SerTrp: 0.866 ± 0.02	1.18SerTyr: 1.18 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.295ThrAla: 9.295 ± 0.076	0.452ThrCys: 0.452 ± 0.015	3.48ThrAsp: 3.48 ± 0.037	3.196ThrGlu: 3.196 ± 0.036	1.589ThrPhe: 1.589 ± 0.025	7.193ThrGly: 7.193 ± 0.062	1.207ThrHis: 1.207 ± 0.024	1.379ThrIle: 1.379 ± 0.027	1.045ThrLys: 1.045 ± 0.025	5.672ThrLeu: 5.672 ± 0.055	0.882ThrMet: 0.882 ± 0.022	0.842ThrAsn: 0.842 ± 0.019	4.132ThrPro: 4.132 ± 0.05	1.143ThrGln: 1.143 ± 0.026	4.002ThrArg: 4.002 ± 0.046	2.923ThrSer: 2.923 ± 0.037	3.613ThrThr: 3.613 ± 0.049	5.91ThrVal: 5.91 ± 0.055	0.847ThrTrp: 0.847 ± 0.023	1.264ThrTyr: 1.264 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.9ValAla: 10.9 ± 0.088	0.767ValCys: 0.767 ± 0.018	4.764ValAsp: 4.764 ± 0.053	4.695ValGlu: 4.695 ± 0.049	2.401ValPhe: 2.401 ± 0.039	6.448ValGly: 6.448 ± 0.064	1.904ValHis: 1.904 ± 0.032	2.639ValIle: 2.639 ± 0.044	1.645ValLys: 1.645 ± 0.033	9.586ValLeu: 9.586 ± 0.087	1.408ValMet: 1.408 ± 0.028	1.582ValAsn: 1.582 ± 0.029	5.568ValPro: 5.568 ± 0.05	1.89ValGln: 1.89 ± 0.029	7.459ValArg: 7.459 ± 0.064	4.2ValSer: 4.2 ± 0.043	5.78ValThr: 5.78 ± 0.058	7.932ValVal: 7.932 ± 0.087	1.092ValTrp: 1.092 ± 0.024	1.436ValTyr: 1.436 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.689TrpAla: 1.689 ± 0.03	0.167TrpCys: 0.167 ± 0.008	0.81TrpAsp: 0.81 ± 0.02	0.737TrpGlu: 0.737 ± 0.016	0.486TrpPhe: 0.486 ± 0.015	1.038TrpGly: 1.038 ± 0.021	0.387TrpHis: 0.387 ± 0.013	0.482TrpIle: 0.482 ± 0.015	0.331TrpLys: 0.331 ± 0.014	1.758TrpLeu: 1.758 ± 0.029	0.274TrpMet: 0.274 ± 0.012	0.354TrpAsn: 0.354 ± 0.014	0.815TrpPro: 0.815 ± 0.02	0.57TrpGln: 0.57 ± 0.017	1.379TrpArg: 1.379 ± 0.029	0.897TrpSer: 0.897 ± 0.019	1.027TrpThr: 1.027 ± 0.025	0.955TrpVal: 0.955 ± 0.021	0.338TrpTrp: 0.338 ± 0.014	0.327TrpTyr: 0.327 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.745TyrAla: 2.745 ± 0.04	0.186TyrCys: 0.186 ± 0.009	1.325TyrAsp: 1.325 ± 0.023	1.238TyrGlu: 1.238 ± 0.028	0.615TyrPhe: 0.615 ± 0.017	2.192TyrGly: 2.192 ± 0.037	0.389TyrHis: 0.389 ± 0.014	0.434TyrIle: 0.434 ± 0.015	0.367TyrLys: 0.367 ± 0.014	2.047TyrLeu: 2.047 ± 0.032	0.241TyrMet: 0.241 ± 0.012	0.358TyrAsn: 0.358 ± 0.011	1.066TyrPro: 1.066 ± 0.019	0.523TyrGln: 0.523 ± 0.016	1.827TyrArg: 1.827 ± 0.031	0.843TyrSer: 0.843 ± 0.02	1.064TyrThr: 1.064 ± 0.022	1.556TyrVal: 1.556 ± 0.027	0.355TyrTrp: 0.355 ± 0.013	0.406TyrTyr: 0.406 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6966 proteins (2327136 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---