Amino acid dipepetide frequency for Marinobacter sp. BSs20148

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.908AlaAla: 10.908 ± 0.122
1.028AlaCys: 1.028 ± 0.032
5.881AlaAsp: 5.881 ± 0.085
6.34AlaGlu: 6.34 ± 0.083
3.748AlaPhe: 3.748 ± 0.055
8.554AlaGly: 8.554 ± 0.104
1.877AlaHis: 1.877 ± 0.04
6.012AlaIle: 6.012 ± 0.082
3.655AlaLys: 3.655 ± 0.06
11.88AlaLeu: 11.88 ± 0.124
3.085AlaMet: 3.085 ± 0.056
3.215AlaAsn: 3.215 ± 0.053
3.929AlaPro: 3.929 ± 0.059
3.986AlaGln: 3.986 ± 0.07
6.038AlaArg: 6.038 ± 0.081
6.075AlaSer: 6.075 ± 0.089
4.896AlaThr: 4.896 ± 0.077
7.408AlaVal: 7.408 ± 0.086
1.362AlaTrp: 1.362 ± 0.041
2.222AlaTyr: 2.222 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.887CysAla: 0.887 ± 0.032
0.152CysCys: 0.152 ± 0.013
0.592CysAsp: 0.592 ± 0.022
0.583CysGlu: 0.583 ± 0.021
0.38CysPhe: 0.38 ± 0.016
0.924CysGly: 0.924 ± 0.031
0.308CysHis: 0.308 ± 0.018
0.487CysIle: 0.487 ± 0.021
0.345CysLys: 0.345 ± 0.017
0.956CysLeu: 0.956 ± 0.032
0.235CysMet: 0.235 ± 0.013
0.32CysAsn: 0.32 ± 0.015
0.513CysPro: 0.513 ± 0.026
0.43CysGln: 0.43 ± 0.02
0.623CysArg: 0.623 ± 0.02
0.617CysSer: 0.617 ± 0.021
0.424CysThr: 0.424 ± 0.021
0.696CysVal: 0.696 ± 0.029
0.141CysTrp: 0.141 ± 0.013
0.288CysTyr: 0.288 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.156AspAla: 5.156 ± 0.081
0.513AspCys: 0.513 ± 0.021
3.138AspAsp: 3.138 ± 0.065
3.504AspGlu: 3.504 ± 0.071
2.166AspPhe: 2.166 ± 0.043
4.262AspGly: 4.262 ± 0.063
1.197AspHis: 1.197 ± 0.031
3.43AspIle: 3.43 ± 0.058
2.037AspLys: 2.037 ± 0.042
5.518AspLeu: 5.518 ± 0.071
1.487AspMet: 1.487 ± 0.041
1.998AspAsn: 1.998 ± 0.045
2.469AspPro: 2.469 ± 0.049
2.287AspGln: 2.287 ± 0.046
3.106AspArg: 3.106 ± 0.054
3.165AspSer: 3.165 ± 0.05
2.847AspThr: 2.847 ± 0.05
4.03AspVal: 4.03 ± 0.066
0.884AspTrp: 0.884 ± 0.03
1.775AspTyr: 1.775 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
5.816GluAla: 5.816 ± 0.079
0.495GluCys: 0.495 ± 0.021
2.781GluAsp: 2.781 ± 0.057
3.193GluGlu: 3.193 ± 0.072
2.165GluPhe: 2.165 ± 0.049
3.921GluGly: 3.921 ± 0.071
1.52GluHis: 1.52 ± 0.036
3.241GluIle: 3.241 ± 0.05
2.654GluLys: 2.654 ± 0.053
6.859GluLeu: 6.859 ± 0.091
1.5GluMet: 1.5 ± 0.039
2.161GluAsn: 2.161 ± 0.04
2.476GluPro: 2.476 ± 0.046
3.462GluGln: 3.462 ± 0.062
4.141GluArg: 4.141 ± 0.073
3.182GluSer: 3.182 ± 0.053
3.084GluThr: 3.084 ± 0.049
3.944GluVal: 3.944 ± 0.066
0.711GluTrp: 0.711 ± 0.026
1.304GluTyr: 1.304 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.737PheAla: 3.737 ± 0.059
0.479PheCys: 0.479 ± 0.019
2.491PheAsp: 2.491 ± 0.058
2.261PheGlu: 2.261 ± 0.039
1.639PhePhe: 1.639 ± 0.044
3.409PheGly: 3.409 ± 0.046
0.817PheHis: 0.817 ± 0.027
2.138PheIle: 2.138 ± 0.044
1.282PheLys: 1.282 ± 0.033
3.546PheLeu: 3.546 ± 0.064
1.009PheMet: 1.009 ± 0.033
1.462PheAsn: 1.462 ± 0.04
1.559PhePro: 1.559 ± 0.032
1.249PheGln: 1.249 ± 0.035
2.137PheArg: 2.137 ± 0.04
2.832PheSer: 2.832 ± 0.048
2.064PheThr: 2.064 ± 0.041
2.742PheVal: 2.742 ± 0.053
0.55PheTrp: 0.55 ± 0.024
1.113PheTyr: 1.113 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
7.064GlyAla: 7.064 ± 0.091
0.951GlyCys: 0.951 ± 0.03
4.172GlyAsp: 4.172 ± 0.072
4.607GlyGlu: 4.607 ± 0.073
3.492GlyPhe: 3.492 ± 0.061
5.899GlyGly: 5.899 ± 0.089
1.817GlyHis: 1.817 ± 0.04
4.724GlyIle: 4.724 ± 0.077
3.457GlyLys: 3.457 ± 0.062
8.484GlyLeu: 8.484 ± 0.114
2.345GlyMet: 2.345 ± 0.05
2.516GlyAsn: 2.516 ± 0.05
2.438GlyPro: 2.438 ± 0.051
3.283GlyGln: 3.283 ± 0.06
4.449GlyArg: 4.449 ± 0.067
4.701GlySer: 4.701 ± 0.079
3.837GlyThr: 3.837 ± 0.065
5.979GlyVal: 5.979 ± 0.074
1.158GlyTrp: 1.158 ± 0.04
2.505GlyTyr: 2.505 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.88HisAla: 1.88 ± 0.041
0.319HisCys: 0.319 ± 0.017
1.094HisAsp: 1.094 ± 0.027
1.178HisGlu: 1.178 ± 0.032
0.975HisPhe: 0.975 ± 0.028
1.752HisGly: 1.752 ± 0.037
0.694HisHis: 0.694 ± 0.029
1.133HisIle: 1.133 ± 0.033
0.777HisLys: 0.777 ± 0.024
2.146HisLeu: 2.146 ± 0.04
0.534HisMet: 0.534 ± 0.019
0.832HisAsn: 0.832 ± 0.025
1.283HisPro: 1.283 ± 0.034
1.089HisGln: 1.089 ± 0.031
1.398HisArg: 1.398 ± 0.033
1.465HisSer: 1.465 ± 0.042
1.068HisThr: 1.068 ± 0.029
1.291HisVal: 1.291 ± 0.034
0.424HisTrp: 0.424 ± 0.02
0.746HisTyr: 0.746 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.23IleAla: 6.23 ± 0.071
0.575IleCys: 0.575 ± 0.024
3.442IleAsp: 3.442 ± 0.057
3.613IleGlu: 3.613 ± 0.059
1.836IlePhe: 1.836 ± 0.047
4.539IleGly: 4.539 ± 0.07
1.206IleHis: 1.206 ± 0.031
2.924IleIle: 2.924 ± 0.063
2.005IleLys: 2.005 ± 0.05
4.925IleLeu: 4.925 ± 0.083
1.302IleMet: 1.302 ± 0.035
2.241IleAsn: 2.241 ± 0.041
2.566IlePro: 2.566 ± 0.048
1.82IleGln: 1.82 ± 0.041
3.359IleArg: 3.359 ± 0.049
3.598IleSer: 3.598 ± 0.056
3.252IleThr: 3.252 ± 0.048
3.925IleVal: 3.925 ± 0.062
0.588IleTrp: 0.588 ± 0.024
1.31IleTyr: 1.31 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.124LysAla: 4.124 ± 0.063
0.234LysCys: 0.234 ± 0.015
1.986LysAsp: 1.986 ± 0.051
2.042LysGlu: 2.042 ± 0.045
1.063LysPhe: 1.063 ± 0.032
2.664LysGly: 2.664 ± 0.051
0.87LysHis: 0.87 ± 0.03
2.014LysIle: 2.014 ± 0.047
1.899LysLys: 1.899 ± 0.056
3.941LysLeu: 3.941 ± 0.052
0.948LysMet: 0.948 ± 0.031
1.418LysAsn: 1.418 ± 0.039
2.174LysPro: 2.174 ± 0.048
1.658LysGln: 1.658 ± 0.051
2.462LysArg: 2.462 ± 0.05
2.208LysSer: 2.208 ± 0.053
2.348LysThr: 2.348 ± 0.052
2.834LysVal: 2.834 ± 0.051
0.374LysTrp: 0.374 ± 0.018
0.804LysTyr: 0.804 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
12.604LeuAla: 12.604 ± 0.11
1.081LeuCys: 1.081 ± 0.028
5.775LeuAsp: 5.775 ± 0.081
6.127LeuGlu: 6.127 ± 0.091
4.044LeuPhe: 4.044 ± 0.075
8.196LeuGly: 8.196 ± 0.094
2.105LeuHis: 2.105 ± 0.04
5.876LeuIle: 5.876 ± 0.088
4.374LeuLys: 4.374 ± 0.067
11.358LeuLeu: 11.358 ± 0.162
2.92LeuMet: 2.92 ± 0.053
3.92LeuAsn: 3.92 ± 0.065
5.344LeuPro: 5.344 ± 0.079
4.307LeuGln: 4.307 ± 0.071
6.201LeuArg: 6.201 ± 0.087
6.875LeuSer: 6.875 ± 0.08
5.796LeuThr: 5.796 ± 0.075
7.73LeuVal: 7.73 ± 0.107
1.238LeuTrp: 1.238 ± 0.036
2.31LeuTyr: 2.31 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
3.284MetAla: 3.284 ± 0.063
0.194MetCys: 0.194 ± 0.013
1.338MetAsp: 1.338 ± 0.029
1.331MetGlu: 1.331 ± 0.037
0.841MetPhe: 0.841 ± 0.031
2.101MetGly: 2.101 ± 0.051
0.508MetHis: 0.508 ± 0.02
1.39MetIle: 1.39 ± 0.038
1.183MetLys: 1.183 ± 0.034
2.868MetLeu: 2.868 ± 0.059
0.731MetMet: 0.731 ± 0.027
1.109MetAsn: 1.109 ± 0.031
1.418MetPro: 1.418 ± 0.034
0.997MetGln: 0.997 ± 0.031
1.464MetArg: 1.464 ± 0.039
1.823MetSer: 1.823 ± 0.039
1.734MetThr: 1.734 ± 0.039
2.001MetVal: 2.001 ± 0.042
0.201MetTrp: 0.201 ± 0.014
0.457MetTyr: 0.457 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.419AsnAla: 3.419 ± 0.057
0.336AsnCys: 0.336 ± 0.018
1.907AsnAsp: 1.907 ± 0.047
1.899AsnGlu: 1.899 ± 0.042
1.223AsnPhe: 1.223 ± 0.035
2.845AsnGly: 2.845 ± 0.046
0.81AsnHis: 0.81 ± 0.03
1.9AsnIle: 1.9 ± 0.041
1.195AsnLys: 1.195 ± 0.034
3.687AsnLeu: 3.687 ± 0.057
0.831AsnMet: 0.831 ± 0.025
1.317AsnAsn: 1.317 ± 0.04
2.144AsnPro: 2.144 ± 0.048
1.503AsnGln: 1.503 ± 0.035
2.215AsnArg: 2.215 ± 0.048
2.102AsnSer: 2.102 ± 0.049
2.001AsnThr: 2.001 ± 0.042
2.371AsnVal: 2.371 ± 0.051
0.509AsnTrp: 0.509 ± 0.023
0.942AsnTyr: 0.942 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
4.861ProAla: 4.861 ± 0.078
0.324ProCys: 0.324 ± 0.015
3.069ProAsp: 3.069 ± 0.052
3.632ProGlu: 3.632 ± 0.061
1.789ProPhe: 1.789 ± 0.041
3.848ProGly: 3.848 ± 0.07
0.885ProHis: 0.885 ± 0.028
2.111ProIle: 2.111 ± 0.047
1.576ProLys: 1.576 ± 0.039
4.926ProLeu: 4.926 ± 0.071
1.195ProMet: 1.195 ± 0.03
1.435ProAsn: 1.435 ± 0.039
1.728ProPro: 1.728 ± 0.043
1.909ProGln: 1.909 ± 0.044
2.049ProArg: 2.049 ± 0.048
2.421ProSer: 2.421 ± 0.046
2.061ProThr: 2.061 ± 0.043
3.878ProVal: 3.878 ± 0.056
0.716ProTrp: 0.716 ± 0.025
1.09ProTyr: 1.09 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.762GlnAla: 4.762 ± 0.08
0.353GlnCys: 0.353 ± 0.016
1.804GlnAsp: 1.804 ± 0.039
2.016GlnGlu: 2.016 ± 0.046
1.428GlnPhe: 1.428 ± 0.033
2.932GlnGly: 2.932 ± 0.054
1.031GlnHis: 1.031 ± 0.032
2.159GlnIle: 2.159 ± 0.043
1.631GlnLys: 1.631 ± 0.04
4.764GlnLeu: 4.764 ± 0.09
1.087GlnMet: 1.087 ± 0.027
1.408GlnAsn: 1.408 ± 0.035
2.164GlnPro: 2.164 ± 0.043
2.736GlnGln: 2.736 ± 0.068
3.081GlnArg: 3.081 ± 0.064
2.46GlnSer: 2.46 ± 0.05
2.083GlnThr: 2.083 ± 0.043
3.082GlnVal: 3.082 ± 0.058
0.687GlnTrp: 0.687 ± 0.024
0.99GlnTyr: 0.99 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
5.117ArgAla: 5.117 ± 0.073
0.576ArgCys: 0.576 ± 0.024
3.202ArgAsp: 3.202 ± 0.053
3.864ArgGlu: 3.864 ± 0.07
2.741ArgPhe: 2.741 ± 0.045
3.695ArgGly: 3.695 ± 0.066
1.562ArgHis: 1.562 ± 0.039
3.499ArgIle: 3.499 ± 0.058
2.568ArgLys: 2.568 ± 0.048
6.939ArgLeu: 6.939 ± 0.09
1.68ArgMet: 1.68 ± 0.039
2.124ArgAsn: 2.124 ± 0.043
2.47ArgPro: 2.47 ± 0.05
3.069ArgGln: 3.069 ± 0.056
3.883ArgArg: 3.883 ± 0.063
3.348ArgSer: 3.348 ± 0.053
2.657ArgThr: 2.657 ± 0.041
4.23ArgVal: 4.23 ± 0.055
0.944ArgTrp: 0.944 ± 0.031
1.883ArgTyr: 1.883 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
6.402SerAla: 6.402 ± 0.092
0.502SerCys: 0.502 ± 0.022
3.398SerAsp: 3.398 ± 0.063
3.47SerGlu: 3.47 ± 0.059
2.39SerPhe: 2.39 ± 0.046
5.643SerGly: 5.643 ± 0.074
1.366SerHis: 1.366 ± 0.04
3.078SerIle: 3.078 ± 0.056
2.122SerLys: 2.122 ± 0.046
6.507SerLeu: 6.507 ± 0.081
1.653SerMet: 1.653 ± 0.037
1.983SerAsn: 1.983 ± 0.042
2.694SerPro: 2.694 ± 0.048
2.386SerGln: 2.386 ± 0.05
3.647SerArg: 3.647 ± 0.06
3.728SerSer: 3.728 ± 0.069
2.945SerThr: 2.945 ± 0.056
4.498SerVal: 4.498 ± 0.067
0.785SerTrp: 0.785 ± 0.027
1.481SerTyr: 1.481 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.208ThrAla: 5.208 ± 0.071
0.542ThrCys: 0.542 ± 0.024
2.923ThrAsp: 2.923 ± 0.054
2.819ThrGlu: 2.819 ± 0.053
1.905ThrPhe: 1.905 ± 0.045
4.651ThrGly: 4.651 ± 0.068
1.094ThrHis: 1.094 ± 0.031
2.657ThrIle: 2.657 ± 0.054
1.459ThrLys: 1.459 ± 0.037
6.472ThrLeu: 6.472 ± 0.073
1.238ThrMet: 1.238 ± 0.035
1.632ThrAsn: 1.632 ± 0.043
2.885ThrPro: 2.885 ± 0.053
1.832ThrGln: 1.832 ± 0.037
3.014ThrArg: 3.014 ± 0.056
2.954ThrSer: 2.954 ± 0.053
2.733ThrThr: 2.733 ± 0.052
4.03ThrVal: 4.03 ± 0.059
0.625ThrTrp: 0.625 ± 0.023
1.172ThrTyr: 1.172 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
7.519ValAla: 7.519 ± 0.102
0.785ValCys: 0.785 ± 0.029
3.942ValAsp: 3.942 ± 0.06
4.24ValGlu: 4.24 ± 0.068
2.985ValPhe: 2.985 ± 0.056
5.081ValGly: 5.081 ± 0.075
1.45ValHis: 1.45 ± 0.032
4.622ValIle: 4.622 ± 0.072
2.6ValLys: 2.6 ± 0.048
7.58ValLeu: 7.58 ± 0.091
2.218ValMet: 2.218 ± 0.048
2.685ValAsn: 2.685 ± 0.061
3.331ValPro: 3.331 ± 0.054
2.434ValGln: 2.434 ± 0.054
4.076ValArg: 4.076 ± 0.06
4.819ValSer: 4.819 ± 0.07
4.177ValThr: 4.177 ± 0.061
5.788ValVal: 5.788 ± 0.083
0.918ValTrp: 0.918 ± 0.029
1.728ValTyr: 1.728 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.988TrpAla: 0.988 ± 0.034
0.162TrpCys: 0.162 ± 0.011
0.607TrpAsp: 0.607 ± 0.023
0.549TrpGlu: 0.549 ± 0.018
0.606TrpPhe: 0.606 ± 0.025
0.895TrpGly: 0.895 ± 0.031
0.364TrpHis: 0.364 ± 0.019
0.671TrpIle: 0.671 ± 0.023
0.427TrpLys: 0.427 ± 0.02
2.004TrpLeu: 2.004 ± 0.049
0.381TrpMet: 0.381 ± 0.018
0.485TrpAsn: 0.485 ± 0.021
0.637TrpPro: 0.637 ± 0.021
0.898TrpGln: 0.898 ± 0.033
0.912TrpArg: 0.912 ± 0.03
0.722TrpSer: 0.722 ± 0.023
0.586TrpThr: 0.586 ± 0.024
0.96TrpVal: 0.96 ± 0.028
0.197TrpTrp: 0.197 ± 0.016
0.34TrpTyr: 0.34 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.133TyrAla: 2.133 ± 0.044
0.298TyrCys: 0.298 ± 0.017
1.428TyrAsp: 1.428 ± 0.041
1.341TyrGlu: 1.341 ± 0.036
1.098TyrPhe: 1.098 ± 0.035
2.069TyrGly: 2.069 ± 0.038
0.599TyrHis: 0.599 ± 0.025
1.192TyrIle: 1.192 ± 0.03
0.82TyrLys: 0.82 ± 0.027
2.817TyrLeu: 2.817 ± 0.056
0.595TyrMet: 0.595 ± 0.022
0.895TyrAsn: 0.895 ± 0.027
1.279TyrPro: 1.279 ± 0.033
1.326TyrGln: 1.326 ± 0.039
1.796TyrArg: 1.796 ± 0.038
1.583TyrSer: 1.583 ± 0.037
1.251TyrThr: 1.251 ± 0.036
1.56TyrVal: 1.56 ± 0.043
0.38TyrTrp: 0.38 ± 0.018
0.753TyrTyr: 0.753 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3885 proteins (1180275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski