Amino acid dipepetide frequency for Oceanimonas doudoroffii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.962AlaAla: 11.962 ± 0.152	1.239AlaCys: 1.239 ± 0.027	5.78AlaAsp: 5.78 ± 0.082	7.367AlaGlu: 7.367 ± 0.108	3.762AlaPhe: 3.762 ± 0.061	9.756AlaGly: 9.756 ± 0.11	2.132AlaHis: 2.132 ± 0.05	5.313AlaIle: 5.313 ± 0.077	2.98AlaLys: 2.98 ± 0.066	13.582AlaLeu: 13.582 ± 0.139	3.266AlaMet: 3.266 ± 0.063	2.847AlaAsn: 2.847 ± 0.061	4.176AlaPro: 4.176 ± 0.071	4.015AlaGln: 4.015 ± 0.067	7.202AlaArg: 7.202 ± 0.097	5.445AlaSer: 5.445 ± 0.068	4.612AlaThr: 4.612 ± 0.07	7.384AlaVal: 7.384 ± 0.087	1.475AlaTrp: 1.475 ± 0.038	2.148AlaTyr: 2.148 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.003CysAla: 1.003 ± 0.028	0.183CysCys: 0.183 ± 0.015	0.611CysAsp: 0.611 ± 0.027	0.581CysGlu: 0.581 ± 0.025	0.438CysPhe: 0.438 ± 0.022	1.037CysGly: 1.037 ± 0.031	0.379CysHis: 0.379 ± 0.017	0.52CysIle: 0.52 ± 0.019	0.296CysLys: 0.296 ± 0.017	1.09CysLeu: 1.09 ± 0.033	0.238CysMet: 0.238 ± 0.014	0.301CysAsn: 0.301 ± 0.017	0.512CysPro: 0.512 ± 0.02	0.389CysGln: 0.389 ± 0.017	0.825CysArg: 0.825 ± 0.028	0.582CysSer: 0.582 ± 0.02	0.47CysThr: 0.47 ± 0.02	0.67CysVal: 0.67 ± 0.023	0.168CysTrp: 0.168 ± 0.012	0.315CysTyr: 0.315 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.369AspAla: 5.369 ± 0.081	0.561AspCys: 0.561 ± 0.024	3.115AspAsp: 3.115 ± 0.061	3.653AspGlu: 3.653 ± 0.066	2.101AspPhe: 2.101 ± 0.048	4.258AspGly: 4.258 ± 0.068	1.231AspHis: 1.231 ± 0.032	3.169AspIle: 3.169 ± 0.056	2.176AspLys: 2.176 ± 0.054	4.824AspLeu: 4.824 ± 0.068	1.545AspMet: 1.545 ± 0.038	1.816AspAsn: 1.816 ± 0.041	2.159AspPro: 2.159 ± 0.046	1.822AspGln: 1.822 ± 0.042	2.898AspArg: 2.898 ± 0.055	2.534AspSer: 2.534 ± 0.049	2.722AspThr: 2.722 ± 0.045	3.18AspVal: 3.18 ± 0.055	1.087AspTrp: 1.087 ± 0.035	1.867AspTyr: 1.867 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.407GluAla: 6.407 ± 0.088	0.465GluCys: 0.465 ± 0.024	2.548GluAsp: 2.548 ± 0.047	3.303GluGlu: 3.303 ± 0.068	1.945GluPhe: 1.945 ± 0.043	3.979GluGly: 3.979 ± 0.062	1.911GluHis: 1.911 ± 0.043	2.559GluIle: 2.559 ± 0.055	2.147GluLys: 2.147 ± 0.047	8.045GluLeu: 8.045 ± 0.099	1.377GluMet: 1.377 ± 0.033	1.626GluAsn: 1.626 ± 0.043	2.589GluPro: 2.589 ± 0.049	4.947GluGln: 4.947 ± 0.079	4.778GluArg: 4.778 ± 0.067	2.692GluSer: 2.692 ± 0.06	2.458GluThr: 2.458 ± 0.049	4.367GluVal: 4.367 ± 0.073	0.765GluTrp: 0.765 ± 0.03	1.354GluTyr: 1.354 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.824PheAla: 3.824 ± 0.059	0.486PheCys: 0.486 ± 0.019	2.418PheAsp: 2.418 ± 0.053	2.243PheGlu: 2.243 ± 0.044	1.459PhePhe: 1.459 ± 0.042	3.58PheGly: 3.58 ± 0.055	0.827PheHis: 0.827 ± 0.032	2.051PheIle: 2.051 ± 0.053	1.065PheLys: 1.065 ± 0.035	3.07PheLeu: 3.07 ± 0.058	1.004PheMet: 1.004 ± 0.031	1.437PheAsn: 1.437 ± 0.036	1.458PhePro: 1.458 ± 0.036	1.05PheGln: 1.05 ± 0.031	1.921PheArg: 1.921 ± 0.04	2.535PheSer: 2.535 ± 0.056	2.058PheThr: 2.058 ± 0.048	2.771PheVal: 2.771 ± 0.053	0.593PheTrp: 0.593 ± 0.027	1.164PheTyr: 1.164 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.045GlyAla: 7.045 ± 0.095	1.011GlyCys: 1.011 ± 0.032	3.925GlyAsp: 3.925 ± 0.062	5.295GlyGlu: 5.295 ± 0.073	3.553GlyPhe: 3.553 ± 0.062	6.098GlyGly: 6.098 ± 0.09	2.026GlyHis: 2.026 ± 0.049	4.504GlyIle: 4.504 ± 0.066	3.325GlyLys: 3.325 ± 0.057	9.868GlyLeu: 9.868 ± 0.104	2.565GlyMet: 2.565 ± 0.046	2.462GlyAsn: 2.462 ± 0.048	2.68GlyPro: 2.68 ± 0.058	3.372GlyGln: 3.372 ± 0.06	5.346GlyArg: 5.346 ± 0.074	4.166GlySer: 4.166 ± 0.058	3.659GlyThr: 3.659 ± 0.06	6.103GlyVal: 6.103 ± 0.071	1.43GlyTrp: 1.43 ± 0.043	2.493GlyTyr: 2.493 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.156HisAla: 2.156 ± 0.05	0.382HisCys: 0.382 ± 0.019	1.278HisAsp: 1.278 ± 0.038	1.213HisGlu: 1.213 ± 0.033	1.064HisPhe: 1.064 ± 0.029	2.167HisGly: 2.167 ± 0.053	0.885HisHis: 0.885 ± 0.03	1.287HisIle: 1.287 ± 0.036	0.788HisLys: 0.788 ± 0.029	2.576HisLeu: 2.576 ± 0.053	0.576HisMet: 0.576 ± 0.021	0.79HisAsn: 0.79 ± 0.026	1.426HisPro: 1.426 ± 0.04	1.269HisGln: 1.269 ± 0.035	1.625HisArg: 1.625 ± 0.041	1.359HisSer: 1.359 ± 0.035	1.141HisThr: 1.141 ± 0.033	1.297HisVal: 1.297 ± 0.039	0.561HisTrp: 0.561 ± 0.028	0.911HisTyr: 0.911 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.399IleAla: 5.399 ± 0.074	0.62IleCys: 0.62 ± 0.025	3.045IleAsp: 3.045 ± 0.057	3.197IleGlu: 3.197 ± 0.053	1.617IlePhe: 1.617 ± 0.044	4.206IleGly: 4.206 ± 0.082	1.113IleHis: 1.113 ± 0.039	2.502IleIle: 2.502 ± 0.056	1.83IleLys: 1.83 ± 0.047	4.191IleLeu: 4.191 ± 0.068	1.222IleMet: 1.222 ± 0.035	1.947IleAsn: 1.947 ± 0.043	2.291IlePro: 2.291 ± 0.045	1.486IleGln: 1.486 ± 0.043	3.047IleArg: 3.047 ± 0.053	3.076IleSer: 3.076 ± 0.059	2.926IleThr: 2.926 ± 0.05	3.059IleVal: 3.059 ± 0.059	0.591IleTrp: 0.591 ± 0.023	1.275IleTyr: 1.275 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.809LysAla: 3.809 ± 0.07	0.203LysCys: 0.203 ± 0.015	1.77LysAsp: 1.77 ± 0.045	1.969LysGlu: 1.969 ± 0.036	0.823LysPhe: 0.823 ± 0.033	2.699LysGly: 2.699 ± 0.044	0.766LysHis: 0.766 ± 0.028	1.457LysIle: 1.457 ± 0.042	1.506LysLys: 1.506 ± 0.043	3.49LysLeu: 3.49 ± 0.059	0.807LysMet: 0.807 ± 0.028	0.95LysAsn: 0.95 ± 0.031	1.876LysPro: 1.876 ± 0.049	1.604LysGln: 1.604 ± 0.035	2.217LysArg: 2.217 ± 0.048	1.671LysSer: 1.671 ± 0.046	1.751LysThr: 1.751 ± 0.038	2.626LysVal: 2.626 ± 0.058	0.35LysTrp: 0.35 ± 0.02	0.727LysTyr: 0.727 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.965LeuAla: 14.965 ± 0.149	1.365LeuCys: 1.365 ± 0.032	6.137LeuAsp: 6.137 ± 0.082	6.725LeuGlu: 6.725 ± 0.071	4.485LeuPhe: 4.485 ± 0.074	9.314LeuGly: 9.314 ± 0.106	2.564LeuHis: 2.564 ± 0.049	5.071LeuIle: 5.071 ± 0.073	4.123LeuLys: 4.123 ± 0.063	14.411LeuLeu: 14.411 ± 0.18	3.129LeuMet: 3.129 ± 0.061	4.137LeuAsn: 4.137 ± 0.056	6.278LeuPro: 6.278 ± 0.093	4.449LeuGln: 4.449 ± 0.075	6.411LeuArg: 6.411 ± 0.086	7.327LeuSer: 7.327 ± 0.098	6.391LeuThr: 6.391 ± 0.089	8.776LeuVal: 8.776 ± 0.115	1.462LeuTrp: 1.462 ± 0.041	2.613LeuTyr: 2.613 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.262MetAla: 3.262 ± 0.052	0.184MetCys: 0.184 ± 0.012	1.296MetAsp: 1.296 ± 0.032	1.382MetGlu: 1.382 ± 0.034	0.771MetPhe: 0.771 ± 0.026	2.005MetGly: 2.005 ± 0.042	0.562MetHis: 0.562 ± 0.023	1.25MetIle: 1.25 ± 0.037	1.14MetLys: 1.14 ± 0.032	3.057MetLeu: 3.057 ± 0.063	0.831MetMet: 0.831 ± 0.028	0.932MetAsn: 0.932 ± 0.03	1.258MetPro: 1.258 ± 0.035	1.05MetGln: 1.05 ± 0.031	1.267MetArg: 1.267 ± 0.03	1.805MetSer: 1.805 ± 0.04	1.68MetThr: 1.68 ± 0.042	2.05MetVal: 2.05 ± 0.038	0.211MetTrp: 0.211 ± 0.012	0.427MetTyr: 0.427 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.011AsnAla: 3.011 ± 0.06	0.304AsnCys: 0.304 ± 0.018	1.664AsnAsp: 1.664 ± 0.039	1.79AsnGlu: 1.79 ± 0.042	0.979AsnPhe: 0.979 ± 0.032	2.676AsnGly: 2.676 ± 0.057	0.771AsnHis: 0.771 ± 0.024	1.771AsnIle: 1.771 ± 0.043	1.131AsnLys: 1.131 ± 0.037	3.245AsnLeu: 3.245 ± 0.055	0.825AsnMet: 0.825 ± 0.03	1.088AsnAsn: 1.088 ± 0.033	1.883AsnPro: 1.883 ± 0.041	1.35AsnGln: 1.35 ± 0.035	2.025AsnArg: 2.025 ± 0.045	1.505AsnSer: 1.505 ± 0.04	1.713AsnThr: 1.713 ± 0.04	1.868AsnVal: 1.868 ± 0.041	0.433AsnTrp: 0.433 ± 0.022	0.797AsnTyr: 0.797 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.705ProAla: 5.705 ± 0.088	0.384ProCys: 0.384 ± 0.019	2.714ProAsp: 2.714 ± 0.053	3.769ProGlu: 3.769 ± 0.064	1.808ProPhe: 1.808 ± 0.045	4.066ProGly: 4.066 ± 0.067	1.082ProHis: 1.082 ± 0.037	1.802ProIle: 1.802 ± 0.045	1.268ProLys: 1.268 ± 0.04	5.632ProLeu: 5.632 ± 0.083	1.169ProMet: 1.169 ± 0.038	1.251ProAsn: 1.251 ± 0.031	1.756ProPro: 1.756 ± 0.049	1.653ProGln: 1.653 ± 0.04	2.305ProArg: 2.305 ± 0.046	2.187ProSer: 2.187 ± 0.043	1.926ProThr: 1.926 ± 0.041	4.157ProVal: 4.157 ± 0.066	0.786ProTrp: 0.786 ± 0.025	1.15ProTyr: 1.15 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.716GlnAla: 5.716 ± 0.085	0.381GlnCys: 0.381 ± 0.019	2.133GlnAsp: 2.133 ± 0.046	2.168GlnGlu: 2.168 ± 0.045	1.262GlnPhe: 1.262 ± 0.031	3.896GlnGly: 3.896 ± 0.062	1.232GlnHis: 1.232 ± 0.036	1.696GlnIle: 1.696 ± 0.039	1.268GlnLys: 1.268 ± 0.035	5.481GlnLeu: 5.481 ± 0.081	0.918GlnMet: 0.918 ± 0.03	1.033GlnAsn: 1.033 ± 0.028	2.323GlnPro: 2.323 ± 0.056	3.266GlnGln: 3.266 ± 0.1	3.005GlnArg: 3.005 ± 0.055	2.163GlnSer: 2.163 ± 0.042	1.826GlnThr: 1.826 ± 0.038	3.114GlnVal: 3.114 ± 0.053	0.705GlnTrp: 0.705 ± 0.027	1.006GlnTyr: 1.006 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.574ArgAla: 5.574 ± 0.076	0.596ArgCys: 0.596 ± 0.024	3.069ArgAsp: 3.069 ± 0.055	4.185ArgGlu: 4.185 ± 0.066	2.836ArgPhe: 2.836 ± 0.062	3.746ArgGly: 3.746 ± 0.062	2.128ArgHis: 2.128 ± 0.045	3.303ArgIle: 3.303 ± 0.052	1.968ArgLys: 1.968 ± 0.046	9.294ArgLeu: 9.294 ± 0.121	1.543ArgMet: 1.543 ± 0.037	1.848ArgAsn: 1.848 ± 0.041	2.853ArgPro: 2.853 ± 0.053	3.537ArgGln: 3.537 ± 0.063	4.834ArgArg: 4.834 ± 0.075	2.779ArgSer: 2.779 ± 0.053	2.546ArgThr: 2.546 ± 0.046	4.632ArgVal: 4.632 ± 0.066	0.972ArgTrp: 0.972 ± 0.033	1.92ArgTyr: 1.92 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.424SerAla: 5.424 ± 0.079	0.513SerCys: 0.513 ± 0.025	2.504SerAsp: 2.504 ± 0.049	2.876SerGlu: 2.876 ± 0.05	2.146SerPhe: 2.146 ± 0.046	4.836SerGly: 4.836 ± 0.061	1.337SerHis: 1.337 ± 0.037	2.491SerIle: 2.491 ± 0.051	1.594SerLys: 1.594 ± 0.041	7.008SerLeu: 7.008 ± 0.093	1.365SerMet: 1.365 ± 0.031	1.516SerAsn: 1.516 ± 0.044	2.72SerPro: 2.72 ± 0.045	2.221SerGln: 2.221 ± 0.047	4.022SerArg: 4.022 ± 0.051	2.917SerSer: 2.917 ± 0.057	2.545SerThr: 2.545 ± 0.046	3.706SerVal: 3.706 ± 0.06	0.814SerTrp: 0.814 ± 0.027	1.387SerTyr: 1.387 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.729ThrAla: 4.729 ± 0.074	0.399ThrCys: 0.399 ± 0.019	2.539ThrAsp: 2.539 ± 0.052	2.758ThrGlu: 2.758 ± 0.054	1.599ThrPhe: 1.599 ± 0.032	4.616ThrGly: 4.616 ± 0.064	1.121ThrHis: 1.121 ± 0.033	2.326ThrIle: 2.326 ± 0.047	1.122ThrLys: 1.122 ± 0.031	7.023ThrLeu: 7.023 ± 0.1	1.097ThrMet: 1.097 ± 0.033	1.258ThrAsn: 1.258 ± 0.032	2.996ThrPro: 2.996 ± 0.052	1.954ThrGln: 1.954 ± 0.04	3.094ThrArg: 3.094 ± 0.05	2.443ThrSer: 2.443 ± 0.055	2.409ThrThr: 2.409 ± 0.054	3.445ThrVal: 3.445 ± 0.051	0.575ThrTrp: 0.575 ± 0.023	0.975ThrTyr: 0.975 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.745ValAla: 7.745 ± 0.081	0.795ValCys: 0.795 ± 0.026	3.651ValAsp: 3.651 ± 0.069	4.123ValGlu: 4.123 ± 0.062	2.722ValPhe: 2.722 ± 0.061	4.913ValGly: 4.913 ± 0.069	1.474ValHis: 1.474 ± 0.039	3.936ValIle: 3.936 ± 0.061	2.27ValLys: 2.27 ± 0.048	8.498ValLeu: 8.498 ± 0.104	2.038ValMet: 2.038 ± 0.039	2.454ValAsn: 2.454 ± 0.047	3.334ValPro: 3.334 ± 0.061	2.513ValGln: 2.513 ± 0.049	4.21ValArg: 4.21 ± 0.064	4.556ValSer: 4.556 ± 0.07	3.973ValThr: 3.973 ± 0.058	5.538ValVal: 5.538 ± 0.091	0.817ValTrp: 0.817 ± 0.027	1.661ValTyr: 1.661 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.057TrpAla: 1.057 ± 0.03	0.193TrpCys: 0.193 ± 0.014	0.533TrpAsp: 0.533 ± 0.023	0.495TrpGlu: 0.495 ± 0.019	0.56TrpPhe: 0.56 ± 0.024	0.928TrpGly: 0.928 ± 0.027	0.469TrpHis: 0.469 ± 0.02	0.56TrpIle: 0.56 ± 0.025	0.366TrpLys: 0.366 ± 0.017	2.718TrpLeu: 2.718 ± 0.062	0.363TrpMet: 0.363 ± 0.018	0.417TrpAsn: 0.417 ± 0.018	0.742TrpPro: 0.742 ± 0.029	1.192TrpGln: 1.192 ± 0.038	1.051TrpArg: 1.051 ± 0.031	0.791TrpSer: 0.791 ± 0.029	0.533TrpThr: 0.533 ± 0.024	0.872TrpVal: 0.872 ± 0.026	0.28TrpTrp: 0.28 ± 0.015	0.365TrpTyr: 0.365 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.283TyrAla: 2.283 ± 0.047	0.344TyrCys: 0.344 ± 0.018	1.359TyrAsp: 1.359 ± 0.037	1.168TyrGlu: 1.168 ± 0.033	1.082TyrPhe: 1.082 ± 0.033	2.154TyrGly: 2.154 ± 0.049	0.74TyrHis: 0.74 ± 0.028	1.073TyrIle: 1.073 ± 0.028	0.706TyrLys: 0.706 ± 0.025	3.03TyrLeu: 3.03 ± 0.05	0.542TyrMet: 0.542 ± 0.023	0.721TyrAsn: 0.721 ± 0.025	1.26TyrPro: 1.26 ± 0.032	1.453TyrGln: 1.453 ± 0.031	2.081TyrArg: 2.081 ± 0.049	1.406TyrSer: 1.406 ± 0.039	1.142TyrThr: 1.142 ± 0.032	1.602TyrVal: 1.602 ± 0.041	0.407TyrTrp: 0.407 ± 0.019	0.817TyrTyr: 0.817 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3522 proteins (1139482 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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