Amino acid dipepetide frequency for Salmonella phage vB_SenS_SB3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.199AlaAla: 11.199 ± 1.807
0.868AlaCys: 0.868 ± 0.27
6.782AlaAsp: 6.782 ± 0.676
6.625AlaGlu: 6.625 ± 0.816
4.259AlaPhe: 4.259 ± 0.645
7.65AlaGly: 7.65 ± 0.665
1.893AlaHis: 1.893 ± 0.433
4.574AlaIle: 4.574 ± 0.922
5.521AlaLys: 5.521 ± 0.917
7.571AlaLeu: 7.571 ± 0.828
2.129AlaMet: 2.129 ± 0.486
3.47AlaAsn: 3.47 ± 0.42
2.997AlaPro: 2.997 ± 0.398
3.943AlaGln: 3.943 ± 1.225
4.968AlaArg: 4.968 ± 0.651
5.757AlaSer: 5.757 ± 0.831
5.915AlaThr: 5.915 ± 0.782
7.729AlaVal: 7.729 ± 0.932
1.104AlaTrp: 1.104 ± 0.328
3.549AlaTyr: 3.549 ± 0.509
0.0AlaXaa: 0.0 ± 0.0
Cys
0.789CysAla: 0.789 ± 0.227
0.158CysCys: 0.158 ± 0.099
0.789CysAsp: 0.789 ± 0.236
1.025CysGlu: 1.025 ± 0.362
0.237CysPhe: 0.237 ± 0.15
0.473CysGly: 0.473 ± 0.167
0.158CysHis: 0.158 ± 0.104
0.237CysIle: 0.237 ± 0.126
0.868CysLys: 0.868 ± 0.245
0.868CysLeu: 0.868 ± 0.281
0.158CysMet: 0.158 ± 0.104
0.552CysAsn: 0.552 ± 0.256
0.315CysPro: 0.315 ± 0.183
0.079CysGln: 0.079 ± 0.078
0.552CysArg: 0.552 ± 0.207
0.158CysSer: 0.158 ± 0.193
0.552CysThr: 0.552 ± 0.173
0.631CysVal: 0.631 ± 0.216
0.237CysTrp: 0.237 ± 0.113
0.237CysTyr: 0.237 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
7.571AspAla: 7.571 ± 0.794
0.631AspCys: 0.631 ± 0.241
3.549AspAsp: 3.549 ± 0.586
3.864AspGlu: 3.864 ± 0.554
2.76AspPhe: 2.76 ± 0.374
6.23AspGly: 6.23 ± 0.82
0.631AspHis: 0.631 ± 0.233
3.391AspIle: 3.391 ± 0.449
3.785AspLys: 3.785 ± 0.433
4.574AspLeu: 4.574 ± 0.65
1.341AspMet: 1.341 ± 0.27
2.918AspAsn: 2.918 ± 0.63
1.893AspPro: 1.893 ± 0.354
0.71AspGln: 0.71 ± 0.278
2.839AspArg: 2.839 ± 0.388
4.022AspSer: 4.022 ± 0.554
4.18AspThr: 4.18 ± 0.437
3.628AspVal: 3.628 ± 0.46
0.946AspTrp: 0.946 ± 0.259
1.814AspTyr: 1.814 ± 0.437
0.0AspXaa: 0.0 ± 0.0
Glu
6.23GluAla: 6.23 ± 0.88
0.473GluCys: 0.473 ± 0.2
3.391GluAsp: 3.391 ± 0.479
4.968GluGlu: 4.968 ± 0.697
2.997GluPhe: 2.997 ± 0.613
4.89GluGly: 4.89 ± 0.676
0.946GluHis: 0.946 ± 0.264
3.864GluIle: 3.864 ± 0.547
4.495GluLys: 4.495 ± 0.625
6.703GluLeu: 6.703 ± 1.018
2.603GluMet: 2.603 ± 0.42
2.524GluAsn: 2.524 ± 0.501
1.735GluPro: 1.735 ± 0.52
3.155GluGln: 3.155 ± 0.764
3.47GluArg: 3.47 ± 0.54
3.707GluSer: 3.707 ± 0.528
4.101GluThr: 4.101 ± 0.534
4.416GluVal: 4.416 ± 0.454
1.104GluTrp: 1.104 ± 0.298
1.814GluTyr: 1.814 ± 0.441
0.0GluXaa: 0.0 ± 0.0
Phe
2.76PheAla: 2.76 ± 0.572
0.552PheCys: 0.552 ± 0.187
3.549PheAsp: 3.549 ± 0.584
2.524PheGlu: 2.524 ± 0.417
0.552PhePhe: 0.552 ± 0.169
3.076PheGly: 3.076 ± 0.467
0.552PheHis: 0.552 ± 0.227
2.287PheIle: 2.287 ± 0.47
1.893PheLys: 1.893 ± 0.475
1.893PheLeu: 1.893 ± 0.39
0.394PheMet: 0.394 ± 0.172
1.42PheAsn: 1.42 ± 0.419
1.577PhePro: 1.577 ± 0.382
1.341PheGln: 1.341 ± 0.342
2.366PheArg: 2.366 ± 0.353
2.445PheSer: 2.445 ± 0.599
3.391PheThr: 3.391 ± 0.631
2.997PheVal: 2.997 ± 0.504
0.789PheTrp: 0.789 ± 0.27
1.025PheTyr: 1.025 ± 0.31
0.0PheXaa: 0.0 ± 0.0
Gly
7.65GlyAla: 7.65 ± 0.809
0.868GlyCys: 0.868 ± 0.269
3.312GlyAsp: 3.312 ± 0.661
6.073GlyGlu: 6.073 ± 0.818
3.155GlyPhe: 3.155 ± 0.587
6.546GlyGly: 6.546 ± 1.03
1.498GlyHis: 1.498 ± 0.427
3.076GlyIle: 3.076 ± 0.417
4.732GlyLys: 4.732 ± 0.625
5.284GlyLeu: 5.284 ± 0.576
2.366GlyMet: 2.366 ± 0.579
3.864GlyAsn: 3.864 ± 0.587
1.972GlyPro: 1.972 ± 0.34
2.918GlyGln: 2.918 ± 0.475
4.653GlyArg: 4.653 ± 0.534
5.442GlySer: 5.442 ± 0.9
3.707GlyThr: 3.707 ± 0.531
5.757GlyVal: 5.757 ± 0.686
1.262GlyTrp: 1.262 ± 0.287
3.155GlyTyr: 3.155 ± 0.493
0.0GlyXaa: 0.0 ± 0.0
His
1.262HisAla: 1.262 ± 0.312
0.473HisCys: 0.473 ± 0.189
0.868HisAsp: 0.868 ± 0.221
0.789HisGlu: 0.789 ± 0.239
0.789HisPhe: 0.789 ± 0.27
1.025HisGly: 1.025 ± 0.383
0.631HisHis: 0.631 ± 0.259
0.868HisIle: 0.868 ± 0.253
1.025HisLys: 1.025 ± 0.25
1.183HisLeu: 1.183 ± 0.371
0.631HisMet: 0.631 ± 0.221
0.394HisAsn: 0.394 ± 0.128
1.104HisPro: 1.104 ± 0.291
1.262HisGln: 1.262 ± 0.306
0.868HisArg: 0.868 ± 0.205
0.946HisSer: 0.946 ± 0.252
0.71HisThr: 0.71 ± 0.319
0.789HisVal: 0.789 ± 0.249
0.079HisTrp: 0.079 ± 0.083
0.868HisTyr: 0.868 ± 0.275
0.0HisXaa: 0.0 ± 0.0
Ile
5.126IleAla: 5.126 ± 1.009
0.631IleCys: 0.631 ± 0.254
3.864IleAsp: 3.864 ± 0.573
2.603IleGlu: 2.603 ± 0.428
1.42IlePhe: 1.42 ± 0.392
3.47IleGly: 3.47 ± 0.411
1.025IleHis: 1.025 ± 0.323
2.129IleIle: 2.129 ± 0.462
2.918IleLys: 2.918 ± 0.504
2.997IleLeu: 2.997 ± 0.491
0.631IleMet: 0.631 ± 0.237
2.05IleAsn: 2.05 ± 0.475
2.524IlePro: 2.524 ± 0.36
1.972IleGln: 1.972 ± 0.487
2.524IleArg: 2.524 ± 0.381
3.076IleSer: 3.076 ± 0.604
4.653IleThr: 4.653 ± 0.701
3.312IleVal: 3.312 ± 0.488
0.631IleTrp: 0.631 ± 0.212
1.42IleTyr: 1.42 ± 0.421
0.0IleXaa: 0.0 ± 0.0
Lys
5.678LysAla: 5.678 ± 0.789
0.552LysCys: 0.552 ± 0.223
3.864LysAsp: 3.864 ± 0.661
4.416LysGlu: 4.416 ± 0.632
2.445LysPhe: 2.445 ± 0.342
3.47LysGly: 3.47 ± 0.528
1.262LysHis: 1.262 ± 0.278
1.972LysIle: 1.972 ± 0.45
2.997LysLys: 2.997 ± 0.481
5.915LysLeu: 5.915 ± 0.678
2.445LysMet: 2.445 ± 0.523
2.287LysAsn: 2.287 ± 0.428
2.445LysPro: 2.445 ± 0.454
1.814LysGln: 1.814 ± 0.4
4.022LysArg: 4.022 ± 0.642
3.233LysSer: 3.233 ± 0.688
3.943LysThr: 3.943 ± 0.469
3.47LysVal: 3.47 ± 0.612
0.552LysTrp: 0.552 ± 0.171
2.839LysTyr: 2.839 ± 0.457
0.0LysXaa: 0.0 ± 0.0
Leu
7.177LeuAla: 7.177 ± 0.746
0.631LeuCys: 0.631 ± 0.223
4.18LeuAsp: 4.18 ± 0.44
4.732LeuGlu: 4.732 ± 0.818
1.577LeuPhe: 1.577 ± 0.42
4.653LeuGly: 4.653 ± 0.563
1.025LeuHis: 1.025 ± 0.29
4.811LeuIle: 4.811 ± 0.507
5.205LeuLys: 5.205 ± 0.71
5.994LeuLeu: 5.994 ± 0.832
2.287LeuMet: 2.287 ± 0.432
4.022LeuAsn: 4.022 ± 0.486
3.549LeuPro: 3.549 ± 0.549
3.155LeuGln: 3.155 ± 0.515
5.205LeuArg: 5.205 ± 0.645
4.416LeuSer: 4.416 ± 0.486
5.521LeuThr: 5.521 ± 0.57
5.678LeuVal: 5.678 ± 0.682
1.262LeuTrp: 1.262 ± 0.377
2.603LeuTyr: 2.603 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
2.839MetAla: 2.839 ± 0.378
0.394MetCys: 0.394 ± 0.189
1.262MetAsp: 1.262 ± 0.312
1.341MetGlu: 1.341 ± 0.309
0.868MetPhe: 0.868 ± 0.234
1.656MetGly: 1.656 ± 0.348
0.158MetHis: 0.158 ± 0.117
1.262MetIle: 1.262 ± 0.308
1.735MetLys: 1.735 ± 0.341
1.972MetLeu: 1.972 ± 0.394
0.473MetMet: 0.473 ± 0.192
1.262MetAsn: 1.262 ± 0.271
1.262MetPro: 1.262 ± 0.302
0.868MetGln: 0.868 ± 0.259
1.341MetArg: 1.341 ± 0.257
2.208MetSer: 2.208 ± 0.345
1.498MetThr: 1.498 ± 0.356
2.05MetVal: 2.05 ± 0.408
0.473MetTrp: 0.473 ± 0.209
0.552MetTyr: 0.552 ± 0.226
0.0MetXaa: 0.0 ± 0.0
Asn
4.022AsnAla: 4.022 ± 0.754
0.473AsnCys: 0.473 ± 0.212
2.918AsnAsp: 2.918 ± 0.376
2.366AsnGlu: 2.366 ± 0.424
1.341AsnPhe: 1.341 ± 0.289
4.495AsnGly: 4.495 ± 0.707
0.631AsnHis: 0.631 ± 0.233
3.155AsnIle: 3.155 ± 0.46
1.972AsnLys: 1.972 ± 0.401
3.628AsnLeu: 3.628 ± 0.392
0.789AsnMet: 0.789 ± 0.292
2.05AsnAsn: 2.05 ± 0.397
1.656AsnPro: 1.656 ± 0.328
1.104AsnGln: 1.104 ± 0.289
2.603AsnArg: 2.603 ± 0.395
1.735AsnSer: 1.735 ± 0.328
2.208AsnThr: 2.208 ± 0.409
3.233AsnVal: 3.233 ± 0.365
0.789AsnTrp: 0.789 ± 0.232
1.577AsnTyr: 1.577 ± 0.397
0.0AsnXaa: 0.0 ± 0.0
Pro
3.155ProAla: 3.155 ± 0.476
0.394ProCys: 0.394 ± 0.161
3.391ProAsp: 3.391 ± 0.616
2.918ProGlu: 2.918 ± 0.407
1.814ProPhe: 1.814 ± 0.316
3.233ProGly: 3.233 ± 0.48
0.552ProHis: 0.552 ± 0.193
1.498ProIle: 1.498 ± 0.35
2.681ProLys: 2.681 ± 0.451
2.76ProLeu: 2.76 ± 0.437
0.868ProMet: 0.868 ± 0.238
1.498ProAsn: 1.498 ± 0.54
1.498ProPro: 1.498 ± 0.349
1.262ProGln: 1.262 ± 0.335
1.656ProArg: 1.656 ± 0.311
1.972ProSer: 1.972 ± 0.38
1.498ProThr: 1.498 ± 0.322
3.864ProVal: 3.864 ± 0.468
0.394ProTrp: 0.394 ± 0.219
1.42ProTyr: 1.42 ± 0.358
0.0ProXaa: 0.0 ± 0.0
Gln
4.259GlnAla: 4.259 ± 0.719
0.158GlnCys: 0.158 ± 0.116
1.577GlnAsp: 1.577 ± 0.352
1.972GlnGlu: 1.972 ± 0.542
1.262GlnPhe: 1.262 ± 0.349
2.129GlnGly: 2.129 ± 0.418
0.946GlnHis: 0.946 ± 0.283
1.814GlnIle: 1.814 ± 0.487
2.366GlnLys: 2.366 ± 0.412
2.997GlnLeu: 2.997 ± 0.514
1.262GlnMet: 1.262 ± 0.293
2.05GlnAsn: 2.05 ± 0.388
1.972GlnPro: 1.972 ± 0.323
2.603GlnGln: 2.603 ± 0.905
1.893GlnArg: 1.893 ± 0.398
1.893GlnSer: 1.893 ± 0.364
1.814GlnThr: 1.814 ± 0.447
2.603GlnVal: 2.603 ± 0.389
0.552GlnTrp: 0.552 ± 0.178
1.262GlnTyr: 1.262 ± 0.255
0.0GlnXaa: 0.0 ± 0.0
Arg
4.653ArgAla: 4.653 ± 0.494
0.158ArgCys: 0.158 ± 0.101
3.864ArgAsp: 3.864 ± 0.467
4.495ArgGlu: 4.495 ± 0.813
2.05ArgPhe: 2.05 ± 0.365
4.022ArgGly: 4.022 ± 0.514
0.868ArgHis: 0.868 ± 0.244
2.997ArgIle: 2.997 ± 0.486
3.312ArgLys: 3.312 ± 0.611
4.101ArgLeu: 4.101 ± 0.463
2.208ArgMet: 2.208 ± 0.406
3.076ArgAsn: 3.076 ± 0.427
2.129ArgPro: 2.129 ± 0.4
2.76ArgGln: 2.76 ± 0.476
4.574ArgArg: 4.574 ± 0.636
2.287ArgSer: 2.287 ± 0.362
2.918ArgThr: 2.918 ± 0.444
4.495ArgVal: 4.495 ± 0.473
0.946ArgTrp: 0.946 ± 0.262
1.42ArgTyr: 1.42 ± 0.366
0.0ArgXaa: 0.0 ± 0.0
Ser
6.546SerAla: 6.546 ± 0.977
0.237SerCys: 0.237 ± 0.132
3.233SerAsp: 3.233 ± 0.432
3.47SerGlu: 3.47 ± 0.552
2.366SerPhe: 2.366 ± 0.421
6.625SerGly: 6.625 ± 0.856
0.789SerHis: 0.789 ± 0.235
2.208SerIle: 2.208 ± 0.428
3.155SerLys: 3.155 ± 0.518
5.284SerLeu: 5.284 ± 0.696
1.025SerMet: 1.025 ± 0.309
2.445SerAsn: 2.445 ± 0.359
1.814SerPro: 1.814 ± 0.389
2.05SerGln: 2.05 ± 0.319
2.918SerArg: 2.918 ± 0.41
3.076SerSer: 3.076 ± 0.453
4.022SerThr: 4.022 ± 0.721
5.521SerVal: 5.521 ± 0.795
0.552SerTrp: 0.552 ± 0.202
1.656SerTyr: 1.656 ± 0.422
0.0SerXaa: 0.0 ± 0.0
Thr
6.782ThrAla: 6.782 ± 0.888
0.552ThrCys: 0.552 ± 0.207
4.022ThrAsp: 4.022 ± 0.498
3.707ThrGlu: 3.707 ± 0.588
3.155ThrPhe: 3.155 ± 0.564
6.073ThrGly: 6.073 ± 0.795
0.868ThrHis: 0.868 ± 0.293
2.839ThrIle: 2.839 ± 0.522
3.155ThrLys: 3.155 ± 0.466
4.732ThrLeu: 4.732 ± 0.66
0.946ThrMet: 0.946 ± 0.311
1.972ThrAsn: 1.972 ± 0.424
3.864ThrPro: 3.864 ± 0.624
1.42ThrGln: 1.42 ± 0.421
3.391ThrArg: 3.391 ± 0.435
4.574ThrSer: 4.574 ± 0.572
3.47ThrThr: 3.47 ± 0.5
4.653ThrVal: 4.653 ± 0.798
1.42ThrTrp: 1.42 ± 0.337
2.603ThrTyr: 2.603 ± 0.426
0.0ThrXaa: 0.0 ± 0.0
Val
6.703ValAla: 6.703 ± 0.652
0.394ValCys: 0.394 ± 0.166
3.943ValAsp: 3.943 ± 0.455
6.546ValGlu: 6.546 ± 0.759
2.05ValPhe: 2.05 ± 0.466
4.022ValGly: 4.022 ± 0.616
1.104ValHis: 1.104 ± 0.276
4.101ValIle: 4.101 ± 0.575
4.89ValLys: 4.89 ± 0.737
4.811ValLeu: 4.811 ± 0.482
1.577ValMet: 1.577 ± 0.418
2.918ValAsn: 2.918 ± 0.442
2.208ValPro: 2.208 ± 0.607
2.839ValGln: 2.839 ± 0.363
3.785ValArg: 3.785 ± 0.434
5.757ValSer: 5.757 ± 0.838
6.625ValThr: 6.625 ± 0.829
5.836ValVal: 5.836 ± 0.731
0.789ValTrp: 0.789 ± 0.24
2.524ValTyr: 2.524 ± 0.358
0.0ValXaa: 0.0 ± 0.0
Trp
1.183TrpAla: 1.183 ± 0.403
0.079TrpCys: 0.079 ± 0.078
1.025TrpAsp: 1.025 ± 0.286
0.552TrpGlu: 0.552 ± 0.171
0.71TrpPhe: 0.71 ± 0.303
1.025TrpGly: 1.025 ± 0.261
0.315TrpHis: 0.315 ± 0.212
0.394TrpIle: 0.394 ± 0.172
0.631TrpLys: 0.631 ± 0.267
1.814TrpLeu: 1.814 ± 0.388
0.473TrpMet: 0.473 ± 0.182
0.552TrpAsn: 0.552 ± 0.287
0.552TrpPro: 0.552 ± 0.24
0.868TrpGln: 0.868 ± 0.207
1.262TrpArg: 1.262 ± 0.368
0.315TrpSer: 0.315 ± 0.146
0.946TrpThr: 0.946 ± 0.292
1.025TrpVal: 1.025 ± 0.258
0.394TrpTrp: 0.394 ± 0.183
0.237TrpTyr: 0.237 ± 0.133
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.918TyrAla: 2.918 ± 0.582
0.394TyrCys: 0.394 ± 0.146
1.893TyrAsp: 1.893 ± 0.485
2.603TyrGlu: 2.603 ± 0.44
1.577TyrPhe: 1.577 ± 0.4
2.524TyrGly: 2.524 ± 0.43
0.71TyrHis: 0.71 ± 0.19
1.498TyrIle: 1.498 ± 0.322
2.366TyrLys: 2.366 ± 0.435
2.603TyrLeu: 2.603 ± 0.471
0.789TyrMet: 0.789 ± 0.219
1.42TyrAsn: 1.42 ± 0.283
1.262TyrPro: 1.262 ± 0.373
1.262TyrGln: 1.262 ± 0.324
2.445TyrArg: 2.445 ± 0.519
1.972TyrSer: 1.972 ± 0.479
2.524TyrThr: 2.524 ± 0.455
1.735TyrVal: 1.735 ± 0.355
0.079TyrTrp: 0.079 ± 0.091
1.262TyrTyr: 1.262 ± 0.315
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 63 proteins (12681 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski