Amino acid dipepetide frequency for Saccharomonospora sp. CUA-673

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.714AlaAla: 19.714 ± 0.22	1.03AlaCys: 1.03 ± 0.031	9.367AlaAsp: 9.367 ± 0.11	9.292AlaGlu: 9.292 ± 0.131	3.431AlaPhe: 3.431 ± 0.06	12.922AlaGly: 12.922 ± 0.124	2.6AlaHis: 2.6 ± 0.061	4.05AlaIle: 4.05 ± 0.067	2.502AlaLys: 2.502 ± 0.056	12.866AlaLeu: 12.866 ± 0.13	2.718AlaMet: 2.718 ± 0.046	2.043AlaAsn: 2.043 ± 0.044	6.068AlaPro: 6.068 ± 0.086	3.668AlaGln: 3.668 ± 0.056	9.405AlaArg: 9.405 ± 0.111	6.051AlaSer: 6.051 ± 0.072	7.385AlaThr: 7.385 ± 0.088	11.65AlaVal: 11.65 ± 0.12	1.787AlaTrp: 1.787 ± 0.043	2.307AlaTyr: 2.307 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.01CysAla: 1.01 ± 0.033	0.113CysCys: 0.113 ± 0.009	0.533CysAsp: 0.533 ± 0.027	0.387CysGlu: 0.387 ± 0.019	0.197CysPhe: 0.197 ± 0.012	0.934CysGly: 0.934 ± 0.029	0.21CysHis: 0.21 ± 0.013	0.217CysIle: 0.217 ± 0.015	0.1CysLys: 0.1 ± 0.01	0.617CysLeu: 0.617 ± 0.023	0.121CysMet: 0.121 ± 0.009	0.131CysAsn: 0.131 ± 0.011	0.46CysPro: 0.46 ± 0.02	0.194CysGln: 0.194 ± 0.013	0.687CysArg: 0.687 ± 0.027	0.478CysSer: 0.478 ± 0.021	0.521CysThr: 0.521 ± 0.024	0.689CysVal: 0.689 ± 0.031	0.12CysTrp: 0.12 ± 0.01	0.161CysTyr: 0.161 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.254AspAla: 8.254 ± 0.098	0.397AspCys: 0.397 ± 0.018	4.656AspAsp: 4.656 ± 0.084	4.939AspGlu: 4.939 ± 0.076	1.513AspPhe: 1.513 ± 0.04	6.68AspGly: 6.68 ± 0.113	1.528AspHis: 1.528 ± 0.037	2.152AspIle: 2.152 ± 0.047	1.178AspLys: 1.178 ± 0.033	6.264AspLeu: 6.264 ± 0.088	0.939AspMet: 0.939 ± 0.031	1.121AspAsn: 1.121 ± 0.027	4.752AspPro: 4.752 ± 0.069	1.753AspGln: 1.753 ± 0.043	5.022AspArg: 5.022 ± 0.068	2.761AspSer: 2.761 ± 0.056	3.685AspThr: 3.685 ± 0.058	6.372AspVal: 6.372 ± 0.08	0.914AspTrp: 0.914 ± 0.025	1.157AspTyr: 1.157 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.102GluAla: 7.102 ± 0.091	0.369GluCys: 0.369 ± 0.017	2.812GluAsp: 2.812 ± 0.057	3.006GluGlu: 3.006 ± 0.064	1.812GluPhe: 1.812 ± 0.032	4.05GluGly: 4.05 ± 0.064	1.889GluHis: 1.889 ± 0.043	2.386GluIle: 2.386 ± 0.046	1.185GluLys: 1.185 ± 0.036	7.407GluLeu: 7.407 ± 0.096	1.005GluMet: 1.005 ± 0.036	1.216GluAsn: 1.216 ± 0.031	3.833GluPro: 3.833 ± 0.066	2.842GluGln: 2.842 ± 0.053	5.65GluArg: 5.65 ± 0.088	2.996GluSer: 2.996 ± 0.052	3.116GluThr: 3.116 ± 0.054	4.917GluVal: 4.917 ± 0.066	0.895GluTrp: 0.895 ± 0.026	1.145GluTyr: 1.145 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.706PheAla: 3.706 ± 0.055	0.248PheCys: 0.248 ± 0.014	2.204PheAsp: 2.204 ± 0.049	1.432PheGlu: 1.432 ± 0.034	0.797PhePhe: 0.797 ± 0.028	3.232PheGly: 3.232 ± 0.066	0.562PheHis: 0.562 ± 0.021	0.697PheIle: 0.697 ± 0.027	0.343PheLys: 0.343 ± 0.017	2.399PheLeu: 2.399 ± 0.053	0.411PheMet: 0.411 ± 0.019	0.514PheAsn: 0.514 ± 0.022	1.288PhePro: 1.288 ± 0.034	0.617PheGln: 0.617 ± 0.026	1.654PheArg: 1.654 ± 0.039	1.339PheSer: 1.339 ± 0.035	1.95PheThr: 1.95 ± 0.041	2.546PheVal: 2.546 ± 0.045	0.401PheTrp: 0.401 ± 0.021	0.562PheTyr: 0.562 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.822GlyAla: 10.822 ± 0.123	0.815GlyCys: 0.815 ± 0.027	5.752GlyAsp: 5.752 ± 0.084	5.635GlyGlu: 5.635 ± 0.084	2.925GlyPhe: 2.925 ± 0.051	9.125GlyGly: 9.125 ± 0.151	2.102GlyHis: 2.102 ± 0.049	3.729GlyIle: 3.729 ± 0.061	2.161GlyLys: 2.161 ± 0.047	8.788GlyLeu: 8.788 ± 0.097	2.226GlyMet: 2.226 ± 0.05	1.902GlyAsn: 1.902 ± 0.044	4.674GlyPro: 4.674 ± 0.07	2.845GlyGln: 2.845 ± 0.065	6.905GlyArg: 6.905 ± 0.082	5.31GlySer: 5.31 ± 0.079	5.842GlyThr: 5.842 ± 0.08	8.045GlyVal: 8.045 ± 0.093	1.61GlyTrp: 1.61 ± 0.034	2.222GlyTyr: 2.222 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.73HisAla: 2.73 ± 0.057	0.273HisCys: 0.273 ± 0.015	1.473HisAsp: 1.473 ± 0.04	1.341HisGlu: 1.341 ± 0.032	0.589HisPhe: 0.589 ± 0.024	2.429HisGly: 2.429 ± 0.055	0.695HisHis: 0.695 ± 0.027	0.705HisIle: 0.705 ± 0.027	0.319HisLys: 0.319 ± 0.019	2.114HisLeu: 2.114 ± 0.048	0.364HisMet: 0.364 ± 0.017	0.408HisAsn: 0.408 ± 0.02	1.61HisPro: 1.61 ± 0.037	0.605HisGln: 0.605 ± 0.023	2.032HisArg: 2.032 ± 0.051	0.987HisSer: 0.987 ± 0.031	1.256HisThr: 1.256 ± 0.032	1.938HisVal: 1.938 ± 0.043	0.343HisTrp: 0.343 ± 0.019	0.5HisTyr: 0.5 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.289IleAla: 5.289 ± 0.07	0.277IleCys: 0.277 ± 0.016	2.736IleAsp: 2.736 ± 0.049	2.169IleGlu: 2.169 ± 0.052	0.7IlePhe: 0.7 ± 0.027	3.803IleGly: 3.803 ± 0.062	0.67IleHis: 0.67 ± 0.026	1.052IleIle: 1.052 ± 0.03	0.618IleLys: 0.618 ± 0.028	2.363IleLeu: 2.363 ± 0.048	0.503IleMet: 0.503 ± 0.019	0.741IleAsn: 0.741 ± 0.025	1.869IlePro: 1.869 ± 0.042	0.693IleGln: 0.693 ± 0.026	2.24IleArg: 2.24 ± 0.043	1.791IleSer: 1.791 ± 0.037	2.537IleThr: 2.537 ± 0.047	3.349IleVal: 3.349 ± 0.052	0.355IleTrp: 0.355 ± 0.02	0.626IleTyr: 0.626 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.357LysAla: 2.357 ± 0.056	0.086LysCys: 0.086 ± 0.009	1.003LysAsp: 1.003 ± 0.034	0.954LysGlu: 0.954 ± 0.031	0.433LysPhe: 0.433 ± 0.021	1.356LysGly: 1.356 ± 0.044	0.481LysHis: 0.481 ± 0.022	0.769LysIle: 0.769 ± 0.03	0.59LysLys: 0.59 ± 0.027	1.919LysLeu: 1.919 ± 0.036	0.334LysMet: 0.334 ± 0.019	0.455LysAsn: 0.455 ± 0.024	1.226LysPro: 1.226 ± 0.034	0.736LysGln: 0.736 ± 0.028	1.535LysArg: 1.535 ± 0.044	1.004LysSer: 1.004 ± 0.037	1.152LysThr: 1.152 ± 0.04	1.681LysVal: 1.681 ± 0.043	0.204LysTrp: 0.204 ± 0.015	0.378LysTyr: 0.378 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.544LeuAla: 14.544 ± 0.144	0.762LeuCys: 0.762 ± 0.022	6.916LeuAsp: 6.916 ± 0.081	4.848LeuGlu: 4.848 ± 0.066	2.428LeuPhe: 2.428 ± 0.055	9.282LeuGly: 9.282 ± 0.105	2.129LeuHis: 2.129 ± 0.044	3.216LeuIle: 3.216 ± 0.057	1.463LeuLys: 1.463 ± 0.04	10.477LeuLeu: 10.477 ± 0.109	1.464LeuMet: 1.464 ± 0.039	1.583LeuAsn: 1.583 ± 0.038	5.868LeuPro: 5.868 ± 0.078	2.176LeuGln: 2.176 ± 0.045	8.175LeuArg: 8.175 ± 0.1	5.324LeuSer: 5.324 ± 0.072	6.402LeuThr: 6.402 ± 0.071	9.111LeuVal: 9.111 ± 0.114	1.232LeuTrp: 1.232 ± 0.034	1.602LeuTyr: 1.602 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.246MetAla: 2.246 ± 0.046	0.16MetCys: 0.16 ± 0.013	0.938MetAsp: 0.938 ± 0.029	0.694MetGlu: 0.694 ± 0.025	0.547MetPhe: 0.547 ± 0.023	1.333MetGly: 1.333 ± 0.036	0.358MetHis: 0.358 ± 0.017	0.722MetIle: 0.722 ± 0.028	0.372MetLys: 0.372 ± 0.02	2.015MetLeu: 2.015 ± 0.044	0.324MetMet: 0.324 ± 0.017	0.476MetAsn: 0.476 ± 0.022	1.294MetPro: 1.294 ± 0.032	0.535MetGln: 0.535 ± 0.022	1.604MetArg: 1.604 ± 0.034	1.557MetSer: 1.557 ± 0.04	1.72MetThr: 1.72 ± 0.035	1.381MetVal: 1.381 ± 0.039	0.252MetTrp: 0.252 ± 0.016	0.252MetTyr: 0.252 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.245AsnAla: 2.245 ± 0.047	0.169AsnCys: 0.169 ± 0.012	1.095AsnAsp: 1.095 ± 0.031	1.005AsnGlu: 1.005 ± 0.03	0.437AsnPhe: 0.437 ± 0.018	1.825AsnGly: 1.825 ± 0.04	0.377AsnHis: 0.377 ± 0.02	0.659AsnIle: 0.659 ± 0.024	0.347AsnLys: 0.347 ± 0.018	1.894AsnLeu: 1.894 ± 0.039	0.335AsnMet: 0.335 ± 0.019	0.421AsnAsn: 0.421 ± 0.021	1.531AsnPro: 1.531 ± 0.039	0.518AsnGln: 0.518 ± 0.024	1.373AsnArg: 1.373 ± 0.035	0.965AsnSer: 0.965 ± 0.033	1.149AsnThr: 1.149 ± 0.033	1.619AsnVal: 1.619 ± 0.041	0.278AsnTrp: 0.278 ± 0.018	0.413AsnTyr: 0.413 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.573ProAla: 7.573 ± 0.118	0.37ProCys: 0.37 ± 0.019	4.73ProAsp: 4.73 ± 0.07	4.379ProGlu: 4.379 ± 0.061	1.483ProPhe: 1.483 ± 0.038	5.909ProGly: 5.909 ± 0.09	1.362ProHis: 1.362 ± 0.035	1.666ProIle: 1.666 ± 0.037	1.07ProLys: 1.07 ± 0.03	4.703ProLeu: 4.703 ± 0.069	1.142ProMet: 1.142 ± 0.032	1.163ProAsn: 1.163 ± 0.033	3.283ProPro: 3.283 ± 0.074	1.735ProGln: 1.735 ± 0.046	3.789ProArg: 3.789 ± 0.066	3.007ProSer: 3.007 ± 0.052	3.559ProThr: 3.559 ± 0.06	5.17ProVal: 5.17 ± 0.073	0.901ProTrp: 0.901 ± 0.028	1.084ProTyr: 1.084 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.704GlnAla: 3.704 ± 0.062	0.167GlnCys: 0.167 ± 0.013	1.295GlnAsp: 1.295 ± 0.033	1.337GlnGlu: 1.337 ± 0.035	0.772GlnPhe: 0.772 ± 0.027	2.1GlnGly: 2.1 ± 0.045	0.753GlnHis: 0.753 ± 0.027	1.128GlnIle: 1.128 ± 0.03	0.503GlnLys: 0.503 ± 0.023	3.403GlnLeu: 3.403 ± 0.053	0.513GlnMet: 0.513 ± 0.021	0.535GlnAsn: 0.535 ± 0.022	1.871GlnPro: 1.871 ± 0.053	1.517GlnGln: 1.517 ± 0.046	2.775GlnArg: 2.775 ± 0.055	1.342GlnSer: 1.342 ± 0.033	1.356GlnThr: 1.356 ± 0.034	2.508GlnVal: 2.508 ± 0.052	0.444GlnTrp: 0.444 ± 0.023	0.577GlnTyr: 0.577 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.066ArgAla: 9.066 ± 0.123	0.682ArgCys: 0.682 ± 0.024	4.544ArgAsp: 4.544 ± 0.07	4.657ArgGlu: 4.657 ± 0.073	2.246ArgPhe: 2.246 ± 0.051	5.79ArgGly: 5.79 ± 0.073	1.997ArgHis: 1.997 ± 0.049	3.24ArgIle: 3.24 ± 0.052	1.907ArgLys: 1.907 ± 0.05	7.731ArgLeu: 7.731 ± 0.09	2.015ArgMet: 2.015 ± 0.045	1.497ArgAsn: 1.497 ± 0.038	4.447ArgPro: 4.447 ± 0.068	2.264ArgGln: 2.264 ± 0.053	7.744ArgArg: 7.744 ± 0.131	4.285ArgSer: 4.285 ± 0.064	5.022ArgThr: 5.022 ± 0.076	6.009ArgVal: 6.009 ± 0.081	1.418ArgTrp: 1.418 ± 0.034	1.789ArgTyr: 1.789 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.74SerAla: 6.74 ± 0.084	0.416SerCys: 0.416 ± 0.023	3.276SerAsp: 3.276 ± 0.062	2.906SerGlu: 2.906 ± 0.052	1.418SerPhe: 1.418 ± 0.036	6.049SerGly: 6.049 ± 0.087	0.908SerHis: 0.908 ± 0.03	1.813SerIle: 1.813 ± 0.039	0.927SerLys: 0.927 ± 0.034	4.551SerLeu: 4.551 ± 0.067	1.275SerMet: 1.275 ± 0.038	0.981SerAsn: 0.981 ± 0.028	2.919SerPro: 2.919 ± 0.052	1.253SerGln: 1.253 ± 0.035	3.675SerArg: 3.675 ± 0.066	3.108SerSer: 3.108 ± 0.073	3.708SerThr: 3.708 ± 0.065	4.387SerVal: 4.387 ± 0.062	0.88SerTrp: 0.88 ± 0.027	1.05SerTyr: 1.05 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	8.25ThrAla: 8.25 ± 0.092	0.468ThrCys: 0.468 ± 0.023	3.97ThrAsp: 3.97 ± 0.064	3.509ThrGlu: 3.509 ± 0.05	1.677ThrPhe: 1.677 ± 0.037	6.394ThrGly: 6.394 ± 0.078	1.183ThrHis: 1.183 ± 0.031	2.133ThrIle: 2.133 ± 0.049	1.141ThrLys: 1.141 ± 0.035	5.682ThrLeu: 5.682 ± 0.077	1.202ThrMet: 1.202 ± 0.038	1.095ThrAsn: 1.095 ± 0.035	4.095ThrPro: 4.095 ± 0.061	1.379ThrGln: 1.379 ± 0.037	4.09ThrArg: 4.09 ± 0.065	3.592ThrSer: 3.592 ± 0.059	4.239ThrThr: 4.239 ± 0.072	6.102ThrVal: 6.102 ± 0.07	0.986ThrTrp: 0.986 ± 0.034	1.266ThrTyr: 1.266 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.563ValAla: 11.563 ± 0.121	0.713ValCys: 0.713 ± 0.022	6.572ValAsp: 6.572 ± 0.09	5.379ValGlu: 5.379 ± 0.074	2.422ValPhe: 2.422 ± 0.047	7.313ValGly: 7.313 ± 0.082	2.088ValHis: 2.088 ± 0.044	2.881ValIle: 2.881 ± 0.054	1.34ValLys: 1.34 ± 0.037	9.954ValLeu: 9.954 ± 0.113	1.315ValMet: 1.315 ± 0.036	1.639ValAsn: 1.639 ± 0.037	5.083ValPro: 5.083 ± 0.066	2.182ValGln: 2.182 ± 0.046	6.872ValArg: 6.872 ± 0.073	4.51ValSer: 4.51 ± 0.064	5.723ValThr: 5.723 ± 0.075	8.995ValVal: 8.995 ± 0.11	1.128ValTrp: 1.128 ± 0.031	1.556ValTyr: 1.556 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.524TrpAla: 1.524 ± 0.038	0.211TrpCys: 0.211 ± 0.014	0.74TrpAsp: 0.74 ± 0.029	0.666TrpGlu: 0.666 ± 0.022	0.517TrpPhe: 0.517 ± 0.026	0.981TrpGly: 0.981 ± 0.034	0.409TrpHis: 0.409 ± 0.018	0.641TrpIle: 0.641 ± 0.028	0.287TrpLys: 0.287 ± 0.016	1.777TrpLeu: 1.777 ± 0.042	0.343TrpMet: 0.343 ± 0.017	0.352TrpAsn: 0.352 ± 0.021	0.83TrpPro: 0.83 ± 0.024	0.59TrpGln: 0.59 ± 0.02	1.327TrpArg: 1.327 ± 0.036	0.889TrpSer: 0.889 ± 0.026	0.983TrpThr: 0.983 ± 0.033	1.065TrpVal: 1.065 ± 0.033	0.377TrpTrp: 0.377 ± 0.019	0.283TrpTyr: 0.283 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.414TyrAla: 2.414 ± 0.056	0.153TyrCys: 0.153 ± 0.012	1.427TyrAsp: 1.427 ± 0.046	1.1TyrGlu: 1.1 ± 0.031	0.56TyrPhe: 0.56 ± 0.025	1.929TyrGly: 1.929 ± 0.042	0.409TyrHis: 0.409 ± 0.017	0.523TyrIle: 0.523 ± 0.022	0.3TyrLys: 0.3 ± 0.02	2.079TyrLeu: 2.079 ± 0.039	0.229TyrMet: 0.229 ± 0.015	0.383TyrAsn: 0.383 ± 0.018	1.073TyrPro: 1.073 ± 0.035	0.5TyrGln: 0.5 ± 0.019	1.796TyrArg: 1.796 ± 0.046	0.942TyrSer: 0.942 ± 0.026	1.149TyrThr: 1.149 ± 0.035	1.693TyrVal: 1.693 ± 0.038	0.271TyrTrp: 0.271 ± 0.015	0.414TyrTyr: 0.414 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4089 proteins (1144911 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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