Amino acid dipepetide frequency for Merismopedia glauca CCAP 1448/3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.889AlaAla: 6.889 ± 0.091
0.815AlaCys: 0.815 ± 0.024
3.852AlaAsp: 3.852 ± 0.058
5.211AlaGlu: 5.211 ± 0.066
2.797AlaPhe: 2.797 ± 0.049
5.202AlaGly: 5.202 ± 0.077
1.275AlaHis: 1.275 ± 0.03
7.522AlaIle: 7.522 ± 0.092
4.365AlaLys: 4.365 ± 0.06
8.303AlaLeu: 8.303 ± 0.082
1.596AlaMet: 1.596 ± 0.032
3.406AlaAsn: 3.406 ± 0.055
2.827AlaPro: 2.827 ± 0.055
4.217AlaGln: 4.217 ± 0.061
3.526AlaArg: 3.526 ± 0.054
4.888AlaSer: 4.888 ± 0.069
4.708AlaThr: 4.708 ± 0.066
5.147AlaVal: 5.147 ± 0.062
0.979AlaTrp: 0.979 ± 0.027
2.422AlaTyr: 2.422 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.627CysAla: 0.627 ± 0.023
0.161CysCys: 0.161 ± 0.011
0.604CysAsp: 0.604 ± 0.021
0.49CysGlu: 0.49 ± 0.017
0.405CysPhe: 0.405 ± 0.018
0.808CysGly: 0.808 ± 0.022
0.326CysHis: 0.326 ± 0.013
0.56CysIle: 0.56 ± 0.021
0.282CysLys: 0.282 ± 0.015
1.346CysLeu: 1.346 ± 0.036
0.159CysMet: 0.159 ± 0.012
0.368CysAsn: 0.368 ± 0.018
0.581CysPro: 0.581 ± 0.021
0.725CysGln: 0.725 ± 0.025
0.557CysArg: 0.557 ± 0.019
0.656CysSer: 0.656 ± 0.023
0.471CysThr: 0.471 ± 0.016
0.57CysVal: 0.57 ± 0.019
0.162CysTrp: 0.162 ± 0.011
0.365CysTyr: 0.365 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.446AspAla: 3.446 ± 0.048
0.548AspCys: 0.548 ± 0.021
2.043AspAsp: 2.043 ± 0.045
2.85AspGlu: 2.85 ± 0.047
2.306AspPhe: 2.306 ± 0.04
3.384AspGly: 3.384 ± 0.053
0.537AspHis: 0.537 ± 0.02
3.197AspIle: 3.197 ± 0.047
2.275AspLys: 2.275 ± 0.04
6.368AspLeu: 6.368 ± 0.065
0.725AspMet: 0.725 ± 0.024
1.926AspAsn: 1.926 ± 0.037
2.445AspPro: 2.445 ± 0.042
1.121AspGln: 1.121 ± 0.031
4.598AspArg: 4.598 ± 0.058
3.045AspSer: 3.045 ± 0.053
2.41AspThr: 2.41 ± 0.042
2.83AspVal: 2.83 ± 0.048
0.908AspTrp: 0.908 ± 0.027
1.86AspTyr: 1.86 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
5.513GluAla: 5.513 ± 0.061
0.506GluCys: 0.506 ± 0.02
2.677GluAsp: 2.677 ± 0.042
3.792GluGlu: 3.792 ± 0.058
2.449GluPhe: 2.449 ± 0.044
3.217GluGly: 3.217 ± 0.051
0.952GluHis: 0.952 ± 0.025
5.331GluIle: 5.331 ± 0.063
3.444GluLys: 3.444 ± 0.057
7.176GluLeu: 7.176 ± 0.092
1.297GluMet: 1.297 ± 0.031
2.541GluAsn: 2.541 ± 0.047
2.546GluPro: 2.546 ± 0.044
3.279GluGln: 3.279 ± 0.053
3.38GluArg: 3.38 ± 0.046
3.772GluSer: 3.772 ± 0.059
3.815GluThr: 3.815 ± 0.053
4.429GluVal: 4.429 ± 0.058
0.767GluTrp: 0.767 ± 0.025
1.91GluTyr: 1.91 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
2.993PheAla: 2.993 ± 0.045
0.552PheCys: 0.552 ± 0.02
2.19PheAsp: 2.19 ± 0.042
2.035PheGlu: 2.035 ± 0.04
1.606PhePhe: 1.606 ± 0.036
2.869PheGly: 2.869 ± 0.05
0.726PheHis: 0.726 ± 0.024
2.261PheIle: 2.261 ± 0.044
1.665PheLys: 1.665 ± 0.037
4.054PheLeu: 4.054 ± 0.066
0.643PheMet: 0.643 ± 0.024
1.692PheAsn: 1.692 ± 0.035
2.007PhePro: 2.007 ± 0.034
1.807PheGln: 1.807 ± 0.035
1.714PheArg: 1.714 ± 0.041
2.936PheSer: 2.936 ± 0.054
2.253PheThr: 2.253 ± 0.041
2.241PheVal: 2.241 ± 0.039
0.751PheTrp: 0.751 ± 0.027
1.345PheTyr: 1.345 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
4.65GlyAla: 4.65 ± 0.073
0.819GlyCys: 0.819 ± 0.026
3.482GlyAsp: 3.482 ± 0.058
4.245GlyGlu: 4.245 ± 0.056
2.852GlyPhe: 2.852 ± 0.049
4.704GlyGly: 4.704 ± 0.078
1.186GlyHis: 1.186 ± 0.035
5.199GlyIle: 5.199 ± 0.062
4.498GlyLys: 4.498 ± 0.063
6.951GlyLeu: 6.951 ± 0.076
1.475GlyMet: 1.475 ± 0.036
3.11GlyAsn: 3.11 ± 0.061
1.105GlyPro: 1.105 ± 0.032
2.742GlyGln: 2.742 ± 0.052
3.035GlyArg: 3.035 ± 0.053
4.323GlySer: 4.323 ± 0.06
3.87GlyThr: 3.87 ± 0.067
4.616GlyVal: 4.616 ± 0.063
1.176GlyTrp: 1.176 ± 0.03
2.394GlyTyr: 2.394 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
1.009HisAla: 1.009 ± 0.026
0.255HisCys: 0.255 ± 0.012
0.68HisAsp: 0.68 ± 0.021
0.866HisGlu: 0.866 ± 0.025
0.769HisPhe: 0.769 ± 0.025
1.068HisGly: 1.068 ± 0.028
0.681HisHis: 0.681 ± 0.028
1.078HisIle: 1.078 ± 0.027
0.757HisLys: 0.757 ± 0.019
2.364HisLeu: 2.364 ± 0.045
0.262HisMet: 0.262 ± 0.013
0.762HisAsn: 0.762 ± 0.024
1.43HisPro: 1.43 ± 0.031
1.357HisGln: 1.357 ± 0.033
1.093HisArg: 1.093 ± 0.029
1.191HisSer: 1.191 ± 0.033
0.836HisThr: 0.836 ± 0.025
0.794HisVal: 0.794 ± 0.023
0.31HisTrp: 0.31 ± 0.015
0.653HisTyr: 0.653 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.565IleAla: 7.565 ± 0.081
0.806IleCys: 0.806 ± 0.025
3.889IleAsp: 3.889 ± 0.054
4.63IleGlu: 4.63 ± 0.067
2.553IlePhe: 2.553 ± 0.047
4.638IleGly: 4.638 ± 0.064
1.248IleHis: 1.248 ± 0.032
3.782IleIle: 3.782 ± 0.067
3.24IleLys: 3.24 ± 0.05
6.718IleLeu: 6.718 ± 0.082
0.888IleMet: 0.888 ± 0.026
3.085IleAsn: 3.085 ± 0.055
3.759IlePro: 3.759 ± 0.053
3.014IleGln: 3.014 ± 0.053
3.105IleArg: 3.105 ± 0.049
4.957IleSer: 4.957 ± 0.06
3.433IleThr: 3.433 ± 0.054
4.349IleVal: 4.349 ± 0.066
1.006IleTrp: 1.006 ± 0.03
2.14IleTyr: 2.14 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
3.96LysAla: 3.96 ± 0.061
0.394LysCys: 0.394 ± 0.016
2.222LysAsp: 2.222 ± 0.038
2.856LysGlu: 2.856 ± 0.054
1.891LysPhe: 1.891 ± 0.041
2.839LysGly: 2.839 ± 0.051
0.794LysHis: 0.794 ± 0.023
3.84LysIle: 3.84 ± 0.054
2.268LysLys: 2.268 ± 0.044
5.869LysLeu: 5.869 ± 0.077
1.02LysMet: 1.02 ± 0.026
1.986LysAsn: 1.986 ± 0.04
2.521LysPro: 2.521 ± 0.043
2.694LysGln: 2.694 ± 0.044
2.327LysArg: 2.327 ± 0.042
3.305LysSer: 3.305 ± 0.06
3.085LysThr: 3.085 ± 0.052
3.378LysVal: 3.378 ± 0.046
0.593LysTrp: 0.593 ± 0.02
1.639LysTyr: 1.639 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
10.003LeuAla: 10.003 ± 0.091
0.976LeuCys: 0.976 ± 0.027
5.538LeuAsp: 5.538 ± 0.072
7.592LeuGlu: 7.592 ± 0.083
3.761LeuPhe: 3.761 ± 0.056
7.724LeuGly: 7.724 ± 0.081
1.878LeuHis: 1.878 ± 0.04
6.96LeuIle: 6.96 ± 0.085
5.915LeuLys: 5.915 ± 0.078
11.091LeuLeu: 11.091 ± 0.115
2.002LeuMet: 2.002 ± 0.037
4.569LeuAsn: 4.569 ± 0.057
5.859LeuPro: 5.859 ± 0.069
5.518LeuGln: 5.518 ± 0.072
5.248LeuArg: 5.248 ± 0.06
7.676LeuSer: 7.676 ± 0.083
6.435LeuThr: 6.435 ± 0.064
7.615LeuVal: 7.615 ± 0.074
1.568LeuTrp: 1.568 ± 0.037
2.646LeuTyr: 2.646 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.68MetAla: 1.68 ± 0.034
0.125MetCys: 0.125 ± 0.008
0.686MetAsp: 0.686 ± 0.027
1.015MetGlu: 1.015 ± 0.022
0.543MetPhe: 0.543 ± 0.022
1.38MetGly: 1.38 ± 0.034
0.331MetHis: 0.331 ± 0.014
0.881MetIle: 0.881 ± 0.025
1.015MetLys: 1.015 ± 0.028
1.806MetLeu: 1.806 ± 0.037
0.446MetMet: 0.446 ± 0.02
0.81MetAsn: 0.81 ± 0.025
0.875MetPro: 0.875 ± 0.027
0.861MetGln: 0.861 ± 0.025
0.937MetArg: 0.937 ± 0.028
1.414MetSer: 1.414 ± 0.034
1.26MetThr: 1.26 ± 0.028
1.278MetVal: 1.278 ± 0.032
0.187MetTrp: 0.187 ± 0.012
0.358MetTyr: 0.358 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.717AsnAla: 2.717 ± 0.047
0.554AsnCys: 0.554 ± 0.017
1.53AsnAsp: 1.53 ± 0.034
1.691AsnGlu: 1.691 ± 0.032
1.818AsnPhe: 1.818 ± 0.042
2.605AsnGly: 2.605 ± 0.055
0.872AsnHis: 0.872 ± 0.025
2.645AsnIle: 2.645 ± 0.052
1.515AsnLys: 1.515 ± 0.037
5.722AsnLeu: 5.722 ± 0.082
0.645AsnMet: 0.645 ± 0.021
1.94AsnAsn: 1.94 ± 0.048
3.128AsnPro: 3.128 ± 0.048
2.669AsnGln: 2.669 ± 0.042
2.574AsnArg: 2.574 ± 0.043
3.29AsnSer: 3.29 ± 0.055
2.184AsnThr: 2.184 ± 0.042
2.142AsnVal: 2.142 ± 0.042
0.842AsnTrp: 0.842 ± 0.023
1.613AsnTyr: 1.613 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.145ProAla: 3.145 ± 0.054
0.349ProCys: 0.349 ± 0.015
3.053ProAsp: 3.053 ± 0.051
4.063ProGlu: 4.063 ± 0.065
1.646ProPhe: 1.646 ± 0.03
2.938ProGly: 2.938 ± 0.052
0.976ProHis: 0.976 ± 0.024
3.27ProIle: 3.27 ± 0.048
2.444ProLys: 2.444 ± 0.044
4.716ProLeu: 4.716 ± 0.058
0.697ProMet: 0.697 ± 0.021
2.341ProAsn: 2.341 ± 0.041
2.416ProPro: 2.416 ± 0.052
2.828ProGln: 2.828 ± 0.048
1.667ProArg: 1.667 ± 0.037
3.103ProSer: 3.103 ± 0.049
2.993ProThr: 2.993 ± 0.053
3.291ProVal: 3.291 ± 0.052
0.621ProTrp: 0.621 ± 0.021
1.317ProTyr: 1.317 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.565GlnAla: 4.565 ± 0.069
0.358GlnCys: 0.358 ± 0.016
2.152GlnAsp: 2.152 ± 0.037
3.556GlnGlu: 3.556 ± 0.058
1.752GlnPhe: 1.752 ± 0.038
3.244GlnGly: 3.244 ± 0.054
0.877GlnHis: 0.877 ± 0.026
4.278GlnIle: 4.278 ± 0.052
3.126GlnLys: 3.126 ± 0.06
5.705GlnLeu: 5.705 ± 0.076
1.028GlnMet: 1.028 ± 0.027
2.116GlnAsn: 2.116 ± 0.044
2.531GlnPro: 2.531 ± 0.044
3.387GlnGln: 3.387 ± 0.056
2.574GlnArg: 2.574 ± 0.048
2.977GlnSer: 2.977 ± 0.048
3.019GlnThr: 3.019 ± 0.051
3.833GlnVal: 3.833 ± 0.048
0.678GlnTrp: 0.678 ± 0.024
1.241GlnTyr: 1.241 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
3.174ArgAla: 3.174 ± 0.046
0.567ArgCys: 0.567 ± 0.02
2.585ArgAsp: 2.585 ± 0.043
3.399ArgGlu: 3.399 ± 0.058
2.098ArgPhe: 2.098 ± 0.038
3.008ArgGly: 3.008 ± 0.051
1.073ArgHis: 1.073 ± 0.028
3.205ArgIle: 3.205 ± 0.05
2.163ArgLys: 2.163 ± 0.04
6.133ArgLeu: 6.133 ± 0.063
0.952ArgMet: 0.952 ± 0.026
2.064ArgAsn: 2.064 ± 0.039
1.98ArgPro: 1.98 ± 0.043
3.523ArgGln: 3.523 ± 0.054
2.89ArgArg: 2.89 ± 0.048
3.659ArgSer: 3.659 ± 0.053
2.479ArgThr: 2.479 ± 0.047
3.328ArgVal: 3.328 ± 0.046
0.792ArgTrp: 0.792 ± 0.024
1.914ArgTyr: 1.914 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
4.713SerAla: 4.713 ± 0.063
0.718SerCys: 0.718 ± 0.026
3.499SerAsp: 3.499 ± 0.054
3.89SerGlu: 3.89 ± 0.053
2.602SerPhe: 2.602 ± 0.045
4.878SerGly: 4.878 ± 0.073
1.419SerHis: 1.419 ± 0.031
4.051SerIle: 4.051 ± 0.058
2.659SerLys: 2.659 ± 0.043
7.832SerLeu: 7.832 ± 0.082
1.171SerMet: 1.171 ± 0.026
2.819SerAsn: 2.819 ± 0.056
3.671SerPro: 3.671 ± 0.059
4.323SerGln: 4.323 ± 0.064
3.27SerArg: 3.27 ± 0.053
4.819SerSer: 4.819 ± 0.076
3.674SerThr: 3.674 ± 0.066
4.019SerVal: 4.019 ± 0.054
1.015SerTrp: 1.015 ± 0.028
1.982SerTyr: 1.982 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.546ThrAla: 4.546 ± 0.063
0.5ThrCys: 0.5 ± 0.021
2.629ThrAsp: 2.629 ± 0.042
3.359ThrGlu: 3.359 ± 0.047
2.02ThrPhe: 2.02 ± 0.037
4.256ThrGly: 4.256 ± 0.069
1.001ThrHis: 1.001 ± 0.028
4.029ThrIle: 4.029 ± 0.058
2.412ThrLys: 2.412 ± 0.039
6.139ThrLeu: 6.139 ± 0.078
0.803ThrMet: 0.803 ± 0.025
2.443ThrAsn: 2.443 ± 0.045
3.489ThrPro: 3.489 ± 0.059
2.884ThrGln: 2.884 ± 0.048
2.362ThrArg: 2.362 ± 0.041
3.788ThrSer: 3.788 ± 0.06
3.263ThrThr: 3.263 ± 0.062
3.883ThrVal: 3.883 ± 0.058
0.761ThrTrp: 0.761 ± 0.023
1.652ThrTyr: 1.652 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
5.837ValAla: 5.837 ± 0.073
0.669ValCys: 0.669 ± 0.02
3.351ValAsp: 3.351 ± 0.048
4.53ValGlu: 4.53 ± 0.057
2.517ValPhe: 2.517 ± 0.04
4.641ValGly: 4.641 ± 0.068
0.974ValHis: 0.974 ± 0.025
4.133ValIle: 4.133 ± 0.062
3.553ValLys: 3.553 ± 0.055
6.338ValLeu: 6.338 ± 0.063
1.323ValMet: 1.323 ± 0.034
2.882ValAsn: 2.882 ± 0.055
2.836ValPro: 2.836 ± 0.044
2.532ValGln: 2.532 ± 0.043
3.16ValArg: 3.16 ± 0.054
4.384ValSer: 4.384 ± 0.058
3.89ValThr: 3.89 ± 0.06
4.669ValVal: 4.669 ± 0.062
0.891ValTrp: 0.891 ± 0.028
1.863ValTyr: 1.863 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
0.837TrpAla: 0.837 ± 0.026
0.163TrpCys: 0.163 ± 0.011
0.711TrpAsp: 0.711 ± 0.025
1.067TrpGlu: 1.067 ± 0.03
0.625TrpPhe: 0.625 ± 0.022
1.011TrpGly: 1.011 ± 0.027
0.366TrpHis: 0.366 ± 0.016
0.821TrpIle: 0.821 ± 0.022
0.7TrpLys: 0.7 ± 0.025
2.057TrpLeu: 2.057 ± 0.04
0.349TrpMet: 0.349 ± 0.014
0.661TrpAsn: 0.661 ± 0.028
0.182TrpPro: 0.182 ± 0.011
1.251TrpGln: 1.251 ± 0.032
0.893TrpArg: 0.893 ± 0.027
0.949TrpSer: 0.949 ± 0.025
0.561TrpThr: 0.561 ± 0.019
0.936TrpVal: 0.936 ± 0.029
0.275TrpTrp: 0.275 ± 0.015
0.438TrpTyr: 0.438 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.079TyrAla: 2.079 ± 0.04
0.386TyrCys: 0.386 ± 0.019
1.449TyrAsp: 1.449 ± 0.037
1.659TyrGlu: 1.659 ± 0.038
1.329TyrPhe: 1.329 ± 0.03
2.019TyrGly: 2.019 ± 0.04
0.723TyrHis: 0.723 ± 0.024
1.764TyrIle: 1.764 ± 0.032
1.186TyrLys: 1.186 ± 0.03
3.885TyrLeu: 3.885 ± 0.063
0.406TyrMet: 0.406 ± 0.017
1.174TyrAsn: 1.174 ± 0.032
1.684TyrPro: 1.684 ± 0.035
2.263TyrGln: 2.263 ± 0.045
2.08TyrArg: 2.08 ± 0.037
1.889TyrSer: 1.889 ± 0.039
1.579TyrThr: 1.579 ± 0.034
1.625TyrVal: 1.625 ± 0.036
0.572TyrTrp: 0.572 ± 0.023
1.111TyrTyr: 1.111 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4638 proteins (1433816 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski