Amino acid dipepetide frequency for Enterococcus quebecensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.905AlaAla: 4.905 ± 0.096	0.469AlaCys: 0.469 ± 0.025	3.464AlaAsp: 3.464 ± 0.066	4.497AlaGlu: 4.497 ± 0.083	2.941AlaPhe: 2.941 ± 0.063	4.658AlaGly: 4.658 ± 0.092	0.983AlaHis: 0.983 ± 0.037	5.409AlaIle: 5.409 ± 0.092	4.923AlaLys: 4.923 ± 0.082	6.255AlaLeu: 6.255 ± 0.098	1.757AlaMet: 1.757 ± 0.05	3.001AlaAsn: 3.001 ± 0.067	1.954AlaPro: 1.954 ± 0.051	2.413AlaGln: 2.413 ± 0.059	2.159AlaArg: 2.159 ± 0.056	4.008AlaSer: 4.008 ± 0.081	4.019AlaThr: 4.019 ± 0.088	4.905AlaVal: 4.905 ± 0.094	0.532AlaTrp: 0.532 ± 0.025	2.244AlaTyr: 2.244 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.345CysAla: 0.345 ± 0.025	0.076CysCys: 0.076 ± 0.01	0.308CysAsp: 0.308 ± 0.017	0.371CysGlu: 0.371 ± 0.022	0.303CysPhe: 0.303 ± 0.019	0.586CysGly: 0.586 ± 0.025	0.13CysHis: 0.13 ± 0.013	0.431CysIle: 0.431 ± 0.024	0.261CysLys: 0.261 ± 0.015	0.642CysLeu: 0.642 ± 0.025	0.142CysMet: 0.142 ± 0.011	0.209CysAsn: 0.209 ± 0.016	0.238CysPro: 0.238 ± 0.018	0.227CysGln: 0.227 ± 0.017	0.203CysArg: 0.203 ± 0.017	0.471CysSer: 0.471 ± 0.027	0.304CysThr: 0.304 ± 0.021	0.371CysVal: 0.371 ± 0.021	0.058CysTrp: 0.058 ± 0.008	0.253CysTyr: 0.253 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.262AspAla: 3.262 ± 0.066	0.298AspCys: 0.298 ± 0.018	2.574AspAsp: 2.574 ± 0.074	4.349AspGlu: 4.349 ± 0.081	2.909AspPhe: 2.909 ± 0.058	3.614AspGly: 3.614 ± 0.06	0.957AspHis: 0.957 ± 0.032	4.225AspIle: 4.225 ± 0.066	3.95AspLys: 3.95 ± 0.075	5.131AspLeu: 5.131 ± 0.083	1.266AspMet: 1.266 ± 0.038	2.355AspAsn: 2.355 ± 0.058	1.886AspPro: 1.886 ± 0.06	2.223AspGln: 2.223 ± 0.053	1.906AspArg: 1.906 ± 0.056	3.218AspSer: 3.218 ± 0.067	3.017AspThr: 3.017 ± 0.057	3.735AspVal: 3.735 ± 0.074	0.591AspTrp: 0.591 ± 0.028	2.414AspTyr: 2.414 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	5.042GluAla: 5.042 ± 0.108	0.306GluCys: 0.306 ± 0.02	3.656GluAsp: 3.656 ± 0.075	6.429GluGlu: 6.429 ± 0.118	2.584GluPhe: 2.584 ± 0.059	3.804GluGly: 3.804 ± 0.076	1.17GluHis: 1.17 ± 0.038	5.754GluIle: 5.754 ± 0.093	7.264GluLys: 7.264 ± 0.108	7.405GluLeu: 7.405 ± 0.111	2.188GluMet: 2.188 ± 0.057	4.338GluAsn: 4.338 ± 0.069	1.862GluPro: 1.862 ± 0.049	3.563GluGln: 3.563 ± 0.078	2.82GluArg: 2.82 ± 0.068	3.657GluSer: 3.657 ± 0.08	4.396GluThr: 4.396 ± 0.073	4.796GluVal: 4.796 ± 0.084	0.644GluTrp: 0.644 ± 0.03	2.398GluTyr: 2.398 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.793PheAla: 2.793 ± 0.059	0.331PheCys: 0.331 ± 0.018	2.753PheAsp: 2.753 ± 0.056	2.824PheGlu: 2.824 ± 0.058	2.545PhePhe: 2.545 ± 0.074	3.219PheGly: 3.219 ± 0.063	0.823PheHis: 0.823 ± 0.03	3.672PheIle: 3.672 ± 0.084	2.65PheLys: 2.65 ± 0.058	4.528PheLeu: 4.528 ± 0.103	1.139PheMet: 1.139 ± 0.031	2.183PheAsn: 2.183 ± 0.051	1.548PhePro: 1.548 ± 0.044	1.616PheGln: 1.616 ± 0.042	1.303PheArg: 1.303 ± 0.042	3.769PheSer: 3.769 ± 0.071	2.665PheThr: 2.665 ± 0.047	3.12PheVal: 3.12 ± 0.061	0.431PheTrp: 0.431 ± 0.022	1.847PheTyr: 1.847 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.338GlyAla: 4.338 ± 0.09	0.452GlyCys: 0.452 ± 0.024	3.191GlyAsp: 3.191 ± 0.067	4.36GlyGlu: 4.36 ± 0.077	3.09GlyPhe: 3.09 ± 0.068	4.394GlyGly: 4.394 ± 0.097	1.102GlyHis: 1.102 ± 0.037	5.638GlyIle: 5.638 ± 0.089	5.161GlyLys: 5.161 ± 0.087	6.143GlyLeu: 6.143 ± 0.097	1.934GlyMet: 1.934 ± 0.051	3.117GlyAsn: 3.117 ± 0.074	1.342GlyPro: 1.342 ± 0.041	2.313GlyGln: 2.313 ± 0.058	2.249GlyArg: 2.249 ± 0.062	4.064GlySer: 4.064 ± 0.074	4.411GlyThr: 4.411 ± 0.096	4.658GlyVal: 4.658 ± 0.097	0.633GlyTrp: 0.633 ± 0.029	2.762GlyTyr: 2.762 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	0.97HisAla: 0.97 ± 0.032	0.155HisCys: 0.155 ± 0.015	0.863HisAsp: 0.863 ± 0.027	1.072HisGlu: 1.072 ± 0.04	0.948HisPhe: 0.948 ± 0.034	1.151HisGly: 1.151 ± 0.042	0.402HisHis: 0.402 ± 0.024	1.157HisIle: 1.157 ± 0.037	0.846HisLys: 0.846 ± 0.03	1.799HisLeu: 1.799 ± 0.047	0.4HisMet: 0.4 ± 0.021	0.658HisAsn: 0.658 ± 0.032	0.849HisPro: 0.849 ± 0.033	0.76HisGln: 0.76 ± 0.03	0.677HisArg: 0.677 ± 0.03	1.106HisSer: 1.106 ± 0.039	0.926HisThr: 0.926 ± 0.036	1.022HisVal: 1.022 ± 0.037	0.189HisTrp: 0.189 ± 0.014	0.781HisTyr: 0.781 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.405IleAla: 5.405 ± 0.082	0.628IleCys: 0.628 ± 0.028	4.851IleAsp: 4.851 ± 0.079	5.667IleGlu: 5.667 ± 0.094	3.474IlePhe: 3.474 ± 0.072	5.613IleGly: 5.613 ± 0.105	1.41IleHis: 1.41 ± 0.039	5.865IleIle: 5.865 ± 0.091	4.952IleLys: 4.952 ± 0.079	7.178IleLeu: 7.178 ± 0.12	1.611IleMet: 1.611 ± 0.041	3.742IleAsn: 3.742 ± 0.074	3.317IlePro: 3.317 ± 0.068	3.207IleGln: 3.207 ± 0.076	2.955IleArg: 2.955 ± 0.059	5.303IleSer: 5.303 ± 0.075	4.641IleThr: 4.641 ± 0.076	5.307IleVal: 5.307 ± 0.097	0.557IleTrp: 0.557 ± 0.027	2.692IleTyr: 2.692 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.757LysAla: 4.757 ± 0.077	0.262LysCys: 0.262 ± 0.017	4.355LysAsp: 4.355 ± 0.074	7.629LysGlu: 7.629 ± 0.115	2.132LysPhe: 2.132 ± 0.054	4.196LysGly: 4.196 ± 0.078	1.082LysHis: 1.082 ± 0.031	5.905LysIle: 5.905 ± 0.097	7.565LysLys: 7.565 ± 0.118	5.718LysLeu: 5.718 ± 0.096	2.513LysMet: 2.513 ± 0.063	4.729LysAsn: 4.729 ± 0.08	2.099LysPro: 2.099 ± 0.046	3.435LysGln: 3.435 ± 0.069	2.999LysArg: 2.999 ± 0.064	3.732LysSer: 3.732 ± 0.072	4.192LysThr: 4.192 ± 0.072	5.044LysVal: 5.044 ± 0.089	0.654LysTrp: 0.654 ± 0.029	2.355LysTyr: 2.355 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	6.977LeuAla: 6.977 ± 0.098	0.587LeuCys: 0.587 ± 0.024	5.157LeuAsp: 5.157 ± 0.08	6.336LeuGlu: 6.336 ± 0.093	4.875LeuPhe: 4.875 ± 0.091	6.147LeuGly: 6.147 ± 0.097	1.487LeuHis: 1.487 ± 0.044	7.088LeuIle: 7.088 ± 0.105	6.84LeuLys: 6.84 ± 0.08	9.886LeuLeu: 9.886 ± 0.165	2.316LeuMet: 2.316 ± 0.054	4.796LeuAsn: 4.796 ± 0.075	3.835LeuPro: 3.835 ± 0.067	3.133LeuGln: 3.133 ± 0.065	3.117LeuArg: 3.117 ± 0.065	6.878LeuSer: 6.878 ± 0.104	6.299LeuThr: 6.299 ± 0.094	6.381LeuVal: 6.381 ± 0.085	0.691LeuTrp: 0.691 ± 0.031	3.014LeuTyr: 3.014 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.701MetAla: 1.701 ± 0.051	0.127MetCys: 0.127 ± 0.013	1.441MetAsp: 1.441 ± 0.038	1.706MetGlu: 1.706 ± 0.044	0.902MetPhe: 0.902 ± 0.034	1.66MetGly: 1.66 ± 0.045	0.373MetHis: 0.373 ± 0.02	2.233MetIle: 2.233 ± 0.056	2.391MetLys: 2.391 ± 0.051	2.223MetLeu: 2.223 ± 0.059	0.827MetMet: 0.827 ± 0.036	1.621MetAsn: 1.621 ± 0.043	0.886MetPro: 0.886 ± 0.031	0.797MetGln: 0.797 ± 0.033	0.906MetArg: 0.906 ± 0.033	1.608MetSer: 1.608 ± 0.047	1.777MetThr: 1.777 ± 0.05	1.659MetVal: 1.659 ± 0.048	0.157MetTrp: 0.157 ± 0.012	0.76MetTyr: 0.76 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.89AsnAla: 2.89 ± 0.058	0.276AsnCys: 0.276 ± 0.02	2.715AsnAsp: 2.715 ± 0.059	3.773AsnGlu: 3.773 ± 0.073	2.082AsnPhe: 2.082 ± 0.041	3.576AsnGly: 3.576 ± 0.08	1.072AsnHis: 1.072 ± 0.033	3.613AsnIle: 3.613 ± 0.063	3.704AsnLys: 3.704 ± 0.081	4.383AsnLeu: 4.383 ± 0.074	1.133AsnMet: 1.133 ± 0.035	2.68AsnAsn: 2.68 ± 0.064	2.068AsnPro: 2.068 ± 0.053	2.746AsnGln: 2.746 ± 0.063	1.89AsnArg: 1.89 ± 0.048	2.864AsnSer: 2.864 ± 0.066	2.733AsnThr: 2.733 ± 0.071	3.32AsnVal: 3.32 ± 0.066	0.566AsnTrp: 0.566 ± 0.029	2.177AsnTyr: 2.177 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.172ProAla: 2.172 ± 0.062	0.173ProCys: 0.173 ± 0.014	1.904ProAsp: 1.904 ± 0.044	2.985ProGlu: 2.985 ± 0.062	1.766ProPhe: 1.766 ± 0.048	1.774ProGly: 1.774 ± 0.049	0.529ProHis: 0.529 ± 0.024	2.723ProIle: 2.723 ± 0.065	2.502ProLys: 2.502 ± 0.057	3.029ProLeu: 3.029 ± 0.064	0.779ProMet: 0.779 ± 0.034	1.805ProAsn: 1.805 ± 0.049	0.732ProPro: 0.732 ± 0.034	1.13ProGln: 1.13 ± 0.039	0.911ProArg: 0.911 ± 0.031	2.031ProSer: 2.031 ± 0.049	2.335ProThr: 2.335 ± 0.051	2.619ProVal: 2.619 ± 0.058	0.277ProTrp: 0.277 ± 0.02	1.286ProTyr: 1.286 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.87GlnAla: 2.87 ± 0.063	0.144GlnCys: 0.144 ± 0.013	1.671GlnAsp: 1.671 ± 0.046	3.206GlnGlu: 3.206 ± 0.068	1.636GlnPhe: 1.636 ± 0.046	2.221GlnGly: 2.221 ± 0.047	0.602GlnHis: 0.602 ± 0.026	2.799GlnIle: 2.799 ± 0.06	3.403GlnLys: 3.403 ± 0.071	4.56GlnLeu: 4.56 ± 0.084	1.114GlnMet: 1.114 ± 0.037	1.843GlnAsn: 1.843 ± 0.048	1.283GlnPro: 1.283 ± 0.042	2.053GlnGln: 2.053 ± 0.067	1.522GlnArg: 1.522 ± 0.044	2.235GlnSer: 2.235 ± 0.062	2.589GlnThr: 2.589 ± 0.052	2.765GlnVal: 2.765 ± 0.056	0.422GlnTrp: 0.422 ± 0.024	1.309GlnTyr: 1.309 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	1.895ArgAla: 1.895 ± 0.05	0.203ArgCys: 0.203 ± 0.014	1.61ArgAsp: 1.61 ± 0.046	2.589ArgGlu: 2.589 ± 0.068	1.783ArgPhe: 1.783 ± 0.048	2.033ArgGly: 2.033 ± 0.055	0.61ArgHis: 0.61 ± 0.026	2.805ArgIle: 2.805 ± 0.056	3.01ArgLys: 3.01 ± 0.061	3.572ArgLeu: 3.572 ± 0.073	1.043ArgMet: 1.043 ± 0.036	1.799ArgAsn: 1.799 ± 0.048	1.116ArgPro: 1.116 ± 0.036	1.512ArgGln: 1.512 ± 0.042	1.457ArgArg: 1.457 ± 0.046	1.971ArgSer: 1.971 ± 0.041	1.85ArgThr: 1.85 ± 0.047	2.359ArgVal: 2.359 ± 0.055	0.317ArgTrp: 0.317 ± 0.018	1.49ArgTyr: 1.49 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.812SerAla: 3.812 ± 0.077	0.337SerCys: 0.337 ± 0.02	3.436SerAsp: 3.436 ± 0.062	4.494SerGlu: 4.494 ± 0.087	3.401SerPhe: 3.401 ± 0.069	4.697SerGly: 4.697 ± 0.079	1.002SerHis: 1.002 ± 0.037	5.06SerIle: 5.06 ± 0.085	4.334SerLys: 4.334 ± 0.076	6.156SerLeu: 6.156 ± 0.094	1.537SerMet: 1.537 ± 0.045	2.948SerAsn: 2.948 ± 0.065	1.808SerPro: 1.808 ± 0.048	2.333SerGln: 2.333 ± 0.053	1.997SerArg: 1.997 ± 0.05	4.248SerSer: 4.248 ± 0.11	3.521SerThr: 3.521 ± 0.075	4.429SerVal: 4.429 ± 0.072	0.639SerTrp: 0.639 ± 0.024	2.501SerTyr: 2.501 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.101ThrAla: 4.101 ± 0.091	0.316ThrCys: 0.316 ± 0.02	3.394ThrAsp: 3.394 ± 0.069	3.914ThrGlu: 3.914 ± 0.075	2.823ThrPhe: 2.823 ± 0.056	4.492ThrGly: 4.492 ± 0.093	0.993ThrHis: 0.993 ± 0.038	5.389ThrIle: 5.389 ± 0.088	4.148ThrLys: 4.148 ± 0.084	5.74ThrLeu: 5.74 ± 0.097	1.367ThrMet: 1.367 ± 0.041	3.063ThrAsn: 3.063 ± 0.07	2.462ThrPro: 2.462 ± 0.072	1.979ThrGln: 1.979 ± 0.05	1.748ThrArg: 1.748 ± 0.045	3.698ThrSer: 3.698 ± 0.081	3.947ThrThr: 3.947 ± 0.085	4.656ThrVal: 4.656 ± 0.086	0.503ThrTrp: 0.503 ± 0.026	2.272ThrTyr: 2.272 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.721ValAla: 4.721 ± 0.086	0.482ValCys: 0.482 ± 0.025	3.887ValAsp: 3.887 ± 0.069	4.794ValGlu: 4.794 ± 0.086	3.066ValPhe: 3.066 ± 0.065	4.577ValGly: 4.577 ± 0.083	1.067ValHis: 1.067 ± 0.035	5.579ValIle: 5.579 ± 0.096	4.701ValLys: 4.701 ± 0.087	6.593ValLeu: 6.593 ± 0.099	1.672ValMet: 1.672 ± 0.038	3.167ValAsn: 3.167 ± 0.061	2.587ValPro: 2.587 ± 0.057	2.292ValGln: 2.292 ± 0.047	2.249ValArg: 2.249 ± 0.057	4.861ValSer: 4.861 ± 0.079	4.725ValThr: 4.725 ± 0.108	5.05ValVal: 5.05 ± 0.08	0.502ValTrp: 0.502 ± 0.024	2.408ValTyr: 2.408 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.427TrpAla: 0.427 ± 0.023	0.071TrpCys: 0.071 ± 0.008	0.494TrpAsp: 0.494 ± 0.024	0.598TrpGlu: 0.598 ± 0.028	0.447TrpPhe: 0.447 ± 0.025	0.582TrpGly: 0.582 ± 0.025	0.185TrpHis: 0.185 ± 0.016	0.656TrpIle: 0.656 ± 0.028	0.596TrpLys: 0.596 ± 0.027	0.973TrpLeu: 0.973 ± 0.037	0.222TrpMet: 0.222 ± 0.016	0.494TrpAsn: 0.494 ± 0.023	0.181TrpPro: 0.181 ± 0.015	0.527TrpGln: 0.527 ± 0.026	0.366TrpArg: 0.366 ± 0.018	0.596TrpSer: 0.596 ± 0.03	0.507TrpThr: 0.507 ± 0.024	0.529TrpVal: 0.529 ± 0.025	0.116TrpTrp: 0.116 ± 0.01	0.292TrpTyr: 0.292 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.114TyrAla: 2.114 ± 0.051	0.237TyrCys: 0.237 ± 0.017	2.157TyrAsp: 2.157 ± 0.06	2.486TyrGlu: 2.486 ± 0.046	2.053TyrPhe: 2.053 ± 0.056	2.358TyrGly: 2.358 ± 0.049	0.753TyrHis: 0.753 ± 0.03	2.372TyrIle: 2.372 ± 0.054	2.149TyrLys: 2.149 ± 0.056	3.926TyrLeu: 3.926 ± 0.071	0.795TyrMet: 0.795 ± 0.033	1.712TyrAsn: 1.712 ± 0.047	1.41TyrPro: 1.41 ± 0.047	1.989TyrGln: 1.989 ± 0.053	1.589TyrArg: 1.589 ± 0.047	2.372TyrSer: 2.372 ± 0.056	2.15TyrThr: 2.15 ± 0.052	2.256TyrVal: 2.256 ± 0.055	0.379TyrTrp: 0.379 ± 0.018	1.671TyrTyr: 1.671 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2789 proteins (890319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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