Amino acid dipepetide frequency for Cellulomonas sp. HLT2-17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.243AlaAla: 23.243 ± 0.197
0.846AlaCys: 0.846 ± 0.029
8.956AlaAsp: 8.956 ± 0.097
7.556AlaGlu: 7.556 ± 0.09
3.671AlaPhe: 3.671 ± 0.054
14.195AlaGly: 14.195 ± 0.138
2.718AlaHis: 2.718 ± 0.049
5.283AlaIle: 5.283 ± 0.076
2.301AlaLys: 2.301 ± 0.055
15.378AlaLeu: 15.378 ± 0.128
2.729AlaMet: 2.729 ± 0.046
2.223AlaAsn: 2.223 ± 0.043
7.272AlaPro: 7.272 ± 0.11
4.038AlaGln: 4.038 ± 0.068
10.644AlaArg: 10.644 ± 0.115
7.053AlaSer: 7.053 ± 0.071
8.635AlaThr: 8.635 ± 0.09
13.38AlaVal: 13.38 ± 0.141
2.012AlaTrp: 2.012 ± 0.038
2.357AlaTyr: 2.357 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.834CysAla: 0.834 ± 0.029
0.067CysCys: 0.067 ± 0.008
0.354CysAsp: 0.354 ± 0.016
0.299CysGlu: 0.299 ± 0.018
0.178CysPhe: 0.178 ± 0.012
0.67CysGly: 0.67 ± 0.023
0.137CysHis: 0.137 ± 0.011
0.162CysIle: 0.162 ± 0.012
0.072CysLys: 0.072 ± 0.008
0.539CysLeu: 0.539 ± 0.021
0.083CysMet: 0.083 ± 0.008
0.115CysAsn: 0.115 ± 0.009
0.401CysPro: 0.401 ± 0.018
0.151CysGln: 0.151 ± 0.012
0.417CysArg: 0.417 ± 0.017
0.36CysSer: 0.36 ± 0.018
0.392CysThr: 0.392 ± 0.022
0.516CysVal: 0.516 ± 0.021
0.08CysTrp: 0.08 ± 0.008
0.113CysTyr: 0.113 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
8.32AspAla: 8.32 ± 0.088
0.266AspCys: 0.266 ± 0.016
4.17AspAsp: 4.17 ± 0.076
3.596AspGlu: 3.596 ± 0.068
1.476AspPhe: 1.476 ± 0.039
6.196AspGly: 6.196 ± 0.081
1.237AspHis: 1.237 ± 0.036
1.675AspIle: 1.675 ± 0.041
0.807AspLys: 0.807 ± 0.027
7.377AspLeu: 7.377 ± 0.082
0.714AspMet: 0.714 ± 0.024
0.813AspAsn: 0.813 ± 0.025
4.591AspPro: 4.591 ± 0.07
1.712AspGln: 1.712 ± 0.039
4.655AspArg: 4.655 ± 0.07
2.505AspSer: 2.505 ± 0.042
2.771AspThr: 2.771 ± 0.044
6.015AspVal: 6.015 ± 0.071
0.846AspTrp: 0.846 ± 0.028
1.042AspTyr: 1.042 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.458GluAla: 6.458 ± 0.073
0.272GluCys: 0.272 ± 0.017
2.284GluAsp: 2.284 ± 0.047
2.182GluGlu: 2.182 ± 0.05
1.379GluPhe: 1.379 ± 0.032
3.378GluGly: 3.378 ± 0.054
1.416GluHis: 1.416 ± 0.035
2.531GluIle: 2.531 ± 0.051
0.911GluLys: 0.911 ± 0.035
6.447GluLeu: 6.447 ± 0.083
0.898GluMet: 0.898 ± 0.028
0.942GluAsn: 0.942 ± 0.029
3.067GluPro: 3.067 ± 0.057
1.943GluGln: 1.943 ± 0.043
4.455GluArg: 4.455 ± 0.065
2.424GluSer: 2.424 ± 0.048
2.519GluThr: 2.519 ± 0.048
4.853GluVal: 4.853 ± 0.066
0.618GluTrp: 0.618 ± 0.024
0.931GluTyr: 0.931 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.076PheAla: 4.076 ± 0.059
0.212PheCys: 0.212 ± 0.014
1.949PheAsp: 1.949 ± 0.048
1.453PheGlu: 1.453 ± 0.034
0.897PhePhe: 0.897 ± 0.034
3.107PheGly: 3.107 ± 0.061
0.49PheHis: 0.49 ± 0.019
0.892PheIle: 0.892 ± 0.029
0.409PheLys: 0.409 ± 0.017
2.582PheLeu: 2.582 ± 0.058
0.397PheMet: 0.397 ± 0.017
0.553PheAsn: 0.553 ± 0.023
1.29PhePro: 1.29 ± 0.032
0.648PheGln: 0.648 ± 0.026
1.615PheArg: 1.615 ± 0.039
1.49PheSer: 1.49 ± 0.038
1.942PheThr: 1.942 ± 0.045
2.658PheVal: 2.658 ± 0.049
0.423PheTrp: 0.423 ± 0.019
0.55PheTyr: 0.55 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
12.279GlyAla: 12.279 ± 0.125
0.629GlyCys: 0.629 ± 0.024
5.08GlyAsp: 5.08 ± 0.068
4.551GlyGlu: 4.551 ± 0.061
2.96GlyPhe: 2.96 ± 0.057
8.006GlyGly: 8.006 ± 0.114
1.991GlyHis: 1.991 ± 0.044
3.924GlyIle: 3.924 ± 0.058
1.801GlyLys: 1.801 ± 0.044
9.774GlyLeu: 9.774 ± 0.102
1.918GlyMet: 1.918 ± 0.032
1.498GlyAsn: 1.498 ± 0.036
4.97GlyPro: 4.97 ± 0.075
2.648GlyGln: 2.648 ± 0.054
7.062GlyArg: 7.062 ± 0.09
5.577GlySer: 5.577 ± 0.071
6.254GlyThr: 6.254 ± 0.092
8.345GlyVal: 8.345 ± 0.1
1.725GlyTrp: 1.725 ± 0.038
2.045GlyTyr: 2.045 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.597HisAla: 2.597 ± 0.049
0.134HisCys: 0.134 ± 0.01
1.332HisAsp: 1.332 ± 0.033
1.07HisGlu: 1.07 ± 0.03
0.474HisPhe: 0.474 ± 0.02
1.942HisGly: 1.942 ± 0.043
0.563HisHis: 0.563 ± 0.024
0.532HisIle: 0.532 ± 0.022
0.246HisLys: 0.246 ± 0.014
2.428HisLeu: 2.428 ± 0.046
0.25HisMet: 0.25 ± 0.016
0.341HisAsn: 0.341 ± 0.016
1.506HisPro: 1.506 ± 0.036
0.55HisGln: 0.55 ± 0.024
1.769HisArg: 1.769 ± 0.045
0.848HisSer: 0.848 ± 0.025
1.066HisThr: 1.066 ± 0.031
1.752HisVal: 1.752 ± 0.033
0.309HisTrp: 0.309 ± 0.02
0.357HisTyr: 0.357 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
6.067IleAla: 6.067 ± 0.08
0.258IleCys: 0.258 ± 0.014
2.824IleAsp: 2.824 ± 0.047
2.288IleGlu: 2.288 ± 0.045
0.956IlePhe: 0.956 ± 0.032
4.109IleGly: 4.109 ± 0.063
0.548IleHis: 0.548 ± 0.024
1.264IleIle: 1.264 ± 0.036
0.653IleLys: 0.653 ± 0.024
3.008IleLeu: 3.008 ± 0.052
0.509IleMet: 0.509 ± 0.022
0.742IleAsn: 0.742 ± 0.027
1.965IlePro: 1.965 ± 0.038
0.83IleGln: 0.83 ± 0.024
2.174IleArg: 2.174 ± 0.041
1.971IleSer: 1.971 ± 0.043
2.527IleThr: 2.527 ± 0.046
3.747IleVal: 3.747 ± 0.06
0.43IleTrp: 0.43 ± 0.019
0.65IleTyr: 0.65 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.043LysAla: 2.043 ± 0.051
0.077LysCys: 0.077 ± 0.008
0.884LysAsp: 0.884 ± 0.03
0.712LysGlu: 0.712 ± 0.029
0.42LysPhe: 0.42 ± 0.018
1.222LysGly: 1.222 ± 0.037
0.354LysHis: 0.354 ± 0.016
0.823LysIle: 0.823 ± 0.031
0.489LysLys: 0.489 ± 0.025
1.464LysLeu: 1.464 ± 0.036
0.312LysMet: 0.312 ± 0.018
0.396LysAsn: 0.396 ± 0.02
0.859LysPro: 0.859 ± 0.029
0.488LysGln: 0.488 ± 0.021
1.122LysArg: 1.122 ± 0.036
0.93LysSer: 0.93 ± 0.037
0.986LysThr: 0.986 ± 0.033
1.55LysVal: 1.55 ± 0.044
0.171LysTrp: 0.171 ± 0.011
0.377LysTyr: 0.377 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
17.091LeuAla: 17.091 ± 0.159
0.616LeuCys: 0.616 ± 0.025
7.034LeuAsp: 7.034 ± 0.079
5.002LeuGlu: 5.002 ± 0.076
2.503LeuPhe: 2.503 ± 0.057
9.999LeuGly: 9.999 ± 0.099
1.987LeuHis: 1.987 ± 0.043
3.693LeuIle: 3.693 ± 0.07
1.424LeuLys: 1.424 ± 0.04
11.134LeuLeu: 11.134 ± 0.119
1.642LeuMet: 1.642 ± 0.036
1.606LeuAsn: 1.606 ± 0.038
5.886LeuPro: 5.886 ± 0.066
2.268LeuGln: 2.268 ± 0.043
7.864LeuArg: 7.864 ± 0.079
5.244LeuSer: 5.244 ± 0.062
7.26LeuThr: 7.26 ± 0.087
10.814LeuVal: 10.814 ± 0.116
1.227LeuTrp: 1.227 ± 0.032
1.54LeuTyr: 1.54 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.221MetAla: 2.221 ± 0.044
0.103MetCys: 0.103 ± 0.009
0.85MetAsp: 0.85 ± 0.028
0.586MetGlu: 0.586 ± 0.02
0.54MetPhe: 0.54 ± 0.022
1.264MetGly: 1.264 ± 0.039
0.309MetHis: 0.309 ± 0.015
0.753MetIle: 0.753 ± 0.026
0.335MetLys: 0.335 ± 0.017
1.759MetLeu: 1.759 ± 0.035
0.3MetMet: 0.3 ± 0.016
0.393MetAsn: 0.393 ± 0.017
1.071MetPro: 1.071 ± 0.033
0.433MetGln: 0.433 ± 0.019
1.356MetArg: 1.356 ± 0.034
1.419MetSer: 1.419 ± 0.035
1.675MetThr: 1.675 ± 0.039
1.494MetVal: 1.494 ± 0.034
0.194MetTrp: 0.194 ± 0.013
0.285MetTyr: 0.285 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.123AsnAla: 2.123 ± 0.046
0.113AsnCys: 0.113 ± 0.01
0.987AsnAsp: 0.987 ± 0.025
0.776AsnGlu: 0.776 ± 0.025
0.51AsnPhe: 0.51 ± 0.021
1.593AsnGly: 1.593 ± 0.04
0.369AsnHis: 0.369 ± 0.017
0.657AsnIle: 0.657 ± 0.024
0.311AsnLys: 0.311 ± 0.017
1.945AsnLeu: 1.945 ± 0.044
0.274AsnMet: 0.274 ± 0.015
0.375AsnAsn: 0.375 ± 0.02
1.356AsnPro: 1.356 ± 0.032
0.472AsnGln: 0.472 ± 0.021
1.131AsnArg: 1.131 ± 0.032
0.811AsnSer: 0.811 ± 0.028
0.938AsnThr: 0.938 ± 0.031
1.446AsnVal: 1.446 ± 0.034
0.234AsnTrp: 0.234 ± 0.012
0.398AsnTyr: 0.398 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.831ProAla: 8.831 ± 0.105
0.235ProCys: 0.235 ± 0.014
4.223ProAsp: 4.223 ± 0.056
3.321ProGlu: 3.321 ± 0.055
1.528ProPhe: 1.528 ± 0.037
6.025ProGly: 6.025 ± 0.084
1.118ProHis: 1.118 ± 0.029
1.798ProIle: 1.798 ± 0.041
0.78ProLys: 0.78 ± 0.03
4.984ProLeu: 4.984 ± 0.063
0.984ProMet: 0.984 ± 0.034
0.871ProAsn: 0.871 ± 0.029
2.937ProPro: 2.937 ± 0.061
1.512ProGln: 1.512 ± 0.034
3.722ProArg: 3.722 ± 0.064
3.179ProSer: 3.179 ± 0.051
3.982ProThr: 3.982 ± 0.068
5.632ProVal: 5.632 ± 0.073
0.872ProTrp: 0.872 ± 0.029
0.935ProTyr: 0.935 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.696GlnAla: 3.696 ± 0.074
0.121GlnCys: 0.121 ± 0.01
1.353GlnAsp: 1.353 ± 0.037
1.101GlnGlu: 1.101 ± 0.029
0.752GlnPhe: 0.752 ± 0.027
2.023GlnGly: 2.023 ± 0.041
0.596GlnHis: 0.596 ± 0.024
1.329GlnIle: 1.329 ± 0.034
0.439GlnLys: 0.439 ± 0.018
3.056GlnLeu: 3.056 ± 0.052
0.537GlnMet: 0.537 ± 0.023
0.498GlnAsn: 0.498 ± 0.021
1.487GlnPro: 1.487 ± 0.037
0.92GlnGln: 0.92 ± 0.028
2.176GlnArg: 2.176 ± 0.047
1.256GlnSer: 1.256 ± 0.028
1.504GlnThr: 1.504 ± 0.037
2.945GlnVal: 2.945 ± 0.054
0.446GlnTrp: 0.446 ± 0.018
0.556GlnTyr: 0.556 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
10.219ArgAla: 10.219 ± 0.112
0.431ArgCys: 0.431 ± 0.017
4.107ArgAsp: 4.107 ± 0.067
3.778ArgGlu: 3.778 ± 0.06
2.062ArgPhe: 2.062 ± 0.042
5.699ArgGly: 5.699 ± 0.068
1.633ArgHis: 1.633 ± 0.036
2.944ArgIle: 2.944 ± 0.05
1.121ArgLys: 1.121 ± 0.031
7.886ArgLeu: 7.886 ± 0.092
1.544ArgMet: 1.544 ± 0.037
1.132ArgAsn: 1.132 ± 0.028
4.339ArgPro: 4.339 ± 0.071
2.032ArgGln: 2.032 ± 0.039
7.303ArgArg: 7.303 ± 0.109
4.43ArgSer: 4.43 ± 0.059
5.081ArgThr: 5.081 ± 0.06
6.265ArgVal: 6.265 ± 0.074
1.372ArgTrp: 1.372 ± 0.037
1.505ArgTyr: 1.505 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
7.43SerAla: 7.43 ± 0.097
0.349SerCys: 0.349 ± 0.017
2.886SerAsp: 2.886 ± 0.053
2.314SerGlu: 2.314 ± 0.046
1.664SerPhe: 1.664 ± 0.04
5.814SerGly: 5.814 ± 0.078
0.925SerHis: 0.925 ± 0.027
2.147SerIle: 2.147 ± 0.042
0.787SerLys: 0.787 ± 0.029
5.103SerLeu: 5.103 ± 0.067
1.183SerMet: 1.183 ± 0.028
0.904SerAsn: 0.904 ± 0.027
3.213SerPro: 3.213 ± 0.055
1.347SerGln: 1.347 ± 0.034
3.579SerArg: 3.579 ± 0.055
3.352SerSer: 3.352 ± 0.058
3.772SerThr: 3.772 ± 0.06
4.545SerVal: 4.545 ± 0.072
0.927SerTrp: 0.927 ± 0.029
1.056SerTyr: 1.056 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
9.016ThrAla: 9.016 ± 0.093
0.374ThrCys: 0.374 ± 0.017
3.618ThrAsp: 3.618 ± 0.064
2.942ThrGlu: 2.942 ± 0.055
1.92ThrPhe: 1.92 ± 0.04
6.59ThrGly: 6.59 ± 0.082
1.179ThrHis: 1.179 ± 0.032
2.446ThrIle: 2.446 ± 0.048
0.989ThrLys: 0.989 ± 0.034
6.199ThrLeu: 6.199 ± 0.078
1.101ThrMet: 1.101 ± 0.029
1.1ThrAsn: 1.1 ± 0.035
3.959ThrPro: 3.959 ± 0.064
1.516ThrGln: 1.516 ± 0.034
4.033ThrArg: 4.033 ± 0.057
3.826ThrSer: 3.826 ± 0.059
4.457ThrThr: 4.457 ± 0.075
6.205ThrVal: 6.205 ± 0.093
1.068ThrTrp: 1.068 ± 0.034
1.246ThrTyr: 1.246 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
13.856ValAla: 13.856 ± 0.123
0.585ValCys: 0.585 ± 0.024
5.995ValAsp: 5.995 ± 0.063
4.92ValGlu: 4.92 ± 0.075
2.585ValPhe: 2.585 ± 0.046
8.427ValGly: 8.427 ± 0.106
1.86ValHis: 1.86 ± 0.042
3.62ValIle: 3.62 ± 0.063
1.311ValLys: 1.311 ± 0.035
10.784ValLeu: 10.784 ± 0.116
1.492ValMet: 1.492 ± 0.032
1.607ValAsn: 1.607 ± 0.04
5.492ValPro: 5.492 ± 0.076
2.226ValGln: 2.226 ± 0.046
7.08ValArg: 7.08 ± 0.084
4.648ValSer: 4.648 ± 0.069
6.01ValThr: 6.01 ± 0.08
10.835ValVal: 10.835 ± 0.122
1.141ValTrp: 1.141 ± 0.037
1.431ValTyr: 1.431 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.719TrpAla: 1.719 ± 0.035
0.118TrpCys: 0.118 ± 0.01
0.794TrpAsp: 0.794 ± 0.027
0.563TrpGlu: 0.563 ± 0.021
0.536TrpPhe: 0.536 ± 0.024
1.054TrpGly: 1.054 ± 0.033
0.331TrpHis: 0.331 ± 0.02
0.564TrpIle: 0.564 ± 0.02
0.238TrpLys: 0.238 ± 0.015
1.771TrpLeu: 1.771 ± 0.042
0.278TrpMet: 0.278 ± 0.015
0.353TrpAsn: 0.353 ± 0.018
0.768TrpPro: 0.768 ± 0.027
0.529TrpGln: 0.529 ± 0.018
1.229TrpArg: 1.229 ± 0.036
0.985TrpSer: 0.985 ± 0.026
1.005TrpThr: 1.005 ± 0.028
1.259TrpVal: 1.259 ± 0.035
0.365TrpTrp: 0.365 ± 0.019
0.291TrpTyr: 0.291 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.37TyrAla: 2.37 ± 0.048
0.134TyrCys: 0.134 ± 0.011
1.107TyrAsp: 1.107 ± 0.03
0.899TyrGlu: 0.899 ± 0.026
0.62TyrPhe: 0.62 ± 0.024
1.725TyrGly: 1.725 ± 0.041
0.305TyrHis: 0.305 ± 0.015
0.481TyrIle: 0.481 ± 0.021
0.254TyrLys: 0.254 ± 0.015
2.214TyrLeu: 2.214 ± 0.044
0.194TyrMet: 0.194 ± 0.014
0.357TyrAsn: 0.357 ± 0.018
1.044TyrPro: 1.044 ± 0.029
0.53TyrGln: 0.53 ± 0.021
1.497TyrArg: 1.497 ± 0.037
0.99TyrSer: 0.99 ± 0.028
1.005TyrThr: 1.005 ± 0.03
1.648TyrVal: 1.648 ± 0.041
0.293TyrTrp: 0.293 ± 0.019
0.415TyrTyr: 0.415 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3785 proteins (1270143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski