Amino acid dipepetide frequency for Thermodesulfobium narugense DSM 14796

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.838AlaAla: 3.838 ± 0.104	0.816AlaCys: 0.816 ± 0.051	2.44AlaAsp: 2.44 ± 0.069	2.79AlaGlu: 2.79 ± 0.079	3.097AlaPhe: 3.097 ± 0.084	3.782AlaGly: 3.782 ± 0.109	0.891AlaHis: 0.891 ± 0.046	5.741AlaIle: 5.741 ± 0.104	5.032AlaLys: 5.032 ± 0.111	6.616AlaLeu: 6.616 ± 0.123	1.509AlaMet: 1.509 ± 0.06	2.641AlaAsn: 2.641 ± 0.068	1.572AlaPro: 1.572 ± 0.053	1.741AlaGln: 1.741 ± 0.059	2.489AlaArg: 2.489 ± 0.065	3.828AlaSer: 3.828 ± 0.085	2.642AlaThr: 2.642 ± 0.084	3.821AlaVal: 3.821 ± 0.096	0.46AlaTrp: 0.46 ± 0.031	1.839AlaTyr: 1.839 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.8CysAla: 0.8 ± 0.04	0.131CysCys: 0.131 ± 0.014	0.525CysAsp: 0.525 ± 0.032	0.64CysGlu: 0.64 ± 0.034	0.601CysPhe: 0.601 ± 0.033	0.981CysGly: 0.981 ± 0.042	0.227CysHis: 0.227 ± 0.021	0.851CysIle: 0.851 ± 0.042	0.8CysLys: 0.8 ± 0.039	0.957CysLeu: 0.957 ± 0.045	0.261CysMet: 0.261 ± 0.021	0.474CysAsn: 0.474 ± 0.036	0.695CysPro: 0.695 ± 0.04	0.221CysGln: 0.221 ± 0.021	0.376CysArg: 0.376 ± 0.029	0.866CysSer: 0.866 ± 0.045	0.46CysThr: 0.46 ± 0.03	0.749CysVal: 0.749 ± 0.039	0.082CysTrp: 0.082 ± 0.013	0.359CysTyr: 0.359 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	2.838AspAla: 2.838 ± 0.076	0.507AspCys: 0.507 ± 0.03	2.315AspAsp: 2.315 ± 0.059	3.974AspGlu: 3.974 ± 0.087	3.402AspPhe: 3.402 ± 0.082	2.738AspGly: 2.738 ± 0.087	0.634AspHis: 0.634 ± 0.031	5.485AspIle: 5.485 ± 0.101	4.354AspLys: 4.354 ± 0.103	5.767AspLeu: 5.767 ± 0.107	1.203AspMet: 1.203 ± 0.05	2.52AspAsn: 2.52 ± 0.073	2.099AspPro: 2.099 ± 0.068	1.089AspGln: 1.089 ± 0.043	2.041AspArg: 2.041 ± 0.069	3.256AspSer: 3.256 ± 0.08	2.031AspThr: 2.031 ± 0.067	3.479AspVal: 3.479 ± 0.087	0.498AspTrp: 0.498 ± 0.034	2.083AspTyr: 2.083 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	3.916GluAla: 3.916 ± 0.101	0.549GluCys: 0.549 ± 0.03	3.604GluAsp: 3.604 ± 0.072	5.853GluGlu: 5.853 ± 0.14	3.125GluPhe: 3.125 ± 0.082	3.767GluGly: 3.767 ± 0.088	0.901GluHis: 0.901 ± 0.044	7.068GluIle: 7.068 ± 0.138	7.162GluLys: 7.162 ± 0.14	6.43GluLeu: 6.43 ± 0.126	1.516GluMet: 1.516 ± 0.054	4.316GluAsn: 4.316 ± 0.109	1.746GluPro: 1.746 ± 0.06	1.429GluGln: 1.429 ± 0.057	3.529GluArg: 3.529 ± 0.088	3.723GluSer: 3.723 ± 0.088	2.543GluThr: 2.543 ± 0.07	4.359GluVal: 4.359 ± 0.099	0.464GluTrp: 0.464 ± 0.029	2.081GluTyr: 2.081 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.169PheAla: 3.169 ± 0.096	0.748PheCys: 0.748 ± 0.036	3.411PheAsp: 3.411 ± 0.077	3.61PheGlu: 3.61 ± 0.09	3.702PhePhe: 3.702 ± 0.113	3.875PheGly: 3.875 ± 0.094	0.749PheHis: 0.749 ± 0.038	4.579PheIle: 4.579 ± 0.099	4.129PheLys: 4.129 ± 0.088	6.696PheLeu: 6.696 ± 0.124	1.269PheMet: 1.269 ± 0.049	2.784PheAsn: 2.784 ± 0.081	1.963PhePro: 1.963 ± 0.055	1.224PheGln: 1.224 ± 0.042	1.881PheArg: 1.881 ± 0.05	4.753PheSer: 4.753 ± 0.112	2.426PheThr: 2.426 ± 0.068	3.76PheVal: 3.76 ± 0.089	0.553PheTrp: 0.553 ± 0.028	2.416PheTyr: 2.416 ± 0.071	0.0PheXaa: 0.0 ± 0.0
Gly	4.221GlyAla: 4.221 ± 0.114	0.865GlyCys: 0.865 ± 0.049	2.644GlyAsp: 2.644 ± 0.069	3.36GlyGlu: 3.36 ± 0.081	3.885GlyPhe: 3.885 ± 0.099	4.038GlyGly: 4.038 ± 0.117	1.152GlyHis: 1.152 ± 0.048	6.09GlyIle: 6.09 ± 0.121	5.105GlyLys: 5.105 ± 0.098	5.891GlyLeu: 5.891 ± 0.112	1.473GlyMet: 1.473 ± 0.056	2.637GlyAsn: 2.637 ± 0.074	1.759GlyPro: 1.759 ± 0.06	1.546GlyGln: 1.546 ± 0.051	2.489GlyArg: 2.489 ± 0.076	4.201GlySer: 4.201 ± 0.092	3.204GlyThr: 3.204 ± 0.079	4.26GlyVal: 4.26 ± 0.099	0.577GlyTrp: 0.577 ± 0.04	2.672GlyTyr: 2.672 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	0.824HisAla: 0.824 ± 0.037	0.148HisCys: 0.148 ± 0.016	0.659HisAsp: 0.659 ± 0.031	0.798HisGlu: 0.798 ± 0.04	0.746HisPhe: 0.746 ± 0.035	0.978HisGly: 0.978 ± 0.048	0.345HisHis: 0.345 ± 0.027	1.215HisIle: 1.215 ± 0.042	0.88HisLys: 0.88 ± 0.043	1.431HisLeu: 1.431 ± 0.055	0.342HisMet: 0.342 ± 0.025	0.671HisAsn: 0.671 ± 0.037	0.859HisPro: 0.859 ± 0.037	0.356HisGln: 0.356 ± 0.022	0.579HisArg: 0.579 ± 0.031	0.962HisSer: 0.962 ± 0.043	0.704HisThr: 0.704 ± 0.039	0.851HisVal: 0.851 ± 0.039	0.148HisTrp: 0.148 ± 0.017	0.53HisTyr: 0.53 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.494IleAla: 5.494 ± 0.112	1.028IleCys: 1.028 ± 0.043	5.084IleAsp: 5.084 ± 0.101	6.468IleGlu: 6.468 ± 0.129	5.682IlePhe: 5.682 ± 0.123	5.686IleGly: 5.686 ± 0.109	1.128IleHis: 1.128 ± 0.042	7.627IleIle: 7.627 ± 0.136	7.502IleLys: 7.502 ± 0.128	9.935IleLeu: 9.935 ± 0.149	1.773IleMet: 1.773 ± 0.054	5.065IleAsn: 5.065 ± 0.114	3.373IlePro: 3.373 ± 0.082	1.884IleGln: 1.884 ± 0.058	3.465IleArg: 3.465 ± 0.083	7.415IleSer: 7.415 ± 0.134	3.979IleThr: 3.979 ± 0.075	5.961IleVal: 5.961 ± 0.12	0.65IleTrp: 0.65 ± 0.038	3.317IleTyr: 3.317 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	4.221LysAla: 4.221 ± 0.084	0.716LysCys: 0.716 ± 0.038	5.708LysAsp: 5.708 ± 0.095	7.625LysGlu: 7.625 ± 0.136	3.78LysPhe: 3.78 ± 0.091	4.389LysGly: 4.389 ± 0.097	0.87LysHis: 0.87 ± 0.034	8.502LysIle: 8.502 ± 0.135	7.638LysLys: 7.638 ± 0.14	6.967LysLeu: 6.967 ± 0.126	1.816LysMet: 1.816 ± 0.062	5.773LysAsn: 5.773 ± 0.112	2.546LysPro: 2.546 ± 0.066	1.551LysGln: 1.551 ± 0.055	3.887LysArg: 3.887 ± 0.099	5.142LysSer: 5.142 ± 0.106	3.803LysThr: 3.803 ± 0.089	5.067LysVal: 5.067 ± 0.093	0.546LysTrp: 0.546 ± 0.037	3.014LysTyr: 3.014 ± 0.082	0.0LysXaa: 0.0 ± 0.0
Leu	5.992LeuAla: 5.992 ± 0.118	1.138LeuCys: 1.138 ± 0.05	5.32LeuAsp: 5.32 ± 0.104	6.843LeuGlu: 6.843 ± 0.132	5.565LeuPhe: 5.565 ± 0.136	6.466LeuGly: 6.466 ± 0.135	1.403LeuHis: 1.403 ± 0.044	8.734LeuIle: 8.734 ± 0.151	9.375LeuLys: 9.375 ± 0.145	9.565LeuLeu: 9.565 ± 0.147	2.044LeuMet: 2.044 ± 0.061	5.76LeuAsn: 5.76 ± 0.113	4.068LeuPro: 4.068 ± 0.09	2.248LeuGln: 2.248 ± 0.074	4.073LeuArg: 4.073 ± 0.084	8.746LeuSer: 8.746 ± 0.142	4.605LeuThr: 4.605 ± 0.098	5.947LeuVal: 5.947 ± 0.112	0.786LeuTrp: 0.786 ± 0.043	3.406LeuTyr: 3.406 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.469MetAla: 1.469 ± 0.059	0.256MetCys: 0.256 ± 0.019	1.088MetAsp: 1.088 ± 0.04	1.161MetGlu: 1.161 ± 0.047	1.027MetPhe: 1.027 ± 0.041	1.607MetGly: 1.607 ± 0.052	0.319MetHis: 0.319 ± 0.021	1.896MetIle: 1.896 ± 0.058	1.928MetLys: 1.928 ± 0.057	2.18MetLeu: 2.18 ± 0.067	0.457MetMet: 0.457 ± 0.035	1.196MetAsn: 1.196 ± 0.044	1.009MetPro: 1.009 ± 0.047	0.636MetGln: 0.636 ± 0.033	0.866MetArg: 0.866 ± 0.038	1.666MetSer: 1.666 ± 0.058	0.962MetThr: 0.962 ± 0.039	1.415MetVal: 1.415 ± 0.055	0.173MetTrp: 0.173 ± 0.016	0.608MetTyr: 0.608 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.829AsnAla: 2.829 ± 0.085	0.551AsnCys: 0.551 ± 0.031	2.374AsnAsp: 2.374 ± 0.075	3.162AsnGlu: 3.162 ± 0.094	3.676AsnPhe: 3.676 ± 0.097	2.445AsnGly: 2.445 ± 0.08	0.614AsnHis: 0.614 ± 0.031	5.656AsnIle: 5.656 ± 0.118	4.53AsnLys: 4.53 ± 0.112	6.187AsnLeu: 6.187 ± 0.124	1.199AsnMet: 1.199 ± 0.037	3.291AsnAsn: 3.291 ± 0.108	2.503AsnPro: 2.503 ± 0.069	1.354AsnGln: 1.354 ± 0.06	1.766AsnArg: 1.766 ± 0.057	3.93AsnSer: 3.93 ± 0.098	2.14AsnThr: 2.14 ± 0.068	3.519AsnVal: 3.519 ± 0.081	0.444AsnTrp: 0.444 ± 0.033	2.125AsnTyr: 2.125 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.665ProAla: 1.665 ± 0.056	0.319ProCys: 0.319 ± 0.029	2.139ProAsp: 2.139 ± 0.061	2.947ProGlu: 2.947 ± 0.08	2.227ProPhe: 2.227 ± 0.066	2.409ProGly: 2.409 ± 0.071	0.626ProHis: 0.626 ± 0.03	3.183ProIle: 3.183 ± 0.082	2.733ProLys: 2.733 ± 0.067	3.369ProLeu: 3.369 ± 0.077	0.774ProMet: 0.774 ± 0.038	1.849ProAsn: 1.849 ± 0.065	1.157ProPro: 1.157 ± 0.055	0.959ProGln: 0.959 ± 0.045	1.105ProArg: 1.105 ± 0.048	2.262ProSer: 2.262 ± 0.063	1.736ProThr: 1.736 ± 0.053	2.51ProVal: 2.51 ± 0.063	0.343ProTrp: 0.343 ± 0.027	1.574ProTyr: 1.574 ± 0.054	0.0ProXaa: 0.0 ± 0.0
Gln	1.565GlnAla: 1.565 ± 0.054	0.216GlnCys: 0.216 ± 0.022	1.272GlnAsp: 1.272 ± 0.054	1.825GlnGlu: 1.825 ± 0.062	1.072GlnPhe: 1.072 ± 0.044	1.421GlnGly: 1.421 ± 0.051	0.31GlnHis: 0.31 ± 0.024	2.379GlnIle: 2.379 ± 0.064	2.109GlnLys: 2.109 ± 0.063	1.858GlnLeu: 1.858 ± 0.062	0.666GlnMet: 0.666 ± 0.035	1.546GlnAsn: 1.546 ± 0.063	0.657GlnPro: 0.657 ± 0.039	0.549GlnGln: 0.549 ± 0.033	1.089GlnArg: 1.089 ± 0.045	1.476GlnSer: 1.476 ± 0.063	1.225GlnThr: 1.225 ± 0.047	1.408GlnVal: 1.408 ± 0.048	0.16GlnTrp: 0.16 ± 0.016	0.73GlnTyr: 0.73 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.36ArgAla: 2.36 ± 0.068	0.471ArgCys: 0.471 ± 0.034	2.104ArgAsp: 2.104 ± 0.058	3.005ArgGlu: 3.005 ± 0.078	2.306ArgPhe: 2.306 ± 0.063	2.442ArgGly: 2.442 ± 0.078	0.587ArgHis: 0.587 ± 0.03	3.624ArgIle: 3.624 ± 0.079	3.001ArgLys: 3.001 ± 0.072	3.96ArgLeu: 3.96 ± 0.087	0.891ArgMet: 0.891 ± 0.033	1.877ArgAsn: 1.877 ± 0.056	1.272ArgPro: 1.272 ± 0.042	0.906ArgGln: 0.906 ± 0.039	1.696ArgArg: 1.696 ± 0.058	2.459ArgSer: 2.459 ± 0.068	1.794ArgThr: 1.794 ± 0.052	2.752ArgVal: 2.752 ± 0.07	0.356ArgTrp: 0.356 ± 0.027	1.556ArgTyr: 1.556 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	3.578SerAla: 3.578 ± 0.085	0.762SerCys: 0.762 ± 0.038	3.685SerAsp: 3.685 ± 0.079	4.598SerGlu: 4.598 ± 0.104	4.669SerPhe: 4.669 ± 0.109	4.626SerGly: 4.626 ± 0.095	0.952SerHis: 0.952 ± 0.038	6.445SerIle: 6.445 ± 0.106	5.567SerLys: 5.567 ± 0.119	7.843SerLeu: 7.843 ± 0.118	1.482SerMet: 1.482 ± 0.051	3.965SerAsn: 3.965 ± 0.119	2.257SerPro: 2.257 ± 0.069	1.947SerGln: 1.947 ± 0.068	2.444SerArg: 2.444 ± 0.063	5.41SerSer: 5.41 ± 0.119	3.163SerThr: 3.163 ± 0.083	4.333SerVal: 4.333 ± 0.084	0.58SerTrp: 0.58 ± 0.035	2.703SerTyr: 2.703 ± 0.08	0.0SerXaa: 0.0 ± 0.0
Thr	2.48ThrAla: 2.48 ± 0.079	0.439ThrCys: 0.439 ± 0.025	2.048ThrAsp: 2.048 ± 0.063	2.161ThrGlu: 2.161 ± 0.069	2.58ThrPhe: 2.58 ± 0.074	3.413ThrGly: 3.413 ± 0.084	0.708ThrHis: 0.708 ± 0.037	4.065ThrIle: 4.065 ± 0.083	3.282ThrLys: 3.282 ± 0.071	4.722ThrLeu: 4.722 ± 0.092	0.913ThrMet: 0.913 ± 0.038	2.36ThrAsn: 2.36 ± 0.061	1.977ThrPro: 1.977 ± 0.057	1.166ThrGln: 1.166 ± 0.049	1.59ThrArg: 1.59 ± 0.051	3.163ThrSer: 3.163 ± 0.071	2.165ThrThr: 2.165 ± 0.069	2.74ThrVal: 2.74 ± 0.073	0.347ThrTrp: 0.347 ± 0.026	1.644ThrTyr: 1.644 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	3.944ValAla: 3.944 ± 0.097	0.844ValCys: 0.844 ± 0.041	3.509ValAsp: 3.509 ± 0.09	4.479ValGlu: 4.479 ± 0.104	3.655ValPhe: 3.655 ± 0.081	4.392ValGly: 4.392 ± 0.117	0.898ValHis: 0.898 ± 0.041	5.541ValIle: 5.541 ± 0.1	4.837ValLys: 4.837 ± 0.109	6.757ValLeu: 6.757 ± 0.113	1.382ValMet: 1.382 ± 0.049	3.191ValAsn: 3.191 ± 0.077	2.409ValPro: 2.409 ± 0.073	1.394ValGln: 1.394 ± 0.053	2.348ValArg: 2.348 ± 0.076	4.65ValSer: 4.65 ± 0.101	2.548ValThr: 2.548 ± 0.071	4.68ValVal: 4.68 ± 0.096	0.49ValTrp: 0.49 ± 0.031	2.273ValTyr: 2.273 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.547TrpAla: 0.547 ± 0.032	0.108TrpCys: 0.108 ± 0.013	0.429TrpAsp: 0.429 ± 0.031	0.469TrpGlu: 0.469 ± 0.027	0.495TrpPhe: 0.495 ± 0.033	0.544TrpGly: 0.544 ± 0.029	0.148TrpHis: 0.148 ± 0.017	0.718TrpIle: 0.718 ± 0.036	0.565TrpLys: 0.565 ± 0.035	0.887TrpLeu: 0.887 ± 0.041	0.223TrpMet: 0.223 ± 0.022	0.399TrpAsn: 0.399 ± 0.025	0.27TrpPro: 0.27 ± 0.026	0.289TrpGln: 0.289 ± 0.023	0.291TrpArg: 0.291 ± 0.025	0.457TrpSer: 0.457 ± 0.026	0.329TrpThr: 0.329 ± 0.025	0.49TrpVal: 0.49 ± 0.03	0.136TrpTrp: 0.136 ± 0.014	0.298TrpTyr: 0.298 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.834TyrAla: 1.834 ± 0.061	0.446TyrCys: 0.446 ± 0.031	1.957TyrAsp: 1.957 ± 0.067	2.313TyrGlu: 2.313 ± 0.074	2.4TyrPhe: 2.4 ± 0.068	2.071TyrGly: 2.071 ± 0.068	0.565TyrHis: 0.565 ± 0.029	3.116TyrIle: 3.116 ± 0.075	3.033TyrLys: 3.033 ± 0.075	4.066TyrLeu: 4.066 ± 0.098	0.725TyrMet: 0.725 ± 0.035	1.982TyrAsn: 1.982 ± 0.07	1.694TyrPro: 1.694 ± 0.064	1.044TyrGln: 1.044 ± 0.047	1.415TyrArg: 1.415 ± 0.047	2.644TyrSer: 2.644 ± 0.069	1.501TyrThr: 1.501 ± 0.064	2.121TyrVal: 2.121 ± 0.064	0.3TyrTrp: 0.3 ± 0.021	1.448TyrTyr: 1.448 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1797 proteins (573739 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---