Amino acid dipepetide frequency for Thiohalobacter thiocyanaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.648AlaAla: 14.648 ± 0.189	1.104AlaCys: 1.104 ± 0.036	6.169AlaAsp: 6.169 ± 0.085	7.435AlaGlu: 7.435 ± 0.098	3.444AlaPhe: 3.444 ± 0.059	10.524AlaGly: 10.524 ± 0.128	2.351AlaHis: 2.351 ± 0.06	5.01AlaIle: 5.01 ± 0.075	2.223AlaLys: 2.223 ± 0.07	12.609AlaLeu: 12.609 ± 0.159	2.886AlaMet: 2.886 ± 0.054	2.345AlaAsn: 2.345 ± 0.052	4.661AlaPro: 4.661 ± 0.087	3.934AlaGln: 3.934 ± 0.076	8.978AlaArg: 8.978 ± 0.119	4.808AlaSer: 4.808 ± 0.077	4.512AlaThr: 4.512 ± 0.075	7.957AlaVal: 7.957 ± 0.103	1.706AlaTrp: 1.706 ± 0.043	2.47AlaTyr: 2.47 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.883CysAla: 0.883 ± 0.033	0.119CysCys: 0.119 ± 0.013	0.569CysAsp: 0.569 ± 0.026	0.578CysGlu: 0.578 ± 0.026	0.305CysPhe: 0.305 ± 0.02	0.963CysGly: 0.963 ± 0.035	0.349CysHis: 0.349 ± 0.024	0.427CysIle: 0.427 ± 0.021	0.191CysLys: 0.191 ± 0.016	0.935CysLeu: 0.935 ± 0.036	0.186CysMet: 0.186 ± 0.014	0.277CysAsn: 0.277 ± 0.017	0.576CysPro: 0.576 ± 0.026	0.345CysGln: 0.345 ± 0.021	0.803CysArg: 0.803 ± 0.034	0.482CysSer: 0.482 ± 0.024	0.401CysThr: 0.401 ± 0.021	0.615CysVal: 0.615 ± 0.023	0.096CysTrp: 0.096 ± 0.01	0.259CysTyr: 0.259 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.211AspAla: 6.211 ± 0.085	0.612AspCys: 0.612 ± 0.027	3.144AspAsp: 3.144 ± 0.062	3.926AspGlu: 3.926 ± 0.061	2.274AspPhe: 2.274 ± 0.052	4.576AspGly: 4.576 ± 0.087	1.248AspHis: 1.248 ± 0.038	3.281AspIle: 3.281 ± 0.07	1.764AspLys: 1.764 ± 0.053	5.929AspLeu: 5.929 ± 0.086	1.455AspMet: 1.455 ± 0.041	1.682AspAsn: 1.682 ± 0.047	3.573AspPro: 3.573 ± 0.063	2.185AspGln: 2.185 ± 0.052	4.377AspArg: 4.377 ± 0.073	3.042AspSer: 3.042 ± 0.06	3.032AspThr: 3.032 ± 0.056	3.546AspVal: 3.546 ± 0.071	1.253AspTrp: 1.253 ± 0.042	2.085AspTyr: 2.085 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.065GluAla: 8.065 ± 0.11	0.496GluCys: 0.496 ± 0.022	3.24GluAsp: 3.24 ± 0.053	3.728GluGlu: 3.728 ± 0.077	2.161GluPhe: 2.161 ± 0.046	4.361GluGly: 4.361 ± 0.066	1.81GluHis: 1.81 ± 0.044	3.456GluIle: 3.456 ± 0.058	1.957GluLys: 1.957 ± 0.06	7.764GluLeu: 7.764 ± 0.104	1.527GluMet: 1.527 ± 0.042	1.602GluAsn: 1.602 ± 0.04	3.185GluPro: 3.185 ± 0.068	3.884GluGln: 3.884 ± 0.086	5.739GluArg: 5.739 ± 0.09	3.03GluSer: 3.03 ± 0.051	3.476GluThr: 3.476 ± 0.069	4.657GluVal: 4.657 ± 0.067	0.751GluTrp: 0.751 ± 0.028	1.651GluTyr: 1.651 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.348PheAla: 3.348 ± 0.061	0.336PheCys: 0.336 ± 0.019	2.442PheAsp: 2.442 ± 0.051	2.221PheGlu: 2.221 ± 0.048	1.306PhePhe: 1.306 ± 0.037	2.922PheGly: 2.922 ± 0.052	0.837PheHis: 0.837 ± 0.029	1.69PheIle: 1.69 ± 0.048	0.899PheLys: 0.899 ± 0.033	3.242PheLeu: 3.242 ± 0.058	0.756PheMet: 0.756 ± 0.029	1.162PheAsn: 1.162 ± 0.042	1.506PhePro: 1.506 ± 0.043	1.091PheGln: 1.091 ± 0.035	2.243PheArg: 2.243 ± 0.048	2.075PheSer: 2.075 ± 0.052	1.978PheThr: 1.978 ± 0.054	2.315PheVal: 2.315 ± 0.053	0.478PheTrp: 0.478 ± 0.023	0.972PheTyr: 0.972 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.276GlyAla: 7.276 ± 0.094	0.954GlyCys: 0.954 ± 0.038	4.361GlyAsp: 4.361 ± 0.082	5.668GlyGlu: 5.668 ± 0.084	3.173GlyPhe: 3.173 ± 0.057	6.736GlyGly: 6.736 ± 0.105	1.964GlyHis: 1.964 ± 0.056	4.37GlyIle: 4.37 ± 0.074	2.604GlyLys: 2.604 ± 0.058	9.159GlyLeu: 9.159 ± 0.124	2.397GlyMet: 2.397 ± 0.055	2.301GlyAsn: 2.301 ± 0.062	2.82GlyPro: 2.82 ± 0.061	3.042GlyGln: 3.042 ± 0.056	6.684GlyArg: 6.684 ± 0.094	4.09GlySer: 4.09 ± 0.072	3.858GlyThr: 3.858 ± 0.072	5.968GlyVal: 5.968 ± 0.083	1.396GlyTrp: 1.396 ± 0.043	2.514GlyTyr: 2.514 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.537HisAla: 2.537 ± 0.062	0.311HisCys: 0.311 ± 0.018	1.381HisAsp: 1.381 ± 0.036	1.366HisGlu: 1.366 ± 0.04	0.854HisPhe: 0.854 ± 0.031	2.062HisGly: 2.062 ± 0.045	0.722HisHis: 0.722 ± 0.031	1.159HisIle: 1.159 ± 0.033	0.632HisLys: 0.632 ± 0.027	2.518HisLeu: 2.518 ± 0.057	0.527HisMet: 0.527 ± 0.024	0.725HisAsn: 0.725 ± 0.03	1.652HisPro: 1.652 ± 0.044	0.892HisGln: 0.892 ± 0.032	1.81HisArg: 1.81 ± 0.046	1.19HisSer: 1.19 ± 0.04	1.232HisThr: 1.232 ± 0.037	1.418HisVal: 1.418 ± 0.037	0.467HisTrp: 0.467 ± 0.022	0.882HisTyr: 0.882 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.245IleAla: 5.245 ± 0.075	0.425IleCys: 0.425 ± 0.022	3.673IleAsp: 3.673 ± 0.068	4.028IleGlu: 4.028 ± 0.074	1.373IlePhe: 1.373 ± 0.036	4.123IleGly: 4.123 ± 0.066	1.192IleHis: 1.192 ± 0.038	2.203IleIle: 2.203 ± 0.047	1.49IleLys: 1.49 ± 0.043	4.711IleLeu: 4.711 ± 0.073	0.958IleMet: 0.958 ± 0.037	1.668IleAsn: 1.668 ± 0.048	2.496IlePro: 2.496 ± 0.053	1.734IleGln: 1.734 ± 0.039	3.762IleArg: 3.762 ± 0.07	2.529IleSer: 2.529 ± 0.049	2.567IleThr: 2.567 ± 0.058	3.108IleVal: 3.108 ± 0.071	0.458IleTrp: 0.458 ± 0.023	1.138IleTyr: 1.138 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	2.917LysAla: 2.917 ± 0.072	0.212LysCys: 0.212 ± 0.015	1.382LysAsp: 1.382 ± 0.037	1.5LysGlu: 1.5 ± 0.049	0.723LysPhe: 0.723 ± 0.032	2.055LysGly: 2.055 ± 0.064	0.647LysHis: 0.647 ± 0.025	1.213LysIle: 1.213 ± 0.042	1.149LysLys: 1.149 ± 0.077	2.956LysLeu: 2.956 ± 0.06	0.577LysMet: 0.577 ± 0.024	0.767LysAsn: 0.767 ± 0.031	1.54LysPro: 1.54 ± 0.045	1.323LysGln: 1.323 ± 0.042	2.221LysArg: 2.221 ± 0.052	1.446LysSer: 1.446 ± 0.045	1.505LysThr: 1.505 ± 0.043	1.971LysVal: 1.971 ± 0.052	0.307LysTrp: 0.307 ± 0.018	0.737LysTyr: 0.737 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.391LeuAla: 13.391 ± 0.175	0.958LeuCys: 0.958 ± 0.034	7.068LeuAsp: 7.068 ± 0.095	8.025LeuGlu: 8.025 ± 0.119	3.766LeuPhe: 3.766 ± 0.076	8.628LeuGly: 8.628 ± 0.117	2.633LeuHis: 2.633 ± 0.051	5.365LeuIle: 5.365 ± 0.081	3.268LeuLys: 3.268 ± 0.062	12.738LeuLeu: 12.738 ± 0.198	2.456LeuMet: 2.456 ± 0.057	3.004LeuAsn: 3.004 ± 0.055	5.993LeuPro: 5.993 ± 0.076	4.625LeuGln: 4.625 ± 0.094	8.16LeuArg: 8.16 ± 0.105	5.905LeuSer: 5.905 ± 0.073	5.446LeuThr: 5.446 ± 0.087	7.644LeuVal: 7.644 ± 0.127	1.289LeuTrp: 1.289 ± 0.042	2.717LeuTyr: 2.717 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.531MetAla: 2.531 ± 0.056	0.165MetCys: 0.165 ± 0.012	1.344MetAsp: 1.344 ± 0.038	1.421MetGlu: 1.421 ± 0.038	0.609MetPhe: 0.609 ± 0.025	1.619MetGly: 1.619 ± 0.045	0.592MetHis: 0.592 ± 0.026	1.061MetIle: 1.061 ± 0.036	0.94MetLys: 0.94 ± 0.028	2.595MetLeu: 2.595 ± 0.058	0.526MetMet: 0.526 ± 0.025	0.827MetAsn: 0.827 ± 0.029	1.318MetPro: 1.318 ± 0.036	1.179MetGln: 1.179 ± 0.032	1.622MetArg: 1.622 ± 0.041	1.497MetSer: 1.497 ± 0.035	1.366MetThr: 1.366 ± 0.044	1.471MetVal: 1.471 ± 0.042	0.183MetTrp: 0.183 ± 0.014	0.385MetTyr: 0.385 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.622AsnAla: 2.622 ± 0.062	0.295AsnCys: 0.295 ± 0.02	1.544AsnAsp: 1.544 ± 0.054	1.444AsnGlu: 1.444 ± 0.041	0.891AsnPhe: 0.891 ± 0.034	2.089AsnGly: 2.089 ± 0.055	0.649AsnHis: 0.649 ± 0.029	1.467AsnIle: 1.467 ± 0.037	0.808AsnLys: 0.808 ± 0.037	3.065AsnLeu: 3.065 ± 0.069	0.609AsnMet: 0.609 ± 0.026	0.823AsnAsn: 0.823 ± 0.032	1.869AsnPro: 1.869 ± 0.048	0.96AsnGln: 0.96 ± 0.04	2.251AsnArg: 2.251 ± 0.048	1.226AsnSer: 1.226 ± 0.045	1.396AsnThr: 1.396 ± 0.043	1.677AsnVal: 1.677 ± 0.038	0.373AsnTrp: 0.373 ± 0.02	0.745AsnTyr: 0.745 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.296ProAla: 6.296 ± 0.109	0.37ProCys: 0.37 ± 0.021	3.901ProAsp: 3.901 ± 0.077	4.47ProGlu: 4.47 ± 0.081	1.64ProPhe: 1.64 ± 0.042	4.759ProGly: 4.759 ± 0.082	1.111ProHis: 1.111 ± 0.033	1.838ProIle: 1.838 ± 0.048	1.08ProLys: 1.08 ± 0.041	5.132ProLeu: 5.132 ± 0.076	1.044ProMet: 1.044 ± 0.032	1.113ProAsn: 1.113 ± 0.035	2.622ProPro: 2.622 ± 0.061	1.849ProGln: 1.849 ± 0.048	3.045ProArg: 3.045 ± 0.064	2.018ProSer: 2.018 ± 0.051	2.016ProThr: 2.016 ± 0.046	4.399ProVal: 4.399 ± 0.064	0.675ProTrp: 0.675 ± 0.03	1.228ProTyr: 1.228 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.52GlnAla: 5.52 ± 0.095	0.314GlnCys: 0.314 ± 0.02	2.03GlnAsp: 2.03 ± 0.051	2.218GlnGlu: 2.218 ± 0.061	1.071GlnPhe: 1.071 ± 0.036	3.124GlnGly: 3.124 ± 0.07	0.967GlnHis: 0.967 ± 0.032	1.753GlnIle: 1.753 ± 0.048	0.901GlnLys: 0.901 ± 0.031	4.55GlnLeu: 4.55 ± 0.086	0.833GlnMet: 0.833 ± 0.032	0.781GlnAsn: 0.781 ± 0.03	2.176GlnPro: 2.176 ± 0.055	2.226GlnGln: 2.226 ± 0.067	3.534GlnArg: 3.534 ± 0.078	1.777GlnSer: 1.777 ± 0.049	1.88GlnThr: 1.88 ± 0.048	3.128GlnVal: 3.128 ± 0.06	0.553GlnTrp: 0.553 ± 0.026	0.973GlnTyr: 0.973 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.222ArgAla: 7.222 ± 0.101	0.658ArgCys: 0.658 ± 0.028	4.612ArgAsp: 4.612 ± 0.066	5.689ArgGlu: 5.689 ± 0.096	3.028ArgPhe: 3.028 ± 0.06	4.854ArgGly: 4.854 ± 0.075	2.174ArgHis: 2.174 ± 0.055	4.511ArgIle: 4.511 ± 0.078	2.125ArgLys: 2.125 ± 0.05	10.151ArgLeu: 10.151 ± 0.155	1.894ArgMet: 1.894 ± 0.048	2.08ArgAsn: 2.08 ± 0.048	3.7ArgPro: 3.7 ± 0.07	3.408ArgGln: 3.408 ± 0.063	6.735ArgArg: 6.735 ± 0.118	3.57ArgSer: 3.57 ± 0.056	3.188ArgThr: 3.188 ± 0.054	5.272ArgVal: 5.272 ± 0.087	1.097ArgTrp: 1.097 ± 0.033	2.356ArgTyr: 2.356 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.859SerAla: 4.859 ± 0.079	0.47SerCys: 0.47 ± 0.025	2.992SerAsp: 2.992 ± 0.066	3.013SerGlu: 3.013 ± 0.063	1.792SerPhe: 1.792 ± 0.047	5.04SerGly: 5.04 ± 0.087	1.244SerHis: 1.244 ± 0.039	2.363SerIle: 2.363 ± 0.054	1.174SerLys: 1.174 ± 0.043	5.835SerLeu: 5.835 ± 0.088	1.191SerMet: 1.191 ± 0.035	1.286SerAsn: 1.286 ± 0.041	2.475SerPro: 2.475 ± 0.049	1.74SerGln: 1.74 ± 0.049	3.933SerArg: 3.933 ± 0.064	2.466SerSer: 2.466 ± 0.055	2.274SerThr: 2.274 ± 0.052	3.283SerVal: 3.283 ± 0.06	0.578SerTrp: 0.578 ± 0.03	1.276SerTyr: 1.276 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.399ThrAla: 5.399 ± 0.082	0.434ThrCys: 0.434 ± 0.021	2.896ThrAsp: 2.896 ± 0.065	2.748ThrGlu: 2.748 ± 0.047	1.45ThrPhe: 1.45 ± 0.038	4.938ThrGly: 4.938 ± 0.076	1.186ThrHis: 1.186 ± 0.039	1.9ThrIle: 1.9 ± 0.048	0.876ThrLys: 0.876 ± 0.031	6.263ThrLeu: 6.263 ± 0.093	0.751ThrMet: 0.751 ± 0.031	1.103ThrAsn: 1.103 ± 0.04	3.069ThrPro: 3.069 ± 0.059	1.537ThrGln: 1.537 ± 0.039	3.712ThrArg: 3.712 ± 0.067	2.134ThrSer: 2.134 ± 0.05	2.32ThrThr: 2.32 ± 0.067	3.548ThrVal: 3.548 ± 0.079	0.57ThrTrp: 0.57 ± 0.028	1.121ThrTyr: 1.121 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.199ValAla: 7.199 ± 0.094	0.682ValCys: 0.682 ± 0.027	4.146ValAsp: 4.146 ± 0.072	4.82ValGlu: 4.82 ± 0.081	2.44ValPhe: 2.44 ± 0.044	5.024ValGly: 5.024 ± 0.089	1.55ValHis: 1.55 ± 0.041	3.934ValIle: 3.934 ± 0.071	1.985ValLys: 1.985 ± 0.059	7.662ValLeu: 7.662 ± 0.1	1.86ValMet: 1.86 ± 0.051	2.067ValAsn: 2.067 ± 0.045	3.362ValPro: 3.362 ± 0.063	2.431ValGln: 2.431 ± 0.045	5.12ValArg: 5.12 ± 0.078	3.859ValSer: 3.859 ± 0.076	3.726ValThr: 3.726 ± 0.08	5.159ValVal: 5.159 ± 0.086	0.887ValTrp: 0.887 ± 0.038	1.804ValTyr: 1.804 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.003TrpAla: 1.003 ± 0.039	0.156TrpCys: 0.156 ± 0.012	0.711TrpAsp: 0.711 ± 0.025	0.78TrpGlu: 0.78 ± 0.03	0.509TrpPhe: 0.509 ± 0.027	0.877TrpGly: 0.877 ± 0.032	0.374TrpHis: 0.374 ± 0.02	0.662TrpIle: 0.662 ± 0.025	0.392TrpLys: 0.392 ± 0.021	2.17TrpLeu: 2.17 ± 0.067	0.327TrpMet: 0.327 ± 0.018	0.398TrpAsn: 0.398 ± 0.021	0.703TrpPro: 0.703 ± 0.033	0.765TrpGln: 0.765 ± 0.033	1.172TrpArg: 1.172 ± 0.038	0.715TrpSer: 0.715 ± 0.03	0.53TrpThr: 0.53 ± 0.025	0.913TrpVal: 0.913 ± 0.036	0.244TrpTrp: 0.244 ± 0.017	0.369TrpTyr: 0.369 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.605TyrAla: 2.605 ± 0.057	0.288TyrCys: 0.288 ± 0.017	1.59TyrAsp: 1.59 ± 0.05	1.463TyrGlu: 1.463 ± 0.04	1.01TyrPhe: 1.01 ± 0.028	2.059TyrGly: 2.059 ± 0.043	0.738TyrHis: 0.738 ± 0.029	1.216TyrIle: 1.216 ± 0.038	0.691TyrLys: 0.691 ± 0.028	3.096TyrLeu: 3.096 ± 0.058	0.49TyrMet: 0.49 ± 0.025	0.79TyrAsn: 0.79 ± 0.034	1.311TyrPro: 1.311 ± 0.038	1.158TyrGln: 1.158 ± 0.035	2.425TyrArg: 2.425 ± 0.051	1.427TyrSer: 1.427 ± 0.04	1.252TyrThr: 1.252 ± 0.039	1.666TyrVal: 1.666 ± 0.043	0.409TyrTrp: 0.409 ± 0.02	0.835TyrTyr: 0.835 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3024 proteins (944797 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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