Amino acid dipepetide frequency for Red clover associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.506AlaAla: 5.506 ± 2.36
0.0AlaCys: 0.0 ± 0.0
2.002AlaAsp: 2.002 ± 1.653
2.503AlaGlu: 2.503 ± 1.054
5.506AlaPhe: 5.506 ± 1.234
5.005AlaGly: 5.005 ± 4.092
3.003AlaHis: 3.003 ± 0.659
7.007AlaIle: 7.007 ± 1.372
6.507AlaLys: 6.507 ± 2.742
5.005AlaLeu: 5.005 ± 0.509
3.504AlaMet: 3.504 ± 0.575
4.505AlaAsn: 4.505 ± 1.351
5.005AlaPro: 5.005 ± 1.295
3.504AlaGln: 3.504 ± 0.575
4.505AlaArg: 4.505 ± 1.431
5.005AlaSer: 5.005 ± 1.142
3.003AlaThr: 3.003 ± 0.569
8.008AlaVal: 8.008 ± 2.431
0.501AlaTrp: 0.501 ± 0.328
1.502AlaTyr: 1.502 ± 1.427
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.001CysAsp: 1.001 ± 0.369
2.002CysGlu: 2.002 ± 0.436
2.002CysPhe: 2.002 ± 0.887
1.502CysGly: 1.502 ± 0.51
0.0CysHis: 0.0 ± 0.0
1.001CysIle: 1.001 ± 0.655
1.502CysLys: 1.502 ± 0.656
2.503CysLeu: 2.503 ± 1.054
0.0CysMet: 0.0 ± 0.0
1.502CysAsn: 1.502 ± 0.643
2.002CysPro: 2.002 ± 0.918
1.001CysGln: 1.001 ± 0.369
0.0CysArg: 0.0 ± 0.0
2.503CysSer: 2.503 ± 0.897
1.502CysThr: 1.502 ± 1.158
1.001CysVal: 1.001 ± 0.369
0.501CysTrp: 0.501 ± 0.476
1.001CysTyr: 1.001 ± 0.867
0.0CysXaa: 0.0 ± 0.0
Asp
6.006AspAla: 6.006 ± 1.677
1.001AspCys: 1.001 ± 0.369
2.503AspAsp: 2.503 ± 0.428
3.504AspGlu: 3.504 ± 0.969
2.503AspPhe: 2.503 ± 0.648
1.502AspGly: 1.502 ± 0.786
0.0AspHis: 0.0 ± 0.0
3.504AspIle: 3.504 ± 0.784
0.501AspLys: 0.501 ± 0.328
3.003AspLeu: 3.003 ± 1.449
0.0AspMet: 0.0 ± 0.0
2.002AspAsn: 2.002 ± 1.325
1.001AspPro: 1.001 ± 0.655
1.001AspGln: 1.001 ± 0.655
0.501AspArg: 0.501 ± 0.476
4.004AspSer: 4.004 ± 1.553
2.002AspThr: 2.002 ± 1.426
4.004AspVal: 4.004 ± 1.022
0.0AspTrp: 0.0 ± 0.0
1.001AspTyr: 1.001 ± 0.444
0.0AspXaa: 0.0 ± 0.0
Glu
9.009GluAla: 9.009 ± 2.158
3.003GluCys: 3.003 ± 0.827
5.005GluAsp: 5.005 ± 1.207
6.507GluGlu: 6.507 ± 2.742
3.504GluPhe: 3.504 ± 1.551
1.502GluGly: 1.502 ± 1.158
0.501GluHis: 0.501 ± 0.328
3.504GluIle: 3.504 ± 0.575
5.005GluLys: 5.005 ± 2.189
7.007GluLeu: 7.007 ± 2.968
1.001GluMet: 1.001 ± 0.986
1.502GluAsn: 1.502 ± 0.643
3.003GluPro: 3.003 ± 1.049
2.002GluGln: 2.002 ± 0.436
3.003GluArg: 3.003 ± 1.386
3.003GluSer: 3.003 ± 0.569
2.002GluThr: 2.002 ± 2.164
6.507GluVal: 6.507 ± 1.422
1.001GluTrp: 1.001 ± 0.369
1.502GluTyr: 1.502 ± 0.656
0.0GluXaa: 0.0 ± 0.0
Phe
1.001PheAla: 1.001 ± 0.867
2.503PheCys: 2.503 ± 0.657
1.502PheAsp: 1.502 ± 0.643
2.503PheGlu: 2.503 ± 1.054
1.001PhePhe: 1.001 ± 0.444
3.003PheGly: 3.003 ± 0.933
3.003PheHis: 3.003 ± 1.736
0.0PheIle: 0.0 ± 0.0
3.003PheLys: 3.003 ± 0.933
4.505PheLeu: 4.505 ± 1.519
1.001PheMet: 1.001 ± 0.66
2.002PheAsn: 2.002 ± 0.774
3.003PhePro: 3.003 ± 0.659
3.003PheGln: 3.003 ± 0.569
3.003PheArg: 3.003 ± 0.431
5.005PheSer: 5.005 ± 0.878
2.002PheThr: 2.002 ± 0.569
3.504PheVal: 3.504 ± 0.99
0.501PheTrp: 0.501 ± 0.476
0.501PheTyr: 0.501 ± 0.476
0.0PheXaa: 0.0 ± 0.0
Gly
4.505GlyAla: 4.505 ± 0.363
2.002GlyCys: 2.002 ± 1.544
1.001GlyAsp: 1.001 ± 0.655
0.501GlyGlu: 0.501 ± 0.476
3.003GlyPhe: 3.003 ± 0.675
2.503GlyGly: 2.503 ± 1.969
1.001GlyHis: 1.001 ± 0.369
2.002GlyIle: 2.002 ± 0.629
5.506GlyLys: 5.506 ± 0.849
5.005GlyLeu: 5.005 ± 0.911
1.001GlyMet: 1.001 ± 0.369
4.004GlyAsn: 4.004 ± 2.15
1.001GlyPro: 1.001 ± 1.105
2.002GlyGln: 2.002 ± 1.734
3.504GlyArg: 3.504 ± 1.51
4.004GlySer: 4.004 ± 3.26
2.503GlyThr: 2.503 ± 0.72
4.004GlyVal: 4.004 ± 2.025
0.501GlyTrp: 0.501 ± 0.476
3.003GlyTyr: 3.003 ± 1.107
0.0GlyXaa: 0.0 ± 0.0
His
0.501HisAla: 0.501 ± 0.328
1.001HisCys: 1.001 ± 0.444
0.0HisAsp: 0.0 ± 0.0
3.003HisGlu: 3.003 ± 0.659
0.0HisPhe: 0.0 ± 0.0
1.001HisGly: 1.001 ± 0.867
0.0HisHis: 0.0 ± 0.0
1.001HisIle: 1.001 ± 0.444
0.0HisLys: 0.0 ± 0.0
3.003HisLeu: 3.003 ± 1.329
0.0HisMet: 0.0 ± 0.0
0.501HisAsn: 0.501 ± 0.328
0.501HisPro: 0.501 ± 0.476
0.0HisGln: 0.0 ± 0.0
1.001HisArg: 1.001 ± 0.655
3.003HisSer: 3.003 ± 0.654
0.501HisThr: 0.501 ± 1.129
1.502HisVal: 1.502 ± 0.643
0.501HisTrp: 0.501 ± 0.328
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.003IleAla: 3.003 ± 0.933
1.001IleCys: 1.001 ± 0.655
3.504IleAsp: 3.504 ± 2.054
7.007IleGlu: 7.007 ± 1.081
0.0IlePhe: 0.0 ± 0.0
1.502IleGly: 1.502 ± 0.786
0.0IleHis: 0.0 ± 0.0
2.002IleIle: 2.002 ± 0.569
4.004IleLys: 4.004 ± 1.016
3.504IleLeu: 3.504 ± 1.635
1.001IleMet: 1.001 ± 0.655
2.503IleAsn: 2.503 ± 0.651
4.004IlePro: 4.004 ± 1.216
3.504IleGln: 3.504 ± 0.721
0.501IleArg: 0.501 ± 0.328
7.007IleSer: 7.007 ± 2.545
2.002IleThr: 2.002 ± 0.887
2.002IleVal: 2.002 ± 0.569
0.0IleTrp: 0.0 ± 0.0
2.503IleTyr: 2.503 ± 0.648
0.0IleXaa: 0.0 ± 0.0
Lys
10.511LysAla: 10.511 ± 1.461
0.0LysCys: 0.0 ± 0.0
4.505LysAsp: 4.505 ± 0.875
2.503LysGlu: 2.503 ± 1.054
5.506LysPhe: 5.506 ± 0.776
2.503LysGly: 2.503 ± 0.657
0.501LysHis: 0.501 ± 0.328
3.504LysIle: 3.504 ± 0.575
8.509LysLys: 8.509 ± 3.135
4.505LysLeu: 4.505 ± 0.875
1.502LysMet: 1.502 ± 0.653
2.503LysAsn: 2.503 ± 0.856
3.003LysPro: 3.003 ± 0.431
2.002LysGln: 2.002 ± 0.436
4.505LysArg: 4.505 ± 0.587
5.506LysSer: 5.506 ± 0.856
4.505LysThr: 4.505 ± 1.097
2.002LysVal: 2.002 ± 0.774
3.504LysTrp: 3.504 ± 0.99
0.501LysTyr: 0.501 ± 0.476
0.501LysXaa: 0.501 ± 0.476
Leu
4.505LeuAla: 4.505 ± 0.933
2.503LeuCys: 2.503 ± 1.221
4.004LeuAsp: 4.004 ± 1.837
4.505LeuGlu: 4.505 ± 1.871
2.002LeuPhe: 2.002 ± 0.918
4.505LeuGly: 4.505 ± 1.216
1.502LeuHis: 1.502 ± 0.656
4.004LeuIle: 4.004 ± 0.723
6.006LeuLys: 6.006 ± 1.741
9.51LeuLeu: 9.51 ± 2.754
1.502LeuMet: 1.502 ± 0.656
3.504LeuAsn: 3.504 ± 0.358
7.007LeuPro: 7.007 ± 2.06
5.005LeuGln: 5.005 ± 0.712
4.505LeuArg: 4.505 ± 1.956
6.006LeuSer: 6.006 ± 1.946
5.506LeuThr: 5.506 ± 0.771
4.004LeuVal: 4.004 ± 1.608
0.0LeuTrp: 0.0 ± 0.0
2.002LeuTyr: 2.002 ± 1.325
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
1.001MetCys: 1.001 ± 0.655
1.001MetAsp: 1.001 ± 0.444
1.502MetGlu: 1.502 ± 1.028
0.0MetPhe: 0.0 ± 0.0
0.501MetGly: 0.501 ± 0.328
1.001MetHis: 1.001 ± 0.655
0.0MetIle: 0.0 ± 0.0
1.502MetLys: 1.502 ± 0.656
0.501MetLeu: 0.501 ± 0.328
0.0MetMet: 0.0 ± 0.0
0.501MetAsn: 0.501 ± 0.476
2.002MetPro: 2.002 ± 0.629
0.0MetGln: 0.0 ± 0.0
2.002MetArg: 2.002 ± 1.01
2.503MetSer: 2.503 ± 1.22
0.501MetThr: 0.501 ± 0.328
4.004MetVal: 4.004 ± 0.664
0.0MetTrp: 0.0 ± 0.0
0.501MetTyr: 0.501 ± 0.476
0.0MetXaa: 0.0 ± 0.0
Asn
4.004AsnAla: 4.004 ± 1.801
0.501AsnCys: 0.501 ± 0.328
1.001AsnAsp: 1.001 ± 0.369
2.002AsnGlu: 2.002 ± 0.436
1.001AsnPhe: 1.001 ± 0.444
3.003AsnGly: 3.003 ± 1.312
0.0AsnHis: 0.0 ± 0.0
0.501AsnIle: 0.501 ± 0.328
3.003AsnLys: 3.003 ± 0.569
0.501AsnLeu: 0.501 ± 0.328
1.001AsnMet: 1.001 ± 0.369
1.001AsnAsn: 1.001 ± 1.105
2.002AsnPro: 2.002 ± 0.629
1.001AsnGln: 1.001 ± 0.867
4.505AsnArg: 4.505 ± 0.964
4.004AsnSer: 4.004 ± 1.4
3.504AsnThr: 3.504 ± 0.575
2.002AsnVal: 2.002 ± 0.569
1.001AsnTrp: 1.001 ± 0.867
2.503AsnTyr: 2.503 ± 1.216
0.0AsnXaa: 0.0 ± 0.0
Pro
2.002ProAla: 2.002 ± 0.436
0.501ProCys: 0.501 ± 0.476
1.001ProAsp: 1.001 ± 0.369
5.506ProGlu: 5.506 ± 1.001
0.501ProPhe: 0.501 ± 0.328
0.0ProGly: 0.0 ± 0.0
1.001ProHis: 1.001 ± 0.444
5.005ProIle: 5.005 ± 0.963
2.503ProLys: 2.503 ± 1.969
5.506ProLeu: 5.506 ± 1.809
1.001ProMet: 1.001 ± 0.444
0.0ProAsn: 0.0 ± 0.0
6.006ProPro: 6.006 ± 2.097
2.503ProGln: 2.503 ± 0.651
3.504ProArg: 3.504 ± 1.551
3.003ProSer: 3.003 ± 1.676
8.008ProThr: 8.008 ± 1.754
4.505ProVal: 4.505 ± 0.973
0.501ProTrp: 0.501 ± 1.129
1.502ProTyr: 1.502 ± 0.414
0.0ProXaa: 0.0 ± 0.0
Gln
4.004GlnAla: 4.004 ± 1.37
0.501GlnCys: 0.501 ± 0.328
0.501GlnAsp: 0.501 ± 0.476
1.001GlnGlu: 1.001 ± 0.444
2.503GlnPhe: 2.503 ± 1.502
3.504GlnGly: 3.504 ± 0.721
1.001GlnHis: 1.001 ± 0.655
1.502GlnIle: 1.502 ± 1.586
3.003GlnLys: 3.003 ± 0.798
2.002GlnLeu: 2.002 ± 0.887
0.0GlnMet: 0.0 ± 0.0
2.503GlnAsn: 2.503 ± 1.99
1.001GlnPro: 1.001 ± 0.369
2.002GlnGln: 2.002 ± 0.887
1.001GlnArg: 1.001 ± 0.444
4.004GlnSer: 4.004 ± 1.837
2.002GlnThr: 2.002 ± 0.569
2.503GlnVal: 2.503 ± 1.494
1.001GlnTrp: 1.001 ± 0.369
3.003GlnTyr: 3.003 ± 1.449
0.0GlnXaa: 0.0 ± 0.0
Arg
6.507ArgAla: 6.507 ± 1.149
0.501ArgCys: 0.501 ± 0.328
0.501ArgAsp: 0.501 ± 1.129
3.003ArgGlu: 3.003 ± 0.675
2.002ArgPhe: 2.002 ± 0.907
2.503ArgGly: 2.503 ± 0.72
1.001ArgHis: 1.001 ± 0.444
2.002ArgIle: 2.002 ± 0.569
2.002ArgLys: 2.002 ± 1.31
5.506ArgLeu: 5.506 ± 1.72
2.002ArgMet: 2.002 ± 0.832
3.504ArgAsn: 3.504 ± 1.673
3.003ArgPro: 3.003 ± 0.933
1.001ArgGln: 1.001 ± 1.143
8.509ArgArg: 8.509 ± 0.958
6.006ArgSer: 6.006 ± 0.959
5.005ArgThr: 5.005 ± 1.592
3.504ArgVal: 3.504 ± 0.937
0.0ArgTrp: 0.0 ± 0.0
2.503ArgTyr: 2.503 ± 0.651
0.0ArgXaa: 0.0 ± 0.0
Ser
6.507SerAla: 6.507 ± 2.227
1.001SerCys: 1.001 ± 0.867
2.002SerAsp: 2.002 ± 0.436
5.005SerGlu: 5.005 ± 2.788
7.508SerPhe: 7.508 ± 1.902
7.508SerGly: 7.508 ± 1.755
0.501SerHis: 0.501 ± 0.328
6.507SerIle: 6.507 ± 1.994
4.505SerLys: 4.505 ± 1.426
9.009SerLeu: 9.009 ± 3.65
2.503SerMet: 2.503 ± 1.221
0.0SerAsn: 0.0 ± 0.0
3.504SerPro: 3.504 ± 1.489
3.003SerGln: 3.003 ± 0.569
5.005SerArg: 5.005 ± 0.509
7.508SerSer: 7.508 ± 0.705
5.506SerThr: 5.506 ± 1.399
3.504SerVal: 3.504 ± 0.99
0.501SerTrp: 0.501 ± 0.476
2.503SerTyr: 2.503 ± 0.651
0.0SerXaa: 0.0 ± 0.0
Thr
7.007ThrAla: 7.007 ± 1.29
1.001ThrCys: 1.001 ± 0.444
2.002ThrAsp: 2.002 ± 1.105
2.002ThrGlu: 2.002 ± 0.918
1.001ThrPhe: 1.001 ± 0.951
3.504ThrGly: 3.504 ± 2.411
1.001ThrHis: 1.001 ± 1.105
3.504ThrIle: 3.504 ± 1.673
5.005ThrLys: 5.005 ± 1.163
4.505ThrLeu: 4.505 ± 2.306
0.0ThrMet: 0.0 ± 0.0
4.004ThrAsn: 4.004 ± 1.028
4.505ThrPro: 4.505 ± 2.421
1.502ThrGln: 1.502 ± 0.656
1.502ThrArg: 1.502 ± 0.643
8.008ThrSer: 8.008 ± 2.953
4.505ThrThr: 4.505 ± 1.351
3.504ThrVal: 3.504 ± 1.51
1.001ThrTrp: 1.001 ± 0.444
1.502ThrTyr: 1.502 ± 0.643
0.0ThrXaa: 0.0 ± 0.0
Val
5.005ValAla: 5.005 ± 1.839
3.003ValCys: 3.003 ± 0.798
4.505ValAsp: 4.505 ± 1.123
10.01ValGlu: 10.01 ± 3.221
4.505ValPhe: 4.505 ± 0.875
3.003ValGly: 3.003 ± 1.533
1.502ValHis: 1.502 ± 0.414
1.502ValIle: 1.502 ± 0.983
5.506ValLys: 5.506 ± 1.864
5.005ValLeu: 5.005 ± 1.206
0.501ValMet: 0.501 ± 0.476
1.001ValAsn: 1.001 ± 0.867
1.502ValPro: 1.502 ± 0.786
3.003ValGln: 3.003 ± 1.329
6.006ValArg: 6.006 ± 0.7
2.503ValSer: 2.503 ± 0.648
4.505ValThr: 4.505 ± 2.654
4.505ValVal: 4.505 ± 0.748
1.001ValTrp: 1.001 ± 0.444
2.002ValTyr: 2.002 ± 0.887
0.0ValXaa: 0.0 ± 0.0
Trp
0.501TrpAla: 0.501 ± 0.476
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.503TrpGlu: 2.503 ± 0.897
0.501TrpPhe: 0.501 ± 0.328
2.002TrpGly: 2.002 ± 1.903
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.501TrpMet: 0.501 ± 0.328
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.502TrpGln: 1.502 ± 0.51
1.001TrpArg: 1.001 ± 0.655
0.0TrpSer: 0.0 ± 0.0
0.501TrpThr: 0.501 ± 0.476
4.004TrpVal: 4.004 ± 0.93
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.001TyrAla: 1.001 ± 0.444
1.502TyrCys: 1.502 ± 0.414
2.002TyrAsp: 2.002 ± 0.436
2.002TyrGlu: 2.002 ± 0.773
1.502TyrPhe: 1.502 ± 0.51
2.503TyrGly: 2.503 ± 1.216
0.501TyrHis: 0.501 ± 1.129
2.503TyrIle: 2.503 ± 0.714
5.005TyrLys: 5.005 ± 1.142
2.002TyrLeu: 2.002 ± 0.738
0.501TyrMet: 0.501 ± 0.328
1.001TyrAsn: 1.001 ± 0.655
1.001TyrPro: 1.001 ± 0.444
0.0TyrGln: 0.0 ± 0.0
2.503TyrArg: 2.503 ± 1.502
1.001TyrSer: 1.001 ± 0.951
1.001TyrThr: 1.001 ± 0.369
1.001TyrVal: 1.001 ± 0.369
1.001TyrTrp: 1.001 ± 0.369
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.501XaaVal: 0.501 ± 0.476
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1999 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski