Amino acid dipepetide frequency for Dioscorea bacilliform RT virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.176AlaAla: 4.176 ± 1.229
0.928AlaCys: 0.928 ± 0.46
3.248AlaAsp: 3.248 ± 1.162
6.032AlaGlu: 6.032 ± 2.763
3.712AlaPhe: 3.712 ± 1.841
4.176AlaGly: 4.176 ± 1.229
1.856AlaHis: 1.856 ± 1.525
3.712AlaIle: 3.712 ± 1.841
1.856AlaLys: 1.856 ± 0.921
6.032AlaLeu: 6.032 ± 2.345
2.784AlaMet: 2.784 ± 1.381
1.856AlaAsn: 1.856 ± 0.921
2.32AlaPro: 2.32 ± 1.269
3.248AlaGln: 3.248 ± 1.611
4.64AlaArg: 4.64 ± 2.301
4.176AlaSer: 4.176 ± 1.229
3.248AlaThr: 3.248 ± 1.162
5.568AlaVal: 5.568 ± 4.746
1.392AlaTrp: 1.392 ± 0.69
2.784AlaTyr: 2.784 ± 3.414
0.0AlaXaa: 0.0 ± 0.0
Cys
1.392CysAla: 1.392 ± 0.69
0.464CysCys: 0.464 ± 0.23
0.464CysAsp: 0.464 ± 0.23
1.856CysGlu: 1.856 ± 0.921
0.928CysPhe: 0.928 ± 0.46
0.928CysGly: 0.928 ± 0.46
0.0CysHis: 0.0 ± 0.0
0.928CysIle: 0.928 ± 0.46
2.32CysLys: 2.32 ± 1.151
0.0CysLeu: 0.0 ± 0.0
0.464CysMet: 0.464 ± 0.408
0.464CysAsn: 0.464 ± 0.23
0.0CysPro: 0.0 ± 0.0
0.928CysGln: 0.928 ± 0.46
0.464CysArg: 0.464 ± 0.23
3.248CysSer: 3.248 ± 1.611
0.0CysThr: 0.0 ± 0.0
0.464CysVal: 0.464 ± 0.23
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.784AspAla: 2.784 ± 1.381
1.392AspCys: 1.392 ± 0.69
4.176AspAsp: 4.176 ± 2.071
3.712AspGlu: 3.712 ± 1.174
2.784AspPhe: 2.784 ± 1.195
0.928AspGly: 0.928 ± 0.46
0.928AspHis: 0.928 ± 0.46
2.32AspIle: 2.32 ± 1.358
1.856AspLys: 1.856 ± 0.921
5.104AspLeu: 5.104 ± 4.754
0.464AspMet: 0.464 ± 0.23
2.784AspAsn: 2.784 ± 1.381
3.248AspPro: 3.248 ± 1.162
2.32AspGln: 2.32 ± 1.269
0.928AspArg: 0.928 ± 1.9
0.928AspSer: 0.928 ± 0.46
2.32AspThr: 2.32 ± 1.151
0.0AspVal: 0.0 ± 0.0
0.464AspTrp: 0.464 ± 0.23
3.712AspTyr: 3.712 ± 1.841
0.0AspXaa: 0.0 ± 0.0
Glu
7.889GluAla: 7.889 ± 0.238
0.928GluCys: 0.928 ± 0.46
7.425GluAsp: 7.425 ± 1.88
11.601GluGlu: 11.601 ± 3.355
1.392GluPhe: 1.392 ± 0.69
6.032GluGly: 6.032 ± 1.343
2.32GluHis: 2.32 ± 1.151
4.176GluIle: 4.176 ± 3.597
7.889GluLys: 7.889 ± 7.918
8.353GluLeu: 8.353 ± 4.18
1.392GluMet: 1.392 ± 0.69
2.784GluAsn: 2.784 ± 3.414
2.32GluPro: 2.32 ± 5.187
5.104GluGln: 5.104 ± 1.086
2.784GluArg: 2.784 ± 1.212
5.568GluSer: 5.568 ± 2.967
3.248GluThr: 3.248 ± 1.611
8.353GluVal: 8.353 ± 2.285
0.928GluTrp: 0.928 ± 0.46
3.248GluTyr: 3.248 ± 2.144
0.0GluXaa: 0.0 ± 0.0
Phe
3.248PheAla: 3.248 ± 1.611
0.928PheCys: 0.928 ± 0.46
1.392PheAsp: 1.392 ± 0.69
2.784PheGlu: 2.784 ± 2.373
0.0PhePhe: 0.0 ± 0.0
1.392PheGly: 1.392 ± 0.69
0.928PheHis: 0.928 ± 0.46
3.248PheIle: 3.248 ± 1.162
0.928PheLys: 0.928 ± 0.46
2.784PheLeu: 2.784 ± 1.381
0.928PheMet: 0.928 ± 0.46
3.248PheAsn: 3.248 ± 1.162
2.32PhePro: 2.32 ± 1.151
1.856PheGln: 1.856 ± 0.921
3.248PheArg: 3.248 ± 1.162
2.32PheSer: 2.32 ± 1.151
2.784PheThr: 2.784 ± 1.381
0.464PheVal: 0.464 ± 0.23
0.464PheTrp: 0.464 ± 0.23
1.856PheTyr: 1.856 ± 0.921
0.0PheXaa: 0.0 ± 0.0
Gly
4.64GlyAla: 4.64 ± 1.012
0.928GlyCys: 0.928 ± 0.46
2.32GlyAsp: 2.32 ± 1.151
5.568GlyGlu: 5.568 ± 2.762
2.32GlyPhe: 2.32 ± 1.269
5.104GlyGly: 5.104 ± 2.532
0.928GlyHis: 0.928 ± 0.46
4.176GlyIle: 4.176 ± 2.071
4.64GlyLys: 4.64 ± 2.301
5.568GlyLeu: 5.568 ± 1.596
2.784GlyMet: 2.784 ± 1.381
0.928GlyAsn: 0.928 ± 0.46
0.928GlyPro: 0.928 ± 0.46
0.928GlyGln: 0.928 ± 0.46
3.248GlyArg: 3.248 ± 1.162
2.32GlySer: 2.32 ± 1.151
3.248GlyThr: 3.248 ± 1.611
4.64GlyVal: 4.64 ± 2.301
0.928GlyTrp: 0.928 ± 0.46
1.856GlyTyr: 1.856 ± 0.921
0.0GlyXaa: 0.0 ± 0.0
His
0.464HisAla: 0.464 ± 0.23
0.928HisCys: 0.928 ± 0.46
0.0HisAsp: 0.0 ± 0.0
1.392HisGlu: 1.392 ± 0.69
0.464HisPhe: 0.464 ± 0.23
0.0HisGly: 0.0 ± 0.0
0.464HisHis: 0.464 ± 0.23
2.32HisIle: 2.32 ± 1.151
1.392HisLys: 1.392 ± 1.707
1.856HisLeu: 1.856 ± 1.525
0.464HisMet: 0.464 ± 0.23
2.32HisAsn: 2.32 ± 1.358
1.856HisPro: 1.856 ± 0.921
0.928HisGln: 0.928 ± 0.46
0.928HisArg: 0.928 ± 0.46
2.32HisSer: 2.32 ± 1.151
1.392HisThr: 1.392 ± 1.515
1.856HisVal: 1.856 ± 0.921
0.928HisTrp: 0.928 ± 0.46
0.928HisTyr: 0.928 ± 0.46
0.0HisXaa: 0.0 ± 0.0
Ile
5.104IleAla: 5.104 ± 1.228
0.464IleCys: 0.464 ± 0.23
2.784IleAsp: 2.784 ± 1.381
6.497IleGlu: 6.497 ± 1.508
2.784IlePhe: 2.784 ± 1.195
3.248IleGly: 3.248 ± 1.611
1.392IleHis: 1.392 ± 0.69
6.032IleIle: 6.032 ± 1.762
3.712IleLys: 3.712 ± 1.174
6.497IleLeu: 6.497 ± 2.564
0.0IleMet: 0.0 ± 0.0
2.32IleAsn: 2.32 ± 1.151
4.176IlePro: 4.176 ± 2.071
4.64IleGln: 4.64 ± 1.456
3.248IleArg: 3.248 ± 1.162
4.176IleSer: 4.176 ± 0.988
3.248IleThr: 3.248 ± 2.144
2.784IleVal: 2.784 ± 1.212
0.0IleTrp: 0.0 ± 0.0
0.928IleTyr: 0.928 ± 0.46
0.0IleXaa: 0.0 ± 0.0
Lys
1.856LysAla: 1.856 ± 0.921
1.392LysCys: 1.392 ± 0.69
2.32LysAsp: 2.32 ± 3.605
4.64LysGlu: 4.64 ± 3.622
3.248LysPhe: 3.248 ± 1.611
6.497LysGly: 6.497 ± 3.222
2.32LysHis: 2.32 ± 1.358
6.032LysIle: 6.032 ± 0.775
6.032LysLys: 6.032 ± 2.992
7.889LysLeu: 7.889 ± 7.349
1.392LysMet: 1.392 ± 0.69
3.712LysAsn: 3.712 ± 1.841
3.712LysPro: 3.712 ± 4.072
2.32LysGln: 2.32 ± 1.269
5.104LysArg: 5.104 ± 1.228
3.712LysSer: 3.712 ± 3.051
2.32LysThr: 2.32 ± 1.151
6.961LysVal: 6.961 ± 2.514
0.928LysTrp: 0.928 ± 1.9
1.392LysTyr: 1.392 ± 0.69
0.0LysXaa: 0.0 ± 0.0
Leu
5.104LeuAla: 5.104 ± 1.228
0.464LeuCys: 0.464 ± 0.23
3.712LeuAsp: 3.712 ± 4.072
12.993LeuGlu: 12.993 ± 5.466
3.712LeuPhe: 3.712 ± 1.841
6.961LeuGly: 6.961 ± 2.131
1.856LeuHis: 1.856 ± 0.921
2.32LeuIle: 2.32 ± 1.358
9.745LeuLys: 9.745 ± 3.569
4.176LeuLeu: 4.176 ± 3.597
2.784LeuMet: 2.784 ± 0.972
2.784LeuAsn: 2.784 ± 1.212
4.176LeuPro: 4.176 ± 1.229
6.961LeuGln: 6.961 ± 5.903
4.176LeuArg: 4.176 ± 3.847
7.889LeuSer: 7.889 ± 3.599
5.104LeuThr: 5.104 ± 2.564
6.961LeuVal: 6.961 ± 0.342
0.464LeuTrp: 0.464 ± 0.23
1.856LeuTyr: 1.856 ± 1.525
0.0LeuXaa: 0.0 ± 0.0
Met
0.464MetAla: 0.464 ± 0.23
0.928MetCys: 0.928 ± 0.46
0.928MetAsp: 0.928 ± 0.46
1.392MetGlu: 1.392 ± 0.69
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.464MetHis: 0.464 ± 0.23
0.0MetIle: 0.0 ± 0.0
4.176MetLys: 4.176 ± 2.071
0.928MetLeu: 0.928 ± 0.46
0.464MetMet: 0.464 ± 0.23
3.248MetAsn: 3.248 ± 1.162
0.928MetPro: 0.928 ± 0.46
1.856MetGln: 1.856 ± 0.921
3.248MetArg: 3.248 ± 1.611
1.392MetSer: 1.392 ± 1.707
2.784MetThr: 2.784 ± 1.381
1.392MetVal: 1.392 ± 0.69
0.0MetTrp: 0.0 ± 0.0
0.464MetTyr: 0.464 ± 0.23
0.0MetXaa: 0.0 ± 0.0
Asn
1.856AsnAla: 1.856 ± 0.921
1.856AsnCys: 1.856 ± 0.921
0.928AsnAsp: 0.928 ± 0.46
3.712AsnGlu: 3.712 ± 1.841
0.464AsnPhe: 0.464 ± 0.23
1.392AsnGly: 1.392 ± 0.69
0.928AsnHis: 0.928 ± 0.46
4.176AsnIle: 4.176 ± 0.988
4.176AsnLys: 4.176 ± 1.685
5.104AsnLeu: 5.104 ± 1.086
0.464AsnMet: 0.464 ± 0.23
0.928AsnAsn: 0.928 ± 1.673
1.392AsnPro: 1.392 ± 0.69
0.464AsnGln: 0.464 ± 0.23
0.464AsnArg: 0.464 ± 2.099
4.64AsnSer: 4.64 ± 2.539
3.248AsnThr: 3.248 ± 1.162
1.392AsnVal: 1.392 ± 0.69
0.0AsnTrp: 0.0 ± 0.0
1.392AsnTyr: 1.392 ± 1.707
0.0AsnXaa: 0.0 ± 0.0
Pro
3.712ProAla: 3.712 ± 2.757
1.392ProCys: 1.392 ± 0.69
2.784ProAsp: 2.784 ± 1.195
5.568ProGlu: 5.568 ± 1.001
2.32ProPhe: 2.32 ± 1.151
2.32ProGly: 2.32 ± 1.151
0.464ProHis: 0.464 ± 0.23
1.392ProIle: 1.392 ± 0.69
2.784ProLys: 2.784 ± 1.212
2.784ProLeu: 2.784 ± 3.414
0.464ProMet: 0.464 ± 0.23
1.392ProAsn: 1.392 ± 0.69
3.248ProPro: 3.248 ± 2.144
2.32ProGln: 2.32 ± 1.151
1.856ProArg: 1.856 ± 1.379
3.712ProSer: 3.712 ± 1.174
2.784ProThr: 2.784 ± 1.381
0.928ProVal: 0.928 ± 1.673
0.0ProTrp: 0.0 ± 0.0
0.928ProTyr: 0.928 ± 0.46
0.0ProXaa: 0.0 ± 0.0
Gln
3.248GlnAla: 3.248 ± 5.894
0.0GlnCys: 0.0 ± 0.0
1.856GlnAsp: 1.856 ± 0.921
4.64GlnGlu: 4.64 ± 4.936
1.856GlnPhe: 1.856 ± 0.921
3.248GlnGly: 3.248 ± 1.611
1.392GlnHis: 1.392 ± 0.69
3.712GlnIle: 3.712 ± 1.174
0.928GlnLys: 0.928 ± 1.673
6.032GlnLeu: 6.032 ± 2.763
1.392GlnMet: 1.392 ± 0.69
1.856GlnAsn: 1.856 ± 1.379
3.248GlnPro: 3.248 ± 1.095
4.176GlnGln: 4.176 ± 0.988
2.784GlnArg: 2.784 ± 1.381
1.392GlnSer: 1.392 ± 1.707
0.464GlnThr: 0.464 ± 0.23
3.712GlnVal: 3.712 ± 1.841
0.464GlnTrp: 0.464 ± 0.23
1.392GlnTyr: 1.392 ± 0.69
0.0GlnXaa: 0.0 ± 0.0
Arg
3.712ArgAla: 3.712 ± 2.757
0.0ArgCys: 0.0 ± 0.0
1.856ArgAsp: 1.856 ± 0.921
3.712ArgGlu: 3.712 ± 1.841
2.784ArgPhe: 2.784 ± 1.195
3.248ArgGly: 3.248 ± 1.162
1.392ArgHis: 1.392 ± 0.69
5.568ArgIle: 5.568 ± 1.596
3.712ArgLys: 3.712 ± 4.072
7.425ArgLeu: 7.425 ± 2.035
1.392ArgMet: 1.392 ± 0.69
1.392ArgAsn: 1.392 ± 0.69
2.784ArgPro: 2.784 ± 1.212
0.928ArgGln: 0.928 ± 0.46
3.248ArgArg: 3.248 ± 1.095
2.32ArgSer: 2.32 ± 1.151
4.176ArgThr: 4.176 ± 1.229
1.856ArgVal: 1.856 ± 1.525
0.928ArgTrp: 0.928 ± 0.46
0.464ArgTyr: 0.464 ± 0.23
0.0ArgXaa: 0.0 ± 0.0
Ser
5.104SerAla: 5.104 ± 1.448
0.464SerCys: 0.464 ± 0.23
1.856SerAsp: 1.856 ± 0.921
7.889SerGlu: 7.889 ± 4.029
0.928SerPhe: 0.928 ± 0.46
4.64SerGly: 4.64 ± 2.301
0.928SerHis: 0.928 ± 1.9
5.104SerIle: 5.104 ± 1.228
5.104SerLys: 5.104 ± 2.564
6.032SerLeu: 6.032 ± 6.35
2.32SerMet: 2.32 ± 1.151
2.32SerAsn: 2.32 ± 1.151
2.32SerPro: 2.32 ± 1.151
2.32SerGln: 2.32 ± 1.358
5.568SerArg: 5.568 ± 1.596
2.32SerSer: 2.32 ± 1.358
5.104SerThr: 5.104 ± 2.532
5.104SerVal: 5.104 ± 2.564
0.928SerTrp: 0.928 ± 0.46
1.392SerTyr: 1.392 ± 0.69
0.0SerXaa: 0.0 ± 0.0
Thr
4.64ThrAla: 4.64 ± 1.323
0.928ThrCys: 0.928 ± 0.46
2.32ThrAsp: 2.32 ± 1.269
3.712ThrGlu: 3.712 ± 1.017
2.784ThrPhe: 2.784 ± 1.381
4.176ThrGly: 4.176 ± 2.071
1.856ThrHis: 1.856 ± 0.921
3.712ThrIle: 3.712 ± 1.914
4.176ThrLys: 4.176 ± 0.988
6.032ThrLeu: 6.032 ± 1.762
0.928ThrMet: 0.928 ± 0.46
0.928ThrAsn: 0.928 ± 0.46
1.856ThrPro: 1.856 ± 0.921
1.392ThrGln: 1.392 ± 0.69
1.392ThrArg: 1.392 ± 0.69
5.568ThrSer: 5.568 ± 1.001
5.104ThrThr: 5.104 ± 2.532
1.856ThrVal: 1.856 ± 1.525
0.464ThrTrp: 0.464 ± 0.23
2.784ThrTyr: 2.784 ± 1.381
0.0ThrXaa: 0.0 ± 0.0
Val
5.568ValAla: 5.568 ± 2.762
1.392ValCys: 1.392 ± 0.69
1.392ValAsp: 1.392 ± 0.69
2.32ValGlu: 2.32 ± 4.75
3.248ValPhe: 3.248 ± 1.611
2.784ValGly: 2.784 ± 1.381
2.32ValHis: 2.32 ± 1.269
3.248ValIle: 3.248 ± 1.611
4.64ValLys: 4.64 ± 3.622
5.568ValLeu: 5.568 ± 1.199
3.248ValMet: 3.248 ± 0.874
1.856ValAsn: 1.856 ± 2.832
0.928ValPro: 0.928 ± 0.46
3.712ValGln: 3.712 ± 4.072
3.248ValArg: 3.248 ± 1.611
4.64ValSer: 4.64 ± 1.012
3.248ValThr: 3.248 ± 1.095
1.392ValVal: 1.392 ± 1.707
0.0ValTrp: 0.0 ± 0.0
2.32ValTyr: 2.32 ± 1.151
0.0ValXaa: 0.0 ± 0.0
Trp
0.464TrpAla: 0.464 ± 0.23
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.928TrpGlu: 0.928 ± 1.9
0.0TrpPhe: 0.0 ± 0.0
0.464TrpGly: 0.464 ± 0.23
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.928TrpLys: 0.928 ± 0.46
2.32TrpLeu: 2.32 ± 1.151
0.0TrpMet: 0.0 ± 0.0
0.928TrpAsn: 0.928 ± 0.46
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.928TrpArg: 0.928 ± 0.46
1.392TrpSer: 1.392 ± 0.69
0.928TrpThr: 0.928 ± 0.46
0.464TrpVal: 0.464 ± 0.23
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.32TyrAla: 2.32 ± 1.151
0.0TyrCys: 0.0 ± 0.0
1.392TyrAsp: 1.392 ± 0.69
2.784TyrGlu: 2.784 ± 1.381
1.392TyrPhe: 1.392 ± 1.707
0.464TyrGly: 0.464 ± 0.23
0.464TyrHis: 0.464 ± 0.23
1.856TyrIle: 1.856 ± 0.921
2.784TyrLys: 2.784 ± 1.195
3.712TyrLeu: 3.712 ± 3.051
0.464TyrMet: 0.464 ± 0.23
0.928TyrAsn: 0.928 ± 0.46
1.392TyrPro: 1.392 ± 0.69
1.392TyrGln: 1.392 ± 1.707
1.392TyrArg: 1.392 ± 0.69
3.712TyrSer: 3.712 ± 1.841
1.856TyrThr: 1.856 ± 1.525
0.928TyrVal: 0.928 ± 0.46
0.464TyrTrp: 0.464 ± 0.23
0.928TyrTyr: 0.928 ± 0.46
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski