Amino acid dipepetide frequency for Candidatus Babela massiliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.943AlaAla: 2.943 ± 0.139
0.69AlaCys: 0.69 ± 0.05
2.514AlaAsp: 2.514 ± 0.091
2.404AlaGlu: 2.404 ± 0.109
2.438AlaPhe: 2.438 ± 0.091
2.778AlaGly: 2.778 ± 0.121
0.831AlaHis: 0.831 ± 0.054
5.289AlaIle: 5.289 ± 0.162
4.335AlaLys: 4.335 ± 0.17
7.049AlaLeu: 7.049 ± 0.176
0.947AlaMet: 0.947 ± 0.053
3.578AlaAsn: 3.578 ± 0.149
1.239AlaPro: 1.239 ± 0.071
2.606AlaGln: 2.606 ± 0.101
1.702AlaArg: 1.702 ± 0.087
3.213AlaSer: 3.213 ± 0.132
2.582AlaThr: 2.582 ± 0.114
2.916AlaVal: 2.916 ± 0.116
0.389AlaTrp: 0.389 ± 0.033
2.063AlaTyr: 2.063 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
0.521CysAla: 0.521 ± 0.039
0.196CysCys: 0.196 ± 0.032
0.613CysAsp: 0.613 ± 0.047
0.399CysGlu: 0.399 ± 0.04
0.622CysPhe: 0.622 ± 0.042
0.647CysGly: 0.647 ± 0.049
0.19CysHis: 0.19 ± 0.025
0.871CysIle: 0.871 ± 0.053
0.846CysLys: 0.846 ± 0.056
1.223CysLeu: 1.223 ± 0.067
0.15CysMet: 0.15 ± 0.025
0.822CysAsn: 0.822 ± 0.072
0.457CysPro: 0.457 ± 0.043
0.583CysGln: 0.583 ± 0.043
0.325CysArg: 0.325 ± 0.036
0.966CysSer: 0.966 ± 0.066
0.613CysThr: 0.613 ± 0.057
0.411CysVal: 0.411 ± 0.045
0.104CysTrp: 0.104 ± 0.018
0.567CysTyr: 0.567 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
2.223AspAla: 2.223 ± 0.094
0.57AspCys: 0.57 ± 0.054
1.781AspAsp: 1.781 ± 0.079
2.717AspGlu: 2.717 ± 0.107
2.839AspPhe: 2.839 ± 0.103
1.643AspGly: 1.643 ± 0.084
0.914AspHis: 0.914 ± 0.06
7.208AspIle: 7.208 ± 0.192
5.363AspLys: 5.363 ± 0.164
6.276AspLeu: 6.276 ± 0.192
0.871AspMet: 0.871 ± 0.052
4.066AspAsn: 4.066 ± 0.124
1.545AspPro: 1.545 ± 0.076
2.33AspGln: 2.33 ± 0.099
1.616AspArg: 1.616 ± 0.064
3.308AspSer: 3.308 ± 0.126
2.22AspThr: 2.22 ± 0.096
2.563AspVal: 2.563 ± 0.097
0.414AspTrp: 0.414 ± 0.033
2.499AspTyr: 2.499 ± 0.094
0.0AspXaa: 0.0 ± 0.0
Glu
2.839GluAla: 2.839 ± 0.123
0.503GluCys: 0.503 ± 0.042
2.916GluAsp: 2.916 ± 0.1
4.32GluGlu: 4.32 ± 0.152
2.597GluPhe: 2.597 ± 0.099
2.367GluGly: 2.367 ± 0.096
1.131GluHis: 1.131 ± 0.065
6.169GluIle: 6.169 ± 0.165
5.752GluLys: 5.752 ± 0.182
7.141GluLeu: 7.141 ± 0.171
0.981GluMet: 0.981 ± 0.052
4.44GluAsn: 4.44 ± 0.134
1.361GluPro: 1.361 ± 0.067
2.487GluGln: 2.487 ± 0.101
2.085GluArg: 2.085 ± 0.106
3.928GluSer: 3.928 ± 0.12
2.717GluThr: 2.717 ± 0.102
3.17GluVal: 3.17 ± 0.123
0.426GluTrp: 0.426 ± 0.03
2.275GluTyr: 2.275 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
2.413PheAla: 2.413 ± 0.092
0.638PheCys: 0.638 ± 0.042
3.02PheAsp: 3.02 ± 0.126
2.652PheGlu: 2.652 ± 0.098
2.56PhePhe: 2.56 ± 0.108
2.566PheGly: 2.566 ± 0.12
0.629PheHis: 0.629 ± 0.045
4.955PheIle: 4.955 ± 0.142
4.185PheLys: 4.185 ± 0.13
5.617PheLeu: 5.617 ± 0.173
0.954PheMet: 0.954 ± 0.063
3.833PheAsn: 3.833 ± 0.127
1.079PhePro: 1.079 ± 0.059
1.395PheGln: 1.395 ± 0.07
1.226PheArg: 1.226 ± 0.062
3.839PheSer: 3.839 ± 0.144
2.382PheThr: 2.382 ± 0.113
2.109PheVal: 2.109 ± 0.082
0.408PheTrp: 0.408 ± 0.036
2.413PheTyr: 2.413 ± 0.087
0.0PheXaa: 0.0 ± 0.0
Gly
3.321GlyAla: 3.321 ± 0.136
0.619GlyCys: 0.619 ± 0.063
1.827GlyAsp: 1.827 ± 0.086
1.757GlyGlu: 1.757 ± 0.085
2.646GlyPhe: 2.646 ± 0.125
2.6GlyGly: 2.6 ± 0.192
1.131GlyHis: 1.131 ± 0.072
4.234GlyIle: 4.234 ± 0.136
3.275GlyLys: 3.275 ± 0.116
4.581GlyLeu: 4.581 ± 0.152
0.77GlyMet: 0.77 ± 0.053
2.753GlyAsn: 2.753 ± 0.124
1.312GlyPro: 1.312 ± 0.092
1.88GlyGln: 1.88 ± 0.085
1.646GlyArg: 1.646 ± 0.097
3.364GlySer: 3.364 ± 0.2
2.695GlyThr: 2.695 ± 0.167
2.459GlyVal: 2.459 ± 0.108
0.448GlyTrp: 0.448 ± 0.039
2.487GlyTyr: 2.487 ± 0.094
0.0GlyXaa: 0.0 ± 0.0
His
0.742HisAla: 0.742 ± 0.048
0.138HisCys: 0.138 ± 0.023
0.665HisAsp: 0.665 ± 0.05
0.788HisGlu: 0.788 ± 0.05
0.714HisPhe: 0.714 ± 0.045
0.966HisGly: 0.966 ± 0.059
0.282HisHis: 0.282 ± 0.032
1.57HisIle: 1.57 ± 0.073
1.472HisLys: 1.472 ± 0.071
1.662HisLeu: 1.662 ± 0.069
0.322HisMet: 0.322 ± 0.033
1.168HisAsn: 1.168 ± 0.063
0.632HisPro: 0.632 ± 0.054
0.604HisGln: 0.604 ± 0.044
0.54HisArg: 0.54 ± 0.04
0.938HisSer: 0.938 ± 0.058
0.595HisThr: 0.595 ± 0.044
0.739HisVal: 0.739 ± 0.05
0.208HisTrp: 0.208 ± 0.027
0.705HisTyr: 0.705 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
5.709IleAla: 5.709 ± 0.151
1.033IleCys: 1.033 ± 0.061
6.381IleAsp: 6.381 ± 0.143
6.764IleGlu: 6.764 ± 0.176
5.387IlePhe: 5.387 ± 0.17
3.759IleGly: 3.759 ± 0.143
1.214IleHis: 1.214 ± 0.068
9.621IleIle: 9.621 ± 0.257
10.072IleLys: 10.072 ± 0.276
11.142IleLeu: 11.142 ± 0.256
1.542IleMet: 1.542 ± 0.063
8.702IleAsn: 8.702 ± 0.2
2.818IlePro: 2.818 ± 0.102
2.579IleGln: 2.579 ± 0.087
2.894IleArg: 2.894 ± 0.101
7.99IleSer: 7.99 ± 0.195
4.74IleThr: 4.74 ± 0.164
5.412IleVal: 5.412 ± 0.141
0.638IleTrp: 0.638 ± 0.042
3.787IleTyr: 3.787 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
4.366LysAla: 4.366 ± 0.123
0.754LysCys: 0.754 ± 0.054
6.264LysAsp: 6.264 ± 0.176
7.622LysGlu: 7.622 ± 0.235
3.701LysPhe: 3.701 ± 0.115
2.996LysGly: 2.996 ± 0.119
1.475LysHis: 1.475 ± 0.075
8.784LysIle: 8.784 ± 0.223
7.944LysLys: 7.944 ± 0.23
8.965LysLeu: 8.965 ± 0.244
1.548LysMet: 1.548 ± 0.071
8.021LysAsn: 8.021 ± 0.242
2.033LysPro: 2.033 ± 0.092
2.885LysGln: 2.885 ± 0.13
2.983LysArg: 2.983 ± 0.117
6.037LysSer: 6.037 ± 0.162
4.228LysThr: 4.228 ± 0.125
4.335LysVal: 4.335 ± 0.138
0.561LysTrp: 0.561 ± 0.043
3.912LysTyr: 3.912 ± 0.112
0.0LysXaa: 0.0 ± 0.0
Leu
5.252LeuAla: 5.252 ± 0.145
0.975LeuCys: 0.975 ± 0.053
6.166LeuAsp: 6.166 ± 0.163
6.85LeuGlu: 6.85 ± 0.18
5.387LeuPhe: 5.387 ± 0.167
4.985LeuGly: 4.985 ± 0.154
1.334LeuHis: 1.334 ± 0.078
12.494LeuIle: 12.494 ± 0.278
10.13LeuLys: 10.13 ± 0.272
12.246LeuLeu: 12.246 ± 0.269
2.576LeuMet: 2.576 ± 0.119
8.416LeuAsn: 8.416 ± 0.203
3.219LeuPro: 3.219 ± 0.095
2.643LeuGln: 2.643 ± 0.111
3.36LeuArg: 3.36 ± 0.128
9.027LeuSer: 9.027 ± 0.2
5.378LeuThr: 5.378 ± 0.167
5.05LeuVal: 5.05 ± 0.131
0.73LeuTrp: 0.73 ± 0.046
3.802LeuTyr: 3.802 ± 0.114
0.0LeuXaa: 0.0 ± 0.0
Met
0.972MetAla: 0.972 ± 0.057
0.12MetCys: 0.12 ± 0.018
0.73MetAsp: 0.73 ± 0.042
0.886MetGlu: 0.886 ± 0.052
0.901MetPhe: 0.901 ± 0.049
0.699MetGly: 0.699 ± 0.048
0.448MetHis: 0.448 ± 0.03
1.613MetIle: 1.613 ± 0.073
1.745MetLys: 1.745 ± 0.075
2.195MetLeu: 2.195 ± 0.096
0.322MetMet: 0.322 ± 0.031
1.144MetAsn: 1.144 ± 0.054
0.782MetPro: 0.782 ± 0.054
0.785MetGln: 0.785 ± 0.053
0.653MetArg: 0.653 ± 0.043
1.205MetSer: 1.205 ± 0.059
0.77MetThr: 0.77 ± 0.047
0.929MetVal: 0.929 ± 0.053
0.169MetTrp: 0.169 ± 0.021
0.57MetTyr: 0.57 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.554AsnAla: 3.554 ± 0.128
0.914AsnCys: 0.914 ± 0.058
2.922AsnAsp: 2.922 ± 0.117
3.462AsnGlu: 3.462 ± 0.115
4.087AsnPhe: 4.087 ± 0.135
2.867AsnGly: 2.867 ± 0.146
1.177AsnHis: 1.177 ± 0.066
9.318AsnIle: 9.318 ± 0.221
7.632AsnLys: 7.632 ± 0.216
9.076AsnLeu: 9.076 ± 0.197
1.217AsnMet: 1.217 ± 0.067
7.021AsnAsn: 7.021 ± 0.225
2.407AsnPro: 2.407 ± 0.125
3.437AsnGln: 3.437 ± 0.114
2.251AsnArg: 2.251 ± 0.102
5.035AsnSer: 5.035 ± 0.143
3.713AsnThr: 3.713 ± 0.121
3.431AsnVal: 3.431 ± 0.149
0.598AsnTrp: 0.598 ± 0.05
3.857AsnTyr: 3.857 ± 0.156
0.0AsnXaa: 0.0 ± 0.0
Pro
1.315ProAla: 1.315 ± 0.086
0.288ProCys: 0.288 ± 0.036
1.539ProAsp: 1.539 ± 0.066
2.404ProGlu: 2.404 ± 0.108
1.309ProPhe: 1.309 ± 0.058
1.389ProGly: 1.389 ± 0.086
0.457ProHis: 0.457 ± 0.037
2.793ProIle: 2.793 ± 0.112
2.143ProLys: 2.143 ± 0.086
2.885ProLeu: 2.885 ± 0.085
0.414ProMet: 0.414 ± 0.037
2.186ProAsn: 2.186 ± 0.137
0.659ProPro: 0.659 ± 0.073
1.107ProGln: 1.107 ± 0.065
0.865ProArg: 0.865 ± 0.05
1.757ProSer: 1.757 ± 0.079
1.441ProThr: 1.441 ± 0.078
1.763ProVal: 1.763 ± 0.116
0.251ProTrp: 0.251 ± 0.032
1.306ProTyr: 1.306 ± 0.081
0.0ProXaa: 0.0 ± 0.0
Gln
2.508GlnAla: 2.508 ± 0.095
0.316GlnCys: 0.316 ± 0.03
2.845GlnAsp: 2.845 ± 0.099
3.741GlnGlu: 3.741 ± 0.121
1.374GlnPhe: 1.374 ± 0.071
1.714GlnGly: 1.714 ± 0.084
0.408GlnHis: 0.408 ± 0.033
3.155GlnIle: 3.155 ± 0.109
2.922GlnLys: 2.922 ± 0.11
3.29GlnLeu: 3.29 ± 0.112
0.589GlnMet: 0.589 ± 0.046
3.026GlnAsn: 3.026 ± 0.095
0.92GlnPro: 0.92 ± 0.073
1.272GlnGln: 1.272 ± 0.087
1.187GlnArg: 1.187 ± 0.064
2.211GlnSer: 2.211 ± 0.088
1.628GlnThr: 1.628 ± 0.066
1.984GlnVal: 1.984 ± 0.11
0.356GlnTrp: 0.356 ± 0.053
1.371GlnTyr: 1.371 ± 0.073
0.0GlnXaa: 0.0 ± 0.0
Arg
1.732ArgAla: 1.732 ± 0.077
0.408ArgCys: 0.408 ± 0.032
1.763ArgAsp: 1.763 ± 0.077
1.978ArgGlu: 1.978 ± 0.09
1.806ArgPhe: 1.806 ± 0.099
1.524ArgGly: 1.524 ± 0.076
0.613ArgHis: 0.613 ± 0.046
2.714ArgIle: 2.714 ± 0.111
2.56ArgLys: 2.56 ± 0.086
3.446ArgLeu: 3.446 ± 0.108
0.573ArgMet: 0.573 ± 0.044
2.03ArgAsn: 2.03 ± 0.082
1.0ArgPro: 1.0 ± 0.066
1.171ArgGln: 1.171 ± 0.067
1.23ArgArg: 1.23 ± 0.081
2.195ArgSer: 2.195 ± 0.095
1.61ArgThr: 1.61 ± 0.069
1.65ArgVal: 1.65 ± 0.077
0.261ArgTrp: 0.261 ± 0.031
1.432ArgTyr: 1.432 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
3.189SerAla: 3.189 ± 0.12
0.941SerCys: 0.941 ± 0.068
3.59SerAsp: 3.59 ± 0.129
3.354SerGlu: 3.354 ± 0.104
3.333SerPhe: 3.333 ± 0.11
4.164SerGly: 4.164 ± 0.262
0.935SerHis: 0.935 ± 0.053
7.481SerIle: 7.481 ± 0.19
6.384SerLys: 6.384 ± 0.186
7.441SerLeu: 7.441 ± 0.181
1.72SerMet: 1.72 ± 0.063
5.488SerAsn: 5.488 ± 0.223
1.889SerPro: 1.889 ± 0.114
2.983SerGln: 2.983 ± 0.1
2.456SerArg: 2.456 ± 0.095
5.47SerSer: 5.47 ± 0.243
3.544SerThr: 3.544 ± 0.198
3.241SerVal: 3.241 ± 0.167
0.579SerTrp: 0.579 ± 0.048
3.054SerTyr: 3.054 ± 0.097
0.0SerXaa: 0.0 ± 0.0
Thr
3.621ThrAla: 3.621 ± 0.166
0.632ThrCys: 0.632 ± 0.047
2.349ThrAsp: 2.349 ± 0.119
2.336ThrGlu: 2.336 ± 0.09
2.211ThrPhe: 2.211 ± 0.097
3.039ThrGly: 3.039 ± 0.164
0.668ThrHis: 0.668 ± 0.055
4.679ThrIle: 4.679 ± 0.168
3.624ThrLys: 3.624 ± 0.128
5.663ThrLeu: 5.663 ± 0.188
0.625ThrMet: 0.625 ± 0.047
2.864ThrAsn: 2.864 ± 0.103
2.002ThrPro: 2.002 ± 0.084
1.929ThrGln: 1.929 ± 0.079
1.509ThrArg: 1.509 ± 0.078
3.324ThrSer: 3.324 ± 0.187
2.554ThrThr: 2.554 ± 0.124
2.916ThrVal: 2.916 ± 0.224
0.34ThrTrp: 0.34 ± 0.035
1.944ThrTyr: 1.944 ± 0.136
0.0ThrXaa: 0.0 ± 0.0
Val
2.649ValAla: 2.649 ± 0.119
0.717ValCys: 0.717 ± 0.073
2.778ValAsp: 2.778 ± 0.107
3.069ValGlu: 3.069 ± 0.106
2.128ValPhe: 2.128 ± 0.082
2.545ValGly: 2.545 ± 0.123
0.745ValHis: 0.745 ± 0.045
4.618ValIle: 4.618 ± 0.133
4.673ValLys: 4.673 ± 0.152
4.734ValLeu: 4.734 ± 0.14
0.724ValMet: 0.724 ± 0.053
4.299ValAsn: 4.299 ± 0.156
1.527ValPro: 1.527 ± 0.076
1.646ValGln: 1.646 ± 0.076
1.561ValArg: 1.561 ± 0.089
3.692ValSer: 3.692 ± 0.157
2.824ValThr: 2.824 ± 0.258
2.658ValVal: 2.658 ± 0.128
0.383ValTrp: 0.383 ± 0.037
1.827ValTyr: 1.827 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.555TrpAla: 0.555 ± 0.043
0.101TrpCys: 0.101 ± 0.02
0.389TrpAsp: 0.389 ± 0.037
0.23TrpGlu: 0.23 ± 0.033
0.426TrpPhe: 0.426 ± 0.035
0.402TrpGly: 0.402 ± 0.035
0.169TrpHis: 0.169 ± 0.024
0.696TrpIle: 0.696 ± 0.044
0.325TrpLys: 0.325 ± 0.034
0.865TrpLeu: 0.865 ± 0.056
0.153TrpMet: 0.153 ± 0.023
0.488TrpAsn: 0.488 ± 0.038
0.233TrpPro: 0.233 ± 0.031
0.445TrpGln: 0.445 ± 0.031
0.27TrpArg: 0.27 ± 0.028
0.647TrpSer: 0.647 ± 0.039
0.46TrpThr: 0.46 ± 0.053
0.386TrpVal: 0.386 ± 0.035
0.08TrpTrp: 0.08 ± 0.019
0.325TrpTyr: 0.325 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.082TyrAla: 2.082 ± 0.078
0.573TyrCys: 0.573 ± 0.043
1.913TyrAsp: 1.913 ± 0.086
1.873TyrGlu: 1.873 ± 0.084
2.407TyrPhe: 2.407 ± 0.099
2.155TyrGly: 2.155 ± 0.086
0.699TyrHis: 0.699 ± 0.051
3.922TyrIle: 3.922 ± 0.125
4.035TyrLys: 4.035 ± 0.12
4.523TyrLeu: 4.523 ± 0.129
0.635TyrMet: 0.635 ± 0.045
3.633TyrAsn: 3.633 ± 0.13
1.159TyrPro: 1.159 ± 0.063
2.048TyrGln: 2.048 ± 0.126
1.337TyrArg: 1.337 ± 0.057
3.094TyrSer: 3.094 ± 0.128
2.134TyrThr: 2.134 ± 0.132
1.674TyrVal: 1.674 ± 0.078
0.3TyrTrp: 0.3 ± 0.032
1.95TyrTyr: 1.95 ± 0.092
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 981 proteins (326148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski