Amino acid dipepetide frequency for Grapevine leafroll-associated virus 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.393AlaAla: 5.393 ± 0.617
1.124AlaCys: 1.124 ± 0.621
3.82AlaAsp: 3.82 ± 1.361
5.169AlaGlu: 5.169 ± 0.934
1.573AlaPhe: 1.573 ± 0.78
3.596AlaGly: 3.596 ± 0.603
0.899AlaHis: 0.899 ± 0.724
3.596AlaIle: 3.596 ± 1.345
4.045AlaLys: 4.045 ± 0.848
7.64AlaLeu: 7.64 ± 1.119
1.124AlaMet: 1.124 ± 0.359
2.697AlaAsn: 2.697 ± 0.836
2.247AlaPro: 2.247 ± 0.708
1.348AlaGln: 1.348 ± 0.225
2.921AlaArg: 2.921 ± 1.371
4.045AlaSer: 4.045 ± 1.051
2.921AlaThr: 2.921 ± 0.689
7.416AlaVal: 7.416 ± 1.419
0.899AlaTrp: 0.899 ± 0.61
1.573AlaTyr: 1.573 ± 0.273
0.0AlaXaa: 0.0 ± 0.0
Cys
1.798CysAla: 1.798 ± 0.605
0.674CysCys: 0.674 ± 0.354
1.124CysAsp: 1.124 ± 0.395
1.124CysGlu: 1.124 ± 0.621
1.573CysPhe: 1.573 ± 0.566
1.124CysGly: 1.124 ± 0.621
0.225CysHis: 0.225 ± 0.124
1.348CysIle: 1.348 ± 0.487
0.899CysLys: 0.899 ± 0.497
2.247CysLeu: 2.247 ± 1.076
0.225CysMet: 0.225 ± 0.341
0.899CysAsn: 0.899 ± 0.439
0.225CysPro: 0.225 ± 0.124
0.0CysGln: 0.0 ± 0.0
0.449CysArg: 0.449 ± 0.27
2.247CysSer: 2.247 ± 0.917
0.225CysThr: 0.225 ± 0.341
1.124CysVal: 1.124 ± 1.281
0.674CysTrp: 0.674 ± 0.373
0.674CysTyr: 0.674 ± 0.373
0.0CysXaa: 0.0 ± 0.0
Asp
3.596AspAla: 3.596 ± 0.657
1.348AspCys: 1.348 ± 0.421
1.348AspAsp: 1.348 ± 0.458
4.045AspGlu: 4.045 ± 1.366
3.82AspPhe: 3.82 ± 0.514
2.247AspGly: 2.247 ± 0.617
0.225AspHis: 0.225 ± 0.124
3.596AspIle: 3.596 ± 0.865
3.146AspLys: 3.146 ± 0.466
4.494AspLeu: 4.494 ± 0.961
0.674AspMet: 0.674 ± 0.552
2.697AspAsn: 2.697 ± 1.077
2.247AspPro: 2.247 ± 0.485
1.124AspGln: 1.124 ± 0.621
2.921AspArg: 2.921 ± 0.584
4.27AspSer: 4.27 ± 0.84
3.146AspThr: 3.146 ± 1.711
6.292AspVal: 6.292 ± 1.241
0.674AspTrp: 0.674 ± 0.373
0.899AspTyr: 0.899 ± 0.806
0.0AspXaa: 0.0 ± 0.0
Glu
3.596GluAla: 3.596 ± 0.889
1.124GluCys: 1.124 ± 0.621
3.146GluAsp: 3.146 ± 0.819
5.169GluGlu: 5.169 ± 2.009
1.573GluPhe: 1.573 ± 0.491
3.371GluGly: 3.371 ± 1.442
0.674GluHis: 0.674 ± 0.373
4.494GluIle: 4.494 ± 1.309
4.494GluLys: 4.494 ± 1.273
4.719GluLeu: 4.719 ± 1.075
0.225GluMet: 0.225 ± 0.124
2.022GluAsn: 2.022 ± 0.303
2.697GluPro: 2.697 ± 0.846
0.899GluGln: 0.899 ± 0.282
3.146GluArg: 3.146 ± 1.179
5.169GluSer: 5.169 ± 1.47
2.697GluThr: 2.697 ± 0.81
7.416GluVal: 7.416 ± 1.588
0.0GluTrp: 0.0 ± 0.0
1.798GluTyr: 1.798 ± 0.736
0.0GluXaa: 0.0 ± 0.0
Phe
2.921PheAla: 2.921 ± 0.696
1.573PheCys: 1.573 ± 0.87
2.697PheAsp: 2.697 ± 0.451
2.697PheGlu: 2.697 ± 0.601
2.921PhePhe: 2.921 ± 1.012
3.82PheGly: 3.82 ± 0.917
0.225PheHis: 0.225 ± 0.124
3.371PheIle: 3.371 ± 0.662
2.697PheLys: 2.697 ± 0.678
3.82PheLeu: 3.82 ± 1.275
0.674PheMet: 0.674 ± 0.288
2.921PheAsn: 2.921 ± 0.827
2.472PhePro: 2.472 ± 0.475
2.472PheGln: 2.472 ± 1.04
2.472PheArg: 2.472 ± 0.543
6.966PheSer: 6.966 ± 1.049
2.472PheThr: 2.472 ± 0.791
3.371PheVal: 3.371 ± 0.906
0.0PheTrp: 0.0 ± 0.0
2.022PheTyr: 2.022 ± 1.439
0.0PheXaa: 0.0 ± 0.0
Gly
4.719GlyAla: 4.719 ± 0.739
0.899GlyCys: 0.899 ± 0.541
3.596GlyAsp: 3.596 ± 0.694
2.697GlyGlu: 2.697 ± 0.879
2.472GlyPhe: 2.472 ± 0.781
5.169GlyGly: 5.169 ± 0.928
0.449GlyHis: 0.449 ± 0.27
2.472GlyIle: 2.472 ± 0.69
6.966GlyLys: 6.966 ± 1.66
5.393GlyLeu: 5.393 ± 0.753
1.348GlyMet: 1.348 ± 0.222
3.82GlyAsn: 3.82 ± 1.355
1.573GlyPro: 1.573 ± 0.561
0.899GlyGln: 0.899 ± 0.497
4.045GlyArg: 4.045 ± 0.588
6.742GlySer: 6.742 ± 1.152
2.472GlyThr: 2.472 ± 1.076
5.618GlyVal: 5.618 ± 2.802
0.674GlyTrp: 0.674 ± 0.288
1.348GlyTyr: 1.348 ± 0.673
0.0GlyXaa: 0.0 ± 0.0
His
0.449HisAla: 0.449 ± 0.249
0.449HisCys: 0.449 ± 0.249
0.674HisAsp: 0.674 ± 0.368
1.124HisGlu: 1.124 ± 0.359
0.674HisPhe: 0.674 ± 0.373
0.449HisGly: 0.449 ± 0.365
0.225HisHis: 0.225 ± 0.124
0.0HisIle: 0.0 ± 0.0
1.348HisLys: 1.348 ± 0.573
0.899HisLeu: 0.899 ± 0.321
0.449HisMet: 0.449 ± 0.733
1.573HisAsn: 1.573 ± 0.674
0.674HisPro: 0.674 ± 0.247
0.449HisGln: 0.449 ± 0.365
0.449HisArg: 0.449 ± 0.249
1.348HisSer: 1.348 ± 0.573
0.674HisThr: 0.674 ± 0.288
2.247HisVal: 2.247 ± 1.009
0.0HisTrp: 0.0 ± 0.0
0.674HisTyr: 0.674 ± 0.288
0.0HisXaa: 0.0 ± 0.0
Ile
1.573IleAla: 1.573 ± 0.273
1.798IleCys: 1.798 ± 0.658
2.472IleAsp: 2.472 ± 0.595
3.371IleGlu: 3.371 ± 0.601
2.022IlePhe: 2.022 ± 0.271
4.045IleGly: 4.045 ± 0.978
0.674IleHis: 0.674 ± 0.288
2.472IleIle: 2.472 ± 0.547
3.596IleLys: 3.596 ± 0.513
4.494IleLeu: 4.494 ± 1.349
0.449IleMet: 0.449 ± 0.328
2.697IleAsn: 2.697 ± 0.906
3.146IlePro: 3.146 ± 0.725
0.899IleGln: 0.899 ± 0.411
0.899IleArg: 0.899 ± 0.282
4.045IleSer: 4.045 ± 1.164
2.921IleThr: 2.921 ± 0.924
3.82IleVal: 3.82 ± 1.128
0.674IleTrp: 0.674 ± 0.368
0.449IleTyr: 0.449 ± 0.682
0.0IleXaa: 0.0 ± 0.0
Lys
5.393LysAla: 5.393 ± 1.656
0.674LysCys: 0.674 ± 0.373
2.697LysAsp: 2.697 ± 0.386
4.944LysGlu: 4.944 ± 0.864
3.82LysPhe: 3.82 ± 0.723
4.944LysGly: 4.944 ± 0.678
1.573LysHis: 1.573 ± 0.646
2.472LysIle: 2.472 ± 0.69
3.596LysLys: 3.596 ± 1.267
7.64LysLeu: 7.64 ± 1.466
3.146LysMet: 3.146 ± 0.598
5.393LysAsn: 5.393 ± 1.422
4.045LysPro: 4.045 ± 0.596
1.573LysGln: 1.573 ± 0.87
4.045LysArg: 4.045 ± 0.939
6.517LysSer: 6.517 ± 1.395
4.719LysThr: 4.719 ± 0.327
5.393LysVal: 5.393 ± 1.797
0.225LysTrp: 0.225 ± 0.367
2.697LysTyr: 2.697 ± 0.761
0.0LysXaa: 0.0 ± 0.0
Leu
5.169LeuAla: 5.169 ± 1.564
1.348LeuCys: 1.348 ± 0.629
6.517LeuAsp: 6.517 ± 1.788
3.371LeuGlu: 3.371 ± 1.049
4.27LeuPhe: 4.27 ± 1.588
7.191LeuGly: 7.191 ± 2.452
1.348LeuHis: 1.348 ± 0.421
5.618LeuIle: 5.618 ± 0.659
7.416LeuLys: 7.416 ± 2.413
9.663LeuLeu: 9.663 ± 3.333
2.247LeuMet: 2.247 ± 0.366
6.067LeuAsn: 6.067 ± 1.78
4.944LeuPro: 4.944 ± 0.608
1.798LeuGln: 1.798 ± 0.456
2.921LeuArg: 2.921 ± 0.749
10.112LeuSer: 10.112 ± 1.395
4.494LeuThr: 4.494 ± 1.184
5.169LeuVal: 5.169 ± 0.895
0.449LeuTrp: 0.449 ± 0.364
2.022LeuTyr: 2.022 ± 0.894
0.0LeuXaa: 0.0 ± 0.0
Met
0.899MetAla: 0.899 ± 0.685
0.449MetCys: 0.449 ± 0.249
1.124MetAsp: 1.124 ± 0.707
1.798MetGlu: 1.798 ± 0.864
1.348MetPhe: 1.348 ± 0.225
1.124MetGly: 1.124 ± 0.393
0.225MetHis: 0.225 ± 0.124
0.674MetIle: 0.674 ± 0.373
1.573MetLys: 1.573 ± 0.591
2.247MetLeu: 2.247 ± 0.977
1.573MetMet: 1.573 ± 0.87
1.124MetAsn: 1.124 ± 1.207
0.674MetPro: 0.674 ± 0.247
0.674MetGln: 0.674 ± 0.441
0.899MetArg: 0.899 ± 0.437
2.022MetSer: 2.022 ± 0.894
1.348MetThr: 1.348 ± 0.458
1.798MetVal: 1.798 ± 0.93
0.225MetTrp: 0.225 ± 0.341
0.899MetTyr: 0.899 ± 0.321
0.0MetXaa: 0.0 ± 0.0
Asn
2.921AsnAla: 2.921 ± 0.944
0.899AsnCys: 0.899 ± 0.437
2.022AsnAsp: 2.022 ± 0.463
2.472AsnGlu: 2.472 ± 0.701
3.596AsnPhe: 3.596 ± 0.944
2.472AsnGly: 2.472 ± 0.624
0.674AsnHis: 0.674 ± 0.373
2.697AsnIle: 2.697 ± 1.491
4.719AsnLys: 4.719 ± 0.478
5.169AsnLeu: 5.169 ± 1.167
2.022AsnMet: 2.022 ± 0.695
2.022AsnAsn: 2.022 ± 0.831
3.371AsnPro: 3.371 ± 1.173
0.899AsnGln: 0.899 ± 0.497
2.022AsnArg: 2.022 ± 1.105
5.618AsnSer: 5.618 ± 1.409
3.82AsnThr: 3.82 ± 1.104
2.921AsnVal: 2.921 ± 0.737
1.124AsnTrp: 1.124 ± 0.586
1.348AsnTyr: 1.348 ± 0.709
0.0AsnXaa: 0.0 ± 0.0
Pro
3.596ProAla: 3.596 ± 1.231
0.225ProCys: 0.225 ± 0.124
2.247ProAsp: 2.247 ± 0.339
3.371ProGlu: 3.371 ± 0.58
1.573ProPhe: 1.573 ± 0.424
2.472ProGly: 2.472 ± 0.469
0.449ProHis: 0.449 ± 0.249
1.348ProIle: 1.348 ± 0.225
4.27ProLys: 4.27 ± 0.705
4.27ProLeu: 4.27 ± 1.037
0.674ProMet: 0.674 ± 0.288
1.348ProAsn: 1.348 ± 0.573
2.472ProPro: 2.472 ± 0.898
0.899ProGln: 0.899 ± 0.411
2.247ProArg: 2.247 ± 0.683
4.045ProSer: 4.045 ± 1.101
4.045ProThr: 4.045 ± 0.671
4.045ProVal: 4.045 ± 1.316
0.0ProTrp: 0.0 ± 0.0
1.348ProTyr: 1.348 ± 0.352
0.0ProXaa: 0.0 ± 0.0
Gln
1.798GlnAla: 1.798 ± 0.837
0.0GlnCys: 0.0 ± 0.0
0.674GlnAsp: 0.674 ± 0.441
0.674GlnGlu: 0.674 ± 0.373
2.022GlnPhe: 2.022 ± 1.145
2.022GlnGly: 2.022 ± 0.771
0.449GlnHis: 0.449 ± 0.249
0.674GlnIle: 0.674 ± 0.744
1.348GlnLys: 1.348 ± 0.569
1.573GlnLeu: 1.573 ± 0.591
0.225GlnMet: 0.225 ± 0.124
1.348GlnAsn: 1.348 ± 0.487
1.348GlnPro: 1.348 ± 0.365
0.0GlnGln: 0.0 ± 0.0
1.124GlnArg: 1.124 ± 0.393
0.674GlnSer: 0.674 ± 0.373
2.921GlnThr: 2.921 ± 0.652
1.348GlnVal: 1.348 ± 0.746
0.225GlnTrp: 0.225 ± 0.367
0.225GlnTyr: 0.225 ± 0.124
0.0GlnXaa: 0.0 ± 0.0
Arg
3.596ArgAla: 3.596 ± 0.785
1.348ArgCys: 1.348 ± 0.746
1.798ArgAsp: 1.798 ± 1.082
1.798ArgGlu: 1.798 ± 0.477
1.798ArgPhe: 1.798 ± 1.22
2.472ArgGly: 2.472 ± 0.951
0.674ArgHis: 0.674 ± 0.288
1.798ArgIle: 1.798 ± 0.837
4.045ArgLys: 4.045 ± 1.618
5.169ArgLeu: 5.169 ± 0.623
0.674ArgMet: 0.674 ± 0.373
3.146ArgAsn: 3.146 ± 0.847
2.022ArgPro: 2.022 ± 0.798
1.573ArgGln: 1.573 ± 0.403
2.022ArgArg: 2.022 ± 0.798
4.045ArgSer: 4.045 ± 1.092
2.921ArgThr: 2.921 ± 0.545
3.146ArgVal: 3.146 ± 1.416
0.0ArgTrp: 0.0 ± 0.0
0.899ArgTyr: 0.899 ± 0.685
0.0ArgXaa: 0.0 ± 0.0
Ser
6.067SerAla: 6.067 ± 1.485
1.348SerCys: 1.348 ± 0.575
6.067SerAsp: 6.067 ± 0.805
6.742SerGlu: 6.742 ± 0.671
6.067SerPhe: 6.067 ± 1.462
6.067SerGly: 6.067 ± 0.862
2.247SerHis: 2.247 ± 1.009
4.045SerIle: 4.045 ± 1.124
7.416SerLys: 7.416 ± 0.457
8.989SerLeu: 8.989 ± 1.426
2.022SerMet: 2.022 ± 0.994
5.843SerAsn: 5.843 ± 1.836
2.247SerPro: 2.247 ± 0.966
1.798SerGln: 1.798 ± 0.59
4.944SerArg: 4.944 ± 1.085
11.236SerSer: 11.236 ± 2.296
4.719SerThr: 4.719 ± 0.917
7.191SerVal: 7.191 ± 1.227
0.0SerTrp: 0.0 ± 0.0
2.247SerTyr: 2.247 ± 0.757
0.0SerXaa: 0.0 ± 0.0
Thr
3.596ThrAla: 3.596 ± 0.631
1.124ThrCys: 1.124 ± 0.395
2.472ThrAsp: 2.472 ± 0.842
3.371ThrGlu: 3.371 ± 0.665
3.596ThrPhe: 3.596 ± 1.462
3.82ThrGly: 3.82 ± 0.591
1.798ThrHis: 1.798 ± 0.822
2.247ThrIle: 2.247 ± 0.753
4.045ThrLys: 4.045 ± 0.788
3.146ThrLeu: 3.146 ± 1.275
0.674ThrMet: 0.674 ± 0.247
2.472ThrAsn: 2.472 ± 0.379
2.921ThrPro: 2.921 ± 0.647
0.899ThrGln: 0.899 ± 0.61
1.348ThrArg: 1.348 ± 0.397
6.067ThrSer: 6.067 ± 0.744
2.921ThrThr: 2.921 ± 0.795
6.517ThrVal: 6.517 ± 1.053
0.899ThrTrp: 0.899 ± 0.321
2.472ThrTyr: 2.472 ± 1.486
0.0ThrXaa: 0.0 ± 0.0
Val
5.843ValAla: 5.843 ± 0.986
1.798ValCys: 1.798 ± 0.549
5.618ValAsp: 5.618 ± 1.127
3.146ValGlu: 3.146 ± 0.509
6.067ValPhe: 6.067 ± 1.355
4.944ValGly: 4.944 ± 1.476
0.674ValHis: 0.674 ± 0.373
2.472ValIle: 2.472 ± 0.626
8.09ValLys: 8.09 ± 1.325
8.09ValLeu: 8.09 ± 1.383
2.022ValMet: 2.022 ± 0.303
3.596ValAsn: 3.596 ± 0.513
3.596ValPro: 3.596 ± 0.776
2.247ValGln: 2.247 ± 1.096
3.596ValArg: 3.596 ± 1.027
7.865ValSer: 7.865 ± 1.446
5.393ValThr: 5.393 ± 0.695
7.416ValVal: 7.416 ± 1.823
0.225ValTrp: 0.225 ± 0.124
2.921ValTyr: 2.921 ± 0.619
0.0ValXaa: 0.0 ± 0.0
Trp
0.674TrpAla: 0.674 ± 0.288
0.225TrpCys: 0.225 ± 0.367
0.225TrpAsp: 0.225 ± 0.124
0.225TrpGlu: 0.225 ± 0.124
0.899TrpPhe: 0.899 ± 0.497
0.449TrpGly: 0.449 ± 0.305
0.225TrpHis: 0.225 ± 0.124
0.225TrpIle: 0.225 ± 0.124
0.449TrpLys: 0.449 ± 0.305
0.674TrpLeu: 0.674 ± 0.373
0.225TrpMet: 0.225 ± 0.124
0.225TrpAsn: 0.225 ± 0.402
0.449TrpPro: 0.449 ± 0.305
0.0TrpGln: 0.0 ± 0.0
0.449TrpArg: 0.449 ± 0.249
0.449TrpSer: 0.449 ± 0.595
0.0TrpThr: 0.0 ± 0.0
0.674TrpVal: 0.674 ± 0.703
0.0TrpTrp: 0.0 ± 0.0
0.674TrpTyr: 0.674 ± 0.288
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.449TyrAla: 0.449 ± 0.27
0.449TyrCys: 0.449 ± 0.364
2.472TyrAsp: 2.472 ± 0.87
1.124TyrGlu: 1.124 ± 0.722
0.899TyrPhe: 0.899 ± 0.282
1.573TyrGly: 1.573 ± 0.423
0.899TyrHis: 0.899 ± 0.497
1.124TyrIle: 1.124 ± 0.585
1.348TyrLys: 1.348 ± 0.225
1.798TyrLeu: 1.798 ± 0.837
1.798TyrMet: 1.798 ± 0.562
0.899TyrAsn: 0.899 ± 0.64
1.573TyrPro: 1.573 ± 0.692
0.225TyrGln: 0.225 ± 0.367
2.022TyrArg: 2.022 ± 0.862
3.82TyrSer: 3.82 ± 1.107
1.573TyrThr: 1.573 ± 0.273
2.697TyrVal: 2.697 ± 0.711
0.449TyrTrp: 0.449 ± 0.249
0.899TyrTyr: 0.899 ± 0.374
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (4451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski