Amino acid dipepetide frequency for Caedimonas varicaedens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.864AlaAla: 5.864 ± 0.189
0.896AlaCys: 0.896 ± 0.048
3.187AlaAsp: 3.187 ± 0.09
4.719AlaGlu: 4.719 ± 0.112
3.558AlaPhe: 3.558 ± 0.087
5.259AlaGly: 5.259 ± 0.103
1.978AlaHis: 1.978 ± 0.075
4.813AlaIle: 4.813 ± 0.12
3.847AlaLys: 3.847 ± 0.104
9.271AlaLeu: 9.271 ± 0.148
1.8AlaMet: 1.8 ± 0.068
2.252AlaAsn: 2.252 ± 0.089
2.797AlaPro: 2.797 ± 0.074
3.705AlaGln: 3.705 ± 0.123
4.436AlaArg: 4.436 ± 0.102
4.76AlaSer: 4.76 ± 0.105
3.678AlaThr: 3.678 ± 0.087
4.46AlaVal: 4.46 ± 0.114
0.769AlaTrp: 0.769 ± 0.036
2.428AlaTyr: 2.428 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.742CysAla: 0.742 ± 0.045
0.129CysCys: 0.129 ± 0.016
0.611CysAsp: 0.611 ± 0.035
0.574CysGlu: 0.574 ± 0.035
0.615CysPhe: 0.615 ± 0.038
0.943CysGly: 0.943 ± 0.051
0.358CysHis: 0.358 ± 0.026
0.624CysIle: 0.624 ± 0.033
0.45CysLys: 0.45 ± 0.033
1.179CysLeu: 1.179 ± 0.058
0.238CysMet: 0.238 ± 0.023
0.27CysAsn: 0.27 ± 0.022
0.544CysPro: 0.544 ± 0.034
0.501CysGln: 0.501 ± 0.034
0.57CysArg: 0.57 ± 0.038
0.746CysSer: 0.746 ± 0.036
0.484CysThr: 0.484 ± 0.028
0.806CysVal: 0.806 ± 0.046
0.161CysTrp: 0.161 ± 0.02
0.354CysTyr: 0.354 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.538AspAla: 3.538 ± 0.096
0.512AspCys: 0.512 ± 0.032
2.231AspAsp: 2.231 ± 0.086
2.947AspGlu: 2.947 ± 0.1
2.76AspPhe: 2.76 ± 0.078
2.636AspGly: 2.636 ± 0.103
1.309AspHis: 1.309 ± 0.053
3.744AspIle: 3.744 ± 0.09
2.739AspLys: 2.739 ± 0.093
5.778AspLeu: 5.778 ± 0.135
1.091AspMet: 1.091 ± 0.048
1.633AspAsn: 1.633 ± 0.06
2.516AspPro: 2.516 ± 0.082
2.12AspGln: 2.12 ± 0.069
2.63AspArg: 2.63 ± 0.079
2.516AspSer: 2.516 ± 0.087
2.092AspThr: 2.092 ± 0.057
3.161AspVal: 3.161 ± 0.09
0.613AspTrp: 0.613 ± 0.039
1.766AspTyr: 1.766 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.259GluAla: 5.259 ± 0.121
0.497GluCys: 0.497 ± 0.031
3.14GluAsp: 3.14 ± 0.08
5.403GluGlu: 5.403 ± 0.139
2.171GluPhe: 2.171 ± 0.069
4.22GluGly: 4.22 ± 0.107
1.348GluHis: 1.348 ± 0.052
5.332GluIle: 5.332 ± 0.116
5.576GluLys: 5.576 ± 0.129
5.107GluLeu: 5.107 ± 0.117
1.749GluMet: 1.749 ± 0.055
3.015GluAsn: 3.015 ± 0.092
1.933GluPro: 1.933 ± 0.076
2.777GluGln: 2.777 ± 0.082
3.834GluArg: 3.834 ± 0.105
3.446GluSer: 3.446 ± 0.096
3.712GluThr: 3.712 ± 0.093
3.678GluVal: 3.678 ± 0.087
0.742GluTrp: 0.742 ± 0.044
1.481GluTyr: 1.481 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.981PheAla: 2.981 ± 0.092
0.737PheCys: 0.737 ± 0.042
2.37PheAsp: 2.37 ± 0.064
2.533PheGlu: 2.533 ± 0.079
2.597PhePhe: 2.597 ± 0.094
3.09PheGly: 3.09 ± 0.091
0.999PheHis: 0.999 ± 0.046
3.352PheIle: 3.352 ± 0.1
2.636PheLys: 2.636 ± 0.079
5.3PheLeu: 5.3 ± 0.137
1.239PheMet: 1.239 ± 0.056
1.822PheAsn: 1.822 ± 0.07
2.042PhePro: 2.042 ± 0.071
1.738PheGln: 1.738 ± 0.057
2.023PheArg: 2.023 ± 0.056
3.958PheSer: 3.958 ± 0.09
2.351PheThr: 2.351 ± 0.081
2.722PheVal: 2.722 ± 0.08
0.639PheTrp: 0.639 ± 0.038
1.753PheTyr: 1.753 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
4.768GlyAla: 4.768 ± 0.125
0.836GlyCys: 0.836 ± 0.047
3.052GlyAsp: 3.052 ± 0.095
4.085GlyGlu: 4.085 ± 0.104
3.378GlyPhe: 3.378 ± 0.095
4.828GlyGly: 4.828 ± 0.143
1.738GlyHis: 1.738 ± 0.067
5.165GlyIle: 5.165 ± 0.106
4.638GlyLys: 4.638 ± 0.12
6.764GlyLeu: 6.764 ± 0.131
1.989GlyMet: 1.989 ± 0.075
2.272GlyAsn: 2.272 ± 0.084
1.395GlyPro: 1.395 ± 0.056
2.649GlyGln: 2.649 ± 0.07
3.341GlyArg: 3.341 ± 0.082
3.96GlySer: 3.96 ± 0.095
3.568GlyThr: 3.568 ± 0.106
4.563GlyVal: 4.563 ± 0.092
0.911GlyTrp: 0.911 ± 0.048
2.544GlyTyr: 2.544 ± 0.086
0.0GlyXaa: 0.0 ± 0.0
His
1.678HisAla: 1.678 ± 0.06
0.285HisCys: 0.285 ± 0.023
1.172HisAsp: 1.172 ± 0.053
1.447HisGlu: 1.447 ± 0.055
1.204HisPhe: 1.204 ± 0.051
1.399HisGly: 1.399 ± 0.055
0.947HisHis: 0.947 ± 0.052
1.684HisIle: 1.684 ± 0.059
1.354HisLys: 1.354 ± 0.055
2.773HisLeu: 2.773 ± 0.089
0.602HisMet: 0.602 ± 0.036
0.853HisAsn: 0.853 ± 0.046
1.53HisPro: 1.53 ± 0.062
1.129HisGln: 1.129 ± 0.048
1.402HisArg: 1.402 ± 0.052
1.483HisSer: 1.483 ± 0.058
1.179HisThr: 1.179 ± 0.052
1.374HisVal: 1.374 ± 0.051
0.328HisTrp: 0.328 ± 0.027
0.857HisTyr: 0.857 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.761IleAla: 5.761 ± 0.119
0.784IleCys: 0.784 ± 0.048
3.772IleAsp: 3.772 ± 0.102
4.481IleGlu: 4.481 ± 0.099
3.369IlePhe: 3.369 ± 0.101
4.494IleGly: 4.494 ± 0.101
1.65IleHis: 1.65 ± 0.054
4.747IleIle: 4.747 ± 0.128
3.965IleLys: 3.965 ± 0.098
8.02IleLeu: 8.02 ± 0.136
1.502IleMet: 1.502 ± 0.066
2.525IleAsn: 2.525 ± 0.086
3.36IlePro: 3.36 ± 0.082
2.769IleGln: 2.769 ± 0.079
3.277IleArg: 3.277 ± 0.088
5.008IleSer: 5.008 ± 0.105
3.626IleThr: 3.626 ± 0.093
4.175IleVal: 4.175 ± 0.111
0.652IleTrp: 0.652 ± 0.039
1.897IleTyr: 1.897 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.698LysAla: 4.698 ± 0.17
0.444LysCys: 0.444 ± 0.031
3.075LysAsp: 3.075 ± 0.087
4.681LysGlu: 4.681 ± 0.117
2.049LysPhe: 2.049 ± 0.072
4.085LysGly: 4.085 ± 0.099
1.183LysHis: 1.183 ± 0.048
5.15LysIle: 5.15 ± 0.098
5.388LysLys: 5.388 ± 0.143
5.611LysLeu: 5.611 ± 0.125
1.603LysMet: 1.603 ± 0.06
3.429LysAsn: 3.429 ± 0.092
2.488LysPro: 2.488 ± 0.072
2.167LysGln: 2.167 ± 0.083
3.198LysArg: 3.198 ± 0.085
3.924LysSer: 3.924 ± 0.099
3.969LysThr: 3.969 ± 0.091
3.594LysVal: 3.594 ± 0.098
0.568LysTrp: 0.568 ± 0.038
1.624LysTyr: 1.624 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
8.12LeuAla: 8.12 ± 0.16
1.222LeuCys: 1.222 ± 0.063
5.113LeuAsp: 5.113 ± 0.11
6.927LeuGlu: 6.927 ± 0.136
5.011LeuPhe: 5.011 ± 0.127
7.304LeuGly: 7.304 ± 0.132
2.39LeuHis: 2.39 ± 0.077
6.942LeuIle: 6.942 ± 0.144
7.899LeuLys: 7.899 ± 0.146
10.48LeuLeu: 10.48 ± 0.179
2.844LeuMet: 2.844 ± 0.079
4.301LeuAsn: 4.301 ± 0.109
5.131LeuPro: 5.131 ± 0.098
4.381LeuGln: 4.381 ± 0.121
5.486LeuArg: 5.486 ± 0.112
8.662LeuSer: 8.662 ± 0.141
6.018LeuThr: 6.018 ± 0.12
5.969LeuVal: 5.969 ± 0.131
1.226LeuTrp: 1.226 ± 0.057
3.195LeuTyr: 3.195 ± 0.093
0.0LeuXaa: 0.0 ± 0.0
Met
2.145MetAla: 2.145 ± 0.087
0.206MetCys: 0.206 ± 0.022
1.117MetAsp: 1.117 ± 0.046
1.282MetGlu: 1.282 ± 0.05
0.776MetPhe: 0.776 ± 0.039
1.828MetGly: 1.828 ± 0.065
0.358MetHis: 0.358 ± 0.025
2.072MetIle: 2.072 ± 0.07
1.774MetLys: 1.774 ± 0.062
2.297MetLeu: 2.297 ± 0.07
0.883MetMet: 0.883 ± 0.049
1.138MetAsn: 1.138 ± 0.048
1.219MetPro: 1.219 ± 0.052
0.868MetGln: 0.868 ± 0.043
1.41MetArg: 1.41 ± 0.051
1.693MetSer: 1.693 ± 0.061
1.982MetThr: 1.982 ± 0.07
1.487MetVal: 1.487 ± 0.065
0.165MetTrp: 0.165 ± 0.019
0.439MetTyr: 0.439 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.675AsnAla: 2.675 ± 0.079
0.371AsnCys: 0.371 ± 0.024
1.796AsnAsp: 1.796 ± 0.066
1.931AsnGlu: 1.931 ± 0.068
1.772AsnPhe: 1.772 ± 0.064
1.927AsnGly: 1.927 ± 0.075
0.939AsnHis: 0.939 ± 0.043
2.915AsnIle: 2.915 ± 0.086
2.051AsnLys: 2.051 ± 0.079
4.104AsnLeu: 4.104 ± 0.096
0.973AsnMet: 0.973 ± 0.046
1.417AsnAsn: 1.417 ± 0.063
2.462AsnPro: 2.462 ± 0.077
1.603AsnGln: 1.603 ± 0.052
1.862AsnArg: 1.862 ± 0.062
2.195AsnSer: 2.195 ± 0.07
1.862AsnThr: 1.862 ± 0.068
2.315AsnVal: 2.315 ± 0.078
0.411AsnTrp: 0.411 ± 0.03
1.226AsnTyr: 1.226 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.885ProAla: 2.885 ± 0.088
0.433ProCys: 0.433 ± 0.031
2.477ProAsp: 2.477 ± 0.071
3.333ProGlu: 3.333 ± 0.079
2.231ProPhe: 2.231 ± 0.071
2.54ProGly: 2.54 ± 0.078
1.252ProHis: 1.252 ± 0.041
2.244ProIle: 2.244 ± 0.075
2.143ProLys: 2.143 ± 0.073
5.293ProLeu: 5.293 ± 0.107
0.928ProMet: 0.928 ± 0.044
1.155ProAsn: 1.155 ± 0.05
1.513ProPro: 1.513 ± 0.057
2.156ProGln: 2.156 ± 0.068
1.895ProArg: 1.895 ± 0.069
3.202ProSer: 3.202 ± 0.089
2.051ProThr: 2.051 ± 0.065
3.204ProVal: 3.204 ± 0.091
0.566ProTrp: 0.566 ± 0.034
1.695ProTyr: 1.695 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
3.596GlnAla: 3.596 ± 0.098
0.369GlnCys: 0.369 ± 0.025
2.068GlnAsp: 2.068 ± 0.071
3.525GlnGlu: 3.525 ± 0.088
1.404GlnPhe: 1.404 ± 0.053
3.288GlnGly: 3.288 ± 0.089
1.119GlnHis: 1.119 ± 0.059
2.707GlnIle: 2.707 ± 0.076
3.832GlnLys: 3.832 ± 0.129
3.51GlnLeu: 3.51 ± 0.101
1.123GlnMet: 1.123 ± 0.051
1.764GlnAsn: 1.764 ± 0.073
1.453GlnPro: 1.453 ± 0.066
1.929GlnGln: 1.929 ± 0.068
2.441GlnArg: 2.441 ± 0.089
2.409GlnSer: 2.409 ± 0.078
2.323GlnThr: 2.323 ± 0.071
2.169GlnVal: 2.169 ± 0.074
0.54GlnTrp: 0.54 ± 0.031
1.087GlnTyr: 1.087 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.605ArgAla: 3.605 ± 0.089
0.572ArgCys: 0.572 ± 0.033
2.642ArgAsp: 2.642 ± 0.088
3.875ArgGlu: 3.875 ± 0.107
2.51ArgPhe: 2.51 ± 0.068
3.082ArgGly: 3.082 ± 0.092
1.38ArgHis: 1.38 ± 0.055
3.519ArgIle: 3.519 ± 0.081
3.339ArgLys: 3.339 ± 0.085
6.136ArgLeu: 6.136 ± 0.129
1.147ArgMet: 1.147 ± 0.049
1.783ArgAsn: 1.783 ± 0.066
2.057ArgPro: 2.057 ± 0.061
2.424ArgGln: 2.424 ± 0.078
2.842ArgArg: 2.842 ± 0.099
2.852ArgSer: 2.852 ± 0.074
2.439ArgThr: 2.439 ± 0.07
3.296ArgVal: 3.296 ± 0.093
0.643ArgTrp: 0.643 ± 0.038
1.708ArgTyr: 1.708 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
4.805SerAla: 4.805 ± 0.104
0.784SerCys: 0.784 ± 0.036
2.942SerAsp: 2.942 ± 0.083
3.564SerGlu: 3.564 ± 0.097
3.855SerPhe: 3.855 ± 0.099
4.378SerGly: 4.378 ± 0.089
1.755SerHis: 1.755 ± 0.065
4.119SerIle: 4.119 ± 0.088
3.067SerLys: 3.067 ± 0.09
8.677SerLeu: 8.677 ± 0.162
1.689SerMet: 1.689 ± 0.058
1.933SerAsn: 1.933 ± 0.07
3.292SerPro: 3.292 ± 0.087
2.825SerGln: 2.825 ± 0.075
3.294SerArg: 3.294 ± 0.08
5.056SerSer: 5.056 ± 0.112
3.118SerThr: 3.118 ± 0.091
4.134SerVal: 4.134 ± 0.096
0.887SerTrp: 0.887 ± 0.039
2.158SerTyr: 2.158 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.873ThrAla: 3.873 ± 0.103
0.474ThrCys: 0.474 ± 0.036
2.456ThrAsp: 2.456 ± 0.071
2.981ThrGlu: 2.981 ± 0.08
2.647ThrPhe: 2.647 ± 0.075
3.958ThrGly: 3.958 ± 0.097
1.399ThrHis: 1.399 ± 0.048
3.296ThrIle: 3.296 ± 0.084
2.52ThrLys: 2.52 ± 0.075
6.984ThrLeu: 6.984 ± 0.148
1.061ThrMet: 1.061 ± 0.046
1.609ThrAsn: 1.609 ± 0.063
3.097ThrPro: 3.097 ± 0.086
2.355ThrGln: 2.355 ± 0.078
2.383ThrArg: 2.383 ± 0.069
3.515ThrSer: 3.515 ± 0.089
2.882ThrThr: 2.882 ± 0.075
3.251ThrVal: 3.251 ± 0.085
0.555ThrTrp: 0.555 ± 0.035
1.727ThrTyr: 1.727 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
4.498ValAla: 4.498 ± 0.121
0.851ValCys: 0.851 ± 0.049
2.908ValAsp: 2.908 ± 0.088
3.665ValGlu: 3.665 ± 0.098
2.891ValPhe: 2.891 ± 0.079
4.1ValGly: 4.1 ± 0.104
1.286ValHis: 1.286 ± 0.052
4.621ValIle: 4.621 ± 0.114
3.427ValLys: 3.427 ± 0.089
6.47ValLeu: 6.47 ± 0.113
1.717ValMet: 1.717 ± 0.062
2.053ValAsn: 2.053 ± 0.07
2.582ValPro: 2.582 ± 0.081
2.381ValGln: 2.381 ± 0.078
3.097ValArg: 3.097 ± 0.089
4.353ValSer: 4.353 ± 0.097
3.609ValThr: 3.609 ± 0.093
3.948ValVal: 3.948 ± 0.119
0.682ValTrp: 0.682 ± 0.039
1.736ValTyr: 1.736 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.731TrpAla: 0.731 ± 0.039
0.137TrpCys: 0.137 ± 0.015
0.519TrpAsp: 0.519 ± 0.038
0.639TrpGlu: 0.639 ± 0.037
0.489TrpPhe: 0.489 ± 0.033
0.829TrpGly: 0.829 ± 0.039
0.388TrpHis: 0.388 ± 0.03
0.887TrpIle: 0.887 ± 0.05
0.684TrpLys: 0.684 ± 0.042
1.307TrpLeu: 1.307 ± 0.051
0.345TrpMet: 0.345 ± 0.027
0.444TrpAsn: 0.444 ± 0.03
0.386TrpPro: 0.386 ± 0.032
0.619TrpGln: 0.619 ± 0.04
0.699TrpArg: 0.699 ± 0.036
0.679TrpSer: 0.679 ± 0.035
0.542TrpThr: 0.542 ± 0.033
0.81TrpVal: 0.81 ± 0.041
0.154TrpTrp: 0.154 ± 0.021
0.296TrpTyr: 0.296 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.257TyrAla: 2.257 ± 0.069
0.36TyrCys: 0.36 ± 0.026
1.682TyrAsp: 1.682 ± 0.055
1.832TyrGlu: 1.832 ± 0.065
1.597TyrPhe: 1.597 ± 0.055
2.255TyrGly: 2.255 ± 0.068
0.907TyrHis: 0.907 ± 0.05
1.901TyrIle: 1.901 ± 0.066
1.597TyrLys: 1.597 ± 0.07
3.558TyrLeu: 3.558 ± 0.09
0.617TyrMet: 0.617 ± 0.036
1.138TyrAsn: 1.138 ± 0.056
1.395TyrPro: 1.395 ± 0.064
1.558TyrGln: 1.558 ± 0.068
1.732TyrArg: 1.732 ± 0.054
1.916TyrSer: 1.916 ± 0.056
1.539TyrThr: 1.539 ± 0.054
1.759TyrVal: 1.759 ± 0.063
0.373TyrTrp: 0.373 ± 0.027
1.057TyrTyr: 1.057 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1663 proteins (466613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski