Amino acid dipepetide frequency for Prevotella multisaccharivorax DSM 17128

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.049AlaAla: 6.049 ± 0.11	1.067AlaCys: 1.067 ± 0.033	4.622AlaAsp: 4.622 ± 0.08	4.289AlaGlu: 4.289 ± 0.076	3.144AlaPhe: 3.144 ± 0.059	4.88AlaGly: 4.88 ± 0.068	1.491AlaHis: 1.491 ± 0.035	4.571AlaIle: 4.571 ± 0.077	4.455AlaLys: 4.455 ± 0.083	6.725AlaLeu: 6.725 ± 0.096	2.117AlaMet: 2.117 ± 0.05	3.346AlaAsn: 3.346 ± 0.06	2.341AlaPro: 2.341 ± 0.053	2.885AlaGln: 2.885 ± 0.056	3.373AlaArg: 3.373 ± 0.058	4.472AlaSer: 4.472 ± 0.087	4.192AlaThr: 4.192 ± 0.075	5.03AlaVal: 5.03 ± 0.084	0.885AlaTrp: 0.885 ± 0.036	2.974AlaTyr: 2.974 ± 0.062	0.001AlaXaa: 0.001 ± 0.001
Cys	0.805CysAla: 0.805 ± 0.033	0.232CysCys: 0.232 ± 0.017	0.714CysAsp: 0.714 ± 0.028	0.65CysGlu: 0.65 ± 0.029	0.594CysPhe: 0.594 ± 0.027	1.088CysGly: 1.088 ± 0.038	0.367CysHis: 0.367 ± 0.021	0.837CysIle: 0.837 ± 0.034	0.713CysLys: 0.713 ± 0.027	1.121CysLeu: 1.121 ± 0.036	0.349CysMet: 0.349 ± 0.019	0.617CysAsn: 0.617 ± 0.022	0.552CysPro: 0.552 ± 0.027	0.433CysGln: 0.433 ± 0.021	0.737CysArg: 0.737 ± 0.032	0.778CysSer: 0.778 ± 0.024	0.683CysThr: 0.683 ± 0.031	0.795CysVal: 0.795 ± 0.031	0.191CysTrp: 0.191 ± 0.013	0.576CysTyr: 0.576 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.416AspAla: 4.416 ± 0.072	0.755AspCys: 0.755 ± 0.026	3.56AspAsp: 3.56 ± 0.071	3.857AspGlu: 3.857 ± 0.064	3.067AspPhe: 3.067 ± 0.058	4.65AspGly: 4.65 ± 0.085	1.165AspHis: 1.165 ± 0.034	4.312AspIle: 4.312 ± 0.079	4.078AspLys: 4.078 ± 0.072	4.791AspLeu: 4.791 ± 0.065	1.676AspMet: 1.676 ± 0.048	3.324AspAsn: 3.324 ± 0.066	2.065AspPro: 2.065 ± 0.045	1.528AspGln: 1.528 ± 0.045	2.932AspArg: 2.932 ± 0.061	3.376AspSer: 3.376 ± 0.071	3.002AspThr: 3.002 ± 0.055	3.773AspVal: 3.773 ± 0.064	0.9AspTrp: 0.9 ± 0.034	3.07AspTyr: 3.07 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.471GluAla: 4.471 ± 0.087	0.599GluCys: 0.599 ± 0.028	3.138GluAsp: 3.138 ± 0.056	3.91GluGlu: 3.91 ± 0.075	1.877GluPhe: 1.877 ± 0.042	3.628GluGly: 3.628 ± 0.069	1.282GluHis: 1.282 ± 0.039	3.57GluIle: 3.57 ± 0.061	4.441GluLys: 4.441 ± 0.074	4.926GluLeu: 4.926 ± 0.082	1.844GluMet: 1.844 ± 0.042	2.887GluAsn: 2.887 ± 0.062	1.723GluPro: 1.723 ± 0.048	2.307GluGln: 2.307 ± 0.059	3.195GluArg: 3.195 ± 0.062	2.844GluSer: 2.844 ± 0.05	3.04GluThr: 3.04 ± 0.059	3.665GluVal: 3.665 ± 0.07	0.787GluTrp: 0.787 ± 0.029	2.249GluTyr: 2.249 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.967PheAla: 2.967 ± 0.058	0.716PheCys: 0.716 ± 0.024	2.85PheAsp: 2.85 ± 0.058	2.059PheGlu: 2.059 ± 0.042	2.124PhePhe: 2.124 ± 0.055	3.228PheGly: 3.228 ± 0.06	1.033PheHis: 1.033 ± 0.036	2.799PheIle: 2.799 ± 0.068	2.343PheLys: 2.343 ± 0.063	3.778PheLeu: 3.778 ± 0.064	1.182PheMet: 1.182 ± 0.04	2.303PheAsn: 2.303 ± 0.045	1.65PhePro: 1.65 ± 0.041	1.183PheGln: 1.183 ± 0.035	2.105PheArg: 2.105 ± 0.045	3.315PheSer: 3.315 ± 0.064	2.752PheThr: 2.752 ± 0.055	2.744PheVal: 2.744 ± 0.058	0.525PheTrp: 0.525 ± 0.024	1.826PheTyr: 1.826 ± 0.043	0.001PheXaa: 0.001 ± 0.001
Gly	4.456GlyAla: 4.456 ± 0.083	0.999GlyCys: 0.999 ± 0.033	3.831GlyAsp: 3.831 ± 0.064	3.7GlyGlu: 3.7 ± 0.075	3.105GlyPhe: 3.105 ± 0.064	4.724GlyGly: 4.724 ± 0.07	1.673GlyHis: 1.673 ± 0.043	4.885GlyIle: 4.885 ± 0.071	5.282GlyLys: 5.282 ± 0.078	5.85GlyLeu: 5.85 ± 0.083	2.096GlyMet: 2.096 ± 0.042	3.63GlyAsn: 3.63 ± 0.071	1.429GlyPro: 1.429 ± 0.04	2.376GlyGln: 2.376 ± 0.049	3.396GlyArg: 3.396 ± 0.069	4.4GlySer: 4.4 ± 0.082	4.292GlyThr: 4.292 ± 0.093	4.651GlyVal: 4.651 ± 0.072	1.092GlyTrp: 1.092 ± 0.038	3.389GlyTyr: 3.389 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.443HisAla: 1.443 ± 0.036	0.374HisCys: 0.374 ± 0.023	1.352HisAsp: 1.352 ± 0.042	1.163HisGlu: 1.163 ± 0.035	1.147HisPhe: 1.147 ± 0.035	1.612HisGly: 1.612 ± 0.048	0.691HisHis: 0.691 ± 0.027	1.621HisIle: 1.621 ± 0.046	1.153HisLys: 1.153 ± 0.035	1.967HisLeu: 1.967 ± 0.047	0.454HisMet: 0.454 ± 0.024	1.071HisAsn: 1.071 ± 0.032	1.137HisPro: 1.137 ± 0.034	0.787HisGln: 0.787 ± 0.027	1.191HisArg: 1.191 ± 0.035	1.32HisSer: 1.32 ± 0.042	1.213HisThr: 1.213 ± 0.037	1.405HisVal: 1.405 ± 0.037	0.324HisTrp: 0.324 ± 0.019	1.131HisTyr: 1.131 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	4.945IleAla: 4.945 ± 0.079	0.815IleCys: 0.815 ± 0.034	4.472IleAsp: 4.472 ± 0.074	3.582IleGlu: 3.582 ± 0.068	2.567IlePhe: 2.567 ± 0.053	4.495IleGly: 4.495 ± 0.084	1.442IleHis: 1.442 ± 0.039	4.229IleIle: 4.229 ± 0.083	3.676IleLys: 3.676 ± 0.058	5.195IleLeu: 5.195 ± 0.095	1.52IleMet: 1.52 ± 0.039	3.357IleAsn: 3.357 ± 0.068	2.808IlePro: 2.808 ± 0.056	1.938IleGln: 1.938 ± 0.049	3.329IleArg: 3.329 ± 0.061	4.275IleSer: 4.275 ± 0.068	3.788IleThr: 3.788 ± 0.059	4.431IleVal: 4.431 ± 0.082	0.627IleTrp: 0.627 ± 0.024	2.402IleTyr: 2.402 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.264LysAla: 5.264 ± 0.088	0.583LysCys: 0.583 ± 0.025	4.208LysAsp: 4.208 ± 0.078	4.516LysGlu: 4.516 ± 0.091	2.03LysPhe: 2.03 ± 0.049	4.616LysGly: 4.616 ± 0.072	1.326LysHis: 1.326 ± 0.042	3.78LysIle: 3.78 ± 0.065	4.35LysLys: 4.35 ± 0.082	5.054LysLeu: 5.054 ± 0.069	2.072LysMet: 2.072 ± 0.048	3.294LysAsn: 3.294 ± 0.056	2.146LysPro: 2.146 ± 0.049	2.338LysGln: 2.338 ± 0.052	3.324LysArg: 3.324 ± 0.073	3.416LysSer: 3.416 ± 0.059	3.838LysThr: 3.838 ± 0.064	4.269LysVal: 4.269 ± 0.061	0.845LysTrp: 0.845 ± 0.029	2.811LysTyr: 2.811 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.245LeuAla: 6.245 ± 0.088	1.357LeuCys: 1.357 ± 0.04	4.867LeuAsp: 4.867 ± 0.084	4.099LeuGlu: 4.099 ± 0.068	3.976LeuPhe: 3.976 ± 0.08	5.67LeuGly: 5.67 ± 0.098	2.125LeuHis: 2.125 ± 0.045	4.948LeuIle: 4.948 ± 0.086	5.76LeuLys: 5.76 ± 0.09	8.245LeuLeu: 8.245 ± 0.118	2.507LeuMet: 2.507 ± 0.057	4.549LeuAsn: 4.549 ± 0.066	3.969LeuPro: 3.969 ± 0.065	3.325LeuGln: 3.325 ± 0.061	4.956LeuArg: 4.956 ± 0.075	6.915LeuSer: 6.915 ± 0.09	5.484LeuThr: 5.484 ± 0.079	4.966LeuVal: 4.966 ± 0.084	1.039LeuTrp: 1.039 ± 0.036	3.466LeuTyr: 3.466 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.29MetAla: 2.29 ± 0.051	0.276MetCys: 0.276 ± 0.018	1.595MetAsp: 1.595 ± 0.04	1.632MetGlu: 1.632 ± 0.041	0.963MetPhe: 0.963 ± 0.035	1.837MetGly: 1.837 ± 0.047	0.52MetHis: 0.52 ± 0.024	1.481MetIle: 1.481 ± 0.038	2.361MetLys: 2.361 ± 0.053	2.485MetLeu: 2.485 ± 0.056	0.927MetMet: 0.927 ± 0.037	1.57MetAsn: 1.57 ± 0.041	1.308MetPro: 1.308 ± 0.036	1.175MetGln: 1.175 ± 0.034	1.627MetArg: 1.627 ± 0.042	1.775MetSer: 1.775 ± 0.042	1.699MetThr: 1.699 ± 0.045	1.671MetVal: 1.671 ± 0.046	0.235MetTrp: 0.235 ± 0.016	0.8MetTyr: 0.8 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.692AsnAla: 3.692 ± 0.069	0.507AsnCys: 0.507 ± 0.023	2.969AsnAsp: 2.969 ± 0.053	2.627AsnGlu: 2.627 ± 0.049	2.178AsnPhe: 2.178 ± 0.048	4.129AsnGly: 4.129 ± 0.074	1.1AsnHis: 1.1 ± 0.034	3.77AsnIle: 3.77 ± 0.07	2.955AsnLys: 2.955 ± 0.06	3.999AsnLeu: 3.999 ± 0.064	1.288AsnMet: 1.288 ± 0.041	2.765AsnAsn: 2.765 ± 0.071	2.4AsnPro: 2.4 ± 0.051	1.524AsnGln: 1.524 ± 0.04	2.52AsnArg: 2.52 ± 0.052	2.899AsnSer: 2.899 ± 0.06	2.823AsnThr: 2.823 ± 0.051	3.337AsnVal: 3.337 ± 0.063	0.639AsnTrp: 0.639 ± 0.025	2.433AsnTyr: 2.433 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.548ProAla: 2.548 ± 0.052	0.407ProCys: 0.407 ± 0.022	2.711ProAsp: 2.711 ± 0.051	2.648ProGlu: 2.648 ± 0.05	1.77ProPhe: 1.77 ± 0.044	2.318ProGly: 2.318 ± 0.051	0.824ProHis: 0.824 ± 0.027	2.146ProIle: 2.146 ± 0.055	2.176ProLys: 2.176 ± 0.056	3.252ProLeu: 3.252 ± 0.062	1.043ProMet: 1.043 ± 0.034	1.638ProAsn: 1.638 ± 0.04	0.759ProPro: 0.759 ± 0.031	1.54ProGln: 1.54 ± 0.038	1.507ProArg: 1.507 ± 0.045	2.42ProSer: 2.42 ± 0.051	2.198ProThr: 2.198 ± 0.045	2.827ProVal: 2.827 ± 0.053	0.564ProTrp: 0.564 ± 0.028	1.715ProTyr: 1.715 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.613GlnAla: 2.613 ± 0.058	0.396GlnCys: 0.396 ± 0.018	1.758GlnAsp: 1.758 ± 0.041	1.998GlnGlu: 1.998 ± 0.049	1.361GlnPhe: 1.361 ± 0.041	2.331GlnGly: 2.331 ± 0.055	0.792GlnHis: 0.792 ± 0.025	2.234GlnIle: 2.234 ± 0.05	2.458GlnLys: 2.458 ± 0.056	3.664GlnLeu: 3.664 ± 0.068	1.078GlnMet: 1.078 ± 0.038	1.642GlnAsn: 1.642 ± 0.044	1.393GlnPro: 1.393 ± 0.041	1.941GlnGln: 1.941 ± 0.048	2.025GlnArg: 2.025 ± 0.046	2.03GlnSer: 2.03 ± 0.046	2.187GlnThr: 2.187 ± 0.049	2.08GlnVal: 2.08 ± 0.044	0.583GlnTrp: 0.583 ± 0.026	1.552GlnTyr: 1.552 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.191ArgAla: 3.191 ± 0.064	0.563ArgCys: 0.563 ± 0.025	2.703ArgAsp: 2.703 ± 0.048	3.048ArgGlu: 3.048 ± 0.068	2.358ArgPhe: 2.358 ± 0.047	2.923ArgGly: 2.923 ± 0.053	1.408ArgHis: 1.408 ± 0.037	3.326ArgIle: 3.326 ± 0.064	3.553ArgLys: 3.553 ± 0.067	5.1ArgLeu: 5.1 ± 0.077	1.664ArgMet: 1.664 ± 0.041	2.435ArgAsn: 2.435 ± 0.05	1.785ArgPro: 1.785 ± 0.045	2.584ArgGln: 2.584 ± 0.055	2.96ArgArg: 2.96 ± 0.067	2.633ArgSer: 2.633 ± 0.054	2.553ArgThr: 2.553 ± 0.052	3.019ArgVal: 3.019 ± 0.064	0.832ArgTrp: 0.832 ± 0.03	2.424ArgTyr: 2.424 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.292SerAla: 4.292 ± 0.068	0.874SerCys: 0.874 ± 0.032	3.684SerAsp: 3.684 ± 0.067	3.142SerGlu: 3.142 ± 0.059	3.138SerPhe: 3.138 ± 0.068	4.357SerGly: 4.357 ± 0.074	1.486SerHis: 1.486 ± 0.041	4.047SerIle: 4.047 ± 0.066	3.529SerLys: 3.529 ± 0.064	6.32SerLeu: 6.32 ± 0.08	1.637SerMet: 1.637 ± 0.038	2.885SerAsn: 2.885 ± 0.058	2.297SerPro: 2.297 ± 0.042	2.192SerGln: 2.192 ± 0.046	2.996SerArg: 2.996 ± 0.056	4.079SerSer: 4.079 ± 0.089	3.567SerThr: 3.567 ± 0.069	4.283SerVal: 4.283 ± 0.074	0.902SerTrp: 0.902 ± 0.033	2.95SerTyr: 2.95 ± 0.075	0.0SerXaa: 0.0 ± 0.0
Thr	4.497ThrAla: 4.497 ± 0.071	0.621ThrCys: 0.621 ± 0.029	3.733ThrAsp: 3.733 ± 0.068	2.976ThrGlu: 2.976 ± 0.06	2.778ThrPhe: 2.778 ± 0.061	4.39ThrGly: 4.39 ± 0.074	1.178ThrHis: 1.178 ± 0.035	3.812ThrIle: 3.812 ± 0.054	3.117ThrLys: 3.117 ± 0.063	5.577ThrLeu: 5.577 ± 0.067	1.416ThrMet: 1.416 ± 0.043	2.468ThrAsn: 2.468 ± 0.057	2.656ThrPro: 2.656 ± 0.052	1.866ThrGln: 1.866 ± 0.048	2.459ThrArg: 2.459 ± 0.051	3.442ThrSer: 3.442 ± 0.057	3.52ThrThr: 3.52 ± 0.07	4.388ThrVal: 4.388 ± 0.085	0.699ThrTrp: 0.699 ± 0.029	2.503ThrTyr: 2.503 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.781ValAla: 4.781 ± 0.075	0.96ValCys: 0.96 ± 0.037	3.941ValAsp: 3.941 ± 0.066	3.671ValGlu: 3.671 ± 0.065	2.795ValPhe: 2.795 ± 0.055	4.195ValGly: 4.195 ± 0.076	1.157ValHis: 1.157 ± 0.038	4.129ValIle: 4.129 ± 0.066	4.36ValLys: 4.36 ± 0.066	5.459ValLeu: 5.459 ± 0.081	1.87ValMet: 1.87 ± 0.049	3.418ValAsn: 3.418 ± 0.06	2.552ValPro: 2.552 ± 0.051	1.848ValGln: 1.848 ± 0.048	3.346ValArg: 3.346 ± 0.06	4.843ValSer: 4.843 ± 0.078	3.901ValThr: 3.901 ± 0.07	4.713ValVal: 4.713 ± 0.089	0.751ValTrp: 0.751 ± 0.026	2.633ValTyr: 2.633 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.801TrpAla: 0.801 ± 0.029	0.195TrpCys: 0.195 ± 0.014	0.76TrpAsp: 0.76 ± 0.029	0.615TrpGlu: 0.615 ± 0.024	0.558TrpPhe: 0.558 ± 0.026	1.009TrpGly: 1.009 ± 0.035	0.371TrpHis: 0.371 ± 0.018	0.754TrpIle: 0.754 ± 0.036	0.879TrpLys: 0.879 ± 0.029	1.333TrpLeu: 1.333 ± 0.04	0.451TrpMet: 0.451 ± 0.021	0.806TrpAsn: 0.806 ± 0.029	0.334TrpPro: 0.334 ± 0.022	0.659TrpGln: 0.659 ± 0.03	0.72TrpArg: 0.72 ± 0.029	0.719TrpSer: 0.719 ± 0.027	0.75TrpThr: 0.75 ± 0.03	0.726TrpVal: 0.726 ± 0.03	0.198TrpTrp: 0.198 ± 0.015	0.531TrpTyr: 0.531 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.142TyrAla: 3.142 ± 0.068	0.538TyrCys: 0.538 ± 0.022	2.828TyrAsp: 2.828 ± 0.061	2.203TyrGlu: 2.203 ± 0.049	1.954TyrPhe: 1.954 ± 0.043	3.175TyrGly: 3.175 ± 0.07	1.124TyrHis: 1.124 ± 0.037	2.641TyrIle: 2.641 ± 0.053	2.44TyrLys: 2.44 ± 0.052	3.627TyrLeu: 3.627 ± 0.064	1.033TyrMet: 1.033 ± 0.033	2.548TyrAsn: 2.548 ± 0.067	1.707TyrPro: 1.707 ± 0.041	1.686TyrGln: 1.686 ± 0.044	2.365TyrArg: 2.365 ± 0.05	2.706TyrSer: 2.706 ± 0.068	2.612TyrThr: 2.612 ± 0.064	2.552TyrVal: 2.552 ± 0.048	0.554TyrTrp: 0.554 ± 0.025	2.172TyrTyr: 2.172 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.016XaaXaa: 0.016 ± 0.016

Statistics based on 2694 proteins (975933 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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