Amino acid dipepetide frequency for Spathaspora sp. JA1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.813AlaAla: 3.813 ± 0.062	0.605AlaCys: 0.605 ± 0.016	2.321AlaAsp: 2.321 ± 0.034	2.924AlaGlu: 2.924 ± 0.044	2.055AlaPhe: 2.055 ± 0.033	3.047AlaGly: 3.047 ± 0.042	0.945AlaHis: 0.945 ± 0.019	3.797AlaIle: 3.797 ± 0.039	3.651AlaLys: 3.651 ± 0.045	4.509AlaLeu: 4.509 ± 0.042	1.045AlaMet: 1.045 ± 0.021	2.835AlaAsn: 2.835 ± 0.038	2.381AlaPro: 2.381 ± 0.042	1.977AlaGln: 1.977 ± 0.031	2.23AlaArg: 2.23 ± 0.029	4.28AlaSer: 4.28 ± 0.048	3.541AlaThr: 3.541 ± 0.044	2.944AlaVal: 2.944 ± 0.041	0.469AlaTrp: 0.469 ± 0.014	1.629AlaTyr: 1.629 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.489CysAla: 0.489 ± 0.014	0.233CysCys: 0.233 ± 0.012	0.619CysAsp: 0.619 ± 0.017	0.528CysGlu: 0.528 ± 0.013	0.589CysPhe: 0.589 ± 0.017	0.778CysGly: 0.778 ± 0.02	0.285CysHis: 0.285 ± 0.01	0.886CysIle: 0.886 ± 0.018	0.681CysLys: 0.681 ± 0.019	1.174CysLeu: 1.174 ± 0.023	0.225CysMet: 0.225 ± 0.009	0.561CysAsn: 0.561 ± 0.014	0.479CysPro: 0.479 ± 0.016	0.444CysGln: 0.444 ± 0.014	0.416CysArg: 0.416 ± 0.013	0.862CysSer: 0.862 ± 0.019	0.54CysThr: 0.54 ± 0.016	0.617CysVal: 0.617 ± 0.016	0.164CysTrp: 0.164 ± 0.01	0.426CysTyr: 0.426 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	2.552AspAla: 2.552 ± 0.036	0.607AspCys: 0.607 ± 0.015	4.37AspAsp: 4.37 ± 0.057	5.161AspGlu: 5.161 ± 0.062	2.685AspPhe: 2.685 ± 0.039	2.627AspGly: 2.627 ± 0.042	1.114AspHis: 1.114 ± 0.023	4.418AspIle: 4.418 ± 0.047	3.674AspLys: 3.674 ± 0.036	5.754AspLeu: 5.754 ± 0.053	1.042AspMet: 1.042 ± 0.021	3.079AspAsn: 3.079 ± 0.035	2.539AspPro: 2.539 ± 0.042	2.2AspGln: 2.2 ± 0.031	1.906AspArg: 1.906 ± 0.031	4.864AspSer: 4.864 ± 0.054	2.863AspThr: 2.863 ± 0.046	3.493AspVal: 3.493 ± 0.039	0.636AspTrp: 0.636 ± 0.017	2.294AspTyr: 2.294 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	3.123GluAla: 3.123 ± 0.041	0.591GluCys: 0.591 ± 0.016	4.644GluAsp: 4.644 ± 0.058	7.615GluGlu: 7.615 ± 0.108	3.152GluPhe: 3.152 ± 0.039	2.695GluGly: 2.695 ± 0.036	1.218GluHis: 1.218 ± 0.022	5.026GluIle: 5.026 ± 0.053	4.493GluLys: 4.493 ± 0.062	6.834GluLeu: 6.834 ± 0.064	1.219GluMet: 1.219 ± 0.019	3.703GluAsn: 3.703 ± 0.041	2.506GluPro: 2.506 ± 0.06	3.396GluGln: 3.396 ± 0.05	2.546GluArg: 2.546 ± 0.033	5.213GluSer: 5.213 ± 0.083	3.839GluThr: 3.839 ± 0.058	3.831GluVal: 3.831 ± 0.04	0.599GluTrp: 0.599 ± 0.016	2.492GluTyr: 2.492 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.312PheAla: 2.312 ± 0.036	0.475PheCys: 0.475 ± 0.014	2.85PheAsp: 2.85 ± 0.036	2.923PheGlu: 2.923 ± 0.037	1.885PhePhe: 1.885 ± 0.035	2.796PheGly: 2.796 ± 0.044	0.979PheHis: 0.979 ± 0.02	3.298PheIle: 3.298 ± 0.043	3.224PheLys: 3.224 ± 0.037	3.756PheLeu: 3.756 ± 0.044	0.873PheMet: 0.873 ± 0.019	3.006PheAsn: 3.006 ± 0.037	1.894PhePro: 1.894 ± 0.027	1.936PheGln: 1.936 ± 0.028	1.54PheArg: 1.54 ± 0.023	3.239PheSer: 3.239 ± 0.036	2.717PheThr: 2.717 ± 0.037	2.566PheVal: 2.566 ± 0.034	0.507PheTrp: 0.507 ± 0.014	1.537PheTyr: 1.537 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	2.955GlyAla: 2.955 ± 0.042	0.713GlyCys: 0.713 ± 0.018	2.957GlyAsp: 2.957 ± 0.044	3.135GlyGlu: 3.135 ± 0.041	2.588GlyPhe: 2.588 ± 0.033	3.879GlyGly: 3.879 ± 0.066	1.052GlyHis: 1.052 ± 0.025	3.751GlyIle: 3.751 ± 0.043	3.679GlyLys: 3.679 ± 0.043	4.756GlyLeu: 4.756 ± 0.05	0.904GlyMet: 0.904 ± 0.019	2.932GlyAsn: 2.932 ± 0.042	1.655GlyPro: 1.655 ± 0.029	1.754GlyGln: 1.754 ± 0.026	1.983GlyArg: 1.983 ± 0.036	4.443GlySer: 4.443 ± 0.045	2.978GlyThr: 2.978 ± 0.036	3.302GlyVal: 3.302 ± 0.04	0.633GlyTrp: 0.633 ± 0.017	2.153GlyTyr: 2.153 ± 0.032	0.001GlyXaa: 0.001 ± 0.001
His	0.99HisAla: 0.99 ± 0.018	0.247HisCys: 0.247 ± 0.01	1.254HisAsp: 1.254 ± 0.022	1.43HisGlu: 1.43 ± 0.025	0.907HisPhe: 0.907 ± 0.017	1.132HisGly: 1.132 ± 0.022	0.797HisHis: 0.797 ± 0.025	1.47HisIle: 1.47 ± 0.023	1.28HisLys: 1.28 ± 0.024	1.976HisLeu: 1.976 ± 0.03	0.363HisMet: 0.363 ± 0.014	1.108HisAsn: 1.108 ± 0.025	1.169HisPro: 1.169 ± 0.024	1.095HisGln: 1.095 ± 0.022	0.903HisArg: 0.903 ± 0.018	1.675HisSer: 1.675 ± 0.027	1.141HisThr: 1.141 ± 0.022	1.086HisVal: 1.086 ± 0.021	0.213HisTrp: 0.213 ± 0.008	0.778HisTyr: 0.778 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.717IleAla: 3.717 ± 0.037	0.87IleCys: 0.87 ± 0.02	4.667IleAsp: 4.667 ± 0.045	4.88IleGlu: 4.88 ± 0.051	2.95IlePhe: 2.95 ± 0.037	3.637IleGly: 3.637 ± 0.044	1.583IleHis: 1.583 ± 0.022	5.207IleIle: 5.207 ± 0.059	4.983IleLys: 4.983 ± 0.049	6.427IleLeu: 6.427 ± 0.066	1.301IleMet: 1.301 ± 0.022	4.555IleAsn: 4.555 ± 0.051	3.845IlePro: 3.845 ± 0.041	2.904IleGln: 2.904 ± 0.032	2.766IleArg: 2.766 ± 0.032	6.213IleSer: 6.213 ± 0.051	4.485IleThr: 4.485 ± 0.04	4.167IleVal: 4.167 ± 0.044	0.744IleTrp: 0.744 ± 0.018	2.44IleTyr: 2.44 ± 0.036	0.001IleXaa: 0.001 ± 0.001
Lys	2.977LysAla: 2.977 ± 0.042	0.716LysCys: 0.716 ± 0.018	3.419LysAsp: 3.419 ± 0.044	4.454LysGlu: 4.454 ± 0.055	3.387LysPhe: 3.387 ± 0.041	2.648LysGly: 2.648 ± 0.032	1.515LysHis: 1.515 ± 0.025	4.561LysIle: 4.561 ± 0.044	5.52LysLys: 5.52 ± 0.073	7.766LysLeu: 7.766 ± 0.072	1.119LysMet: 1.119 ± 0.018	3.48LysAsn: 3.48 ± 0.039	3.063LysPro: 3.063 ± 0.04	3.555LysGln: 3.555 ± 0.042	3.373LysArg: 3.373 ± 0.043	5.79LysSer: 5.79 ± 0.051	3.581LysThr: 3.581 ± 0.044	3.937LysVal: 3.937 ± 0.041	0.736LysTrp: 0.736 ± 0.021	2.974LysTyr: 2.974 ± 0.036	0.001LysXaa: 0.001 ± 0.001
Leu	5.21LeuAla: 5.21 ± 0.053	1.051LeuCys: 1.051 ± 0.02	5.266LeuAsp: 5.266 ± 0.043	5.811LeuGlu: 5.811 ± 0.06	4.012LeuPhe: 4.012 ± 0.052	4.702LeuGly: 4.702 ± 0.051	1.946LeuHis: 1.946 ± 0.029	6.815LeuIle: 6.815 ± 0.075	6.509LeuLys: 6.509 ± 0.056	8.608LeuLeu: 8.608 ± 0.089	1.693LeuMet: 1.693 ± 0.027	5.828LeuAsn: 5.828 ± 0.051	4.439LeuPro: 4.439 ± 0.045	4.15LeuGln: 4.15 ± 0.047	3.806LeuArg: 3.806 ± 0.041	7.719LeuSer: 7.719 ± 0.066	5.851LeuThr: 5.851 ± 0.058	5.548LeuVal: 5.548 ± 0.052	0.761LeuTrp: 0.761 ± 0.017	3.198LeuTyr: 3.198 ± 0.04	0.001LeuXaa: 0.001 ± 0.001
Met	1.11MetAla: 1.11 ± 0.022	0.194MetCys: 0.194 ± 0.008	1.009MetAsp: 1.009 ± 0.02	1.028MetGlu: 1.028 ± 0.02	0.857MetPhe: 0.857 ± 0.022	1.034MetGly: 1.034 ± 0.021	0.274MetHis: 0.274 ± 0.012	1.357MetIle: 1.357 ± 0.022	1.279MetLys: 1.279 ± 0.018	1.596MetLeu: 1.596 ± 0.025	0.427MetMet: 0.427 ± 0.014	1.176MetAsn: 1.176 ± 0.023	0.694MetPro: 0.694 ± 0.018	0.537MetGln: 0.537 ± 0.015	0.64MetArg: 0.64 ± 0.017	1.868MetSer: 1.868 ± 0.029	1.15MetThr: 1.15 ± 0.022	1.087MetVal: 1.087 ± 0.02	0.148MetTrp: 0.148 ± 0.008	0.64MetTyr: 0.64 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.467AsnAla: 2.467 ± 0.032	0.651AsnCys: 0.651 ± 0.016	3.362AsnAsp: 3.362 ± 0.041	3.724AsnGlu: 3.724 ± 0.042	2.518AsnPhe: 2.518 ± 0.031	3.022AsnGly: 3.022 ± 0.041	1.311AsnHis: 1.311 ± 0.024	4.144AsnIle: 4.144 ± 0.041	4.127AsnLys: 4.127 ± 0.045	5.563AsnLeu: 5.563 ± 0.049	0.989AsnMet: 0.989 ± 0.02	4.17AsnAsn: 4.17 ± 0.056	2.81AsnPro: 2.81 ± 0.04	2.796AsnGln: 2.796 ± 0.04	2.041AsnArg: 2.041 ± 0.026	5.316AsnSer: 5.316 ± 0.053	3.231AsnThr: 3.231 ± 0.037	3.111AsnVal: 3.111 ± 0.041	0.698AsnTrp: 0.698 ± 0.014	2.372AsnTyr: 2.372 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.392ProAla: 2.392 ± 0.036	0.344ProCys: 0.344 ± 0.014	2.336ProAsp: 2.336 ± 0.033	3.45ProGlu: 3.45 ± 0.051	1.843ProPhe: 1.843 ± 0.025	2.371ProGly: 2.371 ± 0.038	0.956ProHis: 0.956 ± 0.019	3.421ProIle: 3.421 ± 0.039	3.045ProLys: 3.045 ± 0.042	3.606ProLeu: 3.606 ± 0.038	0.783ProMet: 0.783 ± 0.018	2.667ProAsn: 2.667 ± 0.046	3.411ProPro: 3.411 ± 0.09	2.459ProGln: 2.459 ± 0.045	1.762ProArg: 1.762 ± 0.03	4.143ProSer: 4.143 ± 0.061	3.354ProThr: 3.354 ± 0.051	2.888ProVal: 2.888 ± 0.033	0.414ProTrp: 0.414 ± 0.013	1.439ProTyr: 1.439 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	2.402GlnAla: 2.402 ± 0.037	0.439GlnCys: 0.439 ± 0.014	2.626GlnAsp: 2.626 ± 0.036	3.636GlnGlu: 3.636 ± 0.046	2.104GlnPhe: 2.104 ± 0.032	2.068GlnGly: 2.068 ± 0.03	1.045GlnHis: 1.045 ± 0.021	2.864GlnIle: 2.864 ± 0.035	2.195GlnLys: 2.195 ± 0.03	4.553GlnLeu: 4.553 ± 0.051	0.756GlnMet: 0.756 ± 0.018	1.796GlnAsn: 1.796 ± 0.026	2.392GlnPro: 2.392 ± 0.045	4.629GlnGln: 4.629 ± 0.143	1.762GlnArg: 1.762 ± 0.027	3.201GlnSer: 3.201 ± 0.036	2.304GlnThr: 2.304 ± 0.031	2.563GlnVal: 2.563 ± 0.036	0.404GlnTrp: 0.404 ± 0.011	1.632GlnTyr: 1.632 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.103ArgAla: 2.103 ± 0.032	0.423ArgCys: 0.423 ± 0.012	2.205ArgAsp: 2.205 ± 0.027	2.606ArgGlu: 2.606 ± 0.037	1.856ArgPhe: 1.856 ± 0.029	2.039ArgGly: 2.039 ± 0.035	0.888ArgHis: 0.888 ± 0.019	2.953ArgIle: 2.953 ± 0.035	3.198ArgLys: 3.198 ± 0.041	3.784ArgLeu: 3.784 ± 0.039	0.759ArgMet: 0.759 ± 0.016	2.262ArgAsn: 2.262 ± 0.032	1.543ArgPro: 1.543 ± 0.029	1.749ArgGln: 1.749 ± 0.027	2.356ArgArg: 2.356 ± 0.036	3.125ArgSer: 3.125 ± 0.042	2.128ArgThr: 2.128 ± 0.029	2.18ArgVal: 2.18 ± 0.03	0.382ArgTrp: 0.382 ± 0.015	1.395ArgTyr: 1.395 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	3.887SerAla: 3.887 ± 0.04	0.812SerCys: 0.812 ± 0.018	4.464SerAsp: 4.464 ± 0.047	4.986SerGlu: 4.986 ± 0.061	3.694SerPhe: 3.694 ± 0.04	4.577SerGly: 4.577 ± 0.049	1.702SerHis: 1.702 ± 0.027	6.607SerIle: 6.607 ± 0.054	5.836SerLys: 5.836 ± 0.055	7.504SerLeu: 7.504 ± 0.06	1.588SerMet: 1.588 ± 0.022	5.307SerAsn: 5.307 ± 0.057	4.174SerPro: 4.174 ± 0.064	3.543SerGln: 3.543 ± 0.038	3.442SerArg: 3.442 ± 0.039	9.602SerSer: 9.602 ± 0.127	6.34SerThr: 6.34 ± 0.112	4.357SerVal: 4.357 ± 0.045	0.821SerTrp: 0.821 ± 0.018	2.699SerTyr: 2.699 ± 0.034	0.001SerXaa: 0.001 ± 0.0
Thr	3.138ThrAla: 3.138 ± 0.053	0.67ThrCys: 0.67 ± 0.02	2.972ThrAsp: 2.972 ± 0.057	3.511ThrGlu: 3.511 ± 0.103	2.46ThrPhe: 2.46 ± 0.032	3.502ThrGly: 3.502 ± 0.05	1.156ThrHis: 1.156 ± 0.019	4.551ThrIle: 4.551 ± 0.044	4.092ThrLys: 4.092 ± 0.042	5.002ThrLeu: 5.002 ± 0.048	1.044ThrMet: 1.044 ± 0.024	3.72ThrAsn: 3.72 ± 0.041	3.572ThrPro: 3.572 ± 0.043	2.164ThrGln: 2.164 ± 0.035	2.433ThrArg: 2.433 ± 0.031	6.143ThrSer: 6.143 ± 0.071	5.927ThrThr: 5.927 ± 0.135	3.288ThrVal: 3.288 ± 0.038	0.597ThrTrp: 0.597 ± 0.02	1.857ThrTyr: 1.857 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	3.279ValAla: 3.279 ± 0.043	0.67ValCys: 0.67 ± 0.016	3.653ValAsp: 3.653 ± 0.04	4.143ValGlu: 4.143 ± 0.042	2.457ValPhe: 2.457 ± 0.039	3.119ValGly: 3.119 ± 0.041	1.155ValHis: 1.155 ± 0.021	3.975ValIle: 3.975 ± 0.043	4.095ValLys: 4.095 ± 0.049	5.103ValLeu: 5.103 ± 0.045	1.08ValMet: 1.08 ± 0.023	3.34ValAsn: 3.34 ± 0.042	2.716ValPro: 2.716 ± 0.034	2.062ValGln: 2.062 ± 0.03	2.173ValArg: 2.173 ± 0.034	4.616ValSer: 4.616 ± 0.044	3.242ValThr: 3.242 ± 0.043	3.897ValVal: 3.897 ± 0.047	0.573ValTrp: 0.573 ± 0.017	1.989ValTyr: 1.989 ± 0.029	0.001ValXaa: 0.001 ± 0.001
Trp	0.483TrpAla: 0.483 ± 0.013	0.198TrpCys: 0.198 ± 0.009	0.642TrpAsp: 0.642 ± 0.02	0.586TrpGlu: 0.586 ± 0.016	0.549TrpPhe: 0.549 ± 0.015	0.55TrpGly: 0.55 ± 0.017	0.186TrpHis: 0.186 ± 0.009	0.727TrpIle: 0.727 ± 0.017	0.782TrpLys: 0.782 ± 0.016	0.993TrpLeu: 0.993 ± 0.02	0.209TrpMet: 0.209 ± 0.009	0.642TrpAsn: 0.642 ± 0.014	0.289TrpPro: 0.289 ± 0.011	0.351TrpGln: 0.351 ± 0.014	0.448TrpArg: 0.448 ± 0.014	0.758TrpSer: 0.758 ± 0.016	0.519TrpThr: 0.519 ± 0.013	0.554TrpVal: 0.554 ± 0.016	0.167TrpTrp: 0.167 ± 0.008	0.443TrpTyr: 0.443 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.594TyrAla: 1.594 ± 0.026	0.49TyrCys: 0.49 ± 0.016	2.239TyrAsp: 2.239 ± 0.029	2.199TyrGlu: 2.199 ± 0.03	1.765TyrPhe: 1.765 ± 0.026	1.98TyrGly: 1.98 ± 0.029	0.91TyrHis: 0.91 ± 0.022	2.514TyrIle: 2.514 ± 0.031	2.228TyrLys: 2.228 ± 0.029	3.659TyrLeu: 3.659 ± 0.036	0.686TyrMet: 0.686 ± 0.016	2.259TyrAsn: 2.259 ± 0.028	1.514TyrPro: 1.514 ± 0.023	1.673TyrGln: 1.673 ± 0.029	1.406TyrArg: 1.406 ± 0.023	2.874TyrSer: 2.874 ± 0.033	2.068TyrThr: 2.068 ± 0.059	1.922TyrVal: 1.922 ± 0.032	0.408TyrTrp: 0.408 ± 0.015	1.554TyrTyr: 1.554 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 5246 proteins (2781732 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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