Amino acid dipepetide frequency for Lloviu cuevavirus (isolate Bat/Spain/Asturias-Bat86/2003)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.122AlaAla: 4.122 ± 0.916
1.178AlaCys: 1.178 ± 0.315
2.748AlaAsp: 2.748 ± 0.557
4.122AlaGlu: 4.122 ± 0.766
2.944AlaPhe: 2.944 ± 0.628
2.944AlaGly: 2.944 ± 1.407
0.981AlaHis: 0.981 ± 0.723
3.925AlaIle: 3.925 ± 0.359
2.159AlaLys: 2.159 ± 0.559
7.851AlaLeu: 7.851 ± 1.26
0.196AlaMet: 0.196 ± 0.232
3.337AlaAsn: 3.337 ± 0.542
2.944AlaPro: 2.944 ± 0.735
1.963AlaGln: 1.963 ± 0.601
4.907AlaArg: 4.907 ± 0.954
6.084AlaSer: 6.084 ± 0.916
4.514AlaThr: 4.514 ± 1.084
2.944AlaVal: 2.944 ± 1.117
0.981AlaTrp: 0.981 ± 0.484
1.374AlaTyr: 1.374 ± 0.53
0.0AlaXaa: 0.0 ± 0.0
Cys
0.589CysAla: 0.589 ± 0.324
0.393CysCys: 0.393 ± 0.247
0.785CysAsp: 0.785 ± 0.754
1.57CysGlu: 1.57 ± 0.634
0.196CysPhe: 0.196 ± 0.133
0.785CysGly: 0.785 ± 0.465
0.393CysHis: 0.393 ± 0.404
0.981CysIle: 0.981 ± 0.364
1.178CysLys: 1.178 ± 0.426
1.963CysLeu: 1.963 ± 0.53
0.0CysMet: 0.0 ± 0.0
1.374CysAsn: 1.374 ± 0.442
1.57CysPro: 1.57 ± 0.822
0.981CysGln: 0.981 ± 0.384
1.766CysArg: 1.766 ± 0.676
1.766CysSer: 1.766 ± 0.918
0.785CysThr: 0.785 ± 0.347
1.178CysVal: 1.178 ± 0.467
0.785CysTrp: 0.785 ± 0.401
0.785CysTyr: 0.785 ± 0.285
0.0CysXaa: 0.0 ± 0.0
Asp
2.944AspAla: 2.944 ± 0.549
0.589AspCys: 0.589 ± 0.252
2.159AspAsp: 2.159 ± 1.483
2.159AspGlu: 2.159 ± 0.981
1.374AspPhe: 1.374 ± 0.718
1.963AspGly: 1.963 ± 0.478
2.552AspHis: 2.552 ± 0.769
2.944AspIle: 2.944 ± 0.866
3.14AspLys: 3.14 ± 0.39
6.673AspLeu: 6.673 ± 1.7
0.393AspMet: 0.393 ± 0.186
2.159AspAsn: 2.159 ± 0.651
2.748AspPro: 2.748 ± 0.628
2.944AspGln: 2.944 ± 0.502
1.963AspArg: 1.963 ± 0.438
2.355AspSer: 2.355 ± 0.572
2.355AspThr: 2.355 ± 0.544
1.57AspVal: 1.57 ± 0.472
1.57AspTrp: 1.57 ± 0.9
2.944AspTyr: 2.944 ± 0.484
0.0AspXaa: 0.0 ± 0.0
Glu
4.122GluAla: 4.122 ± 1.11
0.196GluCys: 0.196 ± 0.133
3.337GluAsp: 3.337 ± 0.775
2.748GluGlu: 2.748 ± 1.583
1.766GluPhe: 1.766 ± 0.381
4.907GluGly: 4.907 ± 0.734
1.963GluHis: 1.963 ± 0.894
3.729GluIle: 3.729 ± 1.271
1.766GluLys: 1.766 ± 0.502
6.673GluLeu: 6.673 ± 1.086
0.785GluMet: 0.785 ± 0.632
2.552GluAsn: 2.552 ± 0.825
2.944GluPro: 2.944 ± 0.36
3.925GluGln: 3.925 ± 0.966
3.14GluArg: 3.14 ± 0.742
3.337GluSer: 3.337 ± 1.209
3.14GluThr: 3.14 ± 0.422
1.57GluVal: 1.57 ± 0.424
1.178GluTrp: 1.178 ± 0.361
0.981GluTyr: 0.981 ± 0.491
0.0GluXaa: 0.0 ± 0.0
Phe
1.178PheAla: 1.178 ± 0.413
0.981PheCys: 0.981 ± 0.533
1.57PheAsp: 1.57 ± 0.395
2.552PheGlu: 2.552 ± 0.606
1.963PhePhe: 1.963 ± 0.754
1.766PheGly: 1.766 ± 0.653
2.355PheHis: 2.355 ± 0.709
1.766PheIle: 1.766 ± 0.564
2.552PheLys: 2.552 ± 1.053
5.692PheLeu: 5.692 ± 1.219
0.393PheMet: 0.393 ± 0.202
1.178PheAsn: 1.178 ± 0.527
2.552PhePro: 2.552 ± 0.973
0.785PheGln: 0.785 ± 0.471
2.159PheArg: 2.159 ± 0.864
2.552PheSer: 2.552 ± 0.9
1.766PheThr: 1.766 ± 0.511
1.57PheVal: 1.57 ± 0.867
0.393PheTrp: 0.393 ± 0.247
0.785PheTyr: 0.785 ± 0.353
0.0PheXaa: 0.0 ± 0.0
Gly
2.748GlyAla: 2.748 ± 0.538
0.589GlyCys: 0.589 ± 0.445
3.729GlyAsp: 3.729 ± 0.517
2.355GlyGlu: 2.355 ± 0.497
2.159GlyPhe: 2.159 ± 0.553
4.318GlyGly: 4.318 ± 1.506
2.159GlyHis: 2.159 ± 0.813
3.14GlyIle: 3.14 ± 0.843
3.337GlyLys: 3.337 ± 0.983
6.869GlyLeu: 6.869 ± 1.443
1.178GlyMet: 1.178 ± 0.498
2.552GlyAsn: 2.552 ± 0.556
2.944GlyPro: 2.944 ± 1.115
2.159GlyGln: 2.159 ± 0.582
3.925GlyArg: 3.925 ± 0.947
4.711GlySer: 4.711 ± 1.207
3.14GlyThr: 3.14 ± 0.559
3.729GlyVal: 3.729 ± 1.145
1.374GlyTrp: 1.374 ± 0.676
2.159GlyTyr: 2.159 ± 0.717
0.0GlyXaa: 0.0 ± 0.0
His
1.963HisAla: 1.963 ± 0.297
0.785HisCys: 0.785 ± 0.531
1.374HisAsp: 1.374 ± 0.367
1.963HisGlu: 1.963 ± 0.723
1.178HisPhe: 1.178 ± 0.431
2.552HisGly: 2.552 ± 1.142
0.981HisHis: 0.981 ± 0.544
2.159HisIle: 2.159 ± 0.612
0.196HisLys: 0.196 ± 0.258
2.552HisLeu: 2.552 ± 0.607
0.589HisMet: 0.589 ± 0.352
1.178HisAsn: 1.178 ± 0.721
2.159HisPro: 2.159 ± 0.59
1.766HisGln: 1.766 ± 0.888
2.159HisArg: 2.159 ± 0.662
2.355HisSer: 2.355 ± 0.659
1.374HisThr: 1.374 ± 0.525
1.963HisVal: 1.963 ± 0.78
0.785HisTrp: 0.785 ± 0.305
1.57HisTyr: 1.57 ± 0.406
0.0HisXaa: 0.0 ± 0.0
Ile
2.748IleAla: 2.748 ± 0.503
0.785IleCys: 0.785 ± 0.322
2.159IleAsp: 2.159 ± 0.609
2.552IleGlu: 2.552 ± 0.55
2.355IlePhe: 2.355 ± 1.139
3.337IleGly: 3.337 ± 1.114
1.178IleHis: 1.178 ± 0.657
3.14IleIle: 3.14 ± 0.783
3.729IleLys: 3.729 ± 1.446
6.281IleLeu: 6.281 ± 1.197
1.57IleMet: 1.57 ± 0.74
2.944IleAsn: 2.944 ± 0.789
4.318IlePro: 4.318 ± 1.509
3.925IleGln: 3.925 ± 0.739
2.944IleArg: 2.944 ± 0.824
4.122IleSer: 4.122 ± 0.857
4.514IleThr: 4.514 ± 0.886
2.748IleVal: 2.748 ± 0.664
0.196IleTrp: 0.196 ± 0.22
1.766IleTyr: 1.766 ± 0.547
0.0IleXaa: 0.0 ± 0.0
Lys
2.355LysAla: 2.355 ± 0.717
1.178LysCys: 1.178 ± 0.435
3.533LysAsp: 3.533 ± 0.788
2.944LysGlu: 2.944 ± 0.988
1.178LysPhe: 1.178 ± 0.643
2.944LysGly: 2.944 ± 0.781
2.748LysHis: 2.748 ± 0.754
2.748LysIle: 2.748 ± 0.766
3.337LysLys: 3.337 ± 0.633
4.514LysLeu: 4.514 ± 1.299
0.785LysMet: 0.785 ± 0.353
2.355LysAsn: 2.355 ± 0.921
2.552LysPro: 2.552 ± 0.749
1.374LysGln: 1.374 ± 0.763
1.57LysArg: 1.57 ± 0.424
3.337LysSer: 3.337 ± 1.028
4.711LysThr: 4.711 ± 0.696
2.355LysVal: 2.355 ± 0.634
0.393LysTrp: 0.393 ± 0.265
1.57LysTyr: 1.57 ± 0.631
0.0LysXaa: 0.0 ± 0.0
Leu
9.225LeuAla: 9.225 ± 1.561
2.748LeuCys: 2.748 ± 0.997
4.318LeuAsp: 4.318 ± 0.582
6.869LeuGlu: 6.869 ± 0.619
4.711LeuPhe: 4.711 ± 0.879
9.028LeuGly: 9.028 ± 1.544
2.944LeuHis: 2.944 ± 0.796
5.496LeuIle: 5.496 ± 0.676
5.299LeuLys: 5.299 ± 1.088
13.15LeuLeu: 13.15 ± 1.428
1.178LeuMet: 1.178 ± 0.521
4.711LeuAsn: 4.711 ± 1.366
6.281LeuPro: 6.281 ± 1.164
4.907LeuGln: 4.907 ± 0.713
7.655LeuArg: 7.655 ± 1.04
8.832LeuSer: 8.832 ± 2.04
7.262LeuThr: 7.262 ± 1.022
6.869LeuVal: 6.869 ± 1.873
1.57LeuTrp: 1.57 ± 0.414
3.533LeuTyr: 3.533 ± 0.82
0.0LeuXaa: 0.0 ± 0.0
Met
1.57MetAla: 1.57 ± 0.371
0.0MetCys: 0.0 ± 0.0
0.981MetAsp: 0.981 ± 0.35
0.981MetGlu: 0.981 ± 0.719
0.785MetPhe: 0.785 ± 0.299
0.981MetGly: 0.981 ± 0.359
0.785MetHis: 0.785 ± 0.37
0.589MetIle: 0.589 ± 0.398
0.196MetLys: 0.196 ± 0.133
1.374MetLeu: 1.374 ± 0.599
0.785MetMet: 0.785 ± 0.372
0.981MetAsn: 0.981 ± 0.491
0.589MetPro: 0.589 ± 0.316
0.981MetGln: 0.981 ± 0.425
0.393MetArg: 0.393 ± 0.186
2.944MetSer: 2.944 ± 0.462
1.374MetThr: 1.374 ± 0.791
1.57MetVal: 1.57 ± 0.309
0.0MetTrp: 0.0 ± 0.0
0.196MetTyr: 0.196 ± 0.19
0.0MetXaa: 0.0 ± 0.0
Asn
2.552AsnAla: 2.552 ± 0.803
0.785AsnCys: 0.785 ± 0.525
1.766AsnAsp: 1.766 ± 0.479
1.766AsnGlu: 1.766 ± 0.589
1.963AsnPhe: 1.963 ± 0.817
0.196AsnGly: 0.196 ± 0.133
2.159AsnHis: 2.159 ± 0.721
2.355AsnIle: 2.355 ± 0.496
2.355AsnLys: 2.355 ± 0.607
5.496AsnLeu: 5.496 ± 0.824
0.981AsnMet: 0.981 ± 0.275
3.337AsnAsn: 3.337 ± 1.266
3.337AsnPro: 3.337 ± 1.408
1.374AsnGln: 1.374 ± 0.654
2.355AsnArg: 2.355 ± 0.434
3.729AsnSer: 3.729 ± 0.858
4.711AsnThr: 4.711 ± 1.135
2.159AsnVal: 2.159 ± 0.601
0.589AsnTrp: 0.589 ± 0.261
1.57AsnTyr: 1.57 ± 0.349
0.0AsnXaa: 0.0 ± 0.0
Pro
2.355ProAla: 2.355 ± 1.273
1.57ProCys: 1.57 ± 0.903
3.337ProAsp: 3.337 ± 0.764
1.963ProGlu: 1.963 ± 0.557
0.785ProPhe: 0.785 ± 0.279
4.907ProGly: 4.907 ± 1.91
1.963ProHis: 1.963 ± 0.44
1.963ProIle: 1.963 ± 0.647
2.944ProLys: 2.944 ± 1.195
8.047ProLeu: 8.047 ± 1.287
0.589ProMet: 0.589 ± 0.265
2.159ProAsn: 2.159 ± 1.096
5.496ProPro: 5.496 ± 2.006
1.766ProGln: 1.766 ± 0.7
2.748ProArg: 2.748 ± 0.782
5.103ProSer: 5.103 ± 1.251
5.692ProThr: 5.692 ± 1.721
3.14ProVal: 3.14 ± 0.73
1.178ProTrp: 1.178 ± 0.574
1.766ProTyr: 1.766 ± 0.544
0.0ProXaa: 0.0 ± 0.0
Gln
3.14GlnAla: 3.14 ± 0.913
1.178GlnCys: 1.178 ± 0.701
2.159GlnAsp: 2.159 ± 0.527
4.514GlnGlu: 4.514 ± 0.54
1.374GlnPhe: 1.374 ± 0.336
1.963GlnGly: 1.963 ± 0.665
1.963GlnHis: 1.963 ± 0.753
2.355GlnIle: 2.355 ± 0.612
3.14GlnLys: 3.14 ± 0.42
4.907GlnLeu: 4.907 ± 1.396
0.981GlnMet: 0.981 ± 0.419
1.374GlnAsn: 1.374 ± 0.518
2.355GlnPro: 2.355 ± 0.582
2.944GlnGln: 2.944 ± 0.885
0.589GlnArg: 0.589 ± 0.258
3.533GlnSer: 3.533 ± 0.715
2.552GlnThr: 2.552 ± 0.952
2.748GlnVal: 2.748 ± 0.627
0.589GlnTrp: 0.589 ± 0.258
1.766GlnTyr: 1.766 ± 0.86
0.0GlnXaa: 0.0 ± 0.0
Arg
4.318ArgAla: 4.318 ± 0.824
0.981ArgCys: 0.981 ± 0.474
2.159ArgAsp: 2.159 ± 0.718
3.925ArgGlu: 3.925 ± 0.777
1.178ArgPhe: 1.178 ± 0.389
2.944ArgGly: 2.944 ± 0.817
1.374ArgHis: 1.374 ± 0.647
3.337ArgIle: 3.337 ± 1.206
2.552ArgLys: 2.552 ± 0.974
6.673ArgLeu: 6.673 ± 0.89
1.766ArgMet: 1.766 ± 0.718
2.159ArgAsn: 2.159 ± 0.714
3.729ArgPro: 3.729 ± 0.899
2.159ArgGln: 2.159 ± 0.745
3.337ArgArg: 3.337 ± 0.848
4.122ArgSer: 4.122 ± 0.864
3.533ArgThr: 3.533 ± 0.569
1.766ArgVal: 1.766 ± 0.398
0.785ArgTrp: 0.785 ± 0.375
2.355ArgTyr: 2.355 ± 0.587
0.0ArgXaa: 0.0 ± 0.0
Ser
6.281SerAla: 6.281 ± 1.089
1.963SerCys: 1.963 ± 0.625
3.14SerAsp: 3.14 ± 1.091
3.729SerGlu: 3.729 ± 1.188
4.122SerPhe: 4.122 ± 1.108
5.103SerGly: 5.103 ± 0.892
1.766SerHis: 1.766 ± 0.258
5.692SerIle: 5.692 ± 0.766
2.355SerLys: 2.355 ± 0.788
7.851SerLeu: 7.851 ± 1.386
1.374SerMet: 1.374 ± 0.62
3.925SerAsn: 3.925 ± 0.856
2.748SerPro: 2.748 ± 1.249
3.533SerGln: 3.533 ± 0.879
5.299SerArg: 5.299 ± 0.754
6.869SerSer: 6.869 ± 1.22
4.711SerThr: 4.711 ± 0.753
2.944SerVal: 2.944 ± 0.76
1.178SerTrp: 1.178 ± 0.379
2.159SerTyr: 2.159 ± 1.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.925ThrAla: 3.925 ± 1.365
0.981ThrCys: 0.981 ± 0.52
3.729ThrAsp: 3.729 ± 0.4
4.514ThrGlu: 4.514 ± 1.407
3.337ThrPhe: 3.337 ± 0.624
4.122ThrGly: 4.122 ± 1.115
1.178ThrHis: 1.178 ± 0.417
5.103ThrIle: 5.103 ± 1.152
4.122ThrLys: 4.122 ± 0.878
7.851ThrLeu: 7.851 ± 1.327
1.374ThrMet: 1.374 ± 0.276
1.963ThrAsn: 1.963 ± 0.467
3.337ThrPro: 3.337 ± 1.307
3.337ThrGln: 3.337 ± 0.9
3.925ThrArg: 3.925 ± 1.109
5.692ThrSer: 5.692 ± 1.402
6.281ThrThr: 6.281 ± 2.724
2.355ThrVal: 2.355 ± 0.472
0.981ThrTrp: 0.981 ± 0.439
0.785ThrTyr: 0.785 ± 0.303
0.0ThrXaa: 0.0 ± 0.0
Val
3.925ValAla: 3.925 ± 0.537
2.159ValCys: 2.159 ± 1.213
1.374ValAsp: 1.374 ± 0.571
2.159ValGlu: 2.159 ± 0.651
2.159ValPhe: 2.159 ± 0.842
2.748ValGly: 2.748 ± 1.245
0.981ValHis: 0.981 ± 0.296
2.552ValIle: 2.552 ± 0.706
2.552ValLys: 2.552 ± 0.779
5.692ValLeu: 5.692 ± 1.564
1.57ValMet: 1.57 ± 0.414
2.159ValAsn: 2.159 ± 0.828
3.533ValPro: 3.533 ± 0.795
2.355ValGln: 2.355 ± 0.651
2.159ValArg: 2.159 ± 0.597
2.159ValSer: 2.159 ± 0.444
3.337ValThr: 3.337 ± 0.718
2.944ValVal: 2.944 ± 0.752
1.178ValTrp: 1.178 ± 1.199
0.589ValTyr: 0.589 ± 0.49
0.0ValXaa: 0.0 ± 0.0
Trp
0.785TrpAla: 0.785 ± 0.673
0.393TrpCys: 0.393 ± 0.233
0.785TrpAsp: 0.785 ± 0.448
1.374TrpGlu: 1.374 ± 0.439
0.589TrpPhe: 0.589 ± 0.3
0.981TrpGly: 0.981 ± 0.32
0.196TrpHis: 0.196 ± 0.133
1.374TrpIle: 1.374 ± 0.772
0.785TrpLys: 0.785 ± 0.252
1.766TrpLeu: 1.766 ± 0.715
0.785TrpMet: 0.785 ± 0.461
0.196TrpAsn: 0.196 ± 0.258
0.196TrpPro: 0.196 ± 0.19
0.981TrpGln: 0.981 ± 0.56
0.589TrpArg: 0.589 ± 0.265
0.785TrpSer: 0.785 ± 0.299
1.57TrpThr: 1.57 ± 0.736
1.374TrpVal: 1.374 ± 0.493
0.0TrpTrp: 0.0 ± 0.0
0.981TrpTyr: 0.981 ± 0.663
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.374TyrAla: 1.374 ± 0.464
0.393TyrCys: 0.393 ± 0.265
2.355TyrAsp: 2.355 ± 0.494
0.0TyrGlu: 0.0 ± 0.0
0.393TyrPhe: 0.393 ± 0.265
0.785TyrGly: 0.785 ± 0.321
0.981TyrHis: 0.981 ± 0.506
1.963TyrIle: 1.963 ± 0.662
0.785TyrLys: 0.785 ± 0.247
4.907TyrLeu: 4.907 ± 2.058
0.589TyrMet: 0.589 ± 0.398
2.944TyrAsn: 2.944 ± 0.618
3.14TyrPro: 3.14 ± 0.83
1.963TyrGln: 1.963 ± 0.568
1.57TyrArg: 1.57 ± 1.061
2.355TyrSer: 2.355 ± 0.758
1.57TyrThr: 1.57 ± 0.713
0.785TyrVal: 0.785 ± 0.414
0.785TyrTrp: 0.785 ± 0.383
1.57TyrTyr: 1.57 ± 0.504
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (5096 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski