Amino acid dipepetide frequency for Mycetocola reblochoni REB411

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.583AlaAla: 21.583 ± 0.291
0.599AlaCys: 0.599 ± 0.024
8.787AlaAsp: 8.787 ± 0.133
9.664AlaGlu: 9.664 ± 0.149
3.425AlaPhe: 3.425 ± 0.069
13.049AlaGly: 13.049 ± 0.15
2.303AlaHis: 2.303 ± 0.064
5.476AlaIle: 5.476 ± 0.093
2.111AlaLys: 2.111 ± 0.068
14.385AlaLeu: 14.385 ± 0.153
2.256AlaMet: 2.256 ± 0.051
2.055AlaAsn: 2.055 ± 0.057
6.802AlaPro: 6.802 ± 0.108
3.619AlaGln: 3.619 ± 0.075
9.337AlaArg: 9.337 ± 0.145
7.68AlaSer: 7.68 ± 0.114
7.753AlaThr: 7.753 ± 0.117
12.788AlaVal: 12.788 ± 0.167
1.613AlaTrp: 1.613 ± 0.055
2.08AlaTyr: 2.08 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.625CysAla: 0.625 ± 0.027
0.037CysCys: 0.037 ± 0.006
0.246CysAsp: 0.246 ± 0.016
0.2CysGlu: 0.2 ± 0.017
0.151CysPhe: 0.151 ± 0.012
0.544CysGly: 0.544 ± 0.026
0.103CysHis: 0.103 ± 0.01
0.152CysIle: 0.152 ± 0.014
0.05CysLys: 0.05 ± 0.008
0.401CysLeu: 0.401 ± 0.023
0.064CysMet: 0.064 ± 0.009
0.09CysAsn: 0.09 ± 0.012
0.237CysPro: 0.237 ± 0.015
0.097CysGln: 0.097 ± 0.009
0.294CysArg: 0.294 ± 0.021
0.333CysSer: 0.333 ± 0.021
0.315CysThr: 0.315 ± 0.02
0.383CysVal: 0.383 ± 0.023
0.061CysTrp: 0.061 ± 0.008
0.1CysTyr: 0.1 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
9.516AspAla: 9.516 ± 0.15
0.249AspCys: 0.249 ± 0.018
4.656AspAsp: 4.656 ± 0.086
4.717AspGlu: 4.717 ± 0.085
1.523AspPhe: 1.523 ± 0.046
7.355AspGly: 7.355 ± 0.134
1.18AspHis: 1.18 ± 0.035
2.311AspIle: 2.311 ± 0.056
0.799AspLys: 0.799 ± 0.037
4.814AspLeu: 4.814 ± 0.074
0.777AspMet: 0.777 ± 0.032
1.032AspAsn: 1.032 ± 0.041
4.09AspPro: 4.09 ± 0.086
1.445AspGln: 1.445 ± 0.043
5.051AspArg: 5.051 ± 0.08
3.037AspSer: 3.037 ± 0.068
3.339AspThr: 3.339 ± 0.064
5.386AspVal: 5.386 ± 0.1
0.925AspTrp: 0.925 ± 0.035
1.307AspTyr: 1.307 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.897GluAla: 6.897 ± 0.121
0.225GluCys: 0.225 ± 0.016
3.058GluAsp: 3.058 ± 0.06
2.892GluGlu: 2.892 ± 0.069
1.574GluPhe: 1.574 ± 0.047
4.334GluGly: 4.334 ± 0.082
1.508GluHis: 1.508 ± 0.046
2.323GluIle: 2.323 ± 0.056
1.116GluLys: 1.116 ± 0.044
7.55GluLeu: 7.55 ± 0.107
0.83GluMet: 0.83 ± 0.034
1.147GluAsn: 1.147 ± 0.043
3.269GluPro: 3.269 ± 0.085
2.555GluGln: 2.555 ± 0.063
5.792GluArg: 5.792 ± 0.114
3.086GluSer: 3.086 ± 0.069
2.866GluThr: 2.866 ± 0.071
4.38GluVal: 4.38 ± 0.071
0.758GluTrp: 0.758 ± 0.029
1.14GluTyr: 1.14 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.678PheAla: 3.678 ± 0.074
0.148PheCys: 0.148 ± 0.013
2.135PheAsp: 2.135 ± 0.054
1.434PheGlu: 1.434 ± 0.048
0.918PhePhe: 0.918 ± 0.036
3.139PheGly: 3.139 ± 0.073
0.469PheHis: 0.469 ± 0.024
1.082PheIle: 1.082 ± 0.044
0.356PheLys: 0.356 ± 0.019
2.579PheLeu: 2.579 ± 0.06
0.388PheMet: 0.388 ± 0.024
0.593PheAsn: 0.593 ± 0.029
1.252PhePro: 1.252 ± 0.038
0.695PheGln: 0.695 ± 0.028
1.737PheArg: 1.737 ± 0.045
1.765PheSer: 1.765 ± 0.055
1.929PheThr: 1.929 ± 0.051
2.545PheVal: 2.545 ± 0.062
0.398PheTrp: 0.398 ± 0.023
0.577PheTyr: 0.577 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
11.823GlyAla: 11.823 ± 0.132
0.511GlyCys: 0.511 ± 0.025
5.644GlyAsp: 5.644 ± 0.089
5.462GlyGlu: 5.462 ± 0.093
3.109GlyPhe: 3.109 ± 0.074
8.175GlyGly: 8.175 ± 0.151
1.881GlyHis: 1.881 ± 0.053
4.455GlyIle: 4.455 ± 0.074
1.83GlyLys: 1.83 ± 0.06
8.922GlyLeu: 8.922 ± 0.112
1.817GlyMet: 1.817 ± 0.046
1.702GlyAsn: 1.702 ± 0.049
4.0GlyPro: 4.0 ± 0.073
2.701GlyGln: 2.701 ± 0.063
7.058GlyArg: 7.058 ± 0.1
6.274GlySer: 6.274 ± 0.127
6.338GlyThr: 6.338 ± 0.113
8.589GlyVal: 8.589 ± 0.118
1.581GlyTrp: 1.581 ± 0.047
2.127GlyTyr: 2.127 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.216HisAla: 2.216 ± 0.06
0.094HisCys: 0.094 ± 0.011
1.326HisAsp: 1.326 ± 0.051
1.092HisGlu: 1.092 ± 0.037
0.426HisPhe: 0.426 ± 0.025
2.021HisGly: 2.021 ± 0.053
0.485HisHis: 0.485 ± 0.023
0.675HisIle: 0.675 ± 0.029
0.23HisLys: 0.23 ± 0.018
1.761HisLeu: 1.761 ± 0.048
0.265HisMet: 0.265 ± 0.019
0.312HisAsn: 0.312 ± 0.02
1.354HisPro: 1.354 ± 0.039
0.476HisGln: 0.476 ± 0.025
1.721HisArg: 1.721 ± 0.05
0.985HisSer: 0.985 ± 0.035
0.96HisThr: 0.96 ± 0.038
1.454HisVal: 1.454 ± 0.045
0.283HisTrp: 0.283 ± 0.019
0.446HisTyr: 0.446 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.768IleAla: 6.768 ± 0.097
0.205IleCys: 0.205 ± 0.016
3.35IleAsp: 3.35 ± 0.072
2.53IleGlu: 2.53 ± 0.063
0.9IlePhe: 0.9 ± 0.039
4.709IleGly: 4.709 ± 0.084
0.577IleHis: 0.577 ± 0.024
1.715IleIle: 1.715 ± 0.054
0.658IleLys: 0.658 ± 0.033
3.323IleLeu: 3.323 ± 0.076
0.574IleMet: 0.574 ± 0.027
0.945IleAsn: 0.945 ± 0.039
2.301IlePro: 2.301 ± 0.053
0.915IleGln: 0.915 ± 0.035
2.621IleArg: 2.621 ± 0.052
2.245IleSer: 2.245 ± 0.057
2.836IleThr: 2.836 ± 0.06
4.607IleVal: 4.607 ± 0.079
0.442IleTrp: 0.442 ± 0.019
0.597IleTyr: 0.597 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
1.948LysAla: 1.948 ± 0.063
0.043LysCys: 0.043 ± 0.007
0.937LysAsp: 0.937 ± 0.036
0.771LysGlu: 0.771 ± 0.038
0.368LysPhe: 0.368 ± 0.023
1.239LysGly: 1.239 ± 0.039
0.298LysHis: 0.298 ± 0.018
0.719LysIle: 0.719 ± 0.037
0.672LysLys: 0.672 ± 0.036
1.55LysLeu: 1.55 ± 0.052
0.292LysMet: 0.292 ± 0.02
0.504LysAsn: 0.504 ± 0.027
0.994LysPro: 0.994 ± 0.039
0.568LysGln: 0.568 ± 0.03
1.366LysArg: 1.366 ± 0.047
0.923LysSer: 0.923 ± 0.04
1.16LysThr: 1.16 ± 0.041
1.294LysVal: 1.294 ± 0.051
0.18LysTrp: 0.18 ± 0.015
0.344LysTyr: 0.344 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.547LeuAla: 14.547 ± 0.177
0.515LeuCys: 0.515 ± 0.023
6.884LeuAsp: 6.884 ± 0.103
4.508LeuGlu: 4.508 ± 0.076
2.725LeuPhe: 2.725 ± 0.064
9.619LeuGly: 9.619 ± 0.123
1.785LeuHis: 1.785 ± 0.051
4.581LeuIle: 4.581 ± 0.088
1.422LeuLys: 1.422 ± 0.047
10.74LeuLeu: 10.74 ± 0.16
1.511LeuMet: 1.511 ± 0.045
1.79LeuAsn: 1.79 ± 0.049
5.415LeuPro: 5.415 ± 0.089
2.147LeuGln: 2.147 ± 0.05
7.547LeuArg: 7.547 ± 0.12
6.748LeuSer: 6.748 ± 0.091
6.335LeuThr: 6.335 ± 0.09
9.42LeuVal: 9.42 ± 0.14
1.229LeuTrp: 1.229 ± 0.048
1.568LeuTyr: 1.568 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
1.855MetAla: 1.855 ± 0.043
0.075MetCys: 0.075 ± 0.009
0.752MetAsp: 0.752 ± 0.029
0.596MetGlu: 0.596 ± 0.03
0.451MetPhe: 0.451 ± 0.023
1.135MetGly: 1.135 ± 0.038
0.269MetHis: 0.269 ± 0.018
0.789MetIle: 0.789 ± 0.033
0.32MetLys: 0.32 ± 0.021
1.675MetLeu: 1.675 ± 0.051
0.312MetMet: 0.312 ± 0.019
0.435MetAsn: 0.435 ± 0.022
0.949MetPro: 0.949 ± 0.028
0.44MetGln: 0.44 ± 0.023
1.171MetArg: 1.171 ± 0.039
1.503MetSer: 1.503 ± 0.036
1.627MetThr: 1.627 ± 0.047
1.252MetVal: 1.252 ± 0.037
0.142MetTrp: 0.142 ± 0.015
0.246MetTyr: 0.246 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.425AsnAla: 2.425 ± 0.067
0.094AsnCys: 0.094 ± 0.011
1.16AsnAsp: 1.16 ± 0.04
0.935AsnGlu: 0.935 ± 0.033
0.476AsnPhe: 0.476 ± 0.025
1.936AsnGly: 1.936 ± 0.053
0.327AsnHis: 0.327 ± 0.021
0.829AsnIle: 0.829 ± 0.038
0.349AsnLys: 0.349 ± 0.023
1.659AsnLeu: 1.659 ± 0.049
0.317AsnMet: 0.317 ± 0.019
0.424AsnAsn: 0.424 ± 0.025
1.346AsnPro: 1.346 ± 0.044
0.478AsnGln: 0.478 ± 0.026
1.307AsnArg: 1.307 ± 0.039
1.006AsnSer: 1.006 ± 0.038
1.206AsnThr: 1.206 ± 0.046
1.58AsnVal: 1.58 ± 0.045
0.28AsnTrp: 0.28 ± 0.018
0.462AsnTyr: 0.462 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
7.378ProAla: 7.378 ± 0.108
0.189ProCys: 0.189 ± 0.016
3.795ProAsp: 3.795 ± 0.074
4.141ProGlu: 4.141 ± 0.071
1.5ProPhe: 1.5 ± 0.039
5.383ProGly: 5.383 ± 0.095
1.032ProHis: 1.032 ± 0.037
1.876ProIle: 1.876 ± 0.047
0.764ProLys: 0.764 ± 0.033
5.005ProLeu: 5.005 ± 0.099
0.736ProMet: 0.736 ± 0.028
0.909ProAsn: 0.909 ± 0.035
2.138ProPro: 2.138 ± 0.06
1.307ProGln: 1.307 ± 0.041
3.672ProArg: 3.672 ± 0.075
3.856ProSer: 3.856 ± 0.07
3.118ProThr: 3.118 ± 0.086
5.133ProVal: 5.133 ± 0.079
0.76ProTrp: 0.76 ± 0.035
0.969ProTyr: 0.969 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.365GlnAla: 3.365 ± 0.066
0.094GlnCys: 0.094 ± 0.011
1.373GlnAsp: 1.373 ± 0.037
1.239GlnGlu: 1.239 ± 0.043
0.739GlnPhe: 0.739 ± 0.028
2.025GlnGly: 2.025 ± 0.053
0.597GlnHis: 0.597 ± 0.027
1.381GlnIle: 1.381 ± 0.046
0.633GlnLys: 0.633 ± 0.029
3.181GlnLeu: 3.181 ± 0.06
0.478GlnMet: 0.478 ± 0.024
0.648GlnAsn: 0.648 ± 0.029
1.344GlnPro: 1.344 ± 0.047
1.006GlnGln: 1.006 ± 0.042
2.445GlnArg: 2.445 ± 0.061
1.509GlnSer: 1.509 ± 0.042
1.395GlnThr: 1.395 ± 0.041
2.015GlnVal: 2.015 ± 0.051
0.389GlnTrp: 0.389 ± 0.023
0.548GlnTyr: 0.548 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
9.147ArgAla: 9.147 ± 0.126
0.321ArgCys: 0.321 ± 0.023
4.209ArgAsp: 4.209 ± 0.071
4.113ArgGlu: 4.113 ± 0.087
2.365ArgPhe: 2.365 ± 0.057
6.018ArgGly: 6.018 ± 0.096
1.612ArgHis: 1.612 ± 0.046
3.735ArgIle: 3.735 ± 0.064
1.167ArgLys: 1.167 ± 0.038
7.909ArgLeu: 7.909 ± 0.127
1.611ArgMet: 1.611 ± 0.045
1.341ArgAsn: 1.341 ± 0.042
3.94ArgPro: 3.94 ± 0.081
2.055ArgGln: 2.055 ± 0.049
7.54ArgArg: 7.54 ± 0.132
4.884ArgSer: 4.884 ± 0.082
4.582ArgThr: 4.582 ± 0.073
6.52ArgVal: 6.52 ± 0.099
1.188ArgTrp: 1.188 ± 0.039
1.572ArgTyr: 1.572 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
8.523SerAla: 8.523 ± 0.119
0.287SerCys: 0.287 ± 0.019
3.638SerAsp: 3.638 ± 0.083
3.014SerGlu: 3.014 ± 0.068
1.772SerPhe: 1.772 ± 0.047
6.921SerGly: 6.921 ± 0.124
1.013SerHis: 1.013 ± 0.034
2.524SerIle: 2.524 ± 0.057
0.922SerLys: 0.922 ± 0.039
5.495SerLeu: 5.495 ± 0.094
1.087SerMet: 1.087 ± 0.041
1.062SerAsn: 1.062 ± 0.043
3.386SerPro: 3.386 ± 0.064
1.348SerGln: 1.348 ± 0.043
4.288SerArg: 4.288 ± 0.07
4.09SerSer: 4.09 ± 0.092
4.075SerThr: 4.075 ± 0.079
5.173SerVal: 5.173 ± 0.087
1.023SerTrp: 1.023 ± 0.035
1.372SerTyr: 1.372 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
9.293ThrAla: 9.293 ± 0.133
0.158ThrCys: 0.158 ± 0.015
3.568ThrAsp: 3.568 ± 0.073
3.392ThrGlu: 3.392 ± 0.077
1.504ThrPhe: 1.504 ± 0.053
6.463ThrGly: 6.463 ± 0.094
1.033ThrHis: 1.033 ± 0.033
2.831ThrIle: 2.831 ± 0.067
0.951ThrLys: 0.951 ± 0.037
6.004ThrLeu: 6.004 ± 0.084
0.893ThrMet: 0.893 ± 0.031
1.05ThrAsn: 1.05 ± 0.042
4.282ThrPro: 4.282 ± 0.086
1.339ThrGln: 1.339 ± 0.039
4.0ThrArg: 4.0 ± 0.077
3.465ThrSer: 3.465 ± 0.065
4.229ThrThr: 4.229 ± 0.11
6.633ThrVal: 6.633 ± 0.122
0.647ThrTrp: 0.647 ± 0.027
0.665ThrTyr: 0.665 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
12.144ValAla: 12.144 ± 0.158
0.458ValCys: 0.458 ± 0.023
6.097ValAsp: 6.097 ± 0.109
5.03ValGlu: 5.03 ± 0.081
2.849ValPhe: 2.849 ± 0.063
7.194ValGly: 7.194 ± 0.12
1.582ValHis: 1.582 ± 0.047
4.142ValIle: 4.142 ± 0.069
1.322ValLys: 1.322 ± 0.046
10.259ValLeu: 10.259 ± 0.151
1.336ValMet: 1.336 ± 0.049
1.729ValAsn: 1.729 ± 0.045
4.977ValPro: 4.977 ± 0.078
2.17ValGln: 2.17 ± 0.055
6.017ValArg: 6.017 ± 0.087
5.576ValSer: 5.576 ± 0.102
6.23ValThr: 6.23 ± 0.117
9.689ValVal: 9.689 ± 0.157
1.039ValTrp: 1.039 ± 0.035
1.451ValTyr: 1.451 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.467TrpAla: 1.467 ± 0.043
0.077TrpCys: 0.077 ± 0.01
0.744TrpAsp: 0.744 ± 0.03
0.61TrpGlu: 0.61 ± 0.028
0.467TrpPhe: 0.467 ± 0.024
1.016TrpGly: 1.016 ± 0.036
0.26TrpHis: 0.26 ± 0.019
0.559TrpIle: 0.559 ± 0.024
0.235TrpLys: 0.235 ± 0.019
1.704TrpLeu: 1.704 ± 0.053
0.24TrpMet: 0.24 ± 0.018
0.389TrpAsn: 0.389 ± 0.021
0.643TrpPro: 0.643 ± 0.026
0.506TrpGln: 0.506 ± 0.025
1.171TrpArg: 1.171 ± 0.038
0.966TrpSer: 0.966 ± 0.033
0.92TrpThr: 0.92 ± 0.035
0.993TrpVal: 0.993 ± 0.044
0.288TrpTrp: 0.288 ± 0.02
0.247TrpTyr: 0.247 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.165TyrAla: 2.165 ± 0.058
0.105TyrCys: 0.105 ± 0.011
1.151TyrAsp: 1.151 ± 0.036
0.962TyrGlu: 0.962 ± 0.038
0.576TyrPhe: 0.576 ± 0.031
1.724TyrGly: 1.724 ± 0.054
0.266TyrHis: 0.266 ± 0.02
0.662TyrIle: 0.662 ± 0.028
0.264TyrLys: 0.264 ± 0.016
2.12TyrLeu: 2.12 ± 0.046
0.211TyrMet: 0.211 ± 0.017
0.44TyrAsn: 0.44 ± 0.028
0.942TyrPro: 0.942 ± 0.035
0.535TyrGln: 0.535 ± 0.026
1.691TyrArg: 1.691 ± 0.056
1.081TyrSer: 1.081 ± 0.036
1.187TyrThr: 1.187 ± 0.045
1.459TyrVal: 1.459 ± 0.044
0.278TyrTrp: 0.278 ± 0.022
0.408TyrTyr: 0.408 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2621 proteins (853725 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski