Amino acid dipepetide frequency for Pseudomonas virus DMS3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.044AlaAla: 19.044 ± 3.178
0.979AlaCys: 0.979 ± 0.365
8.81AlaAsp: 8.81 ± 0.828
8.543AlaGlu: 8.543 ± 1.427
2.67AlaPhe: 2.67 ± 0.458
9.878AlaGly: 9.878 ± 1.457
1.335AlaHis: 1.335 ± 0.283
6.229AlaIle: 6.229 ± 0.812
4.005AlaLys: 4.005 ± 0.714
13.883AlaLeu: 13.883 ± 1.224
2.937AlaMet: 2.937 ± 0.481
3.471AlaAsn: 3.471 ± 0.67
5.251AlaPro: 5.251 ± 0.767
6.051AlaGln: 6.051 ± 0.985
9.878AlaArg: 9.878 ± 1.284
7.386AlaSer: 7.386 ± 0.925
6.852AlaThr: 6.852 ± 0.536
6.496AlaVal: 6.496 ± 0.728
2.492AlaTrp: 2.492 ± 0.312
2.492AlaTyr: 2.492 ± 0.355
0.0AlaXaa: 0.0 ± 0.0
Cys
0.89CysAla: 0.89 ± 0.291
0.089CysCys: 0.089 ± 0.086
0.623CysAsp: 0.623 ± 0.223
0.445CysGlu: 0.445 ± 0.238
0.534CysPhe: 0.534 ± 0.198
0.534CysGly: 0.534 ± 0.228
0.356CysHis: 0.356 ± 0.161
0.356CysIle: 0.356 ± 0.146
0.089CysLys: 0.089 ± 0.094
0.445CysLeu: 0.445 ± 0.223
0.089CysMet: 0.089 ± 0.12
0.445CysAsn: 0.445 ± 0.209
0.534CysPro: 0.534 ± 0.234
0.089CysGln: 0.089 ± 0.091
0.801CysArg: 0.801 ± 0.293
0.356CysSer: 0.356 ± 0.16
0.534CysThr: 0.534 ± 0.253
0.267CysVal: 0.267 ± 0.144
0.356CysTrp: 0.356 ± 0.176
0.267CysTyr: 0.267 ± 0.162
0.0CysXaa: 0.0 ± 0.0
Asp
7.92AspAla: 7.92 ± 1.022
0.178AspCys: 0.178 ± 0.136
2.848AspAsp: 2.848 ± 0.5
3.827AspGlu: 3.827 ± 0.583
1.602AspPhe: 1.602 ± 0.257
5.962AspGly: 5.962 ± 0.716
1.068AspHis: 1.068 ± 0.251
3.026AspIle: 3.026 ± 0.371
1.424AspLys: 1.424 ± 0.331
5.251AspLeu: 5.251 ± 0.82
1.78AspMet: 1.78 ± 0.448
1.424AspAsn: 1.424 ± 0.367
3.204AspPro: 3.204 ± 0.64
3.115AspGln: 3.115 ± 0.518
3.471AspArg: 3.471 ± 0.443
3.293AspSer: 3.293 ± 0.507
3.293AspThr: 3.293 ± 0.602
3.293AspVal: 3.293 ± 0.613
1.335AspTrp: 1.335 ± 0.318
1.335AspTyr: 1.335 ± 0.391
0.0AspXaa: 0.0 ± 0.0
Glu
7.475GluAla: 7.475 ± 0.803
0.712GluCys: 0.712 ± 0.302
2.937GluAsp: 2.937 ± 0.488
2.581GluGlu: 2.581 ± 0.485
1.869GluPhe: 1.869 ± 0.38
4.005GluGly: 4.005 ± 0.634
0.89GluHis: 0.89 ± 0.29
3.115GluIle: 3.115 ± 0.489
2.492GluLys: 2.492 ± 0.485
7.208GluLeu: 7.208 ± 0.729
1.78GluMet: 1.78 ± 0.472
1.958GluAsn: 1.958 ± 0.496
3.115GluPro: 3.115 ± 0.739
4.183GluGln: 4.183 ± 0.577
4.45GluArg: 4.45 ± 0.743
2.848GluSer: 2.848 ± 0.468
2.67GluThr: 2.67 ± 0.429
4.361GluVal: 4.361 ± 0.733
0.979GluTrp: 0.979 ± 0.26
1.513GluTyr: 1.513 ± 0.325
0.0GluXaa: 0.0 ± 0.0
Phe
3.293PheAla: 3.293 ± 0.607
0.445PheCys: 0.445 ± 0.185
2.492PheAsp: 2.492 ± 0.401
1.691PheGlu: 1.691 ± 0.392
0.534PhePhe: 0.534 ± 0.199
2.581PheGly: 2.581 ± 0.473
0.356PheHis: 0.356 ± 0.163
1.157PheIle: 1.157 ± 0.29
0.979PheLys: 0.979 ± 0.274
2.581PheLeu: 2.581 ± 0.425
0.712PheMet: 0.712 ± 0.201
0.979PheAsn: 0.979 ± 0.263
1.424PhePro: 1.424 ± 0.39
1.246PheGln: 1.246 ± 0.35
1.958PheArg: 1.958 ± 0.453
1.335PheSer: 1.335 ± 0.331
1.602PheThr: 1.602 ± 0.372
1.068PheVal: 1.068 ± 0.237
0.356PheTrp: 0.356 ± 0.177
0.89PheTyr: 0.89 ± 0.264
0.0PheXaa: 0.0 ± 0.0
Gly
7.475GlyAla: 7.475 ± 1.282
0.445GlyCys: 0.445 ± 0.175
4.183GlyAsp: 4.183 ± 0.818
4.45GlyGlu: 4.45 ± 0.498
3.204GlyPhe: 3.204 ± 0.467
6.763GlyGly: 6.763 ± 0.789
0.89GlyHis: 0.89 ± 0.218
3.649GlyIle: 3.649 ± 0.471
2.759GlyLys: 2.759 ± 0.485
7.831GlyLeu: 7.831 ± 0.938
1.424GlyMet: 1.424 ± 0.379
2.492GlyAsn: 2.492 ± 0.461
2.67GlyPro: 2.67 ± 0.451
5.162GlyGln: 5.162 ± 0.595
7.208GlyArg: 7.208 ± 0.777
4.984GlySer: 4.984 ± 0.689
3.293GlyThr: 3.293 ± 0.541
4.895GlyVal: 4.895 ± 0.631
1.335GlyTrp: 1.335 ± 0.213
2.225GlyTyr: 2.225 ± 0.544
0.0GlyXaa: 0.0 ± 0.0
His
1.958HisAla: 1.958 ± 0.351
0.089HisCys: 0.089 ± 0.083
0.89HisAsp: 0.89 ± 0.254
0.712HisGlu: 0.712 ± 0.258
0.356HisPhe: 0.356 ± 0.171
1.246HisGly: 1.246 ± 0.361
0.267HisHis: 0.267 ± 0.131
0.979HisIle: 0.979 ± 0.241
0.178HisLys: 0.178 ± 0.12
1.513HisLeu: 1.513 ± 0.41
0.89HisMet: 0.89 ± 0.325
1.068HisAsn: 1.068 ± 0.349
1.424HisPro: 1.424 ± 0.344
1.068HisGln: 1.068 ± 0.302
1.246HisArg: 1.246 ± 0.296
0.445HisSer: 0.445 ± 0.165
0.712HisThr: 0.712 ± 0.206
0.445HisVal: 0.445 ± 0.159
0.089HisTrp: 0.089 ± 0.074
0.979HisTyr: 0.979 ± 0.318
0.0HisXaa: 0.0 ± 0.0
Ile
4.539IleAla: 4.539 ± 0.917
0.623IleCys: 0.623 ± 0.213
3.827IleAsp: 3.827 ± 0.514
3.293IleGlu: 3.293 ± 0.488
0.712IlePhe: 0.712 ± 0.213
3.293IleGly: 3.293 ± 0.335
0.89IleHis: 0.89 ± 0.236
2.136IleIle: 2.136 ± 0.571
1.424IleLys: 1.424 ± 0.37
3.026IleLeu: 3.026 ± 0.549
0.623IleMet: 0.623 ± 0.211
0.89IleAsn: 0.89 ± 0.293
2.314IlePro: 2.314 ± 0.407
1.513IleGln: 1.513 ± 0.447
4.094IleArg: 4.094 ± 0.523
1.958IleSer: 1.958 ± 0.477
3.649IleThr: 3.649 ± 0.547
2.937IleVal: 2.937 ± 0.453
0.623IleTrp: 0.623 ± 0.211
1.068IleTyr: 1.068 ± 0.308
0.0IleXaa: 0.0 ± 0.0
Lys
4.895LysAla: 4.895 ± 0.606
0.178LysCys: 0.178 ± 0.128
0.979LysAsp: 0.979 ± 0.353
1.869LysGlu: 1.869 ± 0.439
0.623LysPhe: 0.623 ± 0.202
2.581LysGly: 2.581 ± 0.433
0.623LysHis: 0.623 ± 0.202
1.157LysIle: 1.157 ± 0.359
1.424LysLys: 1.424 ± 0.427
2.581LysLeu: 2.581 ± 0.518
0.534LysMet: 0.534 ± 0.209
0.801LysAsn: 0.801 ± 0.225
2.67LysPro: 2.67 ± 0.574
0.89LysGln: 0.89 ± 0.255
3.293LysArg: 3.293 ± 0.702
2.136LysSer: 2.136 ± 0.549
1.958LysThr: 1.958 ± 0.398
2.314LysVal: 2.314 ± 0.427
0.178LysTrp: 0.178 ± 0.124
0.534LysTyr: 0.534 ± 0.206
0.0LysXaa: 0.0 ± 0.0
Leu
14.862LeuAla: 14.862 ± 1.524
0.801LeuCys: 0.801 ± 0.229
6.318LeuAsp: 6.318 ± 0.805
7.297LeuGlu: 7.297 ± 0.815
2.314LeuPhe: 2.314 ± 0.619
7.831LeuGly: 7.831 ± 0.752
2.403LeuHis: 2.403 ± 0.533
3.56LeuIle: 3.56 ± 0.588
3.56LeuLys: 3.56 ± 0.65
9.077LeuLeu: 9.077 ± 0.965
2.047LeuMet: 2.047 ± 0.54
2.848LeuAsn: 2.848 ± 0.477
4.628LeuPro: 4.628 ± 0.669
3.649LeuGln: 3.649 ± 0.447
7.386LeuArg: 7.386 ± 0.775
4.895LeuSer: 4.895 ± 0.8
5.428LeuThr: 5.428 ± 0.812
7.208LeuVal: 7.208 ± 0.664
1.157LeuTrp: 1.157 ± 0.287
2.047LeuTyr: 2.047 ± 0.347
0.0LeuXaa: 0.0 ± 0.0
Met
4.183MetAla: 4.183 ± 0.551
0.089MetCys: 0.089 ± 0.076
2.403MetAsp: 2.403 ± 0.464
1.335MetGlu: 1.335 ± 0.343
0.534MetPhe: 0.534 ± 0.227
1.869MetGly: 1.869 ± 0.455
0.356MetHis: 0.356 ± 0.165
0.356MetIle: 0.356 ± 0.169
0.712MetLys: 0.712 ± 0.231
1.78MetLeu: 1.78 ± 0.308
0.445MetMet: 0.445 ± 0.203
0.356MetAsn: 0.356 ± 0.195
0.979MetPro: 0.979 ± 0.259
1.335MetGln: 1.335 ± 0.434
1.513MetArg: 1.513 ± 0.322
1.513MetSer: 1.513 ± 0.375
1.424MetThr: 1.424 ± 0.281
0.712MetVal: 0.712 ± 0.248
0.267MetTrp: 0.267 ± 0.168
0.267MetTyr: 0.267 ± 0.162
0.0MetXaa: 0.0 ± 0.0
Asn
2.848AsnAla: 2.848 ± 0.602
0.089AsnCys: 0.089 ± 0.09
1.424AsnAsp: 1.424 ± 0.33
1.246AsnGlu: 1.246 ± 0.284
0.623AsnPhe: 0.623 ± 0.29
2.403AsnGly: 2.403 ± 0.434
0.712AsnHis: 0.712 ± 0.219
0.89AsnIle: 0.89 ± 0.378
0.801AsnLys: 0.801 ± 0.274
3.471AsnLeu: 3.471 ± 0.587
0.801AsnMet: 0.801 ± 0.336
1.335AsnAsn: 1.335 ± 0.404
2.403AsnPro: 2.403 ± 0.571
1.246AsnGln: 1.246 ± 0.319
2.759AsnArg: 2.759 ± 0.401
1.78AsnSer: 1.78 ± 0.379
1.246AsnThr: 1.246 ± 0.335
1.335AsnVal: 1.335 ± 0.276
0.534AsnTrp: 0.534 ± 0.191
0.712AsnTyr: 0.712 ± 0.199
0.0AsnXaa: 0.0 ± 0.0
Pro
7.03ProAla: 7.03 ± 0.914
0.712ProCys: 0.712 ± 0.358
3.649ProAsp: 3.649 ± 0.63
3.115ProGlu: 3.115 ± 0.537
1.602ProPhe: 1.602 ± 0.358
4.094ProGly: 4.094 ± 0.441
0.89ProHis: 0.89 ± 0.455
1.78ProIle: 1.78 ± 0.325
1.691ProLys: 1.691 ± 0.416
4.717ProLeu: 4.717 ± 0.583
0.801ProMet: 0.801 ± 0.252
1.335ProAsn: 1.335 ± 0.338
2.136ProPro: 2.136 ± 0.522
2.225ProGln: 2.225 ± 0.563
2.848ProArg: 2.848 ± 0.48
3.115ProSer: 3.115 ± 0.392
2.67ProThr: 2.67 ± 0.527
3.293ProVal: 3.293 ± 0.637
0.356ProTrp: 0.356 ± 0.191
1.246ProTyr: 1.246 ± 0.371
0.0ProXaa: 0.0 ± 0.0
Gln
5.784GlnAla: 5.784 ± 1.104
0.267GlnCys: 0.267 ± 0.134
1.602GlnAsp: 1.602 ± 0.413
2.047GlnGlu: 2.047 ± 0.461
2.047GlnPhe: 2.047 ± 0.359
3.738GlnGly: 3.738 ± 0.585
0.89GlnHis: 0.89 ± 0.235
2.314GlnIle: 2.314 ± 0.359
1.246GlnLys: 1.246 ± 0.392
6.318GlnLeu: 6.318 ± 0.546
0.979GlnMet: 0.979 ± 0.384
1.335GlnAsn: 1.335 ± 0.281
2.492GlnPro: 2.492 ± 0.399
3.204GlnGln: 3.204 ± 0.75
4.005GlnArg: 4.005 ± 0.527
3.026GlnSer: 3.026 ± 0.58
2.314GlnThr: 2.314 ± 0.438
4.45GlnVal: 4.45 ± 0.628
0.89GlnTrp: 0.89 ± 0.248
0.712GlnTyr: 0.712 ± 0.25
0.0GlnXaa: 0.0 ± 0.0
Arg
8.276ArgAla: 8.276 ± 0.965
0.801ArgCys: 0.801 ± 0.273
4.272ArgAsp: 4.272 ± 0.542
5.073ArgGlu: 5.073 ± 0.567
2.047ArgPhe: 2.047 ± 0.431
4.45ArgGly: 4.45 ± 0.556
1.691ArgHis: 1.691 ± 0.375
3.738ArgIle: 3.738 ± 0.533
2.581ArgLys: 2.581 ± 0.486
8.454ArgLeu: 8.454 ± 0.784
1.513ArgMet: 1.513 ± 0.318
1.602ArgAsn: 1.602 ± 0.45
3.56ArgPro: 3.56 ± 0.734
4.806ArgGln: 4.806 ± 0.712
5.962ArgArg: 5.962 ± 0.629
4.272ArgSer: 4.272 ± 0.679
4.094ArgThr: 4.094 ± 0.569
4.183ArgVal: 4.183 ± 0.757
1.335ArgTrp: 1.335 ± 0.463
3.204ArgTyr: 3.204 ± 0.453
0.0ArgXaa: 0.0 ± 0.0
Ser
8.098SerAla: 8.098 ± 0.835
0.534SerCys: 0.534 ± 0.215
3.471SerAsp: 3.471 ± 0.643
3.738SerGlu: 3.738 ± 0.605
1.602SerPhe: 1.602 ± 0.385
4.005SerGly: 4.005 ± 0.578
0.89SerHis: 0.89 ± 0.301
2.403SerIle: 2.403 ± 0.444
1.78SerLys: 1.78 ± 0.272
6.051SerLeu: 6.051 ± 1.102
1.068SerMet: 1.068 ± 0.264
1.335SerAsn: 1.335 ± 0.34
2.848SerPro: 2.848 ± 0.527
2.759SerGln: 2.759 ± 0.468
3.56SerArg: 3.56 ± 0.633
3.827SerSer: 3.827 ± 0.694
4.094SerThr: 4.094 ± 0.847
3.115SerVal: 3.115 ± 0.501
1.424SerTrp: 1.424 ± 0.332
1.513SerTyr: 1.513 ± 0.394
0.0SerXaa: 0.0 ± 0.0
Thr
7.653ThrAla: 7.653 ± 0.994
0.267ThrCys: 0.267 ± 0.281
3.026ThrAsp: 3.026 ± 0.577
2.848ThrGlu: 2.848 ± 0.496
1.335ThrPhe: 1.335 ± 0.349
5.162ThrGly: 5.162 ± 0.894
0.623ThrHis: 0.623 ± 0.274
2.225ThrIle: 2.225 ± 0.43
1.602ThrLys: 1.602 ± 0.323
5.962ThrLeu: 5.962 ± 0.64
1.246ThrMet: 1.246 ± 0.313
1.869ThrAsn: 1.869 ± 0.334
1.691ThrPro: 1.691 ± 0.31
1.246ThrGln: 1.246 ± 0.238
3.471ThrArg: 3.471 ± 0.485
3.738ThrSer: 3.738 ± 0.612
3.738ThrThr: 3.738 ± 0.557
5.606ThrVal: 5.606 ± 0.8
0.979ThrTrp: 0.979 ± 0.321
1.691ThrTyr: 1.691 ± 0.368
0.0ThrXaa: 0.0 ± 0.0
Val
7.742ValAla: 7.742 ± 0.825
0.267ValCys: 0.267 ± 0.148
2.848ValAsp: 2.848 ± 0.43
4.806ValGlu: 4.806 ± 0.662
1.691ValPhe: 1.691 ± 0.34
4.094ValGly: 4.094 ± 0.633
0.801ValHis: 0.801 ± 0.226
2.67ValIle: 2.67 ± 0.449
2.047ValLys: 2.047 ± 0.482
5.251ValLeu: 5.251 ± 0.632
1.424ValMet: 1.424 ± 0.368
1.78ValAsn: 1.78 ± 0.311
3.471ValPro: 3.471 ± 0.513
3.471ValGln: 3.471 ± 0.544
4.895ValArg: 4.895 ± 0.523
4.094ValSer: 4.094 ± 0.602
4.272ValThr: 4.272 ± 0.594
4.272ValVal: 4.272 ± 0.703
1.068ValTrp: 1.068 ± 0.251
2.937ValTyr: 2.937 ± 0.556
0.0ValXaa: 0.0 ± 0.0
Trp
1.691TrpAla: 1.691 ± 0.363
0.356TrpCys: 0.356 ± 0.151
0.445TrpAsp: 0.445 ± 0.183
0.801TrpGlu: 0.801 ± 0.231
0.623TrpPhe: 0.623 ± 0.194
0.801TrpGly: 0.801 ± 0.255
0.089TrpHis: 0.089 ± 0.09
0.801TrpIle: 0.801 ± 0.186
0.712TrpLys: 0.712 ± 0.195
1.602TrpLeu: 1.602 ± 0.402
0.89TrpMet: 0.89 ± 0.348
0.445TrpAsn: 0.445 ± 0.197
0.801TrpPro: 0.801 ± 0.303
0.89TrpGln: 0.89 ± 0.195
1.246TrpArg: 1.246 ± 0.35
1.335TrpSer: 1.335 ± 0.294
0.89TrpThr: 0.89 ± 0.298
1.424TrpVal: 1.424 ± 0.36
0.534TrpTrp: 0.534 ± 0.214
0.267TrpTyr: 0.267 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.026TyrAla: 3.026 ± 0.471
0.267TyrCys: 0.267 ± 0.153
1.602TyrAsp: 1.602 ± 0.338
1.424TyrGlu: 1.424 ± 0.405
1.157TyrPhe: 1.157 ± 0.305
2.047TyrGly: 2.047 ± 0.461
0.534TyrHis: 0.534 ± 0.272
0.89TyrIle: 0.89 ± 0.24
0.712TyrLys: 0.712 ± 0.253
2.314TyrLeu: 2.314 ± 0.447
0.356TyrMet: 0.356 ± 0.168
0.89TyrAsn: 0.89 ± 0.276
1.691TyrPro: 1.691 ± 0.467
1.513TyrGln: 1.513 ± 0.468
1.869TyrArg: 1.869 ± 0.399
1.78TyrSer: 1.78 ± 0.447
1.246TyrThr: 1.246 ± 0.384
2.225TyrVal: 2.225 ± 0.424
0.356TyrTrp: 0.356 ± 0.214
0.445TyrTyr: 0.445 ± 0.186
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (11238 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski