Amino acid dipepetide frequency for Kordia sp. SMS9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.51AlaAla: 4.51 ± 0.083	0.615AlaCys: 0.615 ± 0.022	3.314AlaAsp: 3.314 ± 0.06	4.047AlaGlu: 4.047 ± 0.062	3.481AlaPhe: 3.481 ± 0.051	3.849AlaGly: 3.849 ± 0.071	1.12AlaHis: 1.12 ± 0.03	5.519AlaIle: 5.519 ± 0.078	4.716AlaLys: 4.716 ± 0.076	5.951AlaLeu: 5.951 ± 0.072	1.41AlaMet: 1.41 ± 0.032	3.795AlaAsn: 3.795 ± 0.059	1.826AlaPro: 1.826 ± 0.039	2.554AlaGln: 2.554 ± 0.04	1.913AlaArg: 1.913 ± 0.037	4.364AlaSer: 4.364 ± 0.052	4.553AlaThr: 4.553 ± 0.075	3.938AlaVal: 3.938 ± 0.056	0.63AlaTrp: 0.63 ± 0.029	2.686AlaTyr: 2.686 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.527CysAla: 0.527 ± 0.021	0.146CysCys: 0.146 ± 0.01	0.57CysAsp: 0.57 ± 0.052	0.481CysGlu: 0.481 ± 0.017	0.503CysPhe: 0.503 ± 0.021	0.625CysGly: 0.625 ± 0.024	0.181CysHis: 0.181 ± 0.013	0.67CysIle: 0.67 ± 0.021	0.482CysLys: 0.482 ± 0.019	0.671CysLeu: 0.671 ± 0.022	0.222CysMet: 0.222 ± 0.013	0.451CysAsn: 0.451 ± 0.022	0.382CysPro: 0.382 ± 0.02	0.252CysGln: 0.252 ± 0.011	0.2CysArg: 0.2 ± 0.011	0.572CysSer: 0.572 ± 0.023	0.58CysThr: 0.58 ± 0.025	0.526CysVal: 0.526 ± 0.025	0.085CysTrp: 0.085 ± 0.007	0.353CysTyr: 0.353 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.1AspAla: 4.1 ± 0.056	0.536AspCys: 0.536 ± 0.043	3.259AspAsp: 3.259 ± 0.066	3.852AspGlu: 3.852 ± 0.051	3.556AspPhe: 3.556 ± 0.049	4.008AspGly: 4.008 ± 0.167	0.882AspHis: 0.882 ± 0.026	4.561AspIle: 4.561 ± 0.058	3.59AspLys: 3.59 ± 0.056	4.749AspLeu: 4.749 ± 0.067	1.041AspMet: 1.041 ± 0.029	3.046AspAsn: 3.046 ± 0.061	1.864AspPro: 1.864 ± 0.12	1.655AspGln: 1.655 ± 0.034	1.829AspArg: 1.829 ± 0.035	3.064AspSer: 3.064 ± 0.052	3.397AspThr: 3.397 ± 0.057	3.637AspVal: 3.637 ± 0.052	0.691AspTrp: 0.691 ± 0.022	2.501AspTyr: 2.501 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.773GluAla: 4.773 ± 0.061	0.379GluCys: 0.379 ± 0.019	3.496GluAsp: 3.496 ± 0.047	4.806GluGlu: 4.806 ± 0.063	2.973GluPhe: 2.973 ± 0.049	3.063GluGly: 3.063 ± 0.047	1.133GluHis: 1.133 ± 0.029	5.65GluIle: 5.65 ± 0.063	6.118GluLys: 6.118 ± 0.098	6.138GluLeu: 6.138 ± 0.072	1.451GluMet: 1.451 ± 0.034	4.922GluAsn: 4.922 ± 0.061	1.317GluPro: 1.317 ± 0.029	2.119GluGln: 2.119 ± 0.041	2.455GluArg: 2.455 ± 0.048	3.24GluSer: 3.24 ± 0.043	4.404GluThr: 4.404 ± 0.058	4.253GluVal: 4.253 ± 0.06	0.539GluTrp: 0.539 ± 0.018	2.454GluTyr: 2.454 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.992PheAla: 2.992 ± 0.048	0.488PheCys: 0.488 ± 0.019	3.432PheAsp: 3.432 ± 0.048	3.437PheGlu: 3.437 ± 0.053	2.753PhePhe: 2.753 ± 0.057	3.433PheGly: 3.433 ± 0.054	0.865PheHis: 0.865 ± 0.024	3.891PheIle: 3.891 ± 0.053	3.448PheLys: 3.448 ± 0.047	4.689PheLeu: 4.689 ± 0.068	1.167PheMet: 1.167 ± 0.027	3.046PheAsn: 3.046 ± 0.041	1.755PhePro: 1.755 ± 0.035	1.912PheGln: 1.912 ± 0.037	1.638PheArg: 1.638 ± 0.039	4.079PheSer: 4.079 ± 0.055	3.547PheThr: 3.547 ± 0.06	3.066PheVal: 3.066 ± 0.049	0.553PheTrp: 0.553 ± 0.018	2.233PheTyr: 2.233 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	3.63GlyAla: 3.63 ± 0.069	0.632GlyCys: 0.632 ± 0.032	3.365GlyAsp: 3.365 ± 0.09	3.371GlyGlu: 3.371 ± 0.05	3.446GlyPhe: 3.446 ± 0.053	4.161GlyGly: 4.161 ± 0.081	0.988GlyHis: 0.988 ± 0.027	5.341GlyIle: 5.341 ± 0.068	4.512GlyLys: 4.512 ± 0.06	4.784GlyLeu: 4.784 ± 0.059	1.481GlyMet: 1.481 ± 0.035	4.066GlyAsn: 4.066 ± 0.076	1.1GlyPro: 1.1 ± 0.032	1.774GlyGln: 1.774 ± 0.039	1.906GlyArg: 1.906 ± 0.04	3.663GlySer: 3.663 ± 0.067	4.339GlyThr: 4.339 ± 0.109	3.758GlyVal: 3.758 ± 0.069	0.718GlyTrp: 0.718 ± 0.027	2.579GlyTyr: 2.579 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.035HisAla: 1.035 ± 0.026	0.188HisCys: 0.188 ± 0.013	0.901HisAsp: 0.901 ± 0.024	1.15HisGlu: 1.15 ± 0.029	1.097HisPhe: 1.097 ± 0.025	1.03HisGly: 1.03 ± 0.028	0.518HisHis: 0.518 ± 0.023	1.562HisIle: 1.562 ± 0.034	1.395HisLys: 1.395 ± 0.03	1.742HisLeu: 1.742 ± 0.036	0.289HisMet: 0.289 ± 0.011	0.97HisAsn: 0.97 ± 0.024	0.814HisPro: 0.814 ± 0.021	0.772HisGln: 0.772 ± 0.026	0.671HisArg: 0.671 ± 0.021	0.992HisSer: 0.992 ± 0.028	1.125HisThr: 1.125 ± 0.029	1.045HisVal: 1.045 ± 0.028	0.217HisTrp: 0.217 ± 0.014	0.875HisTyr: 0.875 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.673IleAla: 5.673 ± 0.075	0.695IleCys: 0.695 ± 0.023	4.921IleAsp: 4.921 ± 0.061	5.282IleGlu: 5.282 ± 0.066	3.672IlePhe: 3.672 ± 0.054	4.776IleGly: 4.776 ± 0.071	1.564IleHis: 1.564 ± 0.029	5.785IleIle: 5.785 ± 0.089	5.379IleLys: 5.379 ± 0.067	6.901IleLeu: 6.901 ± 0.086	1.343IleMet: 1.343 ± 0.036	4.58IleAsn: 4.58 ± 0.057	3.452IlePro: 3.452 ± 0.051	3.248IleGln: 3.248 ± 0.054	2.595IleArg: 2.595 ± 0.033	5.73IleSer: 5.73 ± 0.067	5.252IleThr: 5.252 ± 0.075	4.912IleVal: 4.912 ± 0.07	0.673IleTrp: 0.673 ± 0.021	2.948IleTyr: 2.948 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.011LysAla: 5.011 ± 0.072	0.336LysCys: 0.336 ± 0.015	4.166LysAsp: 4.166 ± 0.063	6.098LysGlu: 6.098 ± 0.092	2.844LysPhe: 2.844 ± 0.041	4.19LysGly: 4.19 ± 0.057	1.474LysHis: 1.474 ± 0.031	6.034LysIle: 6.034 ± 0.083	7.595LysLys: 7.595 ± 0.117	6.577LysLeu: 6.577 ± 0.077	1.812LysMet: 1.812 ± 0.042	5.129LysAsn: 5.129 ± 0.073	2.149LysPro: 2.149 ± 0.042	2.781LysGln: 2.781 ± 0.048	3.156LysArg: 3.156 ± 0.06	4.257LysSer: 4.257 ± 0.065	4.71LysThr: 4.71 ± 0.069	4.499LysVal: 4.499 ± 0.07	0.643LysTrp: 0.643 ± 0.021	2.975LysTyr: 2.975 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	5.675LeuAla: 5.675 ± 0.073	0.816LeuCys: 0.816 ± 0.023	4.907LeuAsp: 4.907 ± 0.059	6.04LeuGlu: 6.04 ± 0.076	4.696LeuPhe: 4.696 ± 0.062	5.248LeuGly: 5.248 ± 0.068	1.794LeuHis: 1.794 ± 0.039	6.31LeuIle: 6.31 ± 0.077	7.225LeuLys: 7.225 ± 0.093	8.425LeuLeu: 8.425 ± 0.095	1.85LeuMet: 1.85 ± 0.039	5.362LeuAsn: 5.362 ± 0.057	3.355LeuPro: 3.355 ± 0.053	4.104LeuGln: 4.104 ± 0.072	3.293LeuArg: 3.293 ± 0.054	6.295LeuSer: 6.295 ± 0.078	5.342LeuThr: 5.342 ± 0.069	5.056LeuVal: 5.056 ± 0.057	0.809LeuTrp: 0.809 ± 0.027	3.311LeuTyr: 3.311 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.291MetAla: 1.291 ± 0.032	0.15MetCys: 0.15 ± 0.01	1.003MetAsp: 1.003 ± 0.027	1.36MetGlu: 1.36 ± 0.033	0.806MetPhe: 0.806 ± 0.026	1.021MetGly: 1.021 ± 0.032	0.436MetHis: 0.436 ± 0.019	1.653MetIle: 1.653 ± 0.033	2.192MetLys: 2.192 ± 0.034	1.973MetLeu: 1.973 ± 0.039	0.551MetMet: 0.551 ± 0.021	1.328MetAsn: 1.328 ± 0.032	0.794MetPro: 0.794 ± 0.022	0.86MetGln: 0.86 ± 0.02	0.822MetArg: 0.822 ± 0.022	1.319MetSer: 1.319 ± 0.027	1.164MetThr: 1.164 ± 0.031	1.13MetVal: 1.13 ± 0.03	0.144MetTrp: 0.144 ± 0.01	0.911MetTyr: 0.911 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.284AsnAla: 4.284 ± 0.06	0.538AsnCys: 0.538 ± 0.019	3.701AsnAsp: 3.701 ± 0.086	3.618AsnGlu: 3.618 ± 0.044	3.193AsnPhe: 3.193 ± 0.053	4.18AsnGly: 4.18 ± 0.098	1.052AsnHis: 1.052 ± 0.028	4.925AsnIle: 4.925 ± 0.063	3.743AsnLys: 3.743 ± 0.064	5.311AsnLeu: 5.311 ± 0.063	1.292AsnMet: 1.292 ± 0.031	3.802AsnAsn: 3.802 ± 0.082	2.786AsnPro: 2.786 ± 0.061	2.157AsnGln: 2.157 ± 0.039	2.099AsnArg: 2.099 ± 0.039	3.9AsnSer: 3.9 ± 0.057	4.604AsnThr: 4.604 ± 0.072	3.861AsnVal: 3.861 ± 0.058	0.72AsnTrp: 0.72 ± 0.021	2.97AsnTyr: 2.97 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	1.944ProAla: 1.944 ± 0.044	0.277ProCys: 0.277 ± 0.033	1.751ProAsp: 1.751 ± 0.042	2.368ProGlu: 2.368 ± 0.037	1.845ProPhe: 1.845 ± 0.036	1.556ProGly: 1.556 ± 0.039	0.542ProHis: 0.542 ± 0.018	2.656ProIle: 2.656 ± 0.051	2.711ProLys: 2.711 ± 0.056	2.734ProLeu: 2.734 ± 0.045	0.647ProMet: 0.647 ± 0.021	2.512ProAsn: 2.512 ± 0.073	0.896ProPro: 0.896 ± 0.03	1.159ProGln: 1.159 ± 0.039	0.858ProArg: 0.858 ± 0.024	2.129ProSer: 2.129 ± 0.037	2.366ProThr: 2.366 ± 0.053	2.108ProVal: 2.108 ± 0.044	0.303ProTrp: 0.303 ± 0.014	1.319ProTyr: 1.319 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.077GlnAla: 2.077 ± 0.038	0.224GlnCys: 0.224 ± 0.013	1.721GlnAsp: 1.721 ± 0.043	2.722GlnGlu: 2.722 ± 0.044	1.809GlnPhe: 1.809 ± 0.034	1.801GlnGly: 1.801 ± 0.037	0.836GlnHis: 0.836 ± 0.031	2.715GlnIle: 2.715 ± 0.042	3.425GlnLys: 3.425 ± 0.057	3.986GlnLeu: 3.986 ± 0.068	0.811GlnMet: 0.811 ± 0.021	2.515GlnAsn: 2.515 ± 0.051	1.137GlnPro: 1.137 ± 0.028	2.047GlnGln: 2.047 ± 0.048	1.379GlnArg: 1.379 ± 0.029	1.986GlnSer: 1.986 ± 0.041	2.26GlnThr: 2.26 ± 0.044	1.929GlnVal: 1.929 ± 0.033	0.359GlnTrp: 0.359 ± 0.017	1.539GlnTyr: 1.539 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.014ArgAla: 2.014 ± 0.034	0.204ArgCys: 0.204 ± 0.012	1.69ArgAsp: 1.69 ± 0.033	2.045ArgGlu: 2.045 ± 0.045	1.915ArgPhe: 1.915 ± 0.037	1.831ArgGly: 1.831 ± 0.038	0.559ArgHis: 0.559 ± 0.021	2.984ArgIle: 2.984 ± 0.042	2.943ArgLys: 2.943 ± 0.049	3.176ArgLeu: 3.176 ± 0.048	0.904ArgMet: 0.904 ± 0.026	2.235ArgAsn: 2.235 ± 0.037	0.944ArgPro: 0.944 ± 0.025	1.068ArgGln: 1.068 ± 0.027	1.337ArgArg: 1.337 ± 0.035	1.997ArgSer: 1.997 ± 0.038	1.943ArgThr: 1.943 ± 0.042	2.128ArgVal: 2.128 ± 0.039	0.387ArgTrp: 0.387 ± 0.016	1.552ArgTyr: 1.552 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.636SerAla: 3.636 ± 0.05	0.705SerCys: 0.705 ± 0.022	3.452SerAsp: 3.452 ± 0.053	4.072SerGlu: 4.072 ± 0.052	3.815SerPhe: 3.815 ± 0.055	4.323SerGly: 4.323 ± 0.071	1.055SerHis: 1.055 ± 0.029	5.142SerIle: 5.142 ± 0.068	4.534SerLys: 4.534 ± 0.069	6.042SerLeu: 6.042 ± 0.071	1.29SerMet: 1.29 ± 0.033	3.949SerAsn: 3.949 ± 0.062	1.885SerPro: 1.885 ± 0.034	2.273SerGln: 2.273 ± 0.038	1.952SerArg: 1.952 ± 0.032	3.993SerSer: 3.993 ± 0.064	3.709SerThr: 3.709 ± 0.055	3.871SerVal: 3.871 ± 0.058	0.722SerTrp: 0.722 ± 0.022	2.973SerTyr: 2.973 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.253ThrAla: 4.253 ± 0.074	0.497ThrCys: 0.497 ± 0.022	3.653ThrAsp: 3.653 ± 0.103	3.952ThrGlu: 3.952 ± 0.054	3.664ThrPhe: 3.664 ± 0.051	4.015ThrGly: 4.015 ± 0.082	1.202ThrHis: 1.202 ± 0.03	5.662ThrIle: 5.662 ± 0.071	4.331ThrLys: 4.331 ± 0.075	5.858ThrLeu: 5.858 ± 0.066	1.059ThrMet: 1.059 ± 0.031	4.042ThrAsn: 4.042 ± 0.08	2.573ThrPro: 2.573 ± 0.063	2.354ThrGln: 2.354 ± 0.043	1.773ThrArg: 1.773 ± 0.04	4.357ThrSer: 4.357 ± 0.066	4.563ThrThr: 4.563 ± 0.086	4.231ThrVal: 4.231 ± 0.071	0.615ThrTrp: 0.615 ± 0.022	2.797ThrTyr: 2.797 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.28ValAla: 4.28 ± 0.058	0.551ValCys: 0.551 ± 0.019	3.571ValAsp: 3.571 ± 0.058	3.774ValGlu: 3.774 ± 0.056	3.382ValPhe: 3.382 ± 0.06	3.544ValGly: 3.544 ± 0.052	1.073ValHis: 1.073 ± 0.028	4.528ValIle: 4.528 ± 0.063	4.104ValLys: 4.104 ± 0.063	5.606ValLeu: 5.606 ± 0.063	1.25ValMet: 1.25 ± 0.029	3.649ValAsn: 3.649 ± 0.051	2.045ValPro: 2.045 ± 0.039	2.093ValGln: 2.093 ± 0.035	1.984ValArg: 1.984 ± 0.036	4.409ValSer: 4.409 ± 0.052	4.118ValThr: 4.118 ± 0.087	3.966ValVal: 3.966 ± 0.061	0.589ValTrp: 0.589 ± 0.02	2.408ValTyr: 2.408 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.537TrpAla: 0.537 ± 0.022	0.123TrpCys: 0.123 ± 0.008	0.517TrpAsp: 0.517 ± 0.021	0.633TrpGlu: 0.633 ± 0.02	0.528TrpPhe: 0.528 ± 0.019	0.536TrpGly: 0.536 ± 0.021	0.212TrpHis: 0.212 ± 0.013	0.764TrpIle: 0.764 ± 0.026	0.851TrpLys: 0.851 ± 0.029	0.897TrpLeu: 0.897 ± 0.026	0.289TrpMet: 0.289 ± 0.014	0.731TrpAsn: 0.731 ± 0.025	0.18TrpPro: 0.18 ± 0.011	0.439TrpGln: 0.439 ± 0.017	0.386TrpArg: 0.386 ± 0.017	0.644TrpSer: 0.644 ± 0.023	0.632TrpThr: 0.632 ± 0.022	0.565TrpVal: 0.565 ± 0.02	0.127TrpTrp: 0.127 ± 0.011	0.428TrpTyr: 0.428 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.55TyrAla: 2.55 ± 0.05	0.382TyrCys: 0.382 ± 0.018	2.43TyrAsp: 2.43 ± 0.047	2.574TyrGlu: 2.574 ± 0.041	2.445TyrPhe: 2.445 ± 0.05	2.424TyrGly: 2.424 ± 0.05	0.905TyrHis: 0.905 ± 0.027	3.025TyrIle: 3.025 ± 0.048	3.142TyrLys: 3.142 ± 0.056	3.704TyrLeu: 3.704 ± 0.06	0.752TyrMet: 0.752 ± 0.019	2.604TyrAsn: 2.604 ± 0.05	1.424TyrPro: 1.424 ± 0.031	1.657TyrGln: 1.657 ± 0.033	1.61TyrArg: 1.61 ± 0.032	2.404TyrSer: 2.404 ± 0.042	2.843TyrThr: 2.843 ± 0.044	2.443TyrVal: 2.443 ± 0.046	0.492TyrTrp: 0.492 ± 0.02	2.031TyrTyr: 2.031 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4631 proteins (1592471 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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