Amino acid dipepetide frequency for Rhodococcus pyridinivorans SB3094

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.589AlaAla: 18.589 ± 0.158	0.894AlaCys: 0.894 ± 0.026	8.117AlaAsp: 8.117 ± 0.088	8.09AlaGlu: 8.09 ± 0.083	3.475AlaPhe: 3.475 ± 0.054	11.364AlaGly: 11.364 ± 0.099	2.666AlaHis: 2.666 ± 0.05	4.578AlaIle: 4.578 ± 0.059	2.578AlaLys: 2.578 ± 0.056	13.175AlaLeu: 13.175 ± 0.107	2.482AlaMet: 2.482 ± 0.052	1.958AlaAsn: 1.958 ± 0.039	6.226AlaPro: 6.226 ± 0.077	3.538AlaGln: 3.538 ± 0.053	9.159AlaArg: 9.159 ± 0.091	6.025AlaSer: 6.025 ± 0.059	7.263AlaThr: 7.263 ± 0.062	12.049AlaVal: 12.049 ± 0.104	1.583AlaTrp: 1.583 ± 0.034	2.242AlaTyr: 2.242 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.958CysAla: 0.958 ± 0.026	0.094CysCys: 0.094 ± 0.008	0.463CysAsp: 0.463 ± 0.019	0.398CysGlu: 0.398 ± 0.018	0.22CysPhe: 0.22 ± 0.011	0.863CysGly: 0.863 ± 0.03	0.178CysHis: 0.178 ± 0.011	0.268CysIle: 0.268 ± 0.016	0.109CysLys: 0.109 ± 0.009	0.59CysLeu: 0.59 ± 0.02	0.115CysMet: 0.115 ± 0.009	0.134CysAsn: 0.134 ± 0.01	0.451CysPro: 0.451 ± 0.017	0.126CysGln: 0.126 ± 0.008	0.569CysArg: 0.569 ± 0.02	0.498CysSer: 0.498 ± 0.019	0.502CysThr: 0.502 ± 0.021	0.595CysVal: 0.595 ± 0.019	0.127CysTrp: 0.127 ± 0.008	0.145CysTyr: 0.145 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.06AspAla: 8.06 ± 0.088	0.4AspCys: 0.4 ± 0.019	4.778AspAsp: 4.778 ± 0.071	4.805AspGlu: 4.805 ± 0.059	1.741AspPhe: 1.741 ± 0.034	6.111AspGly: 6.111 ± 0.073	1.521AspHis: 1.521 ± 0.032	2.538AspIle: 2.538 ± 0.043	1.164AspLys: 1.164 ± 0.032	6.995AspLeu: 6.995 ± 0.093	0.895AspMet: 0.895 ± 0.024	1.027AspAsn: 1.027 ± 0.031	4.838AspPro: 4.838 ± 0.066	1.387AspGln: 1.387 ± 0.033	5.394AspArg: 5.394 ± 0.073	2.98AspSer: 2.98 ± 0.045	3.691AspThr: 3.691 ± 0.052	5.536AspVal: 5.536 ± 0.071	0.877AspTrp: 0.877 ± 0.025	1.277AspTyr: 1.277 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.505GluAla: 6.505 ± 0.073	0.382GluCys: 0.382 ± 0.018	3.017GluAsp: 3.017 ± 0.051	3.178GluGlu: 3.178 ± 0.049	1.915GluPhe: 1.915 ± 0.042	3.916GluGly: 3.916 ± 0.07	1.733GluHis: 1.733 ± 0.029	3.08GluIle: 3.08 ± 0.043	1.592GluLys: 1.592 ± 0.039	6.993GluLeu: 6.993 ± 0.08	1.117GluMet: 1.117 ± 0.025	1.435GluAsn: 1.435 ± 0.036	3.312GluPro: 3.312 ± 0.054	2.432GluGln: 2.432 ± 0.05	5.367GluArg: 5.367 ± 0.078	3.167GluSer: 3.167 ± 0.052	3.227GluThr: 3.227 ± 0.051	4.877GluVal: 4.877 ± 0.063	0.895GluTrp: 0.895 ± 0.027	1.258GluTyr: 1.258 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.964PheAla: 3.964 ± 0.057	0.272PheCys: 0.272 ± 0.014	2.574PheAsp: 2.574 ± 0.062	1.819PheGlu: 1.819 ± 0.045	0.975PhePhe: 0.975 ± 0.03	3.427PheGly: 3.427 ± 0.053	0.63PheHis: 0.63 ± 0.021	0.791PheIle: 0.791 ± 0.021	0.429PheLys: 0.429 ± 0.019	2.549PheLeu: 2.549 ± 0.046	0.444PheMet: 0.444 ± 0.018	0.513PheAsn: 0.513 ± 0.019	1.391PhePro: 1.391 ± 0.038	0.59PheGln: 0.59 ± 0.021	1.81PheArg: 1.81 ± 0.037	1.539PheSer: 1.539 ± 0.035	2.069PheThr: 2.069 ± 0.039	3.036PheVal: 3.036 ± 0.042	0.398PheTrp: 0.398 ± 0.016	0.644PheTyr: 0.644 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.023GlyAla: 10.023 ± 0.092	0.738GlyCys: 0.738 ± 0.024	5.231GlyAsp: 5.231 ± 0.056	4.776GlyGlu: 4.776 ± 0.069	2.983GlyPhe: 2.983 ± 0.042	7.592GlyGly: 7.592 ± 0.097	1.982GlyHis: 1.982 ± 0.036	4.255GlyIle: 4.255 ± 0.068	2.107GlyLys: 2.107 ± 0.037	8.462GlyLeu: 8.462 ± 0.095	1.981GlyMet: 1.981 ± 0.038	1.764GlyAsn: 1.764 ± 0.041	4.373GlyPro: 4.373 ± 0.059	2.222GlyGln: 2.222 ± 0.049	7.039GlyArg: 7.039 ± 0.071	5.469GlySer: 5.469 ± 0.068	5.908GlyThr: 5.908 ± 0.075	7.551GlyVal: 7.551 ± 0.071	1.494GlyTrp: 1.494 ± 0.037	2.236GlyTyr: 2.236 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.448HisAla: 2.448 ± 0.042	0.185HisCys: 0.185 ± 0.012	1.46HisAsp: 1.46 ± 0.033	1.239HisGlu: 1.239 ± 0.032	0.641HisPhe: 0.641 ± 0.021	2.168HisGly: 2.168 ± 0.045	0.704HisHis: 0.704 ± 0.024	0.813HisIle: 0.813 ± 0.023	0.317HisLys: 0.317 ± 0.013	2.272HisLeu: 2.272 ± 0.038	0.342HisMet: 0.342 ± 0.015	0.404HisAsn: 0.404 ± 0.017	1.663HisPro: 1.663 ± 0.037	0.513HisGln: 0.513 ± 0.018	2.031HisArg: 2.031 ± 0.038	1.101HisSer: 1.101 ± 0.025	1.296HisThr: 1.296 ± 0.03	1.787HisVal: 1.787 ± 0.032	0.338HisTrp: 0.338 ± 0.017	0.477HisTyr: 0.477 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.956IleAla: 5.956 ± 0.074	0.305IleCys: 0.305 ± 0.014	3.372IleAsp: 3.372 ± 0.049	2.76IleGlu: 2.76 ± 0.048	0.964IlePhe: 0.964 ± 0.031	4.276IleGly: 4.276 ± 0.061	0.738IleHis: 0.738 ± 0.025	1.233IleIle: 1.233 ± 0.032	0.663IleLys: 0.663 ± 0.026	3.261IleLeu: 3.261 ± 0.049	0.558IleMet: 0.558 ± 0.018	0.804IleAsn: 0.804 ± 0.024	2.265IlePro: 2.265 ± 0.037	0.717IleGln: 0.717 ± 0.025	2.718IleArg: 2.718 ± 0.045	2.026IleSer: 2.026 ± 0.041	2.629IleThr: 2.629 ± 0.045	4.124IleVal: 4.124 ± 0.06	0.412IleTrp: 0.412 ± 0.015	0.694IleTyr: 0.694 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.341LysAla: 2.341 ± 0.05	0.103LysCys: 0.103 ± 0.009	1.092LysAsp: 1.092 ± 0.031	1.02LysGlu: 1.02 ± 0.026	0.6LysPhe: 0.6 ± 0.022	1.478LysGly: 1.478 ± 0.031	0.436LysHis: 0.436 ± 0.02	1.027LysIle: 1.027 ± 0.029	0.746LysLys: 0.746 ± 0.031	1.909LysLeu: 1.909 ± 0.04	0.428LysMet: 0.428 ± 0.019	0.508LysAsn: 0.508 ± 0.021	1.147LysPro: 1.147 ± 0.036	0.613LysGln: 0.613 ± 0.02	1.35LysArg: 1.35 ± 0.033	1.084LysSer: 1.084 ± 0.029	1.251LysThr: 1.251 ± 0.036	1.842LysVal: 1.842 ± 0.038	0.27LysTrp: 0.27 ± 0.015	0.488LysTyr: 0.488 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.705LeuAla: 13.705 ± 0.106	0.746LeuCys: 0.746 ± 0.024	7.59LeuAsp: 7.59 ± 0.116	5.392LeuGlu: 5.392 ± 0.066	2.769LeuPhe: 2.769 ± 0.047	9.185LeuGly: 9.185 ± 0.092	2.164LeuHis: 2.164 ± 0.038	3.456LeuIle: 3.456 ± 0.062	1.483LeuLys: 1.483 ± 0.034	9.823LeuLeu: 9.823 ± 0.114	1.556LeuMet: 1.556 ± 0.035	1.585LeuAsn: 1.585 ± 0.033	5.975LeuPro: 5.975 ± 0.084	2.328LeuGln: 2.328 ± 0.042	7.838LeuArg: 7.838 ± 0.082	5.427LeuSer: 5.427 ± 0.058	6.325LeuThr: 6.325 ± 0.076	9.407LeuVal: 9.407 ± 0.09	1.217LeuTrp: 1.217 ± 0.032	1.697LeuTyr: 1.697 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.078MetAla: 2.078 ± 0.038	0.177MetCys: 0.177 ± 0.011	0.826MetAsp: 0.826 ± 0.023	0.68MetGlu: 0.68 ± 0.025	0.615MetPhe: 0.615 ± 0.018	1.301MetGly: 1.301 ± 0.037	0.4MetHis: 0.4 ± 0.015	0.859MetIle: 0.859 ± 0.026	0.418MetLys: 0.418 ± 0.015	1.999MetLeu: 1.999 ± 0.038	0.364MetMet: 0.364 ± 0.018	0.473MetAsn: 0.473 ± 0.018	1.11MetPro: 1.11 ± 0.029	0.526MetGln: 0.526 ± 0.018	1.466MetArg: 1.466 ± 0.03	1.519MetSer: 1.519 ± 0.036	1.688MetThr: 1.688 ± 0.035	1.461MetVal: 1.461 ± 0.028	0.282MetTrp: 0.282 ± 0.013	0.35MetTyr: 0.35 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.225AsnAla: 2.225 ± 0.042	0.148AsnCys: 0.148 ± 0.01	1.079AsnAsp: 1.079 ± 0.031	0.956AsnGlu: 0.956 ± 0.027	0.572AsnPhe: 0.572 ± 0.022	1.76AsnGly: 1.76 ± 0.037	0.392AsnHis: 0.392 ± 0.016	0.859AsnIle: 0.859 ± 0.021	0.416AsnLys: 0.416 ± 0.018	1.852AsnLeu: 1.852 ± 0.039	0.367AsnMet: 0.367 ± 0.015	0.464AsnAsn: 0.464 ± 0.019	1.496AsnPro: 1.496 ± 0.038	0.473AsnGln: 0.473 ± 0.019	1.396AsnArg: 1.396 ± 0.033	1.031AsnSer: 1.031 ± 0.024	1.242AsnThr: 1.242 ± 0.034	1.529AsnVal: 1.529 ± 0.035	0.292AsnTrp: 0.292 ± 0.014	0.471AsnTyr: 0.471 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.034ProAla: 7.034 ± 0.095	0.278ProCys: 0.278 ± 0.015	4.621ProAsp: 4.621 ± 0.073	4.422ProGlu: 4.422 ± 0.061	1.61ProPhe: 1.61 ± 0.035	5.421ProGly: 5.421 ± 0.07	1.26ProHis: 1.26 ± 0.033	2.116ProIle: 2.116 ± 0.036	1.164ProLys: 1.164 ± 0.031	4.87ProLeu: 4.87 ± 0.069	1.015ProMet: 1.015 ± 0.024	1.09ProAsn: 1.09 ± 0.03	2.862ProPro: 2.862 ± 0.069	1.503ProGln: 1.503 ± 0.035	3.62ProArg: 3.62 ± 0.044	3.238ProSer: 3.238 ± 0.049	3.581ProThr: 3.581 ± 0.054	5.467ProVal: 5.467 ± 0.074	0.813ProTrp: 0.813 ± 0.024	1.099ProTyr: 1.099 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.969GlnAla: 2.969 ± 0.049	0.177GlnCys: 0.177 ± 0.012	1.205GlnAsp: 1.205 ± 0.03	1.193GlnGlu: 1.193 ± 0.03	0.862GlnPhe: 0.862 ± 0.027	1.781GlnGly: 1.781 ± 0.042	0.596GlnHis: 0.596 ± 0.021	1.306GlnIle: 1.306 ± 0.037	0.567GlnLys: 0.567 ± 0.024	2.913GlnLeu: 2.913 ± 0.047	0.541GlnMet: 0.541 ± 0.021	0.596GlnAsn: 0.596 ± 0.02	1.4GlnPro: 1.4 ± 0.03	1.223GlnGln: 1.223 ± 0.038	2.323GlnArg: 2.323 ± 0.043	1.267GlnSer: 1.267 ± 0.027	1.316GlnThr: 1.316 ± 0.031	2.515GlnVal: 2.515 ± 0.047	0.494GlnTrp: 0.494 ± 0.017	0.616GlnTyr: 0.616 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.602ArgAla: 8.602 ± 0.084	0.598ArgCys: 0.598 ± 0.022	4.426ArgAsp: 4.426 ± 0.054	4.528ArgGlu: 4.528 ± 0.051	2.57ArgPhe: 2.57 ± 0.039	5.375ArgGly: 5.375 ± 0.059	1.764ArgHis: 1.764 ± 0.038	3.98ArgIle: 3.98 ± 0.053	1.677ArgLys: 1.677 ± 0.037	7.507ArgLeu: 7.507 ± 0.084	1.939ArgMet: 1.939 ± 0.036	1.652ArgAsn: 1.652 ± 0.036	4.197ArgPro: 4.197 ± 0.054	1.914ArgGln: 1.914 ± 0.037	7.127ArgArg: 7.127 ± 0.092	4.448ArgSer: 4.448 ± 0.059	5.157ArgThr: 5.157 ± 0.066	6.085ArgVal: 6.085 ± 0.065	1.39ArgTrp: 1.39 ± 0.033	1.867ArgTyr: 1.867 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.603SerAla: 6.603 ± 0.069	0.393SerCys: 0.393 ± 0.018	3.464SerAsp: 3.464 ± 0.049	2.898SerGlu: 2.898 ± 0.049	1.683SerPhe: 1.683 ± 0.035	5.679SerGly: 5.679 ± 0.071	0.982SerHis: 0.982 ± 0.024	2.123SerIle: 2.123 ± 0.039	1.076SerLys: 1.076 ± 0.029	5.035SerLeu: 5.035 ± 0.062	1.319SerMet: 1.319 ± 0.03	1.048SerAsn: 1.048 ± 0.029	3.03SerPro: 3.03 ± 0.044	1.248SerGln: 1.248 ± 0.028	3.793SerArg: 3.793 ± 0.059	3.226SerSer: 3.226 ± 0.056	3.708SerThr: 3.708 ± 0.061	4.825SerVal: 4.825 ± 0.063	0.899SerTrp: 0.899 ± 0.023	1.13SerTyr: 1.13 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.14ThrAla: 8.14 ± 0.08	0.417ThrCys: 0.417 ± 0.015	4.191ThrAsp: 4.191 ± 0.061	3.783ThrGlu: 3.783 ± 0.054	1.787ThrPhe: 1.787 ± 0.035	6.237ThrGly: 6.237 ± 0.06	1.251ThrHis: 1.251 ± 0.03	2.471ThrIle: 2.471 ± 0.043	1.077ThrLys: 1.077 ± 0.033	5.7ThrLeu: 5.7 ± 0.055	1.06ThrMet: 1.06 ± 0.025	1.101ThrAsn: 1.101 ± 0.027	3.967ThrPro: 3.967 ± 0.051	1.3ThrGln: 1.3 ± 0.029	4.088ThrArg: 4.088 ± 0.052	3.446ThrSer: 3.446 ± 0.045	4.26ThrThr: 4.26 ± 0.076	6.715ThrVal: 6.715 ± 0.069	0.834ThrTrp: 0.834 ± 0.024	1.248ThrTyr: 1.248 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	12.011ValAla: 12.011 ± 0.106	0.763ValCys: 0.763 ± 0.022	6.414ValAsp: 6.414 ± 0.069	5.571ValGlu: 5.571 ± 0.079	2.68ValPhe: 2.68 ± 0.045	7.234ValGly: 7.234 ± 0.081	2.077ValHis: 2.077 ± 0.039	3.365ValIle: 3.365 ± 0.05	1.46ValLys: 1.46 ± 0.034	9.97ValLeu: 9.97 ± 0.101	1.431ValMet: 1.431 ± 0.03	1.654ValAsn: 1.654 ± 0.04	5.495ValPro: 5.495 ± 0.088	2.125ValGln: 2.125 ± 0.035	6.76ValArg: 6.76 ± 0.063	4.654ValSer: 4.654 ± 0.052	5.772ValThr: 5.772 ± 0.065	9.64ValVal: 9.64 ± 0.111	1.135ValTrp: 1.135 ± 0.031	1.556ValTyr: 1.556 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.523TrpAla: 1.523 ± 0.032	0.143TrpCys: 0.143 ± 0.01	0.754TrpAsp: 0.754 ± 0.026	0.699TrpGlu: 0.699 ± 0.021	0.546TrpPhe: 0.546 ± 0.02	1.018TrpGly: 1.018 ± 0.028	0.34TrpHis: 0.34 ± 0.017	0.691TrpIle: 0.691 ± 0.021	0.332TrpLys: 0.332 ± 0.016	1.579TrpLeu: 1.579 ± 0.036	0.34TrpMet: 0.34 ± 0.016	0.413TrpAsn: 0.413 ± 0.017	0.718TrpPro: 0.718 ± 0.024	0.546TrpGln: 0.546 ± 0.021	1.126TrpArg: 1.126 ± 0.028	0.937TrpSer: 0.937 ± 0.027	0.984TrpThr: 0.984 ± 0.025	1.09TrpVal: 1.09 ± 0.026	0.354TrpTrp: 0.354 ± 0.016	0.309TrpTyr: 0.309 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.319TyrAla: 2.319 ± 0.043	0.188TyrCys: 0.188 ± 0.01	1.34TyrAsp: 1.34 ± 0.034	1.192TyrGlu: 1.192 ± 0.029	0.652TyrPhe: 0.652 ± 0.023	2.001TyrGly: 2.001 ± 0.039	0.384TyrHis: 0.384 ± 0.016	0.667TyrIle: 0.667 ± 0.02	0.356TyrLys: 0.356 ± 0.015	2.214TyrLeu: 2.214 ± 0.046	0.299TyrMet: 0.299 ± 0.016	0.397TyrAsn: 0.397 ± 0.017	1.169TyrPro: 1.169 ± 0.028	0.535TyrGln: 0.535 ± 0.02	1.829TyrArg: 1.829 ± 0.038	1.082TyrSer: 1.082 ± 0.027	1.205TyrThr: 1.205 ± 0.031	1.639TyrVal: 1.639 ± 0.043	0.337TyrTrp: 0.337 ± 0.015	0.403TyrTyr: 0.403 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4825 proteins (1519572 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---