Amino acid dipepetide frequency for Cotia virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.027AlaAla: 1.027 ± 0.167
0.323AlaCys: 0.323 ± 0.081
1.141AlaAsp: 1.141 ± 0.135
0.628AlaGlu: 0.628 ± 0.116
0.837AlaPhe: 0.837 ± 0.125
0.818AlaGly: 0.818 ± 0.159
0.476AlaHis: 0.476 ± 0.085
3.253AlaIle: 3.253 ± 0.235
1.769AlaLys: 1.769 ± 0.188
2.187AlaLeu: 2.187 ± 0.2
0.476AlaMet: 0.476 ± 0.098
1.636AlaAsn: 1.636 ± 0.163
0.571AlaPro: 0.571 ± 0.121
0.323AlaGln: 0.323 ± 0.086
0.723AlaArg: 0.723 ± 0.125
1.788AlaSer: 1.788 ± 0.177
1.465AlaThr: 1.465 ± 0.199
1.293AlaVal: 1.293 ± 0.153
0.095AlaTrp: 0.095 ± 0.043
1.122AlaTyr: 1.122 ± 0.163
0.0AlaXaa: 0.0 ± 0.0
Cys
0.342CysAla: 0.342 ± 0.089
0.38CysCys: 0.38 ± 0.093
1.255CysAsp: 1.255 ± 0.127
0.894CysGlu: 0.894 ± 0.138
0.666CysPhe: 0.666 ± 0.111
0.78CysGly: 0.78 ± 0.114
0.19CysHis: 0.19 ± 0.066
2.625CysIle: 2.625 ± 0.243
2.073CysLys: 2.073 ± 0.217
1.503CysLeu: 1.503 ± 0.176
0.456CysMet: 0.456 ± 0.096
1.807CysAsn: 1.807 ± 0.198
0.628CysPro: 0.628 ± 0.131
0.323CysGln: 0.323 ± 0.069
0.476CysArg: 0.476 ± 0.104
1.522CysSer: 1.522 ± 0.186
0.989CysThr: 0.989 ± 0.152
1.198CysVal: 1.198 ± 0.177
0.133CysTrp: 0.133 ± 0.062
1.617CysTyr: 1.617 ± 0.161
0.0CysXaa: 0.0 ± 0.0
Asp
1.522AspAla: 1.522 ± 0.149
1.141AspCys: 1.141 ± 0.156
5.174AspAsp: 5.174 ± 0.41
4.013AspGlu: 4.013 ± 0.281
3.119AspPhe: 3.119 ± 0.268
2.244AspGly: 2.244 ± 0.234
0.495AspHis: 0.495 ± 0.1
10.576AspIle: 10.576 ± 0.448
5.573AspLys: 5.573 ± 0.429
4.375AspLeu: 4.375 ± 0.26
1.35AspMet: 1.35 ± 0.146
6.22AspAsn: 6.22 ± 0.361
1.369AspPro: 1.369 ± 0.152
0.628AspGln: 0.628 ± 0.095
1.503AspArg: 1.503 ± 0.157
4.032AspSer: 4.032 ± 0.219
3.367AspThr: 3.367 ± 0.285
3.557AspVal: 3.557 ± 0.252
0.399AspTrp: 0.399 ± 0.101
3.348AspTyr: 3.348 ± 0.275
0.0AspXaa: 0.0 ± 0.0
Glu
1.16GluAla: 1.16 ± 0.126
1.065GluCys: 1.065 ± 0.154
2.644GluAsp: 2.644 ± 0.268
2.644GluGlu: 2.644 ± 0.283
2.454GluPhe: 2.454 ± 0.24
0.951GluGly: 0.951 ± 0.134
0.894GluHis: 0.894 ± 0.124
5.706GluIle: 5.706 ± 0.334
4.28GluLys: 4.28 ± 0.316
4.812GluLeu: 4.812 ± 0.307
1.389GluMet: 1.389 ± 0.136
4.945GluAsn: 4.945 ± 0.314
1.217GluPro: 1.217 ± 0.195
0.989GluGln: 0.989 ± 0.124
1.484GluArg: 1.484 ± 0.209
3.576GluSer: 3.576 ± 0.237
3.062GluThr: 3.062 ± 0.255
1.997GluVal: 1.997 ± 0.171
0.38GluTrp: 0.38 ± 0.08
4.032GluTyr: 4.032 ± 0.27
0.0GluXaa: 0.0 ± 0.0
Phe
1.027PheAla: 1.027 ± 0.177
1.046PheCys: 1.046 ± 0.167
3.519PheAsp: 3.519 ± 0.306
2.187PheGlu: 2.187 ± 0.187
2.225PhePhe: 2.225 ± 0.221
2.111PheGly: 2.111 ± 0.197
0.723PheHis: 0.723 ± 0.129
6.334PheIle: 6.334 ± 0.418
4.66PheLys: 4.66 ± 0.29
4.622PheLeu: 4.622 ± 0.362
1.217PheMet: 1.217 ± 0.144
5.117PheAsn: 5.117 ± 0.303
1.312PhePro: 1.312 ± 0.159
0.666PheGln: 0.666 ± 0.103
1.179PheArg: 1.179 ± 0.157
4.051PheSer: 4.051 ± 0.286
2.986PheThr: 2.986 ± 0.236
2.948PheVal: 2.948 ± 0.248
0.38PheTrp: 0.38 ± 0.089
2.492PheTyr: 2.492 ± 0.211
0.0PheXaa: 0.0 ± 0.0
Gly
1.065GlyAla: 1.065 ± 0.157
0.495GlyCys: 0.495 ± 0.088
2.149GlyAsp: 2.149 ± 0.199
1.541GlyGlu: 1.541 ± 0.178
1.788GlyPhe: 1.788 ± 0.198
1.845GlyGly: 1.845 ± 0.242
0.342GlyHis: 0.342 ± 0.074
4.318GlyIle: 4.318 ± 0.282
3.443GlyLys: 3.443 ± 0.29
2.473GlyLeu: 2.473 ± 0.16
0.685GlyMet: 0.685 ± 0.106
2.492GlyAsn: 2.492 ± 0.195
0.647GlyPro: 0.647 ± 0.108
0.456GlyGln: 0.456 ± 0.089
1.331GlyArg: 1.331 ± 0.174
2.454GlySer: 2.454 ± 0.257
1.731GlyThr: 1.731 ± 0.164
2.035GlyVal: 2.035 ± 0.255
0.19GlyTrp: 0.19 ± 0.071
2.606GlyTyr: 2.606 ± 0.27
0.0GlyXaa: 0.0 ± 0.0
His
0.304HisAla: 0.304 ± 0.074
0.399HisCys: 0.399 ± 0.104
0.742HisAsp: 0.742 ± 0.115
0.704HisGlu: 0.704 ± 0.099
0.78HisPhe: 0.78 ± 0.119
0.761HisGly: 0.761 ± 0.116
0.228HisHis: 0.228 ± 0.061
2.206HisIle: 2.206 ± 0.241
1.427HisLys: 1.427 ± 0.18
1.217HisLeu: 1.217 ± 0.145
0.533HisMet: 0.533 ± 0.093
1.274HisAsn: 1.274 ± 0.194
0.437HisPro: 0.437 ± 0.099
0.342HisGln: 0.342 ± 0.092
0.361HisArg: 0.361 ± 0.084
1.122HisSer: 1.122 ± 0.165
0.97HisThr: 0.97 ± 0.145
1.046HisVal: 1.046 ± 0.144
0.171HisTrp: 0.171 ± 0.063
0.78HisTyr: 0.78 ± 0.178
0.0HisXaa: 0.0 ± 0.0
Ile
2.263IleAla: 2.263 ± 0.212
2.53IleCys: 2.53 ± 0.254
9.073IleAsp: 9.073 ± 0.404
5.992IleGlu: 5.992 ± 0.345
6.619IlePhe: 6.619 ± 0.414
3.823IleGly: 3.823 ± 0.333
2.092IleHis: 2.092 ± 0.226
13.467IleIle: 13.467 ± 0.616
11.888IleLys: 11.888 ± 0.584
11.393IleLeu: 11.393 ± 0.623
2.53IleMet: 2.53 ± 0.21
12.972IleAsn: 12.972 ± 0.596
3.481IlePro: 3.481 ± 0.259
2.035IleGln: 2.035 ± 0.197
3.614IleArg: 3.614 ± 0.278
10.138IleSer: 10.138 ± 0.464
6.429IleThr: 6.429 ± 0.322
5.706IleVal: 5.706 ± 0.31
0.571IleTrp: 0.571 ± 0.095
7.076IleTyr: 7.076 ± 0.414
0.0IleXaa: 0.0 ± 0.0
Lys
1.369LysAla: 1.369 ± 0.173
1.959LysCys: 1.959 ± 0.211
5.421LysAsp: 5.421 ± 0.342
4.66LysGlu: 4.66 ± 0.286
3.804LysPhe: 3.804 ± 0.265
2.149LysGly: 2.149 ± 0.171
1.788LysHis: 1.788 ± 0.181
11.032LysIle: 11.032 ± 0.489
8.845LysLys: 8.845 ± 0.447
8.217LysLeu: 8.217 ± 0.41
2.263LysMet: 2.263 ± 0.191
9.682LysAsn: 9.682 ± 0.472
2.149LysPro: 2.149 ± 0.2
1.807LysGln: 1.807 ± 0.186
2.796LysArg: 2.796 ± 0.212
6.41LysSer: 6.41 ± 0.371
5.06LysThr: 5.06 ± 0.273
3.88LysVal: 3.88 ± 0.284
0.742LysTrp: 0.742 ± 0.121
7.285LysTyr: 7.285 ± 0.42
0.0LysXaa: 0.0 ± 0.0
Leu
1.978LeuAla: 1.978 ± 0.176
1.674LeuCys: 1.674 ± 0.182
5.021LeuAsp: 5.021 ± 0.27
4.584LeuGlu: 4.584 ± 0.322
5.345LeuPhe: 5.345 ± 0.33
2.435LeuGly: 2.435 ± 0.26
1.883LeuHis: 1.883 ± 0.216
8.654LeuIle: 8.654 ± 0.405
7.475LeuLys: 7.475 ± 0.387
8.654LeuLeu: 8.654 ± 0.507
1.864LeuMet: 1.864 ± 0.201
7.266LeuAsn: 7.266 ± 0.379
2.568LeuPro: 2.568 ± 0.241
1.921LeuGln: 1.921 ± 0.193
2.073LeuArg: 2.073 ± 0.218
8.027LeuSer: 8.027 ± 0.34
4.603LeuThr: 4.603 ± 0.311
4.261LeuVal: 4.261 ± 0.262
0.266LeuTrp: 0.266 ± 0.097
6.277LeuTyr: 6.277 ± 0.352
0.0LeuXaa: 0.0 ± 0.0
Met
0.78MetAla: 0.78 ± 0.109
0.514MetCys: 0.514 ± 0.095
1.674MetAsp: 1.674 ± 0.188
1.312MetGlu: 1.312 ± 0.152
1.465MetPhe: 1.465 ± 0.173
0.932MetGly: 0.932 ± 0.136
0.247MetHis: 0.247 ± 0.074
1.788MetIle: 1.788 ± 0.173
1.636MetLys: 1.636 ± 0.212
2.244MetLeu: 2.244 ± 0.199
0.59MetMet: 0.59 ± 0.108
1.826MetAsn: 1.826 ± 0.178
0.685MetPro: 0.685 ± 0.096
0.361MetGln: 0.361 ± 0.08
0.609MetArg: 0.609 ± 0.109
1.864MetSer: 1.864 ± 0.219
0.989MetThr: 0.989 ± 0.131
1.179MetVal: 1.179 ± 0.157
0.095MetTrp: 0.095 ± 0.044
1.655MetTyr: 1.655 ± 0.183
0.0MetXaa: 0.0 ± 0.0
Asn
1.769AsnAla: 1.769 ± 0.183
1.103AsnCys: 1.103 ± 0.135
6.524AsnAsp: 6.524 ± 0.382
4.66AsnGlu: 4.66 ± 0.348
4.318AsnPhe: 4.318 ± 0.313
3.462AsnGly: 3.462 ± 0.245
1.369AsnHis: 1.369 ± 0.127
14.893AsnIle: 14.893 ± 0.659
10.081AsnLys: 10.081 ± 0.496
5.915AsnLeu: 5.915 ± 0.378
2.225AsnMet: 2.225 ± 0.195
11.793AsnAsn: 11.793 ± 0.616
2.092AsnPro: 2.092 ± 0.218
1.522AsnGln: 1.522 ± 0.14
2.587AsnArg: 2.587 ± 0.219
5.06AsnSer: 5.06 ± 0.33
5.63AsnThr: 5.63 ± 0.348
5.307AsnVal: 5.307 ± 0.268
0.399AsnTrp: 0.399 ± 0.093
4.812AsnTyr: 4.812 ± 0.332
0.0AsnXaa: 0.0 ± 0.0
Pro
0.685ProAla: 0.685 ± 0.115
0.437ProCys: 0.437 ± 0.086
1.522ProAsp: 1.522 ± 0.137
1.712ProGlu: 1.712 ± 0.214
1.56ProPhe: 1.56 ± 0.181
0.875ProGly: 0.875 ± 0.144
0.437ProHis: 0.437 ± 0.089
2.929ProIle: 2.929 ± 0.196
2.149ProLys: 2.149 ± 0.259
2.739ProLeu: 2.739 ± 0.236
0.514ProMet: 0.514 ± 0.08
2.13ProAsn: 2.13 ± 0.201
1.312ProPro: 1.312 ± 0.211
0.666ProGln: 0.666 ± 0.147
0.989ProArg: 0.989 ± 0.156
1.94ProSer: 1.94 ± 0.177
1.579ProThr: 1.579 ± 0.173
1.465ProVal: 1.465 ± 0.183
0.152ProTrp: 0.152 ± 0.055
1.389ProTyr: 1.389 ± 0.171
0.0ProXaa: 0.0 ± 0.0
Gln
0.266GlnAla: 0.266 ± 0.092
0.552GlnCys: 0.552 ± 0.115
1.046GlnAsp: 1.046 ± 0.127
0.742GlnGlu: 0.742 ± 0.102
0.666GlnPhe: 0.666 ± 0.113
0.399GlnGly: 0.399 ± 0.094
0.323GlnHis: 0.323 ± 0.073
1.674GlnIle: 1.674 ± 0.191
1.465GlnLys: 1.465 ± 0.175
1.712GlnLeu: 1.712 ± 0.182
0.304GlnMet: 0.304 ± 0.072
1.179GlnAsn: 1.179 ± 0.163
0.514GlnPro: 0.514 ± 0.163
0.495GlnGln: 0.495 ± 0.101
0.742GlnArg: 0.742 ± 0.128
1.408GlnSer: 1.408 ± 0.176
0.932GlnThr: 0.932 ± 0.141
0.723GlnVal: 0.723 ± 0.115
0.152GlnTrp: 0.152 ± 0.053
1.236GlnTyr: 1.236 ± 0.168
0.0GlnXaa: 0.0 ± 0.0
Arg
0.666ArgAla: 0.666 ± 0.141
0.78ArgCys: 0.78 ± 0.129
1.389ArgAsp: 1.389 ± 0.164
1.484ArgGlu: 1.484 ± 0.183
1.693ArgPhe: 1.693 ± 0.174
1.084ArgGly: 1.084 ± 0.128
0.533ArgHis: 0.533 ± 0.099
2.796ArgIle: 2.796 ± 0.256
2.568ArgLys: 2.568 ± 0.228
2.834ArgLeu: 2.834 ± 0.208
0.495ArgMet: 0.495 ± 0.109
2.13ArgAsn: 2.13 ± 0.233
0.913ArgPro: 0.913 ± 0.131
0.723ArgGln: 0.723 ± 0.091
1.274ArgArg: 1.274 ± 0.15
2.035ArgSer: 2.035 ± 0.208
1.35ArgThr: 1.35 ± 0.206
1.731ArgVal: 1.731 ± 0.183
0.266ArgTrp: 0.266 ± 0.067
1.94ArgTyr: 1.94 ± 0.193
0.0ArgXaa: 0.0 ± 0.0
Ser
1.598SerAla: 1.598 ± 0.242
1.769SerCys: 1.769 ± 0.183
5.06SerAsp: 5.06 ± 0.327
3.709SerGlu: 3.709 ± 0.242
3.88SerPhe: 3.88 ± 0.252
3.062SerGly: 3.062 ± 0.276
1.084SerHis: 1.084 ± 0.123
9.834SerIle: 9.834 ± 0.388
7.095SerLys: 7.095 ± 0.425
6.068SerLeu: 6.068 ± 0.367
1.902SerMet: 1.902 ± 0.204
6.296SerAsn: 6.296 ± 0.328
1.807SerPro: 1.807 ± 0.194
1.236SerGln: 1.236 ± 0.166
2.206SerArg: 2.206 ± 0.237
5.839SerSer: 5.839 ± 0.504
4.147SerThr: 4.147 ± 0.291
4.375SerVal: 4.375 ± 0.327
0.418SerTrp: 0.418 ± 0.096
4.413SerTyr: 4.413 ± 0.286
0.0SerXaa: 0.0 ± 0.0
Thr
1.389ThrAla: 1.389 ± 0.156
1.16ThrCys: 1.16 ± 0.17
3.272ThrAsp: 3.272 ± 0.271
2.568ThrGlu: 2.568 ± 0.249
2.948ThrPhe: 2.948 ± 0.244
1.902ThrGly: 1.902 ± 0.208
0.97ThrHis: 0.97 ± 0.134
6.847ThrIle: 6.847 ± 0.356
4.432ThrLys: 4.432 ± 0.327
5.174ThrLeu: 5.174 ± 0.276
1.122ThrMet: 1.122 ± 0.148
4.451ThrAsn: 4.451 ± 0.333
1.921ThrPro: 1.921 ± 0.211
0.647ThrGln: 0.647 ± 0.121
1.465ThrArg: 1.465 ± 0.151
4.66ThrSer: 4.66 ± 0.379
3.081ThrThr: 3.081 ± 0.262
3.557ThrVal: 3.557 ± 0.31
0.437ThrTrp: 0.437 ± 0.089
3.138ThrTyr: 3.138 ± 0.246
0.0ThrXaa: 0.0 ± 0.0
Val
1.389ValAla: 1.389 ± 0.154
1.16ValCys: 1.16 ± 0.142
3.329ValAsp: 3.329 ± 0.217
2.739ValGlu: 2.739 ± 0.214
2.967ValPhe: 2.967 ± 0.254
1.541ValGly: 1.541 ± 0.177
0.761ValHis: 0.761 ± 0.112
5.44ValIle: 5.44 ± 0.33
4.831ValLys: 4.831 ± 0.344
5.002ValLeu: 5.002 ± 0.304
0.875ValMet: 0.875 ± 0.13
4.983ValAsn: 4.983 ± 0.326
1.408ValPro: 1.408 ± 0.165
0.647ValGln: 0.647 ± 0.11
1.274ValArg: 1.274 ± 0.157
4.945ValSer: 4.945 ± 0.336
2.872ValThr: 2.872 ± 0.217
2.796ValVal: 2.796 ± 0.271
0.304ValTrp: 0.304 ± 0.071
3.272ValTyr: 3.272 ± 0.249
0.0ValXaa: 0.0 ± 0.0
Trp
0.133TrpAla: 0.133 ± 0.049
0.114TrpCys: 0.114 ± 0.048
0.19TrpAsp: 0.19 ± 0.063
0.399TrpGlu: 0.399 ± 0.085
0.437TrpPhe: 0.437 ± 0.094
0.285TrpGly: 0.285 ± 0.07
0.038TrpHis: 0.038 ± 0.03
0.742TrpIle: 0.742 ± 0.112
0.552TrpLys: 0.552 ± 0.094
0.361TrpLeu: 0.361 ± 0.095
0.133TrpMet: 0.133 ± 0.052
0.418TrpAsn: 0.418 ± 0.09
0.171TrpPro: 0.171 ± 0.057
0.057TrpGln: 0.057 ± 0.036
0.228TrpArg: 0.228 ± 0.072
0.647TrpSer: 0.647 ± 0.119
0.38TrpThr: 0.38 ± 0.099
0.304TrpVal: 0.304 ± 0.071
0.0TrpTrp: 0.0 ± 0.0
0.38TrpTyr: 0.38 ± 0.086
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.217TyrAla: 1.217 ± 0.149
1.255TyrCys: 1.255 ± 0.147
3.861TyrAsp: 3.861 ± 0.257
2.511TyrGlu: 2.511 ± 0.227
3.234TyrPhe: 3.234 ± 0.253
2.625TyrGly: 2.625 ± 0.214
0.932TyrHis: 0.932 ± 0.126
8.578TyrIle: 8.578 ± 0.433
5.079TyrLys: 5.079 ± 0.343
5.326TyrLeu: 5.326 ± 0.39
1.503TyrMet: 1.503 ± 0.155
6.905TyrAsn: 6.905 ± 0.387
1.978TyrPro: 1.978 ± 0.172
0.685TyrGln: 0.685 ± 0.127
1.769TyrArg: 1.769 ± 0.169
4.299TyrSer: 4.299 ± 0.261
3.519TyrThr: 3.519 ± 0.259
3.176TyrVal: 3.176 ± 0.212
0.418TyrTrp: 0.418 ± 0.092
3.291TyrTyr: 3.291 ± 0.283
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 170 proteins (52575 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski