Amino acid dipepetide frequency for Sphingobacterium wenxiniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.985AlaAla: 4.985 ± 0.09
0.637AlaCys: 0.637 ± 0.029
4.028AlaAsp: 4.028 ± 0.063
4.709AlaGlu: 4.709 ± 0.078
3.514AlaPhe: 3.514 ± 0.064
4.784AlaGly: 4.784 ± 0.074
1.29AlaHis: 1.29 ± 0.041
5.49AlaIle: 5.49 ± 0.078
4.735AlaLys: 4.735 ± 0.071
6.999AlaLeu: 6.999 ± 0.095
1.717AlaMet: 1.717 ± 0.043
3.549AlaAsn: 3.549 ± 0.056
2.073AlaPro: 2.073 ± 0.05
3.04AlaGln: 3.04 ± 0.054
2.466AlaArg: 2.466 ± 0.055
4.297AlaSer: 4.297 ± 0.07
3.845AlaThr: 3.845 ± 0.07
4.904AlaVal: 4.904 ± 0.076
0.782AlaTrp: 0.782 ± 0.027
2.978AlaTyr: 2.978 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.512CysAla: 0.512 ± 0.028
0.141CysCys: 0.141 ± 0.012
0.358CysAsp: 0.358 ± 0.018
0.399CysGlu: 0.399 ± 0.024
0.398CysPhe: 0.398 ± 0.019
0.599CysGly: 0.599 ± 0.026
0.175CysHis: 0.175 ± 0.013
0.569CysIle: 0.569 ± 0.027
0.389CysLys: 0.389 ± 0.021
0.724CysLeu: 0.724 ± 0.024
0.187CysMet: 0.187 ± 0.011
0.344CysAsn: 0.344 ± 0.019
0.313CysPro: 0.313 ± 0.017
0.257CysGln: 0.257 ± 0.016
0.291CysArg: 0.291 ± 0.018
0.498CysSer: 0.498 ± 0.021
0.425CysThr: 0.425 ± 0.02
0.447CysVal: 0.447 ± 0.02
0.082CysTrp: 0.082 ± 0.008
0.284CysTyr: 0.284 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.777AspAla: 3.777 ± 0.075
0.352AspCys: 0.352 ± 0.017
2.593AspAsp: 2.593 ± 0.057
3.703AspGlu: 3.703 ± 0.068
3.335AspPhe: 3.335 ± 0.059
3.959AspGly: 3.959 ± 0.072
0.891AspHis: 0.891 ± 0.028
4.382AspIle: 4.382 ± 0.065
4.056AspLys: 4.056 ± 0.059
5.031AspLeu: 5.031 ± 0.07
1.289AspMet: 1.289 ± 0.035
2.887AspAsn: 2.887 ± 0.057
1.834AspPro: 1.834 ± 0.043
1.579AspGln: 1.579 ± 0.051
2.374AspArg: 2.374 ± 0.053
2.886AspSer: 2.886 ± 0.059
2.682AspThr: 2.682 ± 0.047
3.648AspVal: 3.648 ± 0.069
0.817AspTrp: 0.817 ± 0.029
2.751AspTyr: 2.751 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
4.628GluAla: 4.628 ± 0.076
0.349GluCys: 0.349 ± 0.02
3.254GluAsp: 3.254 ± 0.053
5.263GluGlu: 5.263 ± 0.093
2.485GluPhe: 2.485 ± 0.05
4.029GluGly: 4.029 ± 0.066
1.324GluHis: 1.324 ± 0.033
4.857GluIle: 4.857 ± 0.077
5.219GluLys: 5.219 ± 0.092
6.128GluLeu: 6.128 ± 0.081
1.57GluMet: 1.57 ± 0.035
3.804GluAsn: 3.804 ± 0.058
1.643GluPro: 1.643 ± 0.041
3.176GluGln: 3.176 ± 0.052
3.132GluArg: 3.132 ± 0.06
3.296GluSer: 3.296 ± 0.058
3.249GluThr: 3.249 ± 0.056
4.408GluVal: 4.408 ± 0.068
0.729GluTrp: 0.729 ± 0.027
2.283GluTyr: 2.283 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.338PheAla: 3.338 ± 0.055
0.45PheCys: 0.45 ± 0.023
3.008PheAsp: 3.008 ± 0.053
3.005PheGlu: 3.005 ± 0.049
2.565PhePhe: 2.565 ± 0.052
3.515PheGly: 3.515 ± 0.069
0.952PheHis: 0.952 ± 0.03
3.436PheIle: 3.436 ± 0.059
2.89PheLys: 2.89 ± 0.056
4.443PheLeu: 4.443 ± 0.064
1.183PheMet: 1.183 ± 0.029
2.58PheAsn: 2.58 ± 0.058
1.775PhePro: 1.775 ± 0.041
1.741PheGln: 1.741 ± 0.04
1.988PheArg: 1.988 ± 0.049
3.543PheSer: 3.543 ± 0.068
2.812PheThr: 2.812 ± 0.05
3.238PheVal: 3.238 ± 0.06
0.574PheTrp: 0.574 ± 0.027
2.079PheTyr: 2.079 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.661GlyAla: 4.661 ± 0.079
0.581GlyCys: 0.581 ± 0.023
3.383GlyAsp: 3.383 ± 0.059
3.952GlyGlu: 3.952 ± 0.067
3.368GlyPhe: 3.368 ± 0.062
4.788GlyGly: 4.788 ± 0.095
1.225GlyHis: 1.225 ± 0.032
5.307GlyIle: 5.307 ± 0.08
4.919GlyLys: 4.919 ± 0.068
6.313GlyLeu: 6.313 ± 0.085
1.759GlyMet: 1.759 ± 0.041
3.57GlyAsn: 3.57 ± 0.07
1.373GlyPro: 1.373 ± 0.043
2.435GlyGln: 2.435 ± 0.049
2.839GlyArg: 2.839 ± 0.061
4.002GlySer: 4.002 ± 0.07
4.032GlyThr: 4.032 ± 0.078
4.59GlyVal: 4.59 ± 0.07
0.862GlyTrp: 0.862 ± 0.031
3.125GlyTyr: 3.125 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.282HisAla: 1.282 ± 0.035
0.201HisCys: 0.201 ± 0.014
0.975HisAsp: 0.975 ± 0.033
1.082HisGlu: 1.082 ± 0.03
1.141HisPhe: 1.141 ± 0.038
1.163HisGly: 1.163 ± 0.034
0.545HisHis: 0.545 ± 0.024
1.703HisIle: 1.703 ± 0.034
1.084HisLys: 1.084 ± 0.037
1.946HisLeu: 1.946 ± 0.046
0.315HisMet: 0.315 ± 0.017
0.954HisAsn: 0.954 ± 0.03
1.006HisPro: 1.006 ± 0.032
0.82HisGln: 0.82 ± 0.028
0.938HisArg: 0.938 ± 0.028
1.109HisSer: 1.109 ± 0.03
1.121HisThr: 1.121 ± 0.034
1.125HisVal: 1.125 ± 0.031
0.271HisTrp: 0.271 ± 0.018
1.034HisTyr: 1.034 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.969IleAla: 5.969 ± 0.082
0.636IleCys: 0.636 ± 0.025
4.336IleAsp: 4.336 ± 0.06
4.618IleGlu: 4.618 ± 0.08
3.262IlePhe: 3.262 ± 0.062
5.17IleGly: 5.17 ± 0.078
1.503IleHis: 1.503 ± 0.042
4.954IleIle: 4.954 ± 0.075
4.433IleLys: 4.433 ± 0.066
6.612IleLeu: 6.612 ± 0.091
1.378IleMet: 1.378 ± 0.039
3.621IleAsn: 3.621 ± 0.061
3.226IlePro: 3.226 ± 0.055
2.906IleGln: 2.906 ± 0.052
3.136IleArg: 3.136 ± 0.051
4.812IleSer: 4.812 ± 0.074
3.982IleThr: 3.982 ± 0.064
4.733IleVal: 4.733 ± 0.068
0.688IleTrp: 0.688 ± 0.024
2.687IleTyr: 2.687 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.781LysAla: 4.781 ± 0.092
0.262LysCys: 0.262 ± 0.016
3.945LysAsp: 3.945 ± 0.058
5.27LysGlu: 5.27 ± 0.084
2.404LysPhe: 2.404 ± 0.043
4.382LysGly: 4.382 ± 0.076
1.405LysHis: 1.405 ± 0.036
4.699LysIle: 4.699 ± 0.074
5.011LysLys: 5.011 ± 0.083
5.714LysLeu: 5.714 ± 0.077
1.776LysMet: 1.776 ± 0.046
3.782LysAsn: 3.782 ± 0.069
2.389LysPro: 2.389 ± 0.046
2.792LysGln: 2.792 ± 0.056
2.934LysArg: 2.934 ± 0.055
3.942LysSer: 3.942 ± 0.061
3.772LysThr: 3.772 ± 0.069
4.422LysVal: 4.422 ± 0.06
0.694LysTrp: 0.694 ± 0.025
2.669LysTyr: 2.669 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.628LeuAla: 6.628 ± 0.099
0.782LeuCys: 0.782 ± 0.028
5.069LeuAsp: 5.069 ± 0.069
5.463LeuGlu: 5.463 ± 0.095
4.834LeuPhe: 4.834 ± 0.078
6.143LeuGly: 6.143 ± 0.076
1.925LeuHis: 1.925 ± 0.044
6.365LeuIle: 6.365 ± 0.1
6.316LeuLys: 6.316 ± 0.078
9.609LeuLeu: 9.609 ± 0.127
2.226LeuMet: 2.226 ± 0.05
4.893LeuAsn: 4.893 ± 0.071
3.905LeuPro: 3.905 ± 0.059
4.067LeuGln: 4.067 ± 0.076
4.141LeuArg: 4.141 ± 0.066
7.186LeuSer: 7.186 ± 0.091
5.367LeuThr: 5.367 ± 0.074
5.646LeuVal: 5.646 ± 0.088
0.908LeuTrp: 0.908 ± 0.026
3.626LeuTyr: 3.626 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
1.722MetAla: 1.722 ± 0.04
0.144MetCys: 0.144 ± 0.012
1.295MetAsp: 1.295 ± 0.036
1.609MetGlu: 1.609 ± 0.039
0.868MetPhe: 0.868 ± 0.03
1.559MetGly: 1.559 ± 0.043
0.47MetHis: 0.47 ± 0.019
1.433MetIle: 1.433 ± 0.036
1.903MetLys: 1.903 ± 0.043
2.256MetLeu: 2.256 ± 0.055
0.607MetMet: 0.607 ± 0.023
1.221MetAsn: 1.221 ± 0.033
0.981MetPro: 0.981 ± 0.028
0.999MetGln: 0.999 ± 0.029
1.056MetArg: 1.056 ± 0.029
1.438MetSer: 1.438 ± 0.038
1.233MetThr: 1.233 ± 0.036
1.468MetVal: 1.468 ± 0.038
0.229MetTrp: 0.229 ± 0.015
0.709MetTyr: 0.709 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.605AsnAla: 3.605 ± 0.067
0.294AsnCys: 0.294 ± 0.015
2.611AsnAsp: 2.611 ± 0.058
3.104AsnGlu: 3.104 ± 0.049
2.604AsnPhe: 2.604 ± 0.06
3.653AsnGly: 3.653 ± 0.072
1.002AsnHis: 1.002 ± 0.031
4.143AsnIle: 4.143 ± 0.063
3.433AsnLys: 3.433 ± 0.055
4.861AsnLeu: 4.861 ± 0.069
1.275AsnMet: 1.275 ± 0.031
3.078AsnAsn: 3.078 ± 0.075
2.601AsnPro: 2.601 ± 0.048
2.093AsnGln: 2.093 ± 0.051
2.56AsnArg: 2.56 ± 0.052
3.026AsnSer: 3.026 ± 0.059
3.153AsnThr: 3.153 ± 0.062
3.042AsnVal: 3.042 ± 0.054
0.703AsnTrp: 0.703 ± 0.028
2.329AsnTyr: 2.329 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.38ProAla: 2.38 ± 0.058
0.219ProCys: 0.219 ± 0.013
2.201ProAsp: 2.201 ± 0.057
2.857ProGlu: 2.857 ± 0.049
1.849ProPhe: 1.849 ± 0.043
2.028ProGly: 2.028 ± 0.049
0.745ProHis: 0.745 ± 0.026
2.604ProIle: 2.604 ± 0.053
2.241ProLys: 2.241 ± 0.043
3.256ProLeu: 3.256 ± 0.058
0.769ProMet: 0.769 ± 0.028
2.042ProAsn: 2.042 ± 0.049
0.857ProPro: 0.857 ± 0.03
1.465ProGln: 1.465 ± 0.042
1.112ProArg: 1.112 ± 0.031
2.229ProSer: 2.229 ± 0.047
2.23ProThr: 2.23 ± 0.041
2.571ProVal: 2.571 ± 0.048
0.415ProTrp: 0.415 ± 0.02
1.578ProTyr: 1.578 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.895GlnAla: 2.895 ± 0.048
0.201GlnCys: 0.201 ± 0.015
2.045GlnAsp: 2.045 ± 0.045
2.922GlnGlu: 2.922 ± 0.059
1.754GlnPhe: 1.754 ± 0.042
2.391GlnGly: 2.391 ± 0.045
0.957GlnHis: 0.957 ± 0.028
2.688GlnIle: 2.688 ± 0.052
2.744GlnLys: 2.744 ± 0.057
3.94GlnLeu: 3.94 ± 0.072
0.936GlnMet: 0.936 ± 0.032
2.057GlnAsn: 2.057 ± 0.045
1.303GlnPro: 1.303 ± 0.036
2.405GlnGln: 2.405 ± 0.054
1.84GlnArg: 1.84 ± 0.045
2.228GlnSer: 2.228 ± 0.046
2.19GlnThr: 2.19 ± 0.039
2.506GlnVal: 2.506 ± 0.048
0.492GlnTrp: 0.492 ± 0.022
1.699GlnTyr: 1.699 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.626ArgAla: 2.626 ± 0.048
0.225ArgCys: 0.225 ± 0.016
2.241ArgAsp: 2.241 ± 0.042
2.829ArgGlu: 2.829 ± 0.051
2.206ArgPhe: 2.206 ± 0.042
2.404ArgGly: 2.404 ± 0.048
0.812ArgHis: 0.812 ± 0.025
3.372ArgIle: 3.372 ± 0.052
3.03ArgLys: 3.03 ± 0.05
4.141ArgLeu: 4.141 ± 0.066
1.151ArgMet: 1.151 ± 0.028
2.392ArgAsn: 2.392 ± 0.043
1.397ArgPro: 1.397 ± 0.033
1.656ArgGln: 1.656 ± 0.045
1.828ArgArg: 1.828 ± 0.043
2.401ArgSer: 2.401 ± 0.047
2.318ArgThr: 2.318 ± 0.039
2.642ArgVal: 2.642 ± 0.05
0.567ArgTrp: 0.567 ± 0.023
2.085ArgTyr: 2.085 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.379SerAla: 4.379 ± 0.065
0.576SerCys: 0.576 ± 0.022
3.261SerAsp: 3.261 ± 0.052
3.344SerGlu: 3.344 ± 0.053
3.542SerPhe: 3.542 ± 0.064
4.368SerGly: 4.368 ± 0.074
1.151SerHis: 1.151 ± 0.035
4.707SerIle: 4.707 ± 0.07
3.825SerLys: 3.825 ± 0.055
6.291SerLeu: 6.291 ± 0.092
1.326SerMet: 1.326 ± 0.034
3.131SerAsn: 3.131 ± 0.06
2.317SerPro: 2.317 ± 0.05
2.052SerGln: 2.052 ± 0.039
2.572SerArg: 2.572 ± 0.055
4.092SerSer: 4.092 ± 0.076
3.532SerThr: 3.532 ± 0.054
4.13SerVal: 4.13 ± 0.069
0.705SerTrp: 0.705 ± 0.028
2.71SerTyr: 2.71 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.26ThrAla: 4.26 ± 0.071
0.339ThrCys: 0.339 ± 0.018
3.222ThrAsp: 3.222 ± 0.062
3.421ThrGlu: 3.421 ± 0.055
2.876ThrPhe: 2.876 ± 0.056
4.14ThrGly: 4.14 ± 0.08
1.084ThrHis: 1.084 ± 0.03
4.097ThrIle: 4.097 ± 0.066
3.288ThrLys: 3.288 ± 0.047
5.505ThrLeu: 5.505 ± 0.075
1.039ThrMet: 1.039 ± 0.032
2.729ThrAsn: 2.729 ± 0.057
2.405ThrPro: 2.405 ± 0.06
1.912ThrGln: 1.912 ± 0.041
1.805ThrArg: 1.805 ± 0.048
3.379ThrSer: 3.379 ± 0.057
3.235ThrThr: 3.235 ± 0.062
3.995ThrVal: 3.995 ± 0.085
0.615ThrTrp: 0.615 ± 0.023
2.463ThrTyr: 2.463 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
4.676ValAla: 4.676 ± 0.075
0.554ValCys: 0.554 ± 0.021
3.944ValAsp: 3.944 ± 0.065
4.156ValGlu: 4.156 ± 0.062
3.183ValPhe: 3.183 ± 0.063
4.372ValGly: 4.372 ± 0.072
1.208ValHis: 1.208 ± 0.039
4.32ValIle: 4.32 ± 0.063
4.17ValLys: 4.17 ± 0.064
6.372ValLeu: 6.372 ± 0.095
1.485ValMet: 1.485 ± 0.039
3.436ValAsn: 3.436 ± 0.062
2.334ValPro: 2.334 ± 0.042
2.481ValGln: 2.481 ± 0.042
2.745ValArg: 2.745 ± 0.058
4.38ValSer: 4.38 ± 0.066
3.478ValThr: 3.478 ± 0.083
4.629ValVal: 4.629 ± 0.082
0.745ValTrp: 0.745 ± 0.026
2.62ValTyr: 2.62 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.739TrpAla: 0.739 ± 0.026
0.11TrpCys: 0.11 ± 0.009
0.674TrpAsp: 0.674 ± 0.026
0.743TrpGlu: 0.743 ± 0.027
0.554TrpPhe: 0.554 ± 0.026
0.83TrpGly: 0.83 ± 0.029
0.231TrpHis: 0.231 ± 0.015
0.759TrpIle: 0.759 ± 0.027
0.802TrpLys: 0.802 ± 0.027
1.082TrpLeu: 1.082 ± 0.031
0.357TrpMet: 0.357 ± 0.017
0.709TrpAsn: 0.709 ± 0.029
0.263TrpPro: 0.263 ± 0.016
0.52TrpGln: 0.52 ± 0.023
0.537TrpArg: 0.537 ± 0.022
0.683TrpSer: 0.683 ± 0.027
0.618TrpThr: 0.618 ± 0.024
0.704TrpVal: 0.704 ± 0.024
0.159TrpTrp: 0.159 ± 0.015
0.47TrpTyr: 0.47 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.978TyrAla: 2.978 ± 0.057
0.339TyrCys: 0.339 ± 0.018
2.381TyrAsp: 2.381 ± 0.049
2.375TyrGlu: 2.375 ± 0.045
2.376TyrPhe: 2.376 ± 0.051
2.81TyrGly: 2.81 ± 0.051
0.918TyrHis: 0.918 ± 0.03
2.779TyrIle: 2.779 ± 0.049
2.557TyrLys: 2.557 ± 0.048
3.874TyrLeu: 3.874 ± 0.069
0.858TyrMet: 0.858 ± 0.026
2.394TyrAsn: 2.394 ± 0.049
1.654TyrPro: 1.654 ± 0.043
1.796TyrGln: 1.796 ± 0.046
2.026TyrArg: 2.026 ± 0.047
2.582TyrSer: 2.582 ± 0.052
2.533TyrThr: 2.533 ± 0.069
2.44TyrVal: 2.44 ± 0.046
0.509TyrTrp: 0.509 ± 0.022
1.952TyrTyr: 1.952 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3412 proteins (1141595 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski