Amino acid dipepetide frequency for Mesoplasma corruscae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.804AlaAla: 2.804 ± 0.154
0.38AlaCys: 0.38 ± 0.041
2.252AlaAsp: 2.252 ± 0.109
2.948AlaGlu: 2.948 ± 0.155
2.624AlaPhe: 2.624 ± 0.097
2.848AlaGly: 2.848 ± 0.128
0.74AlaHis: 0.74 ± 0.063
5.504AlaIle: 5.504 ± 0.188
5.472AlaLys: 5.472 ± 0.285
5.18AlaLeu: 5.18 ± 0.194
1.196AlaMet: 1.196 ± 0.085
3.112AlaAsn: 3.112 ± 0.116
1.164AlaPro: 1.164 ± 0.079
1.464AlaGln: 1.464 ± 0.079
1.628AlaArg: 1.628 ± 0.09
3.392AlaSer: 3.392 ± 0.13
2.912AlaThr: 2.912 ± 0.157
2.796AlaVal: 2.796 ± 0.128
0.484AlaTrp: 0.484 ± 0.053
2.088AlaTyr: 2.088 ± 0.115
0.0AlaXaa: 0.0 ± 0.0
Cys
0.288CysAla: 0.288 ± 0.033
0.072CysCys: 0.072 ± 0.017
0.384CysAsp: 0.384 ± 0.037
0.444CysGlu: 0.444 ± 0.044
0.408CysPhe: 0.408 ± 0.048
0.392CysGly: 0.392 ± 0.041
0.08CysHis: 0.08 ± 0.02
0.552CysIle: 0.552 ± 0.052
0.452CysLys: 0.452 ± 0.046
0.584CysLeu: 0.584 ± 0.053
0.14CysMet: 0.14 ± 0.024
0.336CysAsn: 0.336 ± 0.039
0.148CysPro: 0.148 ± 0.027
0.2CysGln: 0.2 ± 0.032
0.132CysArg: 0.132 ± 0.025
0.448CysSer: 0.448 ± 0.047
0.272CysThr: 0.272 ± 0.034
0.396CysVal: 0.396 ± 0.037
0.076CysTrp: 0.076 ± 0.019
0.268CysTyr: 0.268 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.692AspAla: 2.692 ± 0.14
0.312AspCys: 0.312 ± 0.033
2.536AspAsp: 2.536 ± 0.116
3.876AspGlu: 3.876 ± 0.135
3.82AspPhe: 3.82 ± 0.21
2.732AspGly: 2.732 ± 0.108
0.664AspHis: 0.664 ± 0.05
5.572AspIle: 5.572 ± 0.212
5.216AspLys: 5.216 ± 0.145
6.192AspLeu: 6.192 ± 0.405
1.088AspMet: 1.088 ± 0.067
3.148AspAsn: 3.148 ± 0.143
1.276AspPro: 1.276 ± 0.07
1.984AspGln: 1.984 ± 0.085
1.136AspArg: 1.136 ± 0.067
3.316AspSer: 3.316 ± 0.106
2.284AspThr: 2.284 ± 0.122
3.088AspVal: 3.088 ± 0.144
0.604AspTrp: 0.604 ± 0.055
2.312AspTyr: 2.312 ± 0.112
0.0AspXaa: 0.0 ± 0.0
Glu
3.4GluAla: 3.4 ± 0.163
0.264GluCys: 0.264 ± 0.034
2.928GluAsp: 2.928 ± 0.14
4.928GluGlu: 4.928 ± 0.213
3.604GluPhe: 3.604 ± 0.119
2.676GluGly: 2.676 ± 0.117
0.808GluHis: 0.808 ± 0.067
7.973GluIle: 7.973 ± 0.2
6.876GluLys: 6.876 ± 0.181
6.58GluLeu: 6.58 ± 0.192
1.648GluMet: 1.648 ± 0.092
5.188GluAsn: 5.188 ± 0.156
1.224GluPro: 1.224 ± 0.082
2.552GluGln: 2.552 ± 0.145
1.648GluArg: 1.648 ± 0.091
3.728GluSer: 3.728 ± 0.128
3.052GluThr: 3.052 ± 0.117
4.168GluVal: 4.168 ± 0.152
0.732GluTrp: 0.732 ± 0.061
2.504GluTyr: 2.504 ± 0.107
0.0GluXaa: 0.0 ± 0.0
Phe
3.052PheAla: 3.052 ± 0.108
0.356PheCys: 0.356 ± 0.038
3.324PheAsp: 3.324 ± 0.129
3.788PheGlu: 3.788 ± 0.129
2.744PhePhe: 2.744 ± 0.137
2.728PheGly: 2.728 ± 0.121
0.528PheHis: 0.528 ± 0.05
5.608PheIle: 5.608 ± 0.215
5.416PheLys: 5.416 ± 0.165
4.776PheLeu: 4.776 ± 0.189
1.028PheMet: 1.028 ± 0.065
4.304PheAsn: 4.304 ± 0.251
0.912PhePro: 0.912 ± 0.066
1.404PheGln: 1.404 ± 0.085
1.144PheArg: 1.144 ± 0.071
3.952PheSer: 3.952 ± 0.123
2.58PheThr: 2.58 ± 0.109
3.192PheVal: 3.192 ± 0.121
0.7PheTrp: 0.7 ± 0.058
1.972PheTyr: 1.972 ± 0.106
0.0PheXaa: 0.0 ± 0.0
Gly
2.712GlyAla: 2.712 ± 0.109
0.328GlyCys: 0.328 ± 0.038
2.856GlyAsp: 2.856 ± 0.139
3.0GlyGlu: 3.0 ± 0.133
2.752GlyPhe: 2.752 ± 0.129
2.992GlyGly: 2.992 ± 0.143
0.78GlyHis: 0.78 ± 0.064
5.612GlyIle: 5.612 ± 0.234
4.168GlyLys: 4.168 ± 0.149
4.424GlyLeu: 4.424 ± 0.185
1.224GlyMet: 1.224 ± 0.068
2.692GlyAsn: 2.692 ± 0.129
1.072GlyPro: 1.072 ± 0.062
1.552GlyGln: 1.552 ± 0.086
1.5GlyArg: 1.5 ± 0.102
3.28GlySer: 3.28 ± 0.129
2.692GlyThr: 2.692 ± 0.118
3.704GlyVal: 3.704 ± 0.162
0.616GlyTrp: 0.616 ± 0.055
2.184GlyTyr: 2.184 ± 0.098
0.0GlyXaa: 0.0 ± 0.0
His
0.7HisAla: 0.7 ± 0.063
0.068HisCys: 0.068 ± 0.018
0.72HisAsp: 0.72 ± 0.069
0.868HisGlu: 0.868 ± 0.06
0.708HisPhe: 0.708 ± 0.052
0.716HisGly: 0.716 ± 0.067
0.292HisHis: 0.292 ± 0.033
1.228HisIle: 1.228 ± 0.073
1.184HisLys: 1.184 ± 0.073
1.196HisLeu: 1.196 ± 0.082
0.228HisMet: 0.228 ± 0.033
0.888HisAsn: 0.888 ± 0.065
0.504HisPro: 0.504 ± 0.047
0.472HisGln: 0.472 ± 0.043
0.392HisArg: 0.392 ± 0.04
0.84HisSer: 0.84 ± 0.06
0.552HisThr: 0.552 ± 0.05
0.632HisVal: 0.632 ± 0.057
0.144HisTrp: 0.144 ± 0.024
0.496HisTyr: 0.496 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.368IleAla: 5.368 ± 0.156
0.912IleCys: 0.912 ± 0.078
5.964IleAsp: 5.964 ± 0.177
6.728IleGlu: 6.728 ± 0.179
5.288IlePhe: 5.288 ± 0.192
5.152IleGly: 5.152 ± 0.176
1.124IleHis: 1.124 ± 0.075
10.313IleIle: 10.313 ± 0.282
10.657IleLys: 10.657 ± 0.252
9.353IleLeu: 9.353 ± 0.246
1.824IleMet: 1.824 ± 0.095
8.177IleAsn: 8.177 ± 0.231
2.876IlePro: 2.876 ± 0.116
3.092IleGln: 3.092 ± 0.128
2.444IleArg: 2.444 ± 0.118
8.409IleSer: 8.409 ± 0.31
5.912IleThr: 5.912 ± 0.352
6.292IleVal: 6.292 ± 0.149
0.688IleTrp: 0.688 ± 0.067
3.64IleTyr: 3.64 ± 0.128
0.0IleXaa: 0.0 ± 0.0
Lys
4.768LysAla: 4.768 ± 0.177
0.424LysCys: 0.424 ± 0.043
5.824LysAsp: 5.824 ± 0.182
7.937LysGlu: 7.937 ± 0.2
3.988LysPhe: 3.988 ± 0.142
3.788LysGly: 3.788 ± 0.14
1.4LysHis: 1.4 ± 0.086
10.317LysIle: 10.317 ± 0.226
10.669LysLys: 10.669 ± 0.276
8.161LysLeu: 8.161 ± 0.21
2.532LysMet: 2.532 ± 0.105
8.641LysAsn: 8.641 ± 0.24
2.544LysPro: 2.544 ± 0.099
3.9LysGln: 3.9 ± 0.138
2.848LysArg: 2.848 ± 0.135
5.916LysSer: 5.916 ± 0.191
6.52LysThr: 6.52 ± 0.268
5.92LysVal: 5.92 ± 0.17
1.064LysTrp: 1.064 ± 0.075
4.152LysTyr: 4.152 ± 0.15
0.0LysXaa: 0.0 ± 0.0
Leu
4.732LeuAla: 4.732 ± 0.136
0.572LeuCys: 0.572 ± 0.055
5.324LeuAsp: 5.324 ± 0.201
5.952LeuGlu: 5.952 ± 0.171
4.9LeuPhe: 4.9 ± 0.202
4.336LeuGly: 4.336 ± 0.134
1.14LeuHis: 1.14 ± 0.077
9.677LeuIle: 9.677 ± 0.22
9.877LeuLys: 9.877 ± 0.208
8.045LeuLeu: 8.045 ± 0.226
1.936LeuMet: 1.936 ± 0.094
7.445LeuAsn: 7.445 ± 0.215
2.472LeuPro: 2.472 ± 0.094
2.684LeuGln: 2.684 ± 0.109
2.396LeuArg: 2.396 ± 0.107
7.048LeuSer: 7.048 ± 0.191
5.868LeuThr: 5.868 ± 0.382
5.316LeuVal: 5.316 ± 0.127
0.84LeuTrp: 0.84 ± 0.062
2.504LeuTyr: 2.504 ± 0.107
0.0LeuXaa: 0.0 ± 0.0
Met
1.164MetAla: 1.164 ± 0.076
0.108MetCys: 0.108 ± 0.023
0.924MetAsp: 0.924 ± 0.058
0.912MetGlu: 0.912 ± 0.057
1.548MetPhe: 1.548 ± 0.125
1.268MetGly: 1.268 ± 0.084
0.348MetHis: 0.348 ± 0.04
2.16MetIle: 2.16 ± 0.108
2.12MetLys: 2.12 ± 0.096
1.896MetLeu: 1.896 ± 0.091
0.428MetMet: 0.428 ± 0.043
1.416MetAsn: 1.416 ± 0.081
0.624MetPro: 0.624 ± 0.052
0.712MetGln: 0.712 ± 0.055
0.564MetArg: 0.564 ± 0.052
1.86MetSer: 1.86 ± 0.093
0.916MetThr: 0.916 ± 0.063
1.192MetVal: 1.192 ± 0.069
0.144MetTrp: 0.144 ± 0.025
0.588MetTyr: 0.588 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.372AsnAla: 3.372 ± 0.14
0.408AsnCys: 0.408 ± 0.043
4.424AsnAsp: 4.424 ± 0.229
5.284AsnGlu: 5.284 ± 0.179
4.124AsnPhe: 4.124 ± 0.145
3.448AsnGly: 3.448 ± 0.121
1.008AsnHis: 1.008 ± 0.072
7.296AsnIle: 7.296 ± 0.21
8.785AsnLys: 8.785 ± 0.198
6.8AsnLeu: 6.8 ± 0.244
1.376AsnMet: 1.376 ± 0.098
6.216AsnAsn: 6.216 ± 0.183
1.904AsnPro: 1.904 ± 0.099
3.208AsnGln: 3.208 ± 0.159
1.508AsnArg: 1.508 ± 0.085
4.752AsnSer: 4.752 ± 0.189
2.972AsnThr: 2.972 ± 0.106
3.844AsnVal: 3.844 ± 0.12
1.068AsnTrp: 1.068 ± 0.108
3.068AsnTyr: 3.068 ± 0.131
0.0AsnXaa: 0.0 ± 0.0
Pro
1.124ProAla: 1.124 ± 0.071
0.12ProCys: 0.12 ± 0.019
1.02ProAsp: 1.02 ± 0.064
1.824ProGlu: 1.824 ± 0.102
1.356ProPhe: 1.356 ± 0.08
1.384ProGly: 1.384 ± 0.088
0.4ProHis: 0.4 ± 0.044
2.764ProIle: 2.764 ± 0.128
2.2ProLys: 2.2 ± 0.104
2.264ProLeu: 2.264 ± 0.11
0.448ProMet: 0.448 ± 0.043
1.688ProAsn: 1.688 ± 0.097
0.5ProPro: 0.5 ± 0.049
0.688ProGln: 0.688 ± 0.056
0.584ProArg: 0.584 ± 0.051
1.848ProSer: 1.848 ± 0.094
1.448ProThr: 1.448 ± 0.082
1.604ProVal: 1.604 ± 0.085
0.248ProTrp: 0.248 ± 0.029
0.86ProTyr: 0.86 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
1.792GlnAla: 1.792 ± 0.097
0.104GlnCys: 0.104 ± 0.021
1.656GlnAsp: 1.656 ± 0.107
2.416GlnGlu: 2.416 ± 0.099
1.36GlnPhe: 1.36 ± 0.077
1.504GlnGly: 1.504 ± 0.112
0.328GlnHis: 0.328 ± 0.044
3.652GlnIle: 3.652 ± 0.142
3.492GlnLys: 3.492 ± 0.122
3.068GlnLeu: 3.068 ± 0.118
0.664GlnMet: 0.664 ± 0.05
2.656GlnAsn: 2.656 ± 0.114
0.776GlnPro: 0.776 ± 0.05
1.332GlnGln: 1.332 ± 0.084
0.988GlnArg: 0.988 ± 0.065
1.824GlnSer: 1.824 ± 0.087
1.972GlnThr: 1.972 ± 0.095
1.872GlnVal: 1.872 ± 0.126
0.332GlnTrp: 0.332 ± 0.039
1.16GlnTyr: 1.16 ± 0.074
0.0GlnXaa: 0.0 ± 0.0
Arg
1.38ArgAla: 1.38 ± 0.088
0.144ArgCys: 0.144 ± 0.026
1.232ArgAsp: 1.232 ± 0.081
1.7ArgGlu: 1.7 ± 0.09
1.26ArgPhe: 1.26 ± 0.074
1.26ArgGly: 1.26 ± 0.079
0.356ArgHis: 0.356 ± 0.038
3.004ArgIle: 3.004 ± 0.137
2.572ArgLys: 2.572 ± 0.118
2.128ArgLeu: 2.128 ± 0.119
0.756ArgMet: 0.756 ± 0.06
1.856ArgAsn: 1.856 ± 0.089
0.756ArgPro: 0.756 ± 0.066
0.896ArgGln: 0.896 ± 0.065
0.944ArgArg: 0.944 ± 0.071
1.416ArgSer: 1.416 ± 0.075
1.444ArgThr: 1.444 ± 0.084
1.636ArgVal: 1.636 ± 0.09
0.232ArgTrp: 0.232 ± 0.036
0.976ArgTyr: 0.976 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
3.468SerAla: 3.468 ± 0.218
0.404SerCys: 0.404 ± 0.043
3.412SerAsp: 3.412 ± 0.15
4.032SerGlu: 4.032 ± 0.152
4.244SerPhe: 4.244 ± 0.162
3.66SerGly: 3.66 ± 0.123
0.864SerHis: 0.864 ± 0.057
6.876SerIle: 6.876 ± 0.175
7.136SerLys: 7.136 ± 0.206
6.64SerLeu: 6.64 ± 0.211
1.22SerMet: 1.22 ± 0.08
5.332SerAsn: 5.332 ± 0.286
1.444SerPro: 1.444 ± 0.074
2.08SerGln: 2.08 ± 0.1
1.876SerArg: 1.876 ± 0.109
5.14SerSer: 5.14 ± 0.189
3.584SerThr: 3.584 ± 0.14
4.16SerVal: 4.16 ± 0.214
0.784SerTrp: 0.784 ± 0.058
2.552SerTyr: 2.552 ± 0.124
0.0SerXaa: 0.0 ± 0.0
Thr
2.576ThrAla: 2.576 ± 0.146
0.252ThrCys: 0.252 ± 0.034
2.74ThrAsp: 2.74 ± 0.24
2.544ThrGlu: 2.544 ± 0.097
2.808ThrPhe: 2.808 ± 0.122
3.512ThrGly: 3.512 ± 0.258
0.692ThrHis: 0.692 ± 0.058
5.944ThrIle: 5.944 ± 0.164
5.052ThrLys: 5.052 ± 0.143
5.3ThrLeu: 5.3 ± 0.223
0.86ThrMet: 0.86 ± 0.066
4.136ThrAsn: 4.136 ± 0.144
1.696ThrPro: 1.696 ± 0.094
1.776ThrGln: 1.776 ± 0.137
1.332ThrArg: 1.332 ± 0.066
4.088ThrSer: 4.088 ± 0.171
3.184ThrThr: 3.184 ± 0.147
2.764ThrVal: 2.764 ± 0.122
0.448ThrTrp: 0.448 ± 0.049
1.772ThrTyr: 1.772 ± 0.089
0.0ThrXaa: 0.0 ± 0.0
Val
3.28ValAla: 3.28 ± 0.157
0.504ValCys: 0.504 ± 0.049
3.288ValAsp: 3.288 ± 0.119
4.212ValGlu: 4.212 ± 0.159
3.26ValPhe: 3.26 ± 0.133
3.244ValGly: 3.244 ± 0.164
0.68ValHis: 0.68 ± 0.048
5.784ValIle: 5.784 ± 0.188
5.336ValLys: 5.336 ± 0.176
5.964ValLeu: 5.964 ± 0.226
1.244ValMet: 1.244 ± 0.077
3.812ValAsn: 3.812 ± 0.13
1.508ValPro: 1.508 ± 0.083
1.516ValGln: 1.516 ± 0.088
1.612ValArg: 1.612 ± 0.139
4.18ValSer: 4.18 ± 0.131
3.064ValThr: 3.064 ± 0.143
3.756ValVal: 3.756 ± 0.153
0.548ValTrp: 0.548 ± 0.043
1.96ValTyr: 1.96 ± 0.095
0.0ValXaa: 0.0 ± 0.0
Trp
0.472TrpAla: 0.472 ± 0.044
0.06TrpCys: 0.06 ± 0.015
0.812TrpAsp: 0.812 ± 0.111
0.604TrpGlu: 0.604 ± 0.049
0.532TrpPhe: 0.532 ± 0.043
0.424TrpGly: 0.424 ± 0.041
0.084TrpHis: 0.084 ± 0.021
1.096TrpIle: 1.096 ± 0.081
0.884TrpLys: 0.884 ± 0.058
0.928TrpLeu: 0.928 ± 0.068
0.324TrpMet: 0.324 ± 0.037
1.008TrpAsn: 1.008 ± 0.087
0.176TrpPro: 0.176 ± 0.028
0.232TrpGln: 0.232 ± 0.028
0.252TrpArg: 0.252 ± 0.031
0.696TrpSer: 0.696 ± 0.051
0.584TrpThr: 0.584 ± 0.051
0.628TrpVal: 0.628 ± 0.063
0.164TrpTrp: 0.164 ± 0.027
0.348TrpTyr: 0.348 ± 0.047
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.844TyrAla: 1.844 ± 0.089
0.28TyrCys: 0.28 ± 0.033
2.228TyrAsp: 2.228 ± 0.108
2.484TyrGlu: 2.484 ± 0.101
2.18TyrPhe: 2.18 ± 0.116
2.076TyrGly: 2.076 ± 0.136
0.512TyrHis: 0.512 ± 0.05
3.28TyrIle: 3.28 ± 0.126
3.752TyrLys: 3.752 ± 0.13
3.584TyrLeu: 3.584 ± 0.14
0.724TyrMet: 0.724 ± 0.058
2.816TyrAsn: 2.816 ± 0.122
0.796TyrPro: 0.796 ± 0.052
1.204TyrGln: 1.204 ± 0.07
1.02TyrArg: 1.02 ± 0.064
2.776TyrSer: 2.776 ± 0.13
1.664TyrThr: 1.664 ± 0.085
1.792TyrVal: 1.792 ± 0.092
0.392TyrTrp: 0.392 ± 0.042
1.62TyrTyr: 1.62 ± 0.138
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 701 proteins (249984 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski